Amino acid dipepetide frequency for Pseudaminobacter manganicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.696AlaAla: 16.696 ± 0.158
1.008AlaCys: 1.008 ± 0.03
7.021AlaAsp: 7.021 ± 0.084
7.617AlaGlu: 7.617 ± 0.102
4.702AlaPhe: 4.702 ± 0.065
11.033AlaGly: 11.033 ± 0.101
2.223AlaHis: 2.223 ± 0.047
6.764AlaIle: 6.764 ± 0.078
4.452AlaLys: 4.452 ± 0.068
12.794AlaLeu: 12.794 ± 0.113
3.713AlaMet: 3.713 ± 0.051
3.037AlaAsn: 3.037 ± 0.056
4.982AlaPro: 4.982 ± 0.063
3.473AlaGln: 3.473 ± 0.048
8.474AlaArg: 8.474 ± 0.092
6.474AlaSer: 6.474 ± 0.074
5.772AlaThr: 5.772 ± 0.068
8.814AlaVal: 8.814 ± 0.093
1.463AlaTrp: 1.463 ± 0.036
2.747AlaTyr: 2.747 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.923CysAla: 0.923 ± 0.027
0.106CysCys: 0.106 ± 0.01
0.452CysAsp: 0.452 ± 0.018
0.422CysGlu: 0.422 ± 0.019
0.327CysPhe: 0.327 ± 0.015
0.941CysGly: 0.941 ± 0.031
0.209CysHis: 0.209 ± 0.013
0.376CysIle: 0.376 ± 0.017
0.177CysLys: 0.177 ± 0.011
0.741CysLeu: 0.741 ± 0.025
0.162CysMet: 0.162 ± 0.012
0.197CysAsn: 0.197 ± 0.014
0.405CysPro: 0.405 ± 0.017
0.21CysGln: 0.21 ± 0.014
0.587CysArg: 0.587 ± 0.019
0.441CysSer: 0.441 ± 0.02
0.413CysThr: 0.413 ± 0.02
0.587CysVal: 0.587 ± 0.024
0.122CysTrp: 0.122 ± 0.008
0.205CysTyr: 0.205 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.784AspAla: 6.784 ± 0.085
0.488AspCys: 0.488 ± 0.022
3.217AspAsp: 3.217 ± 0.064
3.68AspGlu: 3.68 ± 0.066
2.261AspPhe: 2.261 ± 0.046
5.202AspGly: 5.202 ± 0.078
1.322AspHis: 1.322 ± 0.036
3.311AspIle: 3.311 ± 0.052
1.988AspLys: 1.988 ± 0.045
5.733AspLeu: 5.733 ± 0.073
1.478AspMet: 1.478 ± 0.03
1.477AspAsn: 1.477 ± 0.037
3.333AspPro: 3.333 ± 0.048
1.644AspGln: 1.644 ± 0.039
4.267AspArg: 4.267 ± 0.059
2.203AspSer: 2.203 ± 0.038
2.603AspThr: 2.603 ± 0.043
3.916AspVal: 3.916 ± 0.053
0.952AspTrp: 0.952 ± 0.027
1.488AspTyr: 1.488 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
7.562GluAla: 7.562 ± 0.091
0.347GluCys: 0.347 ± 0.016
2.787GluAsp: 2.787 ± 0.042
3.11GluGlu: 3.11 ± 0.067
1.822GluPhe: 1.822 ± 0.038
4.287GluGly: 4.287 ± 0.06
1.215GluHis: 1.215 ± 0.035
3.811GluIle: 3.811 ± 0.054
2.799GluLys: 2.799 ± 0.051
5.192GluLeu: 5.192 ± 0.067
1.568GluMet: 1.568 ± 0.029
1.778GluAsn: 1.778 ± 0.031
2.732GluPro: 2.732 ± 0.05
2.073GluGln: 2.073 ± 0.05
5.017GluArg: 5.017 ± 0.073
2.454GluSer: 2.454 ± 0.05
3.546GluThr: 3.546 ± 0.054
3.637GluVal: 3.637 ± 0.063
0.743GluTrp: 0.743 ± 0.025
1.006GluTyr: 1.006 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
4.571PheAla: 4.571 ± 0.073
0.391PheCys: 0.391 ± 0.017
2.65PheAsp: 2.65 ± 0.044
2.192PheGlu: 2.192 ± 0.038
1.479PhePhe: 1.479 ± 0.04
3.92PheGly: 3.92 ± 0.056
0.807PheHis: 0.807 ± 0.023
1.899PheIle: 1.899 ± 0.036
1.082PheLys: 1.082 ± 0.03
3.573PheLeu: 3.573 ± 0.056
0.852PheMet: 0.852 ± 0.028
1.06PheAsn: 1.06 ± 0.028
1.683PhePro: 1.683 ± 0.034
1.044PheGln: 1.044 ± 0.027
2.283PheArg: 2.283 ± 0.04
2.484PheSer: 2.484 ± 0.047
1.98PheThr: 1.98 ± 0.042
2.927PheVal: 2.927 ± 0.051
0.583PheTrp: 0.583 ± 0.024
0.976PheTyr: 0.976 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
9.051GlyAla: 9.051 ± 0.105
0.805GlyCys: 0.805 ± 0.03
4.473GlyAsp: 4.473 ± 0.068
4.999GlyGlu: 4.999 ± 0.055
3.772GlyPhe: 3.772 ± 0.056
7.393GlyGly: 7.393 ± 0.142
1.977GlyHis: 1.977 ± 0.038
5.115GlyIle: 5.115 ± 0.067
3.896GlyLys: 3.896 ± 0.053
8.768GlyLeu: 8.768 ± 0.086
2.449GlyMet: 2.449 ± 0.041
2.344GlyAsn: 2.344 ± 0.046
3.341GlyPro: 3.341 ± 0.052
2.68GlyGln: 2.68 ± 0.05
6.047GlyArg: 6.047 ± 0.081
4.765GlySer: 4.765 ± 0.075
4.719GlyThr: 4.719 ± 0.089
6.125GlyVal: 6.125 ± 0.073
1.3GlyTrp: 1.3 ± 0.032
2.319GlyTyr: 2.319 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.371HisAla: 2.371 ± 0.046
0.246HisCys: 0.246 ± 0.015
1.279HisAsp: 1.279 ± 0.032
1.115HisGlu: 1.115 ± 0.031
0.921HisPhe: 0.921 ± 0.032
1.968HisGly: 1.968 ± 0.038
0.576HisHis: 0.576 ± 0.025
1.071HisIle: 1.071 ± 0.028
0.545HisLys: 0.545 ± 0.021
2.054HisLeu: 2.054 ± 0.041
0.562HisMet: 0.562 ± 0.023
0.486HisAsn: 0.486 ± 0.018
1.236HisPro: 1.236 ± 0.032
0.573HisGln: 0.573 ± 0.019
1.434HisArg: 1.434 ± 0.035
0.971HisSer: 0.971 ± 0.028
0.829HisThr: 0.829 ± 0.025
1.551HisVal: 1.551 ± 0.038
0.344HisTrp: 0.344 ± 0.017
0.59HisTyr: 0.59 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
7.725IleAla: 7.725 ± 0.071
0.493IleCys: 0.493 ± 0.018
3.843IleAsp: 3.843 ± 0.053
3.762IleGlu: 3.762 ± 0.051
1.879IlePhe: 1.879 ± 0.039
5.3IleGly: 5.3 ± 0.07
0.965IleHis: 0.965 ± 0.026
2.491IleIle: 2.491 ± 0.049
1.591IleLys: 1.591 ± 0.041
4.666IleLeu: 4.666 ± 0.076
1.128IleMet: 1.128 ± 0.032
1.477IleAsn: 1.477 ± 0.036
2.3IlePro: 2.3 ± 0.04
1.225IleGln: 1.225 ± 0.034
3.399IleArg: 3.399 ± 0.049
3.059IleSer: 3.059 ± 0.05
2.681IleThr: 2.681 ± 0.05
4.802IleVal: 4.802 ± 0.062
0.631IleTrp: 0.631 ± 0.022
1.152IleTyr: 1.152 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
4.983LysAla: 4.983 ± 0.075
0.191LysCys: 0.191 ± 0.011
2.004LysAsp: 2.004 ± 0.046
1.816LysGlu: 1.816 ± 0.044
0.981LysPhe: 0.981 ± 0.027
3.032LysGly: 3.032 ± 0.054
0.686LysHis: 0.686 ± 0.022
1.905LysIle: 1.905 ± 0.046
1.67LysLys: 1.67 ± 0.047
3.652LysLeu: 3.652 ± 0.059
0.898LysMet: 0.898 ± 0.027
1.047LysAsn: 1.047 ± 0.03
2.416LysPro: 2.416 ± 0.052
1.125LysGln: 1.125 ± 0.036
2.538LysArg: 2.538 ± 0.048
2.033LysSer: 2.033 ± 0.04
2.209LysThr: 2.209 ± 0.041
2.645LysVal: 2.645 ± 0.056
0.421LysTrp: 0.421 ± 0.02
0.668LysTyr: 0.668 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
13.518LeuAla: 13.518 ± 0.116
0.835LeuCys: 0.835 ± 0.024
6.119LeuAsp: 6.119 ± 0.065
5.234LeuGlu: 5.234 ± 0.068
3.737LeuPhe: 3.737 ± 0.055
8.096LeuGly: 8.096 ± 0.09
1.862LeuHis: 1.862 ± 0.037
5.1LeuIle: 5.1 ± 0.074
4.015LeuLys: 4.015 ± 0.066
9.178LeuLeu: 9.178 ± 0.11
2.298LeuMet: 2.298 ± 0.045
2.524LeuAsn: 2.524 ± 0.047
5.247LeuPro: 5.247 ± 0.066
2.518LeuGln: 2.518 ± 0.047
6.264LeuArg: 6.264 ± 0.079
6.499LeuSer: 6.499 ± 0.072
5.358LeuThr: 5.358 ± 0.08
7.468LeuVal: 7.468 ± 0.069
1.082LeuTrp: 1.082 ± 0.029
2.236LeuTyr: 2.236 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
3.314MetAla: 3.314 ± 0.047
0.156MetCys: 0.156 ± 0.011
1.175MetAsp: 1.175 ± 0.032
1.205MetGlu: 1.205 ± 0.032
0.735MetPhe: 0.735 ± 0.023
1.838MetGly: 1.838 ± 0.038
0.446MetHis: 0.446 ± 0.017
1.412MetIle: 1.412 ± 0.039
1.21MetLys: 1.21 ± 0.03
2.662MetLeu: 2.662 ± 0.049
0.698MetMet: 0.698 ± 0.024
0.834MetAsn: 0.834 ± 0.023
1.552MetPro: 1.552 ± 0.034
0.885MetGln: 0.885 ± 0.028
1.872MetArg: 1.872 ± 0.04
1.591MetSer: 1.591 ± 0.033
1.89MetThr: 1.89 ± 0.037
1.807MetVal: 1.807 ± 0.039
0.214MetTrp: 0.214 ± 0.013
0.289MetTyr: 0.289 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
3.283AsnAla: 3.283 ± 0.052
0.225AsnCys: 0.225 ± 0.012
1.504AsnAsp: 1.504 ± 0.034
1.351AsnGlu: 1.351 ± 0.029
1.038AsnPhe: 1.038 ± 0.029
2.599AsnGly: 2.599 ± 0.057
0.523AsnHis: 0.523 ± 0.019
1.464AsnIle: 1.464 ± 0.033
0.778AsnLys: 0.778 ± 0.026
2.636AsnLeu: 2.636 ± 0.044
0.648AsnMet: 0.648 ± 0.021
0.705AsnAsn: 0.705 ± 0.029
1.809AsnPro: 1.809 ± 0.039
0.758AsnGln: 0.758 ± 0.022
1.907AsnArg: 1.907 ± 0.039
1.264AsnSer: 1.264 ± 0.031
1.311AsnThr: 1.311 ± 0.032
1.953AsnVal: 1.953 ± 0.047
0.461AsnTrp: 0.461 ± 0.017
0.674AsnTyr: 0.674 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
6.014ProAla: 6.014 ± 0.075
0.315ProCys: 0.315 ± 0.016
3.542ProAsp: 3.542 ± 0.053
3.392ProGlu: 3.392 ± 0.054
1.994ProPhe: 1.994 ± 0.045
4.198ProGly: 4.198 ± 0.053
1.082ProHis: 1.082 ± 0.024
2.332ProIle: 2.332 ± 0.035
1.863ProLys: 1.863 ± 0.037
4.601ProLeu: 4.601 ± 0.062
1.129ProMet: 1.129 ± 0.026
1.322ProAsn: 1.322 ± 0.036
2.307ProPro: 2.307 ± 0.047
1.675ProGln: 1.675 ± 0.034
2.786ProArg: 2.786 ± 0.051
2.659ProSer: 2.659 ± 0.048
2.373ProThr: 2.373 ± 0.04
4.178ProVal: 4.178 ± 0.057
0.675ProTrp: 0.675 ± 0.024
1.227ProTyr: 1.227 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
3.914GlnAla: 3.914 ± 0.05
0.187GlnCys: 0.187 ± 0.01
1.411GlnAsp: 1.411 ± 0.034
1.472GlnGlu: 1.472 ± 0.029
1.065GlnPhe: 1.065 ± 0.027
2.333GlnGly: 2.333 ± 0.044
0.589GlnHis: 0.589 ± 0.018
1.805GlnIle: 1.805 ± 0.034
1.236GlnLys: 1.236 ± 0.033
2.634GlnLeu: 2.634 ± 0.046
0.93GlnMet: 0.93 ± 0.026
0.863GlnAsn: 0.863 ± 0.027
1.698GlnPro: 1.698 ± 0.035
1.173GlnGln: 1.173 ± 0.04
2.261GlnArg: 2.261 ± 0.042
1.725GlnSer: 1.725 ± 0.033
1.598GlnThr: 1.598 ± 0.035
2.039GlnVal: 2.039 ± 0.04
0.378GlnTrp: 0.378 ± 0.018
0.58GlnTyr: 0.58 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
7.493ArgAla: 7.493 ± 0.084
0.449ArgCys: 0.449 ± 0.019
3.874ArgAsp: 3.874 ± 0.054
4.089ArgGlu: 4.089 ± 0.06
2.994ArgPhe: 2.994 ± 0.053
4.609ArgGly: 4.609 ± 0.052
1.849ArgHis: 1.849 ± 0.038
4.105ArgIle: 4.105 ± 0.055
2.703ArgLys: 2.703 ± 0.053
7.761ArgLeu: 7.761 ± 0.089
1.838ArgMet: 1.838 ± 0.036
1.961ArgAsn: 1.961 ± 0.04
3.411ArgPro: 3.411 ± 0.055
2.607ArgGln: 2.607 ± 0.04
5.718ArgArg: 5.718 ± 0.087
3.706ArgSer: 3.706 ± 0.059
3.361ArgThr: 3.361 ± 0.049
4.363ArgVal: 4.363 ± 0.059
0.887ArgTrp: 0.887 ± 0.028
1.709ArgTyr: 1.709 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
6.257SerAla: 6.257 ± 0.079
0.402SerCys: 0.402 ± 0.018
3.022SerAsp: 3.022 ± 0.046
2.893SerGlu: 2.893 ± 0.048
2.308SerPhe: 2.308 ± 0.044
5.855SerGly: 5.855 ± 0.082
1.182SerHis: 1.182 ± 0.033
2.883SerIle: 2.883 ± 0.047
1.683SerLys: 1.683 ± 0.038
5.43SerLeu: 5.43 ± 0.072
1.378SerMet: 1.378 ± 0.033
1.424SerAsn: 1.424 ± 0.031
2.704SerPro: 2.704 ± 0.047
1.587SerGln: 1.587 ± 0.036
3.739SerArg: 3.739 ± 0.05
2.958SerSer: 2.958 ± 0.056
2.681SerThr: 2.681 ± 0.049
4.071SerVal: 4.071 ± 0.059
0.698SerTrp: 0.698 ± 0.024
1.283SerTyr: 1.283 ± 0.028
0.0SerXaa: 0.0 ± 0.0
Thr
6.164ThrAla: 6.164 ± 0.069
0.396ThrCys: 0.396 ± 0.02
2.865ThrAsp: 2.865 ± 0.05
2.641ThrGlu: 2.641 ± 0.042
2.058ThrPhe: 2.058 ± 0.042
5.185ThrGly: 5.185 ± 0.079
1.008ThrHis: 1.008 ± 0.03
3.052ThrIle: 3.052 ± 0.055
1.515ThrLys: 1.515 ± 0.035
5.655ThrLeu: 5.655 ± 0.077
1.295ThrMet: 1.295 ± 0.031
1.28ThrAsn: 1.28 ± 0.036
2.975ThrPro: 2.975 ± 0.049
1.344ThrGln: 1.344 ± 0.031
3.14ThrArg: 3.14 ± 0.047
2.691ThrSer: 2.691 ± 0.052
2.813ThrThr: 2.813 ± 0.056
4.393ThrVal: 4.393 ± 0.056
0.645ThrTrp: 0.645 ± 0.021
1.181ThrTyr: 1.181 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
8.999ValAla: 8.999 ± 0.105
0.604ValCys: 0.604 ± 0.022
3.999ValAsp: 3.999 ± 0.052
4.665ValGlu: 4.665 ± 0.07
2.882ValPhe: 2.882 ± 0.051
5.571ValGly: 5.571 ± 0.072
1.361ValHis: 1.361 ± 0.035
4.043ValIle: 4.043 ± 0.054
2.548ValLys: 2.548 ± 0.054
7.528ValLeu: 7.528 ± 0.09
1.913ValMet: 1.913 ± 0.042
1.989ValAsn: 1.989 ± 0.039
3.747ValPro: 3.747 ± 0.059
1.969ValGln: 1.969 ± 0.036
4.826ValArg: 4.826 ± 0.064
4.429ValSer: 4.429 ± 0.062
4.299ValThr: 4.299 ± 0.049
5.912ValVal: 5.912 ± 0.076
0.859ValTrp: 0.859 ± 0.025
1.456ValTyr: 1.456 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
1.208TrpAla: 1.208 ± 0.034
0.118TrpCys: 0.118 ± 0.01
0.588TrpAsp: 0.588 ± 0.023
0.562TrpGlu: 0.562 ± 0.021
0.56TrpPhe: 0.56 ± 0.02
0.826TrpGly: 0.826 ± 0.024
0.346TrpHis: 0.346 ± 0.016
0.651TrpIle: 0.651 ± 0.022
0.511TrpLys: 0.511 ± 0.018
1.653TrpLeu: 1.653 ± 0.04
0.381TrpMet: 0.381 ± 0.017
0.467TrpAsn: 0.467 ± 0.019
0.662TrpPro: 0.662 ± 0.023
0.59TrpGln: 0.59 ± 0.022
1.101TrpArg: 1.101 ± 0.031
0.807TrpSer: 0.807 ± 0.026
0.729TrpThr: 0.729 ± 0.023
0.766TrpVal: 0.766 ± 0.029
0.222TrpTrp: 0.222 ± 0.013
0.283TrpTyr: 0.283 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.43TyrAla: 2.43 ± 0.042
0.239TyrCys: 0.239 ± 0.014
1.522TyrAsp: 1.522 ± 0.038
1.269TyrGlu: 1.269 ± 0.034
0.919TyrPhe: 0.919 ± 0.027
2.156TyrGly: 2.156 ± 0.045
0.493TyrHis: 0.493 ± 0.018
0.98TyrIle: 0.98 ± 0.025
0.657TyrLys: 0.657 ± 0.02
2.279TyrLeu: 2.279 ± 0.042
0.464TyrMet: 0.464 ± 0.018
0.62TyrAsn: 0.62 ± 0.022
1.124TyrPro: 1.124 ± 0.03
0.739TyrGln: 0.739 ± 0.023
1.83TyrArg: 1.83 ± 0.037
1.222TyrSer: 1.222 ± 0.03
1.131TyrThr: 1.131 ± 0.032
1.644TyrVal: 1.644 ± 0.032
0.351TyrTrp: 0.351 ± 0.014
0.582TyrTyr: 0.582 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4404 proteins (1361994 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski