Amino acid dipepetide frequency for Paenibacillus paeoniae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.86AlaAla: 8.86 ± 0.117	0.667AlaCys: 0.667 ± 0.022	4.249AlaAsp: 4.249 ± 0.048	5.525AlaGlu: 5.525 ± 0.065	3.382AlaPhe: 3.382 ± 0.049	6.649AlaGly: 6.649 ± 0.086	1.425AlaHis: 1.425 ± 0.03	5.954AlaIle: 5.954 ± 0.067	4.134AlaLys: 4.134 ± 0.058	8.47AlaLeu: 8.47 ± 0.09	2.421AlaMet: 2.421 ± 0.043	2.663AlaAsn: 2.663 ± 0.046	2.634AlaPro: 2.634 ± 0.05	2.685AlaGln: 2.685 ± 0.04	3.561AlaArg: 3.561 ± 0.052	5.633AlaSer: 5.633 ± 0.062	4.157AlaThr: 4.157 ± 0.2	6.334AlaVal: 6.334 ± 0.066	1.0AlaTrp: 1.0 ± 0.026	2.734AlaTyr: 2.734 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.479CysAla: 0.479 ± 0.018	0.101CysCys: 0.101 ± 0.008	0.36CysAsp: 0.36 ± 0.013	0.408CysGlu: 0.408 ± 0.016	0.295CysPhe: 0.295 ± 0.014	0.705CysGly: 0.705 ± 0.021	0.16CysHis: 0.16 ± 0.009	0.445CysIle: 0.445 ± 0.018	0.31CysLys: 0.31 ± 0.013	0.68CysLeu: 0.68 ± 0.02	0.211CysMet: 0.211 ± 0.012	0.234CysAsn: 0.234 ± 0.012	0.298CysPro: 0.298 ± 0.016	0.208CysGln: 0.208 ± 0.012	0.38CysArg: 0.38 ± 0.017	0.526CysSer: 0.526 ± 0.02	0.36CysThr: 0.36 ± 0.016	0.43CysVal: 0.43 ± 0.017	0.086CysTrp: 0.086 ± 0.008	0.256CysTyr: 0.256 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.104AspAla: 4.104 ± 0.058	0.332AspCys: 0.332 ± 0.014	2.49AspAsp: 2.49 ± 0.05	3.889AspGlu: 3.889 ± 0.054	2.037AspPhe: 2.037 ± 0.036	4.14AspGly: 4.14 ± 0.067	1.132AspHis: 1.132 ± 0.027	3.531AspIle: 3.531 ± 0.044	2.72AspLys: 2.72 ± 0.052	4.616AspLeu: 4.616 ± 0.055	1.475AspMet: 1.475 ± 0.036	1.802AspAsn: 1.802 ± 0.038	2.18AspPro: 2.18 ± 0.036	1.863AspGln: 1.863 ± 0.038	2.948AspArg: 2.948 ± 0.049	3.07AspSer: 3.07 ± 0.049	2.7AspThr: 2.7 ± 0.048	3.543AspVal: 3.543 ± 0.055	0.767AspTrp: 0.767 ± 0.023	2.081AspTyr: 2.081 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	6.135GluAla: 6.135 ± 0.071	0.348GluCys: 0.348 ± 0.015	3.1GluAsp: 3.1 ± 0.047	5.504GluGlu: 5.504 ± 0.073	1.956GluPhe: 1.956 ± 0.036	4.642GluGly: 4.642 ± 0.058	1.588GluHis: 1.588 ± 0.036	4.03GluIle: 4.03 ± 0.052	3.893GluLys: 3.893 ± 0.059	7.958GluLeu: 7.958 ± 0.091	1.968GluMet: 1.968 ± 0.038	2.268GluAsn: 2.268 ± 0.038	2.28GluPro: 2.28 ± 0.036	3.764GluGln: 3.764 ± 0.065	4.345GluArg: 4.345 ± 0.073	3.803GluSer: 3.803 ± 0.058	3.273GluThr: 3.273 ± 0.048	4.32GluVal: 4.32 ± 0.058	1.057GluTrp: 1.057 ± 0.029	1.868GluTyr: 1.868 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.117PheAla: 3.117 ± 0.048	0.288PheCys: 0.288 ± 0.014	2.258PheAsp: 2.258 ± 0.038	2.335PheGlu: 2.335 ± 0.036	1.747PhePhe: 1.747 ± 0.041	3.087PheGly: 3.087 ± 0.045	0.931PheHis: 0.931 ± 0.024	2.933PheIle: 2.933 ± 0.051	1.931PheLys: 1.931 ± 0.036	3.83PheLeu: 3.83 ± 0.056	1.159PheMet: 1.159 ± 0.028	1.592PheAsn: 1.592 ± 0.034	1.468PhePro: 1.468 ± 0.034	1.497PheGln: 1.497 ± 0.031	2.008PheArg: 2.008 ± 0.038	2.78PheSer: 2.78 ± 0.042	2.265PheThr: 2.265 ± 0.038	2.821PheVal: 2.821 ± 0.047	0.514PheTrp: 0.514 ± 0.021	1.493PheTyr: 1.493 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	6.098GlyAla: 6.098 ± 0.2	0.607GlyCys: 0.607 ± 0.019	3.707GlyAsp: 3.707 ± 0.064	4.794GlyGlu: 4.794 ± 0.065	3.112GlyPhe: 3.112 ± 0.05	5.594GlyGly: 5.594 ± 0.098	1.516GlyHis: 1.516 ± 0.032	5.599GlyIle: 5.599 ± 0.066	4.385GlyLys: 4.385 ± 0.059	7.351GlyLeu: 7.351 ± 0.074	2.441GlyMet: 2.441 ± 0.042	2.805GlyAsn: 2.805 ± 0.063	1.986GlyPro: 1.986 ± 0.142	2.67GlyGln: 2.67 ± 0.041	3.502GlyArg: 3.502 ± 0.055	4.874GlySer: 4.874 ± 0.061	4.409GlyThr: 4.409 ± 0.074	5.282GlyVal: 5.282 ± 0.076	1.083GlyTrp: 1.083 ± 0.027	2.998GlyTyr: 2.998 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.712HisAla: 1.712 ± 0.033	0.189HisCys: 0.189 ± 0.011	1.067HisAsp: 1.067 ± 0.027	1.341HisGlu: 1.341 ± 0.029	0.94HisPhe: 0.94 ± 0.026	1.503HisGly: 1.503 ± 0.034	0.679HisHis: 0.679 ± 0.02	1.484HisIle: 1.484 ± 0.027	0.886HisLys: 0.886 ± 0.021	2.022HisLeu: 2.022 ± 0.037	0.6HisMet: 0.6 ± 0.02	0.729HisAsn: 0.729 ± 0.022	1.135HisPro: 1.135 ± 0.027	0.8HisGln: 0.8 ± 0.023	1.142HisArg: 1.142 ± 0.025	1.344HisSer: 1.344 ± 0.033	1.149HisThr: 1.149 ± 0.028	1.472HisVal: 1.472 ± 0.028	0.309HisTrp: 0.309 ± 0.015	0.963HisTyr: 0.963 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.374IleAla: 6.374 ± 0.07	0.575IleCys: 0.575 ± 0.02	3.841IleAsp: 3.841 ± 0.06	4.491IleGlu: 4.491 ± 0.061	2.339IlePhe: 2.339 ± 0.045	5.643IleGly: 5.643 ± 0.068	1.573IleHis: 1.573 ± 0.032	4.444IleIle: 4.444 ± 0.066	2.98IleLys: 2.98 ± 0.049	5.682IleLeu: 5.682 ± 0.08	1.829IleMet: 1.829 ± 0.036	2.362IleAsn: 2.362 ± 0.044	3.007IlePro: 3.007 ± 0.051	2.521IleGln: 2.521 ± 0.047	3.837IleArg: 3.837 ± 0.051	4.502IleSer: 4.502 ± 0.056	3.797IleThr: 3.797 ± 0.053	5.415IleVal: 5.415 ± 0.06	0.757IleTrp: 0.757 ± 0.026	2.132IleTyr: 2.132 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.141LysAla: 4.141 ± 0.054	0.224LysCys: 0.224 ± 0.012	2.74LysAsp: 2.74 ± 0.051	4.253LysGlu: 4.253 ± 0.061	1.438LysPhe: 1.438 ± 0.031	3.617LysGly: 3.617 ± 0.052	1.132LysHis: 1.132 ± 0.028	2.843LysIle: 2.843 ± 0.05	3.036LysLys: 3.036 ± 0.058	5.806LysLeu: 5.806 ± 0.067	1.446LysMet: 1.446 ± 0.035	1.898LysAsn: 1.898 ± 0.04	2.199LysPro: 2.199 ± 0.043	2.388LysGln: 2.388 ± 0.041	2.975LysArg: 2.975 ± 0.043	3.082LysSer: 3.082 ± 0.044	2.605LysThr: 2.605 ± 0.047	3.419LysVal: 3.419 ± 0.053	0.724LysTrp: 0.724 ± 0.023	1.538LysTyr: 1.538 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	8.465LeuAla: 8.465 ± 0.094	0.788LeuCys: 0.788 ± 0.027	5.185LeuAsp: 5.185 ± 0.07	6.377LeuGlu: 6.377 ± 0.071	4.582LeuPhe: 4.582 ± 0.07	6.619LeuGly: 6.619 ± 0.08	2.284LeuHis: 2.284 ± 0.043	6.729LeuIle: 6.729 ± 0.078	5.154LeuLys: 5.154 ± 0.053	11.724LeuLeu: 11.724 ± 0.148	2.793LeuMet: 2.793 ± 0.044	3.82LeuAsn: 3.82 ± 0.056	4.358LeuPro: 4.358 ± 0.064	4.135LeuGln: 4.135 ± 0.056	5.18LeuArg: 5.18 ± 0.065	7.536LeuSer: 7.536 ± 0.082	5.811LeuThr: 5.811 ± 0.056	6.396LeuVal: 6.396 ± 0.071	1.076LeuTrp: 1.076 ± 0.033	3.324LeuTyr: 3.324 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.183MetAla: 2.183 ± 0.04	0.147MetCys: 0.147 ± 0.009	1.518MetAsp: 1.518 ± 0.032	1.997MetGlu: 1.997 ± 0.041	1.011MetPhe: 1.011 ± 0.027	1.78MetGly: 1.78 ± 0.037	0.484MetHis: 0.484 ± 0.016	2.001MetIle: 2.001 ± 0.04	2.047MetLys: 2.047 ± 0.037	3.181MetLeu: 3.181 ± 0.052	0.924MetMet: 0.924 ± 0.026	1.54MetAsn: 1.54 ± 0.031	1.152MetPro: 1.152 ± 0.028	0.963MetGln: 0.963 ± 0.025	1.452MetArg: 1.452 ± 0.032	1.952MetSer: 1.952 ± 0.029	1.802MetThr: 1.802 ± 0.034	1.708MetVal: 1.708 ± 0.03	0.226MetTrp: 0.226 ± 0.012	0.796MetTyr: 0.796 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.777AsnAla: 2.777 ± 0.048	0.239AsnCys: 0.239 ± 0.012	1.908AsnAsp: 1.908 ± 0.04	2.683AsnGlu: 2.683 ± 0.036	1.23AsnPhe: 1.23 ± 0.028	3.387AsnGly: 3.387 ± 0.061	0.883AsnHis: 0.883 ± 0.027	2.326AsnIle: 2.326 ± 0.045	2.004AsnLys: 2.004 ± 0.044	3.105AsnLeu: 3.105 ± 0.045	1.042AsnMet: 1.042 ± 0.024	1.555AsnAsn: 1.555 ± 0.046	1.937AsnPro: 1.937 ± 0.041	1.416AsnGln: 1.416 ± 0.037	2.259AsnArg: 2.259 ± 0.035	2.229AsnSer: 2.229 ± 0.046	1.956AsnThr: 1.956 ± 0.045	2.666AsnVal: 2.666 ± 0.046	0.546AsnTrp: 0.546 ± 0.018	1.329AsnTyr: 1.329 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	3.105ProAla: 3.105 ± 0.054	0.221ProCys: 0.221 ± 0.012	2.442ProAsp: 2.442 ± 0.037	3.042ProGlu: 3.042 ± 0.05	1.833ProPhe: 1.833 ± 0.036	2.808ProGly: 2.808 ± 0.044	0.862ProHis: 0.862 ± 0.023	2.66ProIle: 2.66 ± 0.037	1.669ProLys: 1.669 ± 0.034	3.936ProLeu: 3.936 ± 0.059	0.9ProMet: 0.9 ± 0.028	1.501ProAsn: 1.501 ± 0.034	1.285ProPro: 1.285 ± 0.034	1.329ProGln: 1.329 ± 0.026	1.391ProArg: 1.391 ± 0.027	2.726ProSer: 2.726 ± 0.045	2.259ProThr: 2.259 ± 0.147	2.979ProVal: 2.979 ± 0.044	0.478ProTrp: 0.478 ± 0.016	1.524ProTyr: 1.524 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.303GlnAla: 3.303 ± 0.046	0.191GlnCys: 0.191 ± 0.01	1.701GlnAsp: 1.701 ± 0.031	2.606GlnGlu: 2.606 ± 0.047	1.619GlnPhe: 1.619 ± 0.029	2.548GlnGly: 2.548 ± 0.045	0.848GlnHis: 0.848 ± 0.025	2.299GlnIle: 2.299 ± 0.043	1.759GlnLys: 1.759 ± 0.039	4.549GlnLeu: 4.549 ± 0.063	1.041GlnMet: 1.041 ± 0.025	1.285GlnAsn: 1.285 ± 0.027	1.56GlnPro: 1.56 ± 0.029	1.862GlnGln: 1.862 ± 0.037	1.925GlnArg: 1.925 ± 0.037	2.585GlnSer: 2.585 ± 0.041	1.853GlnThr: 1.853 ± 0.038	2.353GlnVal: 2.353 ± 0.036	0.542GlnTrp: 0.542 ± 0.019	1.465GlnTyr: 1.465 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.464ArgAla: 3.464 ± 0.054	0.31ArgCys: 0.31 ± 0.013	2.634ArgAsp: 2.634 ± 0.039	3.823ArgGlu: 3.823 ± 0.054	2.234ArgPhe: 2.234 ± 0.038	3.121ArgGly: 3.121 ± 0.05	1.12ArgHis: 1.12 ± 0.026	3.814ArgIle: 3.814 ± 0.049	2.938ArgLys: 2.938 ± 0.045	5.5ArgLeu: 5.5 ± 0.069	1.844ArgMet: 1.844 ± 0.04	2.149ArgAsn: 2.149 ± 0.036	1.641ArgPro: 1.641 ± 0.034	1.994ArgGln: 1.994 ± 0.038	2.732ArgArg: 2.732 ± 0.051	3.317ArgSer: 3.317 ± 0.045	2.693ArgThr: 2.693 ± 0.043	3.136ArgVal: 3.136 ± 0.048	0.685ArgTrp: 0.685 ± 0.024	2.09ArgTyr: 2.09 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.137SerAla: 5.137 ± 0.07	0.445SerCys: 0.445 ± 0.015	3.292SerAsp: 3.292 ± 0.05	4.165SerGlu: 4.165 ± 0.057	3.094SerPhe: 3.094 ± 0.042	5.737SerGly: 5.737 ± 0.071	1.376SerHis: 1.376 ± 0.03	4.846SerIle: 4.846 ± 0.056	3.212SerLys: 3.212 ± 0.05	6.646SerLeu: 6.646 ± 0.078	1.914SerMet: 1.914 ± 0.041	2.515SerAsn: 2.515 ± 0.059	2.529SerPro: 2.529 ± 0.038	2.066SerGln: 2.066 ± 0.035	3.167SerArg: 3.167 ± 0.047	4.594SerSer: 4.594 ± 0.072	3.301SerThr: 3.301 ± 0.057	4.557SerVal: 4.557 ± 0.06	0.827SerTrp: 0.827 ± 0.023	2.487SerTyr: 2.487 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	4.685ThrAla: 4.685 ± 0.071	0.311ThrCys: 0.311 ± 0.015	2.777ThrAsp: 2.777 ± 0.049	3.287ThrGlu: 3.287 ± 0.045	2.324ThrPhe: 2.324 ± 0.041	5.207ThrGly: 5.207 ± 0.457	0.987ThrHis: 0.987 ± 0.025	4.082ThrIle: 4.082 ± 0.059	2.464ThrLys: 2.464 ± 0.036	5.431ThrLeu: 5.431 ± 0.064	1.378ThrMet: 1.378 ± 0.03	1.987ThrAsn: 1.987 ± 0.043	2.539ThrPro: 2.539 ± 0.069	1.489ThrGln: 1.489 ± 0.036	2.189ThrArg: 2.189 ± 0.036	3.394ThrSer: 3.394 ± 0.05	2.999ThrThr: 2.999 ± 0.056	4.364ThrVal: 4.364 ± 0.06	0.616ThrTrp: 0.616 ± 0.022	1.945ThrTyr: 1.945 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	5.453ValAla: 5.453 ± 0.067	0.557ValCys: 0.557 ± 0.018	3.529ValAsp: 3.529 ± 0.045	4.401ValGlu: 4.401 ± 0.051	2.763ValPhe: 2.763 ± 0.045	4.439ValGly: 4.439 ± 0.059	1.481ValHis: 1.481 ± 0.028	5.024ValIle: 5.024 ± 0.063	3.668ValLys: 3.668 ± 0.049	7.012ValLeu: 7.012 ± 0.075	2.012ValMet: 2.012 ± 0.035	2.738ValAsn: 2.738 ± 0.046	2.883ValPro: 2.883 ± 0.043	2.554ValGln: 2.554 ± 0.042	3.424ValArg: 3.424 ± 0.041	4.77ValSer: 4.77 ± 0.056	4.473ValThr: 4.473 ± 0.086	4.964ValVal: 4.964 ± 0.07	0.861ValTrp: 0.861 ± 0.029	2.321ValTyr: 2.321 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.812TrpAla: 0.812 ± 0.024	0.082TrpCys: 0.082 ± 0.008	0.667TrpAsp: 0.667 ± 0.02	0.758TrpGlu: 0.758 ± 0.021	0.581TrpPhe: 0.581 ± 0.02	0.859TrpGly: 0.859 ± 0.03	0.268TrpHis: 0.268 ± 0.014	0.927TrpIle: 0.927 ± 0.029	0.691TrpLys: 0.691 ± 0.019	1.552TrpLeu: 1.552 ± 0.037	0.446TrpMet: 0.446 ± 0.019	0.673TrpAsn: 0.673 ± 0.023	0.384TrpPro: 0.384 ± 0.017	0.483TrpGln: 0.483 ± 0.017	0.702TrpArg: 0.702 ± 0.02	0.94TrpSer: 0.94 ± 0.028	0.693TrpThr: 0.693 ± 0.021	0.72TrpVal: 0.72 ± 0.024	0.176TrpTrp: 0.176 ± 0.011	0.397TrpTyr: 0.397 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.732TyrAla: 2.732 ± 0.041	0.309TyrCys: 0.309 ± 0.016	1.956TyrAsp: 1.956 ± 0.048	2.421TyrGlu: 2.421 ± 0.043	1.536TyrPhe: 1.536 ± 0.035	2.725TyrGly: 2.725 ± 0.045	0.733TyrHis: 0.733 ± 0.021	2.131TyrIle: 2.131 ± 0.034	1.622TyrLys: 1.622 ± 0.034	3.285TyrLeu: 3.285 ± 0.045	1.024TyrMet: 1.024 ± 0.028	1.362TyrAsn: 1.362 ± 0.031	1.493TyrPro: 1.493 ± 0.032	1.207TyrGln: 1.207 ± 0.028	2.12TyrArg: 2.12 ± 0.038	2.251TyrSer: 2.251 ± 0.042	1.903TyrThr: 1.903 ± 0.039	2.45TyrVal: 2.45 ± 0.045	0.48TyrTrp: 0.48 ± 0.02	1.472TyrTyr: 1.472 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5044 proteins (1661949 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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