Amino acid dipepetide frequency for Primorskyibacter insulae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.682AlaAla: 15.682 ± 0.17	1.061AlaCys: 1.061 ± 0.034	7.323AlaAsp: 7.323 ± 0.092	7.706AlaGlu: 7.706 ± 0.132	4.177AlaPhe: 4.177 ± 0.06	10.192AlaGly: 10.192 ± 0.128	2.231AlaHis: 2.231 ± 0.046	5.928AlaIle: 5.928 ± 0.083	4.517AlaLys: 4.517 ± 0.077	13.084AlaLeu: 13.084 ± 0.135	4.012AlaMet: 4.012 ± 0.066	3.057AlaAsn: 3.057 ± 0.047	5.776AlaPro: 5.776 ± 0.101	4.697AlaGln: 4.697 ± 0.078	7.633AlaArg: 7.633 ± 0.107	5.603AlaSer: 5.603 ± 0.068	6.019AlaThr: 6.019 ± 0.081	8.069AlaVal: 8.069 ± 0.094	1.358AlaTrp: 1.358 ± 0.036	2.611AlaTyr: 2.611 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.024CysAla: 1.024 ± 0.035	0.09CysCys: 0.09 ± 0.01	0.652CysAsp: 0.652 ± 0.024	0.402CysGlu: 0.402 ± 0.021	0.351CysPhe: 0.351 ± 0.019	0.877CysGly: 0.877 ± 0.028	0.266CysHis: 0.266 ± 0.018	0.405CysIle: 0.405 ± 0.02	0.231CysLys: 0.231 ± 0.013	0.808CysLeu: 0.808 ± 0.025	0.186CysMet: 0.186 ± 0.012	0.236CysAsn: 0.236 ± 0.016	0.504CysPro: 0.504 ± 0.02	0.276CysGln: 0.276 ± 0.014	0.508CysArg: 0.508 ± 0.026	0.45CysSer: 0.45 ± 0.021	0.485CysThr: 0.485 ± 0.022	0.625CysVal: 0.625 ± 0.022	0.107CysTrp: 0.107 ± 0.009	0.203CysTyr: 0.203 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.577AspAla: 7.577 ± 0.087	0.582AspCys: 0.582 ± 0.025	4.038AspAsp: 4.038 ± 0.097	3.579AspGlu: 3.579 ± 0.067	2.343AspPhe: 2.343 ± 0.04	6.256AspGly: 6.256 ± 0.127	1.454AspHis: 1.454 ± 0.031	3.24AspIle: 3.24 ± 0.054	1.977AspLys: 1.977 ± 0.04	7.131AspLeu: 7.131 ± 0.091	1.796AspMet: 1.796 ± 0.04	1.427AspAsn: 1.427 ± 0.04	3.437AspPro: 3.437 ± 0.058	2.237AspGln: 2.237 ± 0.05	4.218AspArg: 4.218 ± 0.068	2.365AspSer: 2.365 ± 0.061	3.691AspThr: 3.691 ± 0.113	4.583AspVal: 4.583 ± 0.066	1.228AspTrp: 1.228 ± 0.036	1.636AspTyr: 1.636 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	8.182GluAla: 8.182 ± 0.133	0.364GluCys: 0.364 ± 0.016	3.481GluAsp: 3.481 ± 0.063	3.215GluGlu: 3.215 ± 0.066	1.837GluPhe: 1.837 ± 0.04	4.545GluGly: 4.545 ± 0.066	1.063GluHis: 1.063 ± 0.032	3.372GluIle: 3.372 ± 0.059	2.103GluLys: 2.103 ± 0.051	5.018GluLeu: 5.018 ± 0.065	1.73GluMet: 1.73 ± 0.037	1.717GluAsn: 1.717 ± 0.04	2.316GluPro: 2.316 ± 0.051	1.942GluGln: 1.942 ± 0.046	3.676GluArg: 3.676 ± 0.063	2.087GluSer: 2.087 ± 0.042	3.577GluThr: 3.577 ± 0.057	4.2GluVal: 4.2 ± 0.06	0.666GluTrp: 0.666 ± 0.024	1.069GluTyr: 1.069 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.354PheAla: 4.354 ± 0.064	0.387PheCys: 0.387 ± 0.022	2.977PheAsp: 2.977 ± 0.05	2.219PheGlu: 2.219 ± 0.043	1.399PhePhe: 1.399 ± 0.042	3.829PheGly: 3.829 ± 0.059	0.779PheHis: 0.779 ± 0.024	1.691PheIle: 1.691 ± 0.042	1.015PheLys: 1.015 ± 0.03	3.294PheLeu: 3.294 ± 0.064	0.917PheMet: 0.917 ± 0.032	1.173PheAsn: 1.173 ± 0.034	1.49PhePro: 1.49 ± 0.038	1.094PheGln: 1.094 ± 0.027	2.047PheArg: 2.047 ± 0.049	2.085PheSer: 2.085 ± 0.04	2.085PheThr: 2.085 ± 0.041	2.64PheVal: 2.64 ± 0.042	0.526PheTrp: 0.526 ± 0.019	0.978PheTyr: 0.978 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.968GlyAla: 9.968 ± 0.137	0.844GlyCys: 0.844 ± 0.031	5.491GlyAsp: 5.491 ± 0.127	4.252GlyGlu: 4.252 ± 0.068	3.651GlyPhe: 3.651 ± 0.063	8.035GlyGly: 8.035 ± 0.202	1.969GlyHis: 1.969 ± 0.042	4.506GlyIle: 4.506 ± 0.064	3.42GlyLys: 3.42 ± 0.06	9.022GlyLeu: 9.022 ± 0.103	2.499GlyMet: 2.499 ± 0.05	2.725GlyAsn: 2.725 ± 0.112	3.447GlyPro: 3.447 ± 0.056	3.536GlyGln: 3.536 ± 0.059	5.324GlyArg: 5.324 ± 0.065	4.316GlySer: 4.316 ± 0.089	4.996GlyThr: 4.996 ± 0.123	6.325GlyVal: 6.325 ± 0.074	1.398GlyTrp: 1.398 ± 0.035	2.379GlyTyr: 2.379 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.189HisAla: 2.189 ± 0.047	0.218HisCys: 0.218 ± 0.014	1.258HisAsp: 1.258 ± 0.032	1.017HisGlu: 1.017 ± 0.031	0.828HisPhe: 0.828 ± 0.026	1.957HisGly: 1.957 ± 0.049	0.53HisHis: 0.53 ± 0.023	1.021HisIle: 1.021 ± 0.031	0.585HisLys: 0.585 ± 0.023	2.068HisLeu: 2.068 ± 0.044	0.579HisMet: 0.579 ± 0.024	0.501HisAsn: 0.501 ± 0.02	1.322HisPro: 1.322 ± 0.033	0.639HisGln: 0.639 ± 0.021	1.264HisArg: 1.264 ± 0.035	0.987HisSer: 0.987 ± 0.028	0.863HisThr: 0.863 ± 0.029	1.522HisVal: 1.522 ± 0.034	0.358HisTrp: 0.358 ± 0.016	0.536HisTyr: 0.536 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.925IleAla: 6.925 ± 0.065	0.599IleCys: 0.599 ± 0.025	3.67IleAsp: 3.67 ± 0.058	3.638IleGlu: 3.638 ± 0.056	1.755IlePhe: 1.755 ± 0.05	5.053IleGly: 5.053 ± 0.074	0.915IleHis: 0.915 ± 0.028	2.247IleIle: 2.247 ± 0.051	1.579IleLys: 1.579 ± 0.043	4.744IleLeu: 4.744 ± 0.068	1.076IleMet: 1.076 ± 0.03	1.503IleAsn: 1.503 ± 0.038	2.357IlePro: 2.357 ± 0.049	1.311IleGln: 1.311 ± 0.029	3.088IleArg: 3.088 ± 0.05	2.951IleSer: 2.951 ± 0.051	3.021IleThr: 3.021 ± 0.054	3.853IleVal: 3.853 ± 0.059	0.723IleTrp: 0.723 ± 0.025	1.219IleTyr: 1.219 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.534LysAla: 4.534 ± 0.08	0.19LysCys: 0.19 ± 0.011	2.037LysAsp: 2.037 ± 0.045	1.572LysGlu: 1.572 ± 0.041	1.065LysPhe: 1.065 ± 0.033	3.011LysGly: 3.011 ± 0.052	0.625LysHis: 0.625 ± 0.023	1.785LysIle: 1.785 ± 0.047	1.307LysLys: 1.307 ± 0.043	3.123LysLeu: 3.123 ± 0.056	1.008LysMet: 1.008 ± 0.028	0.852LysAsn: 0.852 ± 0.03	1.96LysPro: 1.96 ± 0.047	0.996LysGln: 0.996 ± 0.032	2.338LysArg: 2.338 ± 0.043	1.995LysSer: 1.995 ± 0.044	2.197LysThr: 2.197 ± 0.048	2.516LysVal: 2.516 ± 0.055	0.412LysTrp: 0.412 ± 0.018	0.685LysTyr: 0.685 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	12.178LeuAla: 12.178 ± 0.127	0.919LeuCys: 0.919 ± 0.035	6.053LeuAsp: 6.053 ± 0.081	5.176LeuGlu: 5.176 ± 0.073	3.444LeuPhe: 3.444 ± 0.062	8.23LeuGly: 8.23 ± 0.094	1.892LeuHis: 1.892 ± 0.04	5.266LeuIle: 5.266 ± 0.076	3.378LeuLys: 3.378 ± 0.064	8.376LeuLeu: 8.376 ± 0.124	2.746LeuMet: 2.746 ± 0.062	3.029LeuAsn: 3.029 ± 0.053	5.387LeuPro: 5.387 ± 0.077	2.813LeuGln: 2.813 ± 0.056	6.849LeuArg: 6.849 ± 0.084	6.466LeuSer: 6.466 ± 0.072	6.422LeuThr: 6.422 ± 0.089	6.523LeuVal: 6.523 ± 0.082	1.187LeuTrp: 1.187 ± 0.038	1.965LeuTyr: 1.965 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.564MetAla: 3.564 ± 0.063	0.2MetCys: 0.2 ± 0.014	1.512MetAsp: 1.512 ± 0.032	1.328MetGlu: 1.328 ± 0.036	0.861MetPhe: 0.861 ± 0.03	2.332MetGly: 2.332 ± 0.046	0.504MetHis: 0.504 ± 0.019	1.609MetIle: 1.609 ± 0.042	1.1MetLys: 1.1 ± 0.034	2.509MetLeu: 2.509 ± 0.052	0.831MetMet: 0.831 ± 0.028	0.85MetAsn: 0.85 ± 0.027	1.584MetPro: 1.584 ± 0.037	1.031MetGln: 1.031 ± 0.034	1.874MetArg: 1.874 ± 0.049	1.818MetSer: 1.818 ± 0.035	2.255MetThr: 2.255 ± 0.041	1.92MetVal: 1.92 ± 0.043	0.255MetTrp: 0.255 ± 0.014	0.365MetTyr: 0.365 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.35AsnAla: 3.35 ± 0.053	0.271AsnCys: 0.271 ± 0.014	2.123AsnAsp: 2.123 ± 0.113	1.285AsnGlu: 1.285 ± 0.033	0.973AsnPhe: 0.973 ± 0.028	2.919AsnGly: 2.919 ± 0.067	0.522AsnHis: 0.522 ± 0.022	1.465AsnIle: 1.465 ± 0.038	0.774AsnLys: 0.774 ± 0.025	2.678AsnLeu: 2.678 ± 0.046	0.754AsnMet: 0.754 ± 0.023	0.745AsnAsn: 0.745 ± 0.028	1.794AsnPro: 1.794 ± 0.035	0.84AsnGln: 0.84 ± 0.03	1.785AsnArg: 1.785 ± 0.037	1.344AsnSer: 1.344 ± 0.034	1.481AsnThr: 1.481 ± 0.03	1.985AsnVal: 1.985 ± 0.039	0.476AsnTrp: 0.476 ± 0.021	0.699AsnTyr: 0.699 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.436ProAla: 5.436 ± 0.084	0.386ProCys: 0.386 ± 0.019	3.921ProAsp: 3.921 ± 0.068	3.83ProGlu: 3.83 ± 0.068	1.846ProPhe: 1.846 ± 0.041	4.096ProGly: 4.096 ± 0.064	1.052ProHis: 1.052 ± 0.029	2.275ProIle: 2.275 ± 0.046	1.901ProLys: 1.901 ± 0.041	4.336ProLeu: 4.336 ± 0.068	1.379ProMet: 1.379 ± 0.036	1.483ProAsn: 1.483 ± 0.039	2.023ProPro: 2.023 ± 0.051	1.577ProGln: 1.577 ± 0.039	2.546ProArg: 2.546 ± 0.053	2.518ProSer: 2.518 ± 0.046	2.504ProThr: 2.504 ± 0.039	4.19ProVal: 4.19 ± 0.07	0.625ProTrp: 0.625 ± 0.021	1.149ProTyr: 1.149 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.284GlnAla: 4.284 ± 0.066	0.202GlnCys: 0.202 ± 0.012	1.972GlnAsp: 1.972 ± 0.047	1.553GlnGlu: 1.553 ± 0.033	1.24GlnPhe: 1.24 ± 0.035	2.671GlnGly: 2.671 ± 0.047	0.627GlnHis: 0.627 ± 0.023	2.266GlnIle: 2.266 ± 0.039	1.152GlnLys: 1.152 ± 0.033	2.925GlnLeu: 2.925 ± 0.055	1.108GlnMet: 1.108 ± 0.03	1.002GlnAsn: 1.002 ± 0.03	1.619GlnPro: 1.619 ± 0.038	1.137GlnGln: 1.137 ± 0.029	2.22GlnArg: 2.22 ± 0.053	2.051GlnSer: 2.051 ± 0.04	2.128GlnThr: 2.128 ± 0.044	2.467GlnVal: 2.467 ± 0.046	0.448GlnTrp: 0.448 ± 0.018	0.61GlnTyr: 0.61 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.069ArgAla: 7.069 ± 0.1	0.46ArgCys: 0.46 ± 0.022	4.335ArgAsp: 4.335 ± 0.068	3.276ArgGlu: 3.276 ± 0.062	2.558ArgPhe: 2.558 ± 0.047	4.266ArgGly: 4.266 ± 0.059	1.401ArgHis: 1.401 ± 0.038	3.648ArgIle: 3.648 ± 0.058	2.388ArgLys: 2.388 ± 0.041	6.815ArgLeu: 6.815 ± 0.094	1.869ArgMet: 1.869 ± 0.039	1.855ArgAsn: 1.855 ± 0.045	3.073ArgPro: 3.073 ± 0.057	2.287ArgGln: 2.287 ± 0.045	4.476ArgArg: 4.476 ± 0.093	3.224ArgSer: 3.224 ± 0.054	2.892ArgThr: 2.892 ± 0.05	4.502ArgVal: 4.502 ± 0.064	0.875ArgTrp: 0.875 ± 0.026	1.532ArgTyr: 1.532 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.866SerAla: 5.866 ± 0.07	0.416SerCys: 0.416 ± 0.019	3.606SerAsp: 3.606 ± 0.061	2.899SerGlu: 2.899 ± 0.045	2.224SerPhe: 2.224 ± 0.04	5.538SerGly: 5.538 ± 0.096	1.074SerHis: 1.074 ± 0.032	2.58SerIle: 2.58 ± 0.054	1.657SerLys: 1.657 ± 0.04	5.008SerLeu: 5.008 ± 0.077	1.405SerMet: 1.405 ± 0.034	1.465SerAsn: 1.465 ± 0.035	2.408SerPro: 2.408 ± 0.048	1.75SerGln: 1.75 ± 0.046	3.021SerArg: 3.021 ± 0.055	2.649SerSer: 2.649 ± 0.049	2.591SerThr: 2.591 ± 0.049	3.923SerVal: 3.923 ± 0.057	0.608SerTrp: 0.608 ± 0.026	1.315SerTyr: 1.315 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.376ThrAla: 6.376 ± 0.08	0.499ThrCys: 0.499 ± 0.025	3.425ThrAsp: 3.425 ± 0.074	3.002ThrGlu: 3.002 ± 0.058	2.11ThrPhe: 2.11 ± 0.048	5.748ThrGly: 5.748 ± 0.104	1.165ThrHis: 1.165 ± 0.029	3.034ThrIle: 3.034 ± 0.058	1.705ThrLys: 1.705 ± 0.042	6.195ThrLeu: 6.195 ± 0.09	1.35ThrMet: 1.35 ± 0.03	1.454ThrAsn: 1.454 ± 0.037	3.388ThrPro: 3.388 ± 0.053	1.791ThrGln: 1.791 ± 0.045	3.346ThrArg: 3.346 ± 0.057	2.839ThrSer: 2.839 ± 0.06	2.947ThrThr: 2.947 ± 0.065	4.468ThrVal: 4.468 ± 0.091	0.678ThrTrp: 0.678 ± 0.027	1.34ThrTyr: 1.34 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.354ValAla: 8.354 ± 0.087	0.622ValCys: 0.622 ± 0.024	4.318ValAsp: 4.318 ± 0.068	4.327ValGlu: 4.327 ± 0.067	2.913ValPhe: 2.913 ± 0.061	5.34ValGly: 5.34 ± 0.081	1.343ValHis: 1.343 ± 0.035	4.19ValIle: 4.19 ± 0.06	2.278ValLys: 2.278 ± 0.056	7.414ValLeu: 7.414 ± 0.097	2.148ValMet: 2.148 ± 0.048	2.107ValAsn: 2.107 ± 0.043	3.507ValPro: 3.507 ± 0.055	2.4ValGln: 2.4 ± 0.045	4.054ValArg: 4.054 ± 0.06	4.224ValSer: 4.224 ± 0.068	4.766ValThr: 4.766 ± 0.087	5.594ValVal: 5.594 ± 0.077	0.983ValTrp: 0.983 ± 0.028	1.522ValTyr: 1.522 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.335TrpAla: 1.335 ± 0.036	0.137TrpCys: 0.137 ± 0.009	0.84TrpAsp: 0.84 ± 0.027	0.601TrpGlu: 0.601 ± 0.026	0.519TrpPhe: 0.519 ± 0.019	1.012TrpGly: 1.012 ± 0.03	0.338TrpHis: 0.338 ± 0.017	0.694TrpIle: 0.694 ± 0.02	0.469TrpLys: 0.469 ± 0.019	1.512TrpLeu: 1.512 ± 0.039	0.417TrpMet: 0.417 ± 0.017	0.43TrpAsn: 0.43 ± 0.021	0.635TrpPro: 0.635 ± 0.024	0.579TrpGln: 0.579 ± 0.019	1.041TrpArg: 1.041 ± 0.032	0.792TrpSer: 0.792 ± 0.028	0.743TrpThr: 0.743 ± 0.025	0.896TrpVal: 0.896 ± 0.022	0.188TrpTrp: 0.188 ± 0.012	0.276TrpTyr: 0.276 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.491TyrAla: 2.491 ± 0.041	0.244TyrCys: 0.244 ± 0.014	1.763TyrAsp: 1.763 ± 0.038	1.279TyrGlu: 1.279 ± 0.034	0.885TyrPhe: 0.885 ± 0.029	2.198TyrGly: 2.198 ± 0.043	0.494TyrHis: 0.494 ± 0.02	1.008TyrIle: 1.008 ± 0.032	0.671TyrLys: 0.671 ± 0.024	2.241TyrLeu: 2.241 ± 0.041	0.49TyrMet: 0.49 ± 0.021	0.648TyrAsn: 0.648 ± 0.025	1.043TyrPro: 1.043 ± 0.03	0.75TyrGln: 0.75 ± 0.023	1.496TyrArg: 1.496 ± 0.037	1.237TyrSer: 1.237 ± 0.033	1.196TyrThr: 1.196 ± 0.036	1.601TyrVal: 1.601 ± 0.035	0.352TyrTrp: 0.352 ± 0.017	0.641TyrTyr: 0.641 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3838 proteins (1215343 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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