Amino acid dipepetide frequency for Streptococcus phage Javan576

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.058AlaAla: 3.058 ± 0.564
0.382AlaCys: 0.382 ± 0.184
5.81AlaAsp: 5.81 ± 0.724
5.734AlaGlu: 5.734 ± 0.672
3.44AlaPhe: 3.44 ± 0.544
4.511AlaGly: 4.511 ± 0.729
0.841AlaHis: 0.841 ± 0.275
5.581AlaIle: 5.581 ± 0.666
6.269AlaLys: 6.269 ± 0.647
6.728AlaLeu: 6.728 ± 0.797
2.217AlaMet: 2.217 ± 0.584
4.434AlaAsn: 4.434 ± 0.565
1.911AlaPro: 1.911 ± 0.383
2.905AlaGln: 2.905 ± 0.475
3.517AlaArg: 3.517 ± 0.517
4.205AlaSer: 4.205 ± 0.692
4.664AlaThr: 4.664 ± 0.636
5.275AlaVal: 5.275 ± 0.663
0.535AlaTrp: 0.535 ± 0.258
2.37AlaTyr: 2.37 ± 0.383
0.0AlaXaa: 0.0 ± 0.0
Cys
0.153CysAla: 0.153 ± 0.117
0.0CysCys: 0.0 ± 0.0
0.306CysAsp: 0.306 ± 0.145
0.382CysGlu: 0.382 ± 0.188
0.153CysPhe: 0.153 ± 0.107
0.382CysGly: 0.382 ± 0.165
0.229CysHis: 0.229 ± 0.122
0.229CysIle: 0.229 ± 0.16
0.382CysLys: 0.382 ± 0.164
0.229CysLeu: 0.229 ± 0.141
0.0CysMet: 0.0 ± 0.0
0.153CysAsn: 0.153 ± 0.105
0.306CysPro: 0.306 ± 0.171
0.076CysGln: 0.076 ± 0.084
0.153CysArg: 0.153 ± 0.141
0.153CysSer: 0.153 ± 0.134
0.229CysThr: 0.229 ± 0.141
0.382CysVal: 0.382 ± 0.14
0.0CysTrp: 0.0 ± 0.0
0.229CysTyr: 0.229 ± 0.139
0.0CysXaa: 0.0 ± 0.0
Asp
3.899AspAla: 3.899 ± 0.46
0.229AspCys: 0.229 ± 0.136
4.358AspAsp: 4.358 ± 0.69
4.664AspGlu: 4.664 ± 0.616
2.217AspPhe: 2.217 ± 0.538
5.352AspGly: 5.352 ± 0.86
0.841AspHis: 0.841 ± 0.288
5.122AspIle: 5.122 ± 0.641
5.352AspLys: 5.352 ± 0.715
6.346AspLeu: 6.346 ± 0.654
1.453AspMet: 1.453 ± 0.362
3.746AspAsn: 3.746 ± 0.448
1.758AspPro: 1.758 ± 0.518
1.835AspGln: 1.835 ± 0.444
2.676AspArg: 2.676 ± 0.493
2.752AspSer: 2.752 ± 0.488
3.287AspThr: 3.287 ± 0.599
4.511AspVal: 4.511 ± 0.557
1.223AspTrp: 1.223 ± 0.256
3.058AspTyr: 3.058 ± 0.552
0.0AspXaa: 0.0 ± 0.0
Glu
6.346GluAla: 6.346 ± 0.74
0.153GluCys: 0.153 ± 0.105
3.67GluAsp: 3.67 ± 0.595
5.428GluGlu: 5.428 ± 0.923
2.982GluPhe: 2.982 ± 0.555
3.058GluGly: 3.058 ± 0.724
1.223GluHis: 1.223 ± 0.334
6.116GluIle: 6.116 ± 0.608
6.04GluLys: 6.04 ± 0.896
7.034GluLeu: 7.034 ± 0.834
1.835GluMet: 1.835 ± 0.449
3.746GluAsn: 3.746 ± 0.467
1.835GluPro: 1.835 ± 0.44
4.052GluGln: 4.052 ± 0.819
4.664GluArg: 4.664 ± 0.75
3.364GluSer: 3.364 ± 0.425
4.511GluThr: 4.511 ± 0.699
5.581GluVal: 5.581 ± 0.609
0.765GluTrp: 0.765 ± 0.178
2.523GluTyr: 2.523 ± 0.522
0.0GluXaa: 0.0 ± 0.0
Phe
2.752PheAla: 2.752 ± 0.454
0.153PheCys: 0.153 ± 0.115
4.128PheAsp: 4.128 ± 0.628
4.511PheGlu: 4.511 ± 0.621
1.147PhePhe: 1.147 ± 0.281
2.676PheGly: 2.676 ± 0.456
0.535PheHis: 0.535 ± 0.198
1.835PheIle: 1.835 ± 0.358
2.905PheLys: 2.905 ± 0.49
3.135PheLeu: 3.135 ± 0.633
0.994PheMet: 0.994 ± 0.285
2.37PheAsn: 2.37 ± 0.528
0.917PhePro: 0.917 ± 0.29
1.07PheGln: 1.07 ± 0.384
1.606PheArg: 1.606 ± 0.431
1.835PheSer: 1.835 ± 0.552
2.064PheThr: 2.064 ± 0.368
2.676PheVal: 2.676 ± 0.46
0.382PheTrp: 0.382 ± 0.164
2.141PheTyr: 2.141 ± 0.411
0.0PheXaa: 0.0 ± 0.0
Gly
3.67GlyAla: 3.67 ± 0.671
0.306GlyCys: 0.306 ± 0.148
3.517GlyAsp: 3.517 ± 0.498
3.67GlyGlu: 3.67 ± 0.515
3.287GlyPhe: 3.287 ± 0.569
4.511GlyGly: 4.511 ± 1.289
0.841GlyHis: 0.841 ± 0.253
5.046GlyIle: 5.046 ± 0.747
5.352GlyLys: 5.352 ± 0.51
5.046GlyLeu: 5.046 ± 0.812
1.911GlyMet: 1.911 ± 0.352
3.823GlyAsn: 3.823 ± 0.517
0.917GlyPro: 0.917 ± 0.319
3.058GlyGln: 3.058 ± 0.671
3.593GlyArg: 3.593 ± 0.435
3.135GlySer: 3.135 ± 0.547
3.058GlyThr: 3.058 ± 0.654
4.281GlyVal: 4.281 ± 0.49
1.07GlyTrp: 1.07 ± 0.293
2.752GlyTyr: 2.752 ± 0.47
0.0GlyXaa: 0.0 ± 0.0
His
0.765HisAla: 0.765 ± 0.327
0.306HisCys: 0.306 ± 0.159
0.917HisAsp: 0.917 ± 0.279
1.147HisGlu: 1.147 ± 0.291
0.841HisPhe: 0.841 ± 0.336
1.606HisGly: 1.606 ± 0.402
0.688HisHis: 0.688 ± 0.229
0.841HisIle: 0.841 ± 0.228
0.994HisLys: 0.994 ± 0.279
1.223HisLeu: 1.223 ± 0.269
0.229HisMet: 0.229 ± 0.131
0.688HisAsn: 0.688 ± 0.236
0.917HisPro: 0.917 ± 0.252
0.765HisGln: 0.765 ± 0.213
0.612HisArg: 0.612 ± 0.186
0.765HisSer: 0.765 ± 0.257
0.917HisThr: 0.917 ± 0.311
0.306HisVal: 0.306 ± 0.136
0.229HisTrp: 0.229 ± 0.104
0.459HisTyr: 0.459 ± 0.209
0.0HisXaa: 0.0 ± 0.0
Ile
6.422IleAla: 6.422 ± 0.623
0.535IleCys: 0.535 ± 0.193
4.969IleAsp: 4.969 ± 0.711
7.187IleGlu: 7.187 ± 0.822
2.37IlePhe: 2.37 ± 0.632
3.44IleGly: 3.44 ± 0.717
1.147IleHis: 1.147 ± 0.286
4.358IleIle: 4.358 ± 0.686
5.275IleLys: 5.275 ± 0.589
5.505IleLeu: 5.505 ± 0.874
1.147IleMet: 1.147 ± 0.353
4.128IleAsn: 4.128 ± 0.465
1.835IlePro: 1.835 ± 0.428
2.982IleGln: 2.982 ± 0.504
3.364IleArg: 3.364 ± 0.477
3.899IleSer: 3.899 ± 0.497
3.517IleThr: 3.517 ± 0.785
4.281IleVal: 4.281 ± 0.748
0.917IleTrp: 0.917 ± 0.258
2.523IleTyr: 2.523 ± 0.475
0.0IleXaa: 0.0 ± 0.0
Lys
5.963LysAla: 5.963 ± 0.764
0.459LysCys: 0.459 ± 0.191
4.205LysAsp: 4.205 ± 0.583
5.734LysGlu: 5.734 ± 0.815
2.294LysPhe: 2.294 ± 0.386
4.434LysGly: 4.434 ± 0.462
1.529LysHis: 1.529 ± 0.406
4.74LysIle: 4.74 ± 0.601
5.657LysLys: 5.657 ± 1.13
7.416LysLeu: 7.416 ± 0.696
2.829LysMet: 2.829 ± 0.497
3.593LysAsn: 3.593 ± 0.496
2.446LysPro: 2.446 ± 0.403
3.67LysGln: 3.67 ± 0.609
3.517LysArg: 3.517 ± 0.428
5.199LysSer: 5.199 ± 0.575
4.969LysThr: 4.969 ± 0.786
5.046LysVal: 5.046 ± 0.743
0.917LysTrp: 0.917 ± 0.3
3.211LysTyr: 3.211 ± 0.632
0.0LysXaa: 0.0 ± 0.0
Leu
5.963LeuAla: 5.963 ± 0.661
0.076LeuCys: 0.076 ± 0.083
7.263LeuAsp: 7.263 ± 0.639
6.957LeuGlu: 6.957 ± 0.704
3.899LeuPhe: 3.899 ± 0.472
5.046LeuGly: 5.046 ± 0.97
1.07LeuHis: 1.07 ± 0.34
5.199LeuIle: 5.199 ± 0.769
7.722LeuLys: 7.722 ± 0.677
7.263LeuLeu: 7.263 ± 0.921
2.064LeuMet: 2.064 ± 0.369
3.823LeuAsn: 3.823 ± 0.654
2.982LeuPro: 2.982 ± 0.553
4.281LeuGln: 4.281 ± 0.574
4.358LeuArg: 4.358 ± 0.616
6.193LeuSer: 6.193 ± 0.879
5.734LeuThr: 5.734 ± 0.965
4.969LeuVal: 4.969 ± 0.837
0.382LeuTrp: 0.382 ± 0.166
1.529LeuTyr: 1.529 ± 0.34
0.0LeuXaa: 0.0 ± 0.0
Met
1.911MetAla: 1.911 ± 0.369
0.0MetCys: 0.0 ± 0.0
0.917MetAsp: 0.917 ± 0.256
1.376MetGlu: 1.376 ± 0.364
1.223MetPhe: 1.223 ± 0.338
1.453MetGly: 1.453 ± 0.472
0.229MetHis: 0.229 ± 0.135
1.758MetIle: 1.758 ± 0.402
1.682MetLys: 1.682 ± 0.305
2.141MetLeu: 2.141 ± 0.384
0.688MetMet: 0.688 ± 0.237
1.223MetAsn: 1.223 ± 0.373
0.841MetPro: 0.841 ± 0.237
0.994MetGln: 0.994 ± 0.302
1.3MetArg: 1.3 ± 0.434
1.758MetSer: 1.758 ± 0.412
1.911MetThr: 1.911 ± 0.405
1.835MetVal: 1.835 ± 0.434
0.153MetTrp: 0.153 ± 0.101
0.994MetTyr: 0.994 ± 0.261
0.0MetXaa: 0.0 ± 0.0
Asn
3.899AsnAla: 3.899 ± 0.59
0.0AsnCys: 0.0 ± 0.0
3.058AsnAsp: 3.058 ± 0.429
3.135AsnGlu: 3.135 ± 0.465
1.988AsnPhe: 1.988 ± 0.381
4.74AsnGly: 4.74 ± 0.762
0.765AsnHis: 0.765 ± 0.259
3.899AsnIle: 3.899 ± 0.841
3.211AsnLys: 3.211 ± 0.432
5.657AsnLeu: 5.657 ± 0.504
0.765AsnMet: 0.765 ± 0.245
2.829AsnAsn: 2.829 ± 0.461
1.758AsnPro: 1.758 ± 0.402
2.446AsnGln: 2.446 ± 0.387
2.523AsnArg: 2.523 ± 0.453
2.523AsnSer: 2.523 ± 0.434
3.287AsnThr: 3.287 ± 0.411
3.211AsnVal: 3.211 ± 0.528
0.841AsnTrp: 0.841 ± 0.289
1.988AsnTyr: 1.988 ± 0.336
0.0AsnXaa: 0.0 ± 0.0
Pro
2.217ProAla: 2.217 ± 0.378
0.076ProCys: 0.076 ± 0.08
1.988ProAsp: 1.988 ± 0.479
2.294ProGlu: 2.294 ± 0.437
1.147ProPhe: 1.147 ± 0.299
1.529ProGly: 1.529 ± 0.352
0.612ProHis: 0.612 ± 0.236
2.294ProIle: 2.294 ± 0.546
2.523ProLys: 2.523 ± 0.516
1.758ProLeu: 1.758 ± 0.375
0.612ProMet: 0.612 ± 0.209
1.147ProAsn: 1.147 ± 0.328
0.306ProPro: 0.306 ± 0.147
0.994ProGln: 0.994 ± 0.3
0.917ProArg: 0.917 ± 0.203
1.606ProSer: 1.606 ± 0.328
1.758ProThr: 1.758 ± 0.339
2.599ProVal: 2.599 ± 0.496
0.535ProTrp: 0.535 ± 0.246
1.376ProTyr: 1.376 ± 0.411
0.0ProXaa: 0.0 ± 0.0
Gln
5.734GlnAla: 5.734 ± 0.956
0.0GlnCys: 0.0 ± 0.0
1.529GlnAsp: 1.529 ± 0.376
2.599GlnGlu: 2.599 ± 0.559
1.911GlnPhe: 1.911 ± 0.309
2.294GlnGly: 2.294 ± 0.521
0.841GlnHis: 0.841 ± 0.289
3.135GlnIle: 3.135 ± 0.534
2.829GlnLys: 2.829 ± 0.517
3.746GlnLeu: 3.746 ± 0.494
1.453GlnMet: 1.453 ± 0.408
1.835GlnAsn: 1.835 ± 0.389
1.223GlnPro: 1.223 ± 0.283
2.217GlnGln: 2.217 ± 0.611
1.376GlnArg: 1.376 ± 0.417
2.446GlnSer: 2.446 ± 0.534
3.135GlnThr: 3.135 ± 0.496
2.982GlnVal: 2.982 ± 0.434
0.459GlnTrp: 0.459 ± 0.173
1.682GlnTyr: 1.682 ± 0.315
0.0GlnXaa: 0.0 ± 0.0
Arg
3.211ArgAla: 3.211 ± 0.541
0.306ArgCys: 0.306 ± 0.14
2.217ArgAsp: 2.217 ± 0.388
3.67ArgGlu: 3.67 ± 0.576
1.988ArgPhe: 1.988 ± 0.43
1.682ArgGly: 1.682 ± 0.473
0.765ArgHis: 0.765 ± 0.263
3.517ArgIle: 3.517 ± 0.386
3.593ArgLys: 3.593 ± 0.692
4.358ArgLeu: 4.358 ± 0.596
1.606ArgMet: 1.606 ± 0.402
2.752ArgAsn: 2.752 ± 0.472
0.994ArgPro: 0.994 ± 0.278
2.217ArgGln: 2.217 ± 0.374
1.758ArgArg: 1.758 ± 0.429
2.446ArgSer: 2.446 ± 0.454
2.905ArgThr: 2.905 ± 0.393
2.982ArgVal: 2.982 ± 0.527
0.765ArgTrp: 0.765 ± 0.226
1.911ArgTyr: 1.911 ± 0.343
0.0ArgXaa: 0.0 ± 0.0
Ser
4.511SerAla: 4.511 ± 0.735
0.0SerCys: 0.0 ± 0.0
4.128SerAsp: 4.128 ± 0.577
3.899SerGlu: 3.899 ± 0.585
2.217SerPhe: 2.217 ± 0.555
4.128SerGly: 4.128 ± 0.556
0.994SerHis: 0.994 ± 0.255
3.976SerIle: 3.976 ± 0.538
4.358SerLys: 4.358 ± 0.647
5.657SerLeu: 5.657 ± 0.794
1.147SerMet: 1.147 ± 0.298
2.523SerAsn: 2.523 ± 0.586
1.3SerPro: 1.3 ± 0.336
2.294SerGln: 2.294 ± 0.775
2.599SerArg: 2.599 ± 0.531
4.128SerSer: 4.128 ± 0.809
3.746SerThr: 3.746 ± 0.526
3.287SerVal: 3.287 ± 0.51
0.917SerTrp: 0.917 ± 0.278
2.523SerTyr: 2.523 ± 0.406
0.0SerXaa: 0.0 ± 0.0
Thr
5.657ThrAla: 5.657 ± 1.056
0.229ThrCys: 0.229 ± 0.127
3.211ThrAsp: 3.211 ± 0.462
4.128ThrGlu: 4.128 ± 0.527
2.217ThrPhe: 2.217 ± 0.469
5.199ThrGly: 5.199 ± 0.875
0.535ThrHis: 0.535 ± 0.226
4.664ThrIle: 4.664 ± 0.507
4.664ThrLys: 4.664 ± 0.7
3.899ThrLeu: 3.899 ± 0.647
1.223ThrMet: 1.223 ± 0.354
2.523ThrAsn: 2.523 ± 0.452
1.606ThrPro: 1.606 ± 0.365
2.217ThrGln: 2.217 ± 0.479
2.294ThrArg: 2.294 ± 0.418
4.052ThrSer: 4.052 ± 0.652
3.287ThrThr: 3.287 ± 0.623
5.428ThrVal: 5.428 ± 1.058
0.535ThrTrp: 0.535 ± 0.201
1.835ThrTyr: 1.835 ± 0.455
0.0ThrXaa: 0.0 ± 0.0
Val
5.963ValAla: 5.963 ± 0.544
0.612ValCys: 0.612 ± 0.21
5.122ValAsp: 5.122 ± 0.496
4.205ValGlu: 4.205 ± 0.485
2.141ValPhe: 2.141 ± 0.485
4.052ValGly: 4.052 ± 0.54
0.841ValHis: 0.841 ± 0.325
3.899ValIle: 3.899 ± 0.701
5.275ValLys: 5.275 ± 0.748
5.199ValLeu: 5.199 ± 0.648
1.3ValMet: 1.3 ± 0.322
4.281ValAsn: 4.281 ± 0.443
2.446ValPro: 2.446 ± 0.406
2.141ValGln: 2.141 ± 0.423
2.141ValArg: 2.141 ± 0.365
4.969ValSer: 4.969 ± 0.592
4.052ValThr: 4.052 ± 0.653
5.046ValVal: 5.046 ± 0.815
0.917ValTrp: 0.917 ± 0.296
3.058ValTyr: 3.058 ± 0.624
0.0ValXaa: 0.0 ± 0.0
Trp
0.306TrpAla: 0.306 ± 0.158
0.076TrpCys: 0.076 ± 0.071
0.841TrpAsp: 0.841 ± 0.361
1.3TrpGlu: 1.3 ± 0.385
0.612TrpPhe: 0.612 ± 0.326
0.917TrpGly: 0.917 ± 0.26
0.153TrpHis: 0.153 ± 0.113
0.459TrpIle: 0.459 ± 0.209
0.765TrpLys: 0.765 ± 0.23
1.147TrpLeu: 1.147 ± 0.298
0.153TrpMet: 0.153 ± 0.101
0.994TrpAsn: 0.994 ± 0.394
0.076TrpPro: 0.076 ± 0.076
0.994TrpGln: 0.994 ± 0.312
0.382TrpArg: 0.382 ± 0.199
0.688TrpSer: 0.688 ± 0.227
0.612TrpThr: 0.612 ± 0.221
0.994TrpVal: 0.994 ± 0.31
0.0TrpTrp: 0.0 ± 0.0
0.382TrpTyr: 0.382 ± 0.169
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.988TyrAla: 1.988 ± 0.426
0.229TyrCys: 0.229 ± 0.13
2.523TyrAsp: 2.523 ± 0.403
2.905TyrGlu: 2.905 ± 0.614
1.758TyrPhe: 1.758 ± 0.331
1.835TyrGly: 1.835 ± 0.455
0.535TyrHis: 0.535 ± 0.19
3.135TyrIle: 3.135 ± 0.655
2.982TyrLys: 2.982 ± 0.556
3.287TyrLeu: 3.287 ± 0.404
0.688TyrMet: 0.688 ± 0.293
1.911TyrAsn: 1.911 ± 0.457
1.911TyrPro: 1.911 ± 0.395
2.217TyrGln: 2.217 ± 0.434
2.294TyrArg: 2.294 ± 0.631
2.294TyrSer: 2.294 ± 0.332
1.758TyrThr: 1.758 ± 0.292
1.988TyrVal: 1.988 ± 0.33
0.306TyrTrp: 0.306 ± 0.15
1.529TyrTyr: 1.529 ± 0.436
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 67 proteins (13081 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski