Amino acid dipepetide frequency for Streptococcus phage Javan275

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.314AlaAla: 4.314 ± 0.849
0.664AlaCys: 0.664 ± 0.255
4.093AlaAsp: 4.093 ± 0.744
5.973AlaGlu: 5.973 ± 1.178
2.655AlaPhe: 2.655 ± 0.413
3.872AlaGly: 3.872 ± 0.61
0.553AlaHis: 0.553 ± 0.285
5.31AlaIle: 5.31 ± 0.683
4.867AlaLys: 4.867 ± 0.766
5.752AlaLeu: 5.752 ± 1.372
1.881AlaMet: 1.881 ± 0.374
3.208AlaAsn: 3.208 ± 0.742
1.327AlaPro: 1.327 ± 0.43
2.544AlaGln: 2.544 ± 0.556
2.876AlaArg: 2.876 ± 0.537
4.535AlaSer: 4.535 ± 0.679
4.646AlaThr: 4.646 ± 0.819
5.31AlaVal: 5.31 ± 0.949
0.332AlaTrp: 0.332 ± 0.17
2.876AlaTyr: 2.876 ± 0.645
0.0AlaXaa: 0.0 ± 0.0
Cys
0.111CysAla: 0.111 ± 0.104
0.111CysCys: 0.111 ± 0.114
0.111CysAsp: 0.111 ± 0.099
0.332CysGlu: 0.332 ± 0.163
0.221CysPhe: 0.221 ± 0.17
0.221CysGly: 0.221 ± 0.142
0.0CysHis: 0.0 ± 0.0
0.885CysIle: 0.885 ± 0.431
0.332CysLys: 0.332 ± 0.174
0.221CysLeu: 0.221 ± 0.191
0.0CysMet: 0.0 ± 0.0
0.221CysAsn: 0.221 ± 0.155
0.0CysPro: 0.0 ± 0.0
0.332CysGln: 0.332 ± 0.172
0.332CysArg: 0.332 ± 0.222
0.553CysSer: 0.553 ± 0.2
0.111CysThr: 0.111 ± 0.086
0.332CysVal: 0.332 ± 0.184
0.0CysTrp: 0.0 ± 0.0
0.664CysTyr: 0.664 ± 0.274
0.0CysXaa: 0.0 ± 0.0
Asp
4.314AspAla: 4.314 ± 0.582
0.332AspCys: 0.332 ± 0.167
4.757AspAsp: 4.757 ± 0.816
4.646AspGlu: 4.646 ± 0.813
3.54AspPhe: 3.54 ± 0.634
4.646AspGly: 4.646 ± 0.853
0.664AspHis: 0.664 ± 0.255
5.531AspIle: 5.531 ± 0.821
4.646AspLys: 4.646 ± 0.675
5.199AspLeu: 5.199 ± 0.596
1.881AspMet: 1.881 ± 0.398
4.425AspAsn: 4.425 ± 0.784
1.438AspPro: 1.438 ± 0.348
1.106AspGln: 1.106 ± 0.294
1.549AspArg: 1.549 ± 0.349
3.429AspSer: 3.429 ± 0.689
1.991AspThr: 1.991 ± 0.441
3.429AspVal: 3.429 ± 0.472
1.438AspTrp: 1.438 ± 0.42
3.097AspTyr: 3.097 ± 0.606
0.0AspXaa: 0.0 ± 0.0
Glu
4.978GluAla: 4.978 ± 0.771
0.221GluCys: 0.221 ± 0.15
2.765GluAsp: 2.765 ± 0.508
7.08GluGlu: 7.08 ± 1.301
2.544GluPhe: 2.544 ± 0.779
3.54GluGly: 3.54 ± 0.662
0.885GluHis: 0.885 ± 0.398
5.863GluIle: 5.863 ± 0.771
6.305GluLys: 6.305 ± 1.005
10.177GluLeu: 10.177 ± 1.21
2.655GluMet: 2.655 ± 0.681
4.425GluAsn: 4.425 ± 0.697
0.996GluPro: 0.996 ± 0.358
3.097GluGln: 3.097 ± 0.724
3.65GluArg: 3.65 ± 0.54
4.093GluSer: 4.093 ± 0.666
4.204GluThr: 4.204 ± 0.779
5.199GluVal: 5.199 ± 0.787
1.106GluTrp: 1.106 ± 0.276
2.655GluTyr: 2.655 ± 0.768
0.0GluXaa: 0.0 ± 0.0
Phe
2.323PheAla: 2.323 ± 0.423
0.111PheCys: 0.111 ± 0.104
3.319PheAsp: 3.319 ± 0.546
3.982PheGlu: 3.982 ± 0.775
1.659PhePhe: 1.659 ± 0.553
3.65PheGly: 3.65 ± 0.559
0.553PheHis: 0.553 ± 0.243
3.65PheIle: 3.65 ± 0.643
4.646PheLys: 4.646 ± 0.662
3.097PheLeu: 3.097 ± 0.598
1.77PheMet: 1.77 ± 0.517
3.208PheAsn: 3.208 ± 0.515
0.885PhePro: 0.885 ± 0.337
1.327PheGln: 1.327 ± 0.43
1.327PheArg: 1.327 ± 0.364
1.659PheSer: 1.659 ± 0.443
1.77PheThr: 1.77 ± 0.438
1.327PheVal: 1.327 ± 0.326
0.332PheTrp: 0.332 ± 0.204
2.102PheTyr: 2.102 ± 0.606
0.0PheXaa: 0.0 ± 0.0
Gly
3.761GlyAla: 3.761 ± 0.663
0.111GlyCys: 0.111 ± 0.086
3.319GlyAsp: 3.319 ± 0.683
2.987GlyGlu: 2.987 ± 0.486
3.097GlyPhe: 3.097 ± 0.529
4.093GlyGly: 4.093 ± 0.814
0.885GlyHis: 0.885 ± 0.394
3.65GlyIle: 3.65 ± 0.675
4.314GlyLys: 4.314 ± 0.664
4.867GlyLeu: 4.867 ± 0.841
1.881GlyMet: 1.881 ± 0.451
4.093GlyAsn: 4.093 ± 0.807
0.553GlyPro: 0.553 ± 0.177
2.876GlyGln: 2.876 ± 0.689
1.659GlyArg: 1.659 ± 0.404
4.314GlySer: 4.314 ± 0.747
3.872GlyThr: 3.872 ± 0.615
3.65GlyVal: 3.65 ± 0.596
0.885GlyTrp: 0.885 ± 0.349
2.987GlyTyr: 2.987 ± 0.735
0.0GlyXaa: 0.0 ± 0.0
His
0.553HisAla: 0.553 ± 0.382
0.221HisCys: 0.221 ± 0.169
0.885HisAsp: 0.885 ± 0.416
1.106HisGlu: 1.106 ± 0.395
0.774HisPhe: 0.774 ± 0.307
0.885HisGly: 0.885 ± 0.332
0.221HisHis: 0.221 ± 0.175
1.881HisIle: 1.881 ± 0.491
0.885HisLys: 0.885 ± 0.308
1.438HisLeu: 1.438 ± 0.406
0.553HisMet: 0.553 ± 0.322
0.774HisAsn: 0.774 ± 0.266
0.332HisPro: 0.332 ± 0.187
0.774HisGln: 0.774 ± 0.266
0.111HisArg: 0.111 ± 0.129
1.327HisSer: 1.327 ± 0.424
0.664HisThr: 0.664 ± 0.324
0.332HisVal: 0.332 ± 0.17
0.111HisTrp: 0.111 ± 0.114
0.885HisTyr: 0.885 ± 0.422
0.0HisXaa: 0.0 ± 0.0
Ile
5.42IleAla: 5.42 ± 0.894
0.885IleCys: 0.885 ± 0.345
5.973IleAsp: 5.973 ± 0.83
5.31IleGlu: 5.31 ± 0.678
1.881IlePhe: 1.881 ± 0.382
2.655IleGly: 2.655 ± 0.549
1.77IleHis: 1.77 ± 0.486
4.757IleIle: 4.757 ± 0.92
7.965IleLys: 7.965 ± 1.15
6.637IleLeu: 6.637 ± 0.818
2.323IleMet: 2.323 ± 0.522
3.65IleAsn: 3.65 ± 0.519
2.434IlePro: 2.434 ± 0.538
1.659IleGln: 1.659 ± 0.503
2.323IleArg: 2.323 ± 0.55
5.42IleSer: 5.42 ± 0.912
5.863IleThr: 5.863 ± 0.894
5.42IleVal: 5.42 ± 0.74
0.553IleTrp: 0.553 ± 0.273
2.102IleTyr: 2.102 ± 0.537
0.0IleXaa: 0.0 ± 0.0
Lys
5.863LysAla: 5.863 ± 0.781
0.332LysCys: 0.332 ± 0.201
4.093LysAsp: 4.093 ± 0.651
7.633LysGlu: 7.633 ± 1.145
3.429LysPhe: 3.429 ± 0.519
2.655LysGly: 2.655 ± 0.539
0.996LysHis: 0.996 ± 0.415
5.088LysIle: 5.088 ± 0.739
6.858LysLys: 6.858 ± 0.946
5.752LysLeu: 5.752 ± 0.725
2.212LysMet: 2.212 ± 0.493
5.199LysAsn: 5.199 ± 0.704
2.987LysPro: 2.987 ± 0.64
3.65LysGln: 3.65 ± 0.612
3.54LysArg: 3.54 ± 0.652
4.757LysSer: 4.757 ± 0.743
6.305LysThr: 6.305 ± 0.974
4.646LysVal: 4.646 ± 0.689
0.996LysTrp: 0.996 ± 0.399
2.212LysTyr: 2.212 ± 0.554
0.0LysXaa: 0.0 ± 0.0
Leu
7.301LeuAla: 7.301 ± 0.818
0.221LeuCys: 0.221 ± 0.165
5.531LeuAsp: 5.531 ± 0.697
6.527LeuGlu: 6.527 ± 0.792
3.54LeuPhe: 3.54 ± 0.907
5.42LeuGly: 5.42 ± 0.644
0.885LeuHis: 0.885 ± 0.277
6.195LeuIle: 6.195 ± 0.887
6.527LeuLys: 6.527 ± 0.659
6.084LeuLeu: 6.084 ± 0.882
1.217LeuMet: 1.217 ± 0.367
4.757LeuAsn: 4.757 ± 0.83
2.765LeuPro: 2.765 ± 0.645
3.319LeuGln: 3.319 ± 0.8
3.429LeuArg: 3.429 ± 0.802
6.195LeuSer: 6.195 ± 1.06
6.084LeuThr: 6.084 ± 0.575
4.646LeuVal: 4.646 ± 0.611
0.442LeuTrp: 0.442 ± 0.155
2.655LeuTyr: 2.655 ± 0.566
0.0LeuXaa: 0.0 ± 0.0
Met
1.659MetAla: 1.659 ± 0.406
0.0MetCys: 0.0 ± 0.0
1.549MetAsp: 1.549 ± 0.356
1.77MetGlu: 1.77 ± 0.487
1.659MetPhe: 1.659 ± 0.51
1.659MetGly: 1.659 ± 0.423
0.442MetHis: 0.442 ± 0.253
1.77MetIle: 1.77 ± 0.434
1.881MetLys: 1.881 ± 0.447
1.881MetLeu: 1.881 ± 0.476
0.221MetMet: 0.221 ± 0.161
2.212MetAsn: 2.212 ± 0.4
0.885MetPro: 0.885 ± 0.372
0.664MetGln: 0.664 ± 0.36
1.659MetArg: 1.659 ± 0.474
2.655MetSer: 2.655 ± 0.466
2.765MetThr: 2.765 ± 0.63
0.885MetVal: 0.885 ± 0.252
0.332MetTrp: 0.332 ± 0.191
0.664MetTyr: 0.664 ± 0.245
0.0MetXaa: 0.0 ± 0.0
Asn
3.429AsnAla: 3.429 ± 0.488
0.553AsnCys: 0.553 ± 0.372
3.872AsnAsp: 3.872 ± 0.59
3.761AsnGlu: 3.761 ± 0.624
2.434AsnPhe: 2.434 ± 0.578
4.535AsnGly: 4.535 ± 0.916
1.106AsnHis: 1.106 ± 0.431
2.987AsnIle: 2.987 ± 0.627
4.535AsnLys: 4.535 ± 0.773
4.535AsnLeu: 4.535 ± 0.859
1.77AsnMet: 1.77 ± 0.445
2.544AsnAsn: 2.544 ± 0.408
2.212AsnPro: 2.212 ± 0.617
2.655AsnGln: 2.655 ± 0.369
2.655AsnArg: 2.655 ± 0.574
4.204AsnSer: 4.204 ± 0.974
4.757AsnThr: 4.757 ± 0.752
4.646AsnVal: 4.646 ± 0.631
0.664AsnTrp: 0.664 ± 0.247
2.102AsnTyr: 2.102 ± 0.536
0.0AsnXaa: 0.0 ± 0.0
Pro
1.549ProAla: 1.549 ± 0.509
0.221ProCys: 0.221 ± 0.124
1.881ProAsp: 1.881 ± 0.685
1.438ProGlu: 1.438 ± 0.36
1.549ProPhe: 1.549 ± 0.388
0.664ProGly: 0.664 ± 0.23
0.442ProHis: 0.442 ± 0.29
2.544ProIle: 2.544 ± 0.535
1.77ProLys: 1.77 ± 0.458
2.102ProLeu: 2.102 ± 0.347
0.332ProMet: 0.332 ± 0.164
0.553ProAsn: 0.553 ± 0.21
0.332ProPro: 0.332 ± 0.216
1.77ProGln: 1.77 ± 0.416
1.327ProArg: 1.327 ± 0.398
2.544ProSer: 2.544 ± 0.596
1.438ProThr: 1.438 ± 0.334
2.102ProVal: 2.102 ± 0.498
0.332ProTrp: 0.332 ± 0.168
0.885ProTyr: 0.885 ± 0.31
0.0ProXaa: 0.0 ± 0.0
Gln
3.982GlnAla: 3.982 ± 0.642
0.111GlnCys: 0.111 ± 0.119
1.991GlnAsp: 1.991 ± 0.557
3.872GlnGlu: 3.872 ± 0.58
2.212GlnPhe: 2.212 ± 0.526
1.991GlnGly: 1.991 ± 0.499
0.442GlnHis: 0.442 ± 0.213
2.212GlnIle: 2.212 ± 0.481
2.765GlnLys: 2.765 ± 0.507
2.987GlnLeu: 2.987 ± 0.712
0.664GlnMet: 0.664 ± 0.206
2.102GlnAsn: 2.102 ± 0.646
1.327GlnPro: 1.327 ± 0.379
2.323GlnGln: 2.323 ± 0.536
2.323GlnArg: 2.323 ± 0.523
1.881GlnSer: 1.881 ± 0.409
1.991GlnThr: 1.991 ± 0.388
2.102GlnVal: 2.102 ± 0.556
0.332GlnTrp: 0.332 ± 0.215
1.327GlnTyr: 1.327 ± 0.354
0.0GlnXaa: 0.0 ± 0.0
Arg
2.323ArgAla: 2.323 ± 0.565
0.0ArgCys: 0.0 ± 0.0
2.323ArgAsp: 2.323 ± 0.561
2.544ArgGlu: 2.544 ± 0.651
1.549ArgPhe: 1.549 ± 0.595
1.549ArgGly: 1.549 ± 0.364
0.885ArgHis: 0.885 ± 0.305
3.097ArgIle: 3.097 ± 0.722
3.761ArgLys: 3.761 ± 0.805
3.097ArgLeu: 3.097 ± 0.502
1.438ArgMet: 1.438 ± 0.394
3.097ArgAsn: 3.097 ± 0.612
1.549ArgPro: 1.549 ± 0.392
2.434ArgGln: 2.434 ± 0.574
1.77ArgArg: 1.77 ± 0.496
2.323ArgSer: 2.323 ± 0.489
1.77ArgThr: 1.77 ± 0.493
2.434ArgVal: 2.434 ± 0.489
0.332ArgTrp: 0.332 ± 0.206
1.881ArgTyr: 1.881 ± 0.495
0.0ArgXaa: 0.0 ± 0.0
Ser
4.314SerAla: 4.314 ± 0.811
0.221SerCys: 0.221 ± 0.17
3.872SerAsp: 3.872 ± 0.604
4.646SerGlu: 4.646 ± 0.736
2.765SerPhe: 2.765 ± 0.605
4.093SerGly: 4.093 ± 0.783
1.217SerHis: 1.217 ± 0.367
5.31SerIle: 5.31 ± 0.752
4.314SerLys: 4.314 ± 0.849
5.199SerLeu: 5.199 ± 0.626
1.659SerMet: 1.659 ± 0.48
4.425SerAsn: 4.425 ± 0.644
2.102SerPro: 2.102 ± 0.547
2.655SerGln: 2.655 ± 0.63
2.655SerArg: 2.655 ± 0.584
5.088SerSer: 5.088 ± 0.99
3.761SerThr: 3.761 ± 0.765
4.314SerVal: 4.314 ± 0.802
0.664SerTrp: 0.664 ± 0.262
2.765SerTyr: 2.765 ± 0.603
0.0SerXaa: 0.0 ± 0.0
Thr
4.204ThrAla: 4.204 ± 0.829
0.111ThrCys: 0.111 ± 0.118
4.757ThrAsp: 4.757 ± 0.815
4.204ThrGlu: 4.204 ± 0.742
2.544ThrPhe: 2.544 ± 0.557
5.199ThrGly: 5.199 ± 0.92
0.885ThrHis: 0.885 ± 0.315
5.752ThrIle: 5.752 ± 1.423
4.535ThrLys: 4.535 ± 0.714
5.088ThrLeu: 5.088 ± 0.804
1.881ThrMet: 1.881 ± 0.443
3.097ThrAsn: 3.097 ± 0.642
0.774ThrPro: 0.774 ± 0.334
1.549ThrGln: 1.549 ± 0.495
2.212ThrArg: 2.212 ± 0.544
3.54ThrSer: 3.54 ± 0.802
3.65ThrThr: 3.65 ± 0.669
5.973ThrVal: 5.973 ± 0.792
0.996ThrTrp: 0.996 ± 0.392
2.987ThrTyr: 2.987 ± 0.559
0.0ThrXaa: 0.0 ± 0.0
Val
4.314ValAla: 4.314 ± 0.761
0.111ValCys: 0.111 ± 0.104
4.093ValAsp: 4.093 ± 0.548
4.757ValGlu: 4.757 ± 0.826
1.991ValPhe: 1.991 ± 0.439
2.987ValGly: 2.987 ± 0.533
0.996ValHis: 0.996 ± 0.351
5.531ValIle: 5.531 ± 0.804
4.646ValLys: 4.646 ± 0.657
4.646ValLeu: 4.646 ± 0.601
1.217ValMet: 1.217 ± 0.346
4.535ValAsn: 4.535 ± 0.65
1.659ValPro: 1.659 ± 0.395
1.549ValGln: 1.549 ± 0.301
1.881ValArg: 1.881 ± 0.5
4.425ValSer: 4.425 ± 0.683
6.305ValThr: 6.305 ± 0.813
3.208ValVal: 3.208 ± 0.471
0.774ValTrp: 0.774 ± 0.565
2.765ValTyr: 2.765 ± 0.63
0.0ValXaa: 0.0 ± 0.0
Trp
0.553TrpAla: 0.553 ± 0.263
0.0TrpCys: 0.0 ± 0.0
0.442TrpAsp: 0.442 ± 0.23
0.664TrpGlu: 0.664 ± 0.297
0.664TrpPhe: 0.664 ± 0.227
0.885TrpGly: 0.885 ± 0.339
0.111TrpHis: 0.111 ± 0.124
0.664TrpIle: 0.664 ± 0.31
0.553TrpLys: 0.553 ± 0.271
0.885TrpLeu: 0.885 ± 0.295
0.332TrpMet: 0.332 ± 0.228
1.217TrpAsn: 1.217 ± 0.368
0.111TrpPro: 0.111 ± 0.086
0.774TrpGln: 0.774 ± 0.322
0.774TrpArg: 0.774 ± 0.278
0.885TrpSer: 0.885 ± 0.308
0.332TrpThr: 0.332 ± 0.166
0.553TrpVal: 0.553 ± 0.21
0.111TrpTrp: 0.111 ± 0.093
0.553TrpTyr: 0.553 ± 0.241
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.323TyrAla: 2.323 ± 0.529
0.553TyrCys: 0.553 ± 0.263
2.434TyrAsp: 2.434 ± 0.528
3.208TyrGlu: 3.208 ± 0.779
1.991TyrPhe: 1.991 ± 0.53
2.655TyrGly: 2.655 ± 0.475
0.774TyrHis: 0.774 ± 0.362
2.323TyrIle: 2.323 ± 0.465
3.208TyrLys: 3.208 ± 0.666
4.093TyrLeu: 4.093 ± 0.864
1.217TyrMet: 1.217 ± 0.36
2.212TyrAsn: 2.212 ± 0.499
1.106TyrPro: 1.106 ± 0.323
1.881TyrGln: 1.881 ± 0.44
2.102TyrArg: 2.102 ± 0.462
2.212TyrSer: 2.212 ± 0.481
1.659TyrThr: 1.659 ± 0.406
1.881TyrVal: 1.881 ± 0.468
0.332TyrTrp: 0.332 ± 0.217
1.991TyrTyr: 1.991 ± 0.509
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 48 proteins (9041 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski