Amino acid dipepetide frequency for Cellulosimicrobium cellulans J1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.148AlaAla: 24.148 ± 0.225	0.785AlaCys: 0.785 ± 0.026	9.429AlaAsp: 9.429 ± 0.1	8.156AlaGlu: 8.156 ± 0.102	3.571AlaPhe: 3.571 ± 0.064	14.333AlaGly: 14.333 ± 0.142	2.849AlaHis: 2.849 ± 0.051	3.582AlaIle: 3.582 ± 0.055	1.854AlaLys: 1.854 ± 0.051	15.278AlaLeu: 15.278 ± 0.16	2.302AlaMet: 2.302 ± 0.048	1.897AlaAsn: 1.897 ± 0.045	9.067AlaPro: 9.067 ± 0.144	3.855AlaGln: 3.855 ± 0.066	12.27AlaArg: 12.27 ± 0.141	6.855AlaSer: 6.855 ± 0.077	8.956AlaThr: 8.956 ± 0.112	14.276AlaVal: 14.276 ± 0.144	2.44AlaTrp: 2.44 ± 0.052	2.542AlaTyr: 2.542 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.728CysAla: 0.728 ± 0.025	0.066CysCys: 0.066 ± 0.008	0.323CysAsp: 0.323 ± 0.018	0.269CysGlu: 0.269 ± 0.016	0.158CysPhe: 0.158 ± 0.011	0.619CysGly: 0.619 ± 0.025	0.107CysHis: 0.107 ± 0.01	0.091CysIle: 0.091 ± 0.009	0.051CysLys: 0.051 ± 0.006	0.463CysLeu: 0.463 ± 0.021	0.068CysMet: 0.068 ± 0.007	0.076CysAsn: 0.076 ± 0.007	0.323CysPro: 0.323 ± 0.016	0.097CysGln: 0.097 ± 0.008	0.35CysArg: 0.35 ± 0.019	0.315CysSer: 0.315 ± 0.017	0.358CysThr: 0.358 ± 0.017	0.487CysVal: 0.487 ± 0.018	0.077CysTrp: 0.077 ± 0.008	0.092CysTyr: 0.092 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	11.054AspAla: 11.054 ± 0.121	0.251AspCys: 0.251 ± 0.015	5.453AspAsp: 5.453 ± 0.071	4.368AspGlu: 4.368 ± 0.064	1.278AspPhe: 1.278 ± 0.037	7.574AspGly: 7.574 ± 0.111	1.272AspHis: 1.272 ± 0.03	1.132AspIle: 1.132 ± 0.032	0.709AspLys: 0.709 ± 0.022	7.058AspLeu: 7.058 ± 0.079	0.671AspMet: 0.671 ± 0.024	0.711AspAsn: 0.711 ± 0.029	5.28AspPro: 5.28 ± 0.077	1.388AspGln: 1.388 ± 0.035	4.787AspArg: 4.787 ± 0.07	1.855AspSer: 1.855 ± 0.036	2.647AspThr: 2.647 ± 0.055	7.807AspVal: 7.807 ± 0.099	0.865AspTrp: 0.865 ± 0.028	1.041AspTyr: 1.041 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	7.1GluAla: 7.1 ± 0.089	0.223GluCys: 0.223 ± 0.015	3.123GluAsp: 3.123 ± 0.053	2.846GluGlu: 2.846 ± 0.057	1.144GluPhe: 1.144 ± 0.033	4.141GluGly: 4.141 ± 0.06	1.739GluHis: 1.739 ± 0.038	2.175GluIle: 2.175 ± 0.046	0.969GluLys: 0.969 ± 0.036	5.875GluLeu: 5.875 ± 0.079	0.71GluMet: 0.71 ± 0.022	1.001GluAsn: 1.001 ± 0.029	3.636GluPro: 3.636 ± 0.06	1.967GluGln: 1.967 ± 0.046	5.561GluArg: 5.561 ± 0.077	2.281GluSer: 2.281 ± 0.045	2.853GluThr: 2.853 ± 0.046	5.164GluVal: 5.164 ± 0.079	0.723GluTrp: 0.723 ± 0.024	0.968GluTyr: 0.968 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.658PheAla: 3.658 ± 0.056	0.172PheCys: 0.172 ± 0.011	1.958PheAsp: 1.958 ± 0.049	1.367PheGlu: 1.367 ± 0.037	0.824PhePhe: 0.824 ± 0.028	2.581PheGly: 2.581 ± 0.051	0.482PheHis: 0.482 ± 0.021	0.504PheIle: 0.504 ± 0.019	0.312PheLys: 0.312 ± 0.015	2.461PheLeu: 2.461 ± 0.054	0.311PheMet: 0.311 ± 0.016	0.429PheAsn: 0.429 ± 0.02	1.231PhePro: 1.231 ± 0.03	0.581PheGln: 0.581 ± 0.022	1.635PheArg: 1.635 ± 0.038	1.307PheSer: 1.307 ± 0.033	1.704PheThr: 1.704 ± 0.038	2.643PheVal: 2.643 ± 0.054	0.452PheTrp: 0.452 ± 0.02	0.551PheTyr: 0.551 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	13.235GlyAla: 13.235 ± 0.136	0.507GlyCys: 0.507 ± 0.025	5.722GlyAsp: 5.722 ± 0.079	5.146GlyGlu: 5.146 ± 0.078	2.75GlyPhe: 2.75 ± 0.048	8.703GlyGly: 8.703 ± 0.118	1.85GlyHis: 1.85 ± 0.039	2.971GlyIle: 2.971 ± 0.049	1.618GlyLys: 1.618 ± 0.039	9.135GlyLeu: 9.135 ± 0.114	1.694GlyMet: 1.694 ± 0.04	1.484GlyAsn: 1.484 ± 0.047	5.609GlyPro: 5.609 ± 0.084	2.333GlyGln: 2.333 ± 0.057	7.428GlyArg: 7.428 ± 0.083	5.397GlySer: 5.397 ± 0.07	7.143GlyThr: 7.143 ± 0.09	9.075GlyVal: 9.075 ± 0.09	1.716GlyTrp: 1.716 ± 0.035	2.13GlyTyr: 2.13 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.839HisAla: 2.839 ± 0.061	0.116HisCys: 0.116 ± 0.009	1.616HisAsp: 1.616 ± 0.034	1.171HisGlu: 1.171 ± 0.032	0.403HisPhe: 0.403 ± 0.019	2.197HisGly: 2.197 ± 0.037	0.553HisHis: 0.553 ± 0.023	0.32HisIle: 0.32 ± 0.017	0.213HisLys: 0.213 ± 0.013	2.211HisLeu: 2.211 ± 0.049	0.237HisMet: 0.237 ± 0.013	0.285HisAsn: 0.285 ± 0.014	1.503HisPro: 1.503 ± 0.039	0.446HisGln: 0.446 ± 0.018	1.674HisArg: 1.674 ± 0.034	0.663HisSer: 0.663 ± 0.023	0.907HisThr: 0.907 ± 0.025	2.223HisVal: 2.223 ± 0.042	0.243HisTrp: 0.243 ± 0.013	0.379HisTyr: 0.379 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	3.724IleAla: 3.724 ± 0.054	0.142IleCys: 0.142 ± 0.011	2.039IleAsp: 2.039 ± 0.042	1.668IleGlu: 1.668 ± 0.041	0.652IlePhe: 0.652 ± 0.024	2.618IleGly: 2.618 ± 0.054	0.408IleHis: 0.408 ± 0.02	0.703IleIle: 0.703 ± 0.025	0.462IleLys: 0.462 ± 0.024	2.187IleLeu: 2.187 ± 0.048	0.356IleMet: 0.356 ± 0.016	0.517IleAsn: 0.517 ± 0.022	1.367IlePro: 1.367 ± 0.034	0.559IleGln: 0.559 ± 0.024	1.522IleArg: 1.522 ± 0.042	1.214IleSer: 1.214 ± 0.032	1.78IleThr: 1.78 ± 0.044	2.711IleVal: 2.711 ± 0.05	0.297IleTrp: 0.297 ± 0.013	0.439IleTyr: 0.439 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	1.753LysAla: 1.753 ± 0.045	0.053LysCys: 0.053 ± 0.006	0.851LysAsp: 0.851 ± 0.03	0.695LysGlu: 0.695 ± 0.026	0.313LysPhe: 0.313 ± 0.017	1.2LysGly: 1.2 ± 0.036	0.309LysHis: 0.309 ± 0.016	0.615LysIle: 0.615 ± 0.025	0.439LysLys: 0.439 ± 0.022	1.108LysLeu: 1.108 ± 0.031	0.202LysMet: 0.202 ± 0.013	0.326LysAsn: 0.326 ± 0.015	0.828LysPro: 0.828 ± 0.029	0.443LysGln: 0.443 ± 0.019	0.954LysArg: 0.954 ± 0.033	0.701LysSer: 0.701 ± 0.028	0.805LysThr: 0.805 ± 0.026	1.384LysVal: 1.384 ± 0.039	0.158LysTrp: 0.158 ± 0.011	0.293LysTyr: 0.293 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	16.974LeuAla: 16.974 ± 0.173	0.517LeuCys: 0.517 ± 0.02	7.788LeuAsp: 7.788 ± 0.092	4.614LeuGlu: 4.614 ± 0.071	2.289LeuPhe: 2.289 ± 0.043	9.541LeuGly: 9.541 ± 0.11	1.881LeuHis: 1.881 ± 0.042	1.703LeuIle: 1.703 ± 0.043	1.094LeuLys: 1.094 ± 0.033	10.125LeuLeu: 10.125 ± 0.145	1.182LeuMet: 1.182 ± 0.03	1.264LeuAsn: 1.264 ± 0.036	5.73LeuPro: 5.73 ± 0.073	2.025LeuGln: 2.025 ± 0.041	8.083LeuArg: 8.083 ± 0.092	4.356LeuSer: 4.356 ± 0.057	5.961LeuThr: 5.961 ± 0.076	11.765LeuVal: 11.765 ± 0.147	1.249LeuTrp: 1.249 ± 0.036	1.545LeuTyr: 1.545 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	1.71MetAla: 1.71 ± 0.032	0.077MetCys: 0.077 ± 0.008	0.657MetAsp: 0.657 ± 0.021	0.522MetGlu: 0.522 ± 0.02	0.386MetPhe: 0.386 ± 0.017	1.051MetGly: 1.051 ± 0.034	0.288MetHis: 0.288 ± 0.013	0.539MetIle: 0.539 ± 0.02	0.233MetLys: 0.233 ± 0.014	1.462MetLeu: 1.462 ± 0.038	0.193MetMet: 0.193 ± 0.011	0.301MetAsn: 0.301 ± 0.015	0.873MetPro: 0.873 ± 0.027	0.325MetGln: 0.325 ± 0.014	1.161MetArg: 1.161 ± 0.036	1.193MetSer: 1.193 ± 0.027	1.609MetThr: 1.609 ± 0.035	1.107MetVal: 1.107 ± 0.035	0.161MetTrp: 0.161 ± 0.011	0.214MetTyr: 0.214 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	1.954AsnAla: 1.954 ± 0.042	0.085AsnCys: 0.085 ± 0.007	0.9AsnAsp: 0.9 ± 0.031	0.709AsnGlu: 0.709 ± 0.024	0.413AsnPhe: 0.413 ± 0.018	1.459AsnGly: 1.459 ± 0.045	0.315AsnHis: 0.315 ± 0.013	0.449AsnIle: 0.449 ± 0.02	0.253AsnLys: 0.253 ± 0.015	1.552AsnLeu: 1.552 ± 0.042	0.187AsnMet: 0.187 ± 0.013	0.325AsnAsn: 0.325 ± 0.019	1.242AsnPro: 1.242 ± 0.034	0.456AsnGln: 0.456 ± 0.02	0.935AsnArg: 0.935 ± 0.028	0.562AsnSer: 0.562 ± 0.022	0.85AsnThr: 0.85 ± 0.035	1.5AsnVal: 1.5 ± 0.035	0.215AsnTrp: 0.215 ± 0.014	0.366AsnTyr: 0.366 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	9.818ProAla: 9.818 ± 0.156	0.19ProCys: 0.19 ± 0.012	5.28ProAsp: 5.28 ± 0.065	3.962ProGlu: 3.962 ± 0.065	1.538ProPhe: 1.538 ± 0.034	7.482ProGly: 7.482 ± 0.106	1.199ProHis: 1.199 ± 0.033	1.145ProIle: 1.145 ± 0.03	0.665ProLys: 0.665 ± 0.03	4.965ProLeu: 4.965 ± 0.067	0.728ProMet: 0.728 ± 0.024	0.764ProAsn: 0.764 ± 0.026	3.299ProPro: 3.299 ± 0.077	1.481ProGln: 1.481 ± 0.034	4.373ProArg: 4.373 ± 0.061	3.303ProSer: 3.303 ± 0.056	3.995ProThr: 3.995 ± 0.072	6.223ProVal: 6.223 ± 0.078	0.968ProTrp: 0.968 ± 0.028	1.126ProTyr: 1.126 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.229GlnAla: 3.229 ± 0.059	0.127GlnCys: 0.127 ± 0.01	1.406GlnAsp: 1.406 ± 0.035	1.203GlnGlu: 1.203 ± 0.036	0.628GlnPhe: 0.628 ± 0.024	2.081GlnGly: 2.081 ± 0.04	0.568GlnHis: 0.568 ± 0.02	0.88GlnIle: 0.88 ± 0.026	0.382GlnLys: 0.382 ± 0.019	2.342GlnLeu: 2.342 ± 0.049	0.381GlnMet: 0.381 ± 0.018	0.474GlnAsn: 0.474 ± 0.021	1.484GlnPro: 1.484 ± 0.041	0.933GlnGln: 0.933 ± 0.034	2.153GlnArg: 2.153 ± 0.051	1.095GlnSer: 1.095 ± 0.031	1.225GlnThr: 1.225 ± 0.034	2.785GlnVal: 2.785 ± 0.044	0.396GlnTrp: 0.396 ± 0.017	0.554GlnTyr: 0.554 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	11.555ArgAla: 11.555 ± 0.131	0.411ArgCys: 0.411 ± 0.02	4.869ArgAsp: 4.869 ± 0.062	4.588ArgGlu: 4.588 ± 0.068	2.068ArgPhe: 2.068 ± 0.036	6.138ArgGly: 6.138 ± 0.075	1.698ArgHis: 1.698 ± 0.042	2.238ArgIle: 2.238 ± 0.051	1.063ArgLys: 1.063 ± 0.033	7.994ArgLeu: 7.994 ± 0.101	1.431ArgMet: 1.431 ± 0.033	1.024ArgAsn: 1.024 ± 0.029	4.988ArgPro: 4.988 ± 0.076	1.742ArgGln: 1.742 ± 0.037	7.989ArgArg: 7.989 ± 0.115	4.032ArgSer: 4.032 ± 0.066	5.514ArgThr: 5.514 ± 0.069	7.35ArgVal: 7.35 ± 0.07	1.517ArgTrp: 1.517 ± 0.038	1.646ArgTyr: 1.646 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.508SerAla: 6.508 ± 0.084	0.253SerCys: 0.253 ± 0.014	2.603SerAsp: 2.603 ± 0.048	2.074SerGlu: 2.074 ± 0.047	1.502SerPhe: 1.502 ± 0.037	5.488SerGly: 5.488 ± 0.081	0.865SerHis: 0.865 ± 0.025	1.388SerIle: 1.388 ± 0.042	0.64SerLys: 0.64 ± 0.025	4.456SerLeu: 4.456 ± 0.055	0.915SerMet: 0.915 ± 0.028	0.72SerAsn: 0.72 ± 0.026	3.166SerPro: 3.166 ± 0.051	1.135SerGln: 1.135 ± 0.033	3.53SerArg: 3.53 ± 0.058	2.692SerSer: 2.692 ± 0.052	3.433SerThr: 3.433 ± 0.054	4.378SerVal: 4.378 ± 0.064	0.872SerTrp: 0.872 ± 0.025	0.989SerTyr: 0.989 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	8.698ThrAla: 8.698 ± 0.102	0.35ThrCys: 0.35 ± 0.016	3.907ThrAsp: 3.907 ± 0.064	2.914ThrGlu: 2.914 ± 0.05	1.942ThrPhe: 1.942 ± 0.045	6.589ThrGly: 6.589 ± 0.082	1.136ThrHis: 1.136 ± 0.03	1.932ThrIle: 1.932 ± 0.043	0.838ThrLys: 0.838 ± 0.027	5.965ThrLeu: 5.965 ± 0.066	0.804ThrMet: 0.804 ± 0.027	1.052ThrAsn: 1.052 ± 0.034	4.623ThrPro: 4.623 ± 0.064	1.381ThrGln: 1.381 ± 0.036	4.134ThrArg: 4.134 ± 0.054	3.49ThrSer: 3.49 ± 0.057	5.103ThrThr: 5.103 ± 0.081	6.664ThrVal: 6.664 ± 0.098	1.087ThrTrp: 1.087 ± 0.03	1.372ThrTyr: 1.372 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	15.507ValAla: 15.507 ± 0.159	0.575ValCys: 0.575 ± 0.023	6.931ValAsp: 6.931 ± 0.078	6.169ValGlu: 6.169 ± 0.084	2.243ValPhe: 2.243 ± 0.055	8.801ValGly: 8.801 ± 0.113	1.997ValHis: 1.997 ± 0.034	2.235ValIle: 2.235 ± 0.044	1.157ValLys: 1.157 ± 0.031	11.378ValLeu: 11.378 ± 0.153	1.269ValMet: 1.269 ± 0.032	1.415ValAsn: 1.415 ± 0.039	6.472ValPro: 6.472 ± 0.075	2.165ValGln: 2.165 ± 0.05	8.441ValArg: 8.441 ± 0.096	4.424ValSer: 4.424 ± 0.077	6.872ValThr: 6.872 ± 0.097	13.543ValVal: 13.543 ± 0.167	1.267ValTrp: 1.267 ± 0.031	1.586ValTyr: 1.586 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.783TrpAla: 1.783 ± 0.045	0.114TrpCys: 0.114 ± 0.009	0.978TrpAsp: 0.978 ± 0.03	0.712TrpGlu: 0.712 ± 0.024	0.56TrpPhe: 0.56 ± 0.022	1.124TrpGly: 1.124 ± 0.03	0.336TrpHis: 0.336 ± 0.017	0.449TrpIle: 0.449 ± 0.019	0.233TrpLys: 0.233 ± 0.015	1.666TrpLeu: 1.666 ± 0.041	0.246TrpMet: 0.246 ± 0.015	0.351TrpAsn: 0.351 ± 0.019	0.766TrpPro: 0.766 ± 0.021	0.487TrpGln: 0.487 ± 0.023	1.321TrpArg: 1.321 ± 0.033	1.014TrpSer: 1.014 ± 0.029	1.154TrpThr: 1.154 ± 0.032	1.358TrpVal: 1.358 ± 0.032	0.432TrpTrp: 0.432 ± 0.021	0.354TrpTyr: 0.354 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.47TyrAla: 2.47 ± 0.048	0.107TyrCys: 0.107 ± 0.01	1.371TyrAsp: 1.371 ± 0.039	1.049TyrGlu: 1.049 ± 0.031	0.502TyrPhe: 0.502 ± 0.018	1.927TyrGly: 1.927 ± 0.041	0.344TyrHis: 0.344 ± 0.018	0.312TyrIle: 0.312 ± 0.015	0.244TyrLys: 0.244 ± 0.013	2.005TyrLeu: 2.005 ± 0.042	0.173TyrMet: 0.173 ± 0.012	0.309TyrAsn: 0.309 ± 0.017	1.014TyrPro: 1.014 ± 0.029	0.531TyrGln: 0.531 ± 0.023	1.552TyrArg: 1.552 ± 0.038	0.859TyrSer: 0.859 ± 0.029	1.111TyrThr: 1.111 ± 0.036	2.004TyrVal: 2.004 ± 0.043	0.301TyrTrp: 0.301 ± 0.014	0.422TyrTyr: 0.422 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3743 proteins (1281283 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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