Amino acid dipepetide frequency for Gaetbulibacter sp. 4G1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.56AlaAla: 3.56 ± 0.085	0.545AlaCys: 0.545 ± 0.025	3.009AlaAsp: 3.009 ± 0.067	3.511AlaGlu: 3.511 ± 0.063	3.328AlaPhe: 3.328 ± 0.059	3.762AlaGly: 3.762 ± 0.072	1.066AlaHis: 1.066 ± 0.029	5.469AlaIle: 5.469 ± 0.084	4.613AlaLys: 4.613 ± 0.077	5.976AlaLeu: 5.976 ± 0.069	1.26AlaMet: 1.26 ± 0.036	3.745AlaAsn: 3.745 ± 0.072	1.727AlaPro: 1.727 ± 0.042	2.11AlaGln: 2.11 ± 0.051	1.669AlaArg: 1.669 ± 0.043	4.247AlaSer: 4.247 ± 0.064	3.55AlaThr: 3.55 ± 0.083	3.621AlaVal: 3.621 ± 0.069	0.607AlaTrp: 0.607 ± 0.023	2.473AlaTyr: 2.473 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.431CysAla: 0.431 ± 0.022	0.093CysCys: 0.093 ± 0.009	0.423CysAsp: 0.423 ± 0.019	0.424CysGlu: 0.424 ± 0.018	0.446CysPhe: 0.446 ± 0.02	0.586CysGly: 0.586 ± 0.021	0.178CysHis: 0.178 ± 0.015	0.642CysIle: 0.642 ± 0.024	0.53CysLys: 0.53 ± 0.023	0.667CysLeu: 0.667 ± 0.029	0.138CysMet: 0.138 ± 0.012	0.438CysAsn: 0.438 ± 0.019	0.304CysPro: 0.304 ± 0.019	0.189CysGln: 0.189 ± 0.012	0.175CysArg: 0.175 ± 0.013	0.555CysSer: 0.555 ± 0.022	0.373CysThr: 0.373 ± 0.024	0.414CysVal: 0.414 ± 0.02	0.075CysTrp: 0.075 ± 0.011	0.296CysTyr: 0.296 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.774AspAla: 3.774 ± 0.059	0.411AspCys: 0.411 ± 0.021	3.334AspAsp: 3.334 ± 0.059	3.692AspGlu: 3.692 ± 0.062	3.69AspPhe: 3.69 ± 0.058	3.777AspGly: 3.777 ± 0.07	0.773AspHis: 0.773 ± 0.026	4.944AspIle: 4.944 ± 0.085	4.287AspLys: 4.287 ± 0.073	5.162AspLeu: 5.162 ± 0.079	1.112AspMet: 1.112 ± 0.036	3.583AspAsn: 3.583 ± 0.061	1.441AspPro: 1.441 ± 0.038	1.166AspGln: 1.166 ± 0.035	1.71AspArg: 1.71 ± 0.043	3.43AspSer: 3.43 ± 0.063	2.82AspThr: 2.82 ± 0.056	3.795AspVal: 3.795 ± 0.07	0.783AspTrp: 0.783 ± 0.026	3.045AspTyr: 3.045 ± 0.065	0.0AspXaa: 0.0 ± 0.0
Glu	4.253GluAla: 4.253 ± 0.066	0.32GluCys: 0.32 ± 0.018	3.637GluAsp: 3.637 ± 0.061	4.198GluGlu: 4.198 ± 0.082	2.978GluPhe: 2.978 ± 0.054	3.569GluGly: 3.569 ± 0.061	1.088GluHis: 1.088 ± 0.035	5.154GluIle: 5.154 ± 0.076	5.434GluLys: 5.434 ± 0.093	5.728GluLeu: 5.728 ± 0.079	1.347GluMet: 1.347 ± 0.035	4.841GluAsn: 4.841 ± 0.069	1.512GluPro: 1.512 ± 0.035	2.09GluGln: 2.09 ± 0.043	2.292GluArg: 2.292 ± 0.055	3.583GluSer: 3.583 ± 0.063	3.776GluThr: 3.776 ± 0.052	3.966GluVal: 3.966 ± 0.065	0.63GluTrp: 0.63 ± 0.026	2.333GluTyr: 2.333 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	2.845PheAla: 2.845 ± 0.055	0.431PheCys: 0.431 ± 0.02	3.401PheAsp: 3.401 ± 0.053	3.423PheGlu: 3.423 ± 0.06	2.862PhePhe: 2.862 ± 0.065	3.646PheGly: 3.646 ± 0.062	0.829PheHis: 0.829 ± 0.028	4.24PheIle: 4.24 ± 0.073	4.39PheLys: 4.39 ± 0.066	4.759PheLeu: 4.759 ± 0.074	1.036PheMet: 1.036 ± 0.029	4.019PheAsn: 4.019 ± 0.068	1.655PhePro: 1.655 ± 0.042	1.401PheGln: 1.401 ± 0.035	1.499PheArg: 1.499 ± 0.036	4.326PheSer: 4.326 ± 0.069	3.078PheThr: 3.078 ± 0.064	2.96PheVal: 2.96 ± 0.055	0.588PheTrp: 0.588 ± 0.024	2.185PheTyr: 2.185 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	3.959GlyAla: 3.959 ± 0.075	0.585GlyCys: 0.585 ± 0.029	3.505GlyAsp: 3.505 ± 0.069	3.488GlyGlu: 3.488 ± 0.058	3.775GlyPhe: 3.775 ± 0.064	4.569GlyGly: 4.569 ± 0.091	1.147GlyHis: 1.147 ± 0.035	5.155GlyIle: 5.155 ± 0.077	4.818GlyLys: 4.818 ± 0.07	5.672GlyLeu: 5.672 ± 0.088	1.372GlyMet: 1.372 ± 0.037	3.968GlyAsn: 3.968 ± 0.074	1.266GlyPro: 1.266 ± 0.035	1.692GlyGln: 1.692 ± 0.041	1.971GlyArg: 1.971 ± 0.049	3.932GlySer: 3.932 ± 0.074	3.833GlyThr: 3.833 ± 0.101	4.326GlyVal: 4.326 ± 0.061	0.821GlyTrp: 0.821 ± 0.033	2.839GlyTyr: 2.839 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	0.935HisAla: 0.935 ± 0.029	0.162HisCys: 0.162 ± 0.013	0.895HisAsp: 0.895 ± 0.024	0.912HisGlu: 0.912 ± 0.03	1.146HisPhe: 1.146 ± 0.033	1.093HisGly: 1.093 ± 0.035	0.446HisHis: 0.446 ± 0.022	1.478HisIle: 1.478 ± 0.035	1.253HisLys: 1.253 ± 0.034	1.72HisLeu: 1.72 ± 0.041	0.296HisMet: 0.296 ± 0.016	1.065HisAsn: 1.065 ± 0.03	0.84HisPro: 0.84 ± 0.031	0.67HisGln: 0.67 ± 0.028	0.607HisArg: 0.607 ± 0.024	1.037HisSer: 1.037 ± 0.029	0.928HisThr: 0.928 ± 0.025	0.958HisVal: 0.958 ± 0.029	0.255HisTrp: 0.255 ± 0.016	0.874HisTyr: 0.874 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.299IleAla: 5.299 ± 0.089	0.622IleCys: 0.622 ± 0.026	5.387IleAsp: 5.387 ± 0.067	5.793IleGlu: 5.793 ± 0.073	3.799IlePhe: 3.799 ± 0.068	5.245IleGly: 5.245 ± 0.079	1.373IleHis: 1.373 ± 0.031	6.903IleIle: 6.903 ± 0.103	6.91IleLys: 6.91 ± 0.095	7.107IleLeu: 7.107 ± 0.098	1.493IleMet: 1.493 ± 0.047	5.749IleAsn: 5.749 ± 0.082	3.213IlePro: 3.213 ± 0.052	2.384IleGln: 2.384 ± 0.042	2.391IleArg: 2.391 ± 0.045	6.122IleSer: 6.122 ± 0.075	5.097IleThr: 5.097 ± 0.085	4.94IleVal: 4.94 ± 0.067	0.722IleTrp: 0.722 ± 0.028	2.981IleTyr: 2.981 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	5.178LysAla: 5.178 ± 0.084	0.351LysCys: 0.351 ± 0.017	4.795LysAsp: 4.795 ± 0.075	6.159LysGlu: 6.159 ± 0.092	3.127LysPhe: 3.127 ± 0.046	4.68LysGly: 4.68 ± 0.072	1.73LysHis: 1.73 ± 0.041	6.312LysIle: 6.312 ± 0.085	7.5LysLys: 7.5 ± 0.1	7.163LysLeu: 7.163 ± 0.097	1.877LysMet: 1.877 ± 0.044	5.843LysAsn: 5.843 ± 0.094	2.633LysPro: 2.633 ± 0.051	3.002LysGln: 3.002 ± 0.054	3.089LysArg: 3.089 ± 0.053	4.984LysSer: 4.984 ± 0.087	5.27LysThr: 5.27 ± 0.073	4.777LysVal: 4.777 ± 0.072	0.875LysTrp: 0.875 ± 0.025	3.244LysTyr: 3.244 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	5.256LeuAla: 5.256 ± 0.068	0.663LeuCys: 0.663 ± 0.025	5.029LeuAsp: 5.029 ± 0.071	5.637LeuGlu: 5.637 ± 0.081	5.03LeuPhe: 5.03 ± 0.083	5.623LeuGly: 5.623 ± 0.072	1.437LeuHis: 1.437 ± 0.038	7.456LeuIle: 7.456 ± 0.089	8.433LeuLys: 8.433 ± 0.106	8.437LeuLeu: 8.437 ± 0.117	1.896LeuMet: 1.896 ± 0.041	6.447LeuAsn: 6.447 ± 0.09	3.201LeuPro: 3.201 ± 0.057	2.901LeuGln: 2.901 ± 0.056	2.824LeuArg: 2.824 ± 0.057	6.652LeuSer: 6.652 ± 0.084	4.956LeuThr: 4.956 ± 0.081	5.188LeuVal: 5.188 ± 0.075	0.812LeuTrp: 0.812 ± 0.029	3.289LeuTyr: 3.289 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.358MetAla: 1.358 ± 0.036	0.136MetCys: 0.136 ± 0.012	0.995MetAsp: 0.995 ± 0.027	1.093MetGlu: 1.093 ± 0.034	0.922MetPhe: 0.922 ± 0.027	1.171MetGly: 1.171 ± 0.037	0.412MetHis: 0.412 ± 0.018	1.515MetIle: 1.515 ± 0.039	2.029MetLys: 2.029 ± 0.045	1.812MetLeu: 1.812 ± 0.044	0.496MetMet: 0.496 ± 0.024	1.229MetAsn: 1.229 ± 0.035	0.814MetPro: 0.814 ± 0.028	0.779MetGln: 0.779 ± 0.024	0.775MetArg: 0.775 ± 0.027	1.405MetSer: 1.405 ± 0.037	1.054MetThr: 1.054 ± 0.028	1.172MetVal: 1.172 ± 0.032	0.157MetTrp: 0.157 ± 0.012	0.708MetTyr: 0.708 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	4.02AsnAla: 4.02 ± 0.067	0.504AsnCys: 0.504 ± 0.021	3.955AsnAsp: 3.955 ± 0.074	4.088AsnGlu: 4.088 ± 0.073	3.247AsnPhe: 3.247 ± 0.062	4.316AsnGly: 4.316 ± 0.08	1.234AsnHis: 1.234 ± 0.034	6.012AsnIle: 6.012 ± 0.082	5.449AsnLys: 5.449 ± 0.095	5.732AsnLeu: 5.732 ± 0.08	1.329AsnMet: 1.329 ± 0.036	5.041AsnAsn: 5.041 ± 0.089	2.829AsnPro: 2.829 ± 0.058	2.34AsnGln: 2.34 ± 0.049	2.236AsnArg: 2.236 ± 0.051	4.398AsnSer: 4.398 ± 0.071	4.237AsnThr: 4.237 ± 0.079	3.903AsnVal: 3.903 ± 0.064	0.847AsnTrp: 0.847 ± 0.026	3.229AsnTyr: 3.229 ± 0.063	0.0AsnXaa: 0.0 ± 0.0
Pro	1.609ProAla: 1.609 ± 0.045	0.204ProCys: 0.204 ± 0.014	1.925ProAsp: 1.925 ± 0.044	2.556ProGlu: 2.556 ± 0.046	1.89ProPhe: 1.89 ± 0.038	1.693ProGly: 1.693 ± 0.042	0.584ProHis: 0.584 ± 0.023	2.824ProIle: 2.824 ± 0.051	2.651ProLys: 2.651 ± 0.049	2.788ProLeu: 2.788 ± 0.046	0.64ProMet: 0.64 ± 0.022	2.485ProAsn: 2.485 ± 0.054	0.792ProPro: 0.792 ± 0.029	1.006ProGln: 1.006 ± 0.029	0.861ProArg: 0.861 ± 0.028	2.134ProSer: 2.134 ± 0.041	1.907ProThr: 1.907 ± 0.049	2.051ProVal: 2.051 ± 0.04	0.354ProTrp: 0.354 ± 0.018	1.319ProTyr: 1.319 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.795GlnAla: 1.795 ± 0.041	0.17GlnCys: 0.17 ± 0.012	1.537GlnAsp: 1.537 ± 0.039	1.964GlnGlu: 1.964 ± 0.05	1.664GlnPhe: 1.664 ± 0.038	1.72GlnGly: 1.72 ± 0.037	0.54GlnHis: 0.54 ± 0.02	2.632GlnIle: 2.632 ± 0.049	2.602GlnLys: 2.602 ± 0.048	3.224GlnLeu: 3.224 ± 0.063	0.698GlnMet: 0.698 ± 0.027	2.188GlnAsn: 2.188 ± 0.044	1.018GlnPro: 1.018 ± 0.031	1.269GlnGln: 1.269 ± 0.037	1.056GlnArg: 1.056 ± 0.038	1.833GlnSer: 1.833 ± 0.045	1.802GlnThr: 1.802 ± 0.042	1.851GlnVal: 1.851 ± 0.041	0.343GlnTrp: 0.343 ± 0.018	1.31GlnTyr: 1.31 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	1.922ArgAla: 1.922 ± 0.049	0.181ArgCys: 0.181 ± 0.012	1.682ArgAsp: 1.682 ± 0.041	1.873ArgGlu: 1.873 ± 0.044	1.817ArgPhe: 1.817 ± 0.042	1.921ArgGly: 1.921 ± 0.043	0.592ArgHis: 0.592 ± 0.023	2.768ArgIle: 2.768 ± 0.052	2.581ArgLys: 2.581 ± 0.052	3.057ArgLeu: 3.057 ± 0.057	0.758ArgMet: 0.758 ± 0.028	2.03ArgAsn: 2.03 ± 0.046	0.956ArgPro: 0.956 ± 0.029	1.002ArgGln: 1.002 ± 0.039	1.261ArgArg: 1.261 ± 0.037	1.788ArgSer: 1.788 ± 0.042	1.654ArgThr: 1.654 ± 0.036	2.029ArgVal: 2.029 ± 0.046	0.391ArgTrp: 0.391 ± 0.019	1.465ArgTyr: 1.465 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	3.603SerAla: 3.603 ± 0.063	0.674SerCys: 0.674 ± 0.024	3.602SerAsp: 3.602 ± 0.059	3.984SerGlu: 3.984 ± 0.058	4.059SerPhe: 4.059 ± 0.066	4.596SerGly: 4.596 ± 0.08	1.109SerHis: 1.109 ± 0.034	5.908SerIle: 5.908 ± 0.072	5.705SerLys: 5.705 ± 0.08	6.055SerLeu: 6.055 ± 0.077	1.183SerMet: 1.183 ± 0.031	4.645SerAsn: 4.645 ± 0.069	2.001SerPro: 2.001 ± 0.047	2.088SerGln: 2.088 ± 0.042	2.085SerArg: 2.085 ± 0.044	4.536SerSer: 4.536 ± 0.077	3.627SerThr: 3.627 ± 0.068	3.985SerVal: 3.985 ± 0.06	0.712SerTrp: 0.712 ± 0.025	2.876SerTyr: 2.876 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	3.391ThrAla: 3.391 ± 0.075	0.362ThrCys: 0.362 ± 0.022	3.193ThrAsp: 3.193 ± 0.063	3.253ThrGlu: 3.253 ± 0.061	3.236ThrPhe: 3.236 ± 0.056	3.797ThrGly: 3.797 ± 0.089	1.044ThrHis: 1.044 ± 0.029	5.267ThrIle: 5.267 ± 0.076	4.3ThrLys: 4.3 ± 0.074	5.406ThrLeu: 5.406 ± 0.074	0.902ThrMet: 0.902 ± 0.03	3.786ThrAsn: 3.786 ± 0.075	2.43ThrPro: 2.43 ± 0.053	1.84ThrGln: 1.84 ± 0.04	1.554ThrArg: 1.554 ± 0.04	4.103ThrSer: 4.103 ± 0.078	3.526ThrThr: 3.526 ± 0.086	3.535ThrVal: 3.535 ± 0.071	0.619ThrTrp: 0.619 ± 0.026	2.495ThrTyr: 2.495 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	3.652ValAla: 3.652 ± 0.065	0.511ValCys: 0.511 ± 0.022	3.554ValAsp: 3.554 ± 0.058	3.823ValGlu: 3.823 ± 0.055	3.459ValPhe: 3.459 ± 0.065	3.603ValGly: 3.603 ± 0.066	0.901ValHis: 0.901 ± 0.026	5.054ValIle: 5.054 ± 0.065	4.58ValLys: 4.58 ± 0.062	5.937ValLeu: 5.937 ± 0.089	1.193ValMet: 1.193 ± 0.033	3.836ValAsn: 3.836 ± 0.059	1.954ValPro: 1.954 ± 0.044	1.473ValGln: 1.473 ± 0.037	1.732ValArg: 1.732 ± 0.04	4.5ValSer: 4.5 ± 0.066	3.499ValThr: 3.499 ± 0.078	3.943ValVal: 3.943 ± 0.059	0.636ValTrp: 0.636 ± 0.023	2.403ValTyr: 2.403 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.582TrpAla: 0.582 ± 0.023	0.108TrpCys: 0.108 ± 0.01	0.614TrpAsp: 0.614 ± 0.022	0.69TrpGlu: 0.69 ± 0.027	0.604TrpPhe: 0.604 ± 0.023	0.72TrpGly: 0.72 ± 0.027	0.276TrpHis: 0.276 ± 0.017	0.778TrpIle: 0.778 ± 0.03	0.85TrpLys: 0.85 ± 0.028	0.988TrpLeu: 0.988 ± 0.028	0.281TrpMet: 0.281 ± 0.017	0.808TrpAsn: 0.808 ± 0.029	0.241TrpPro: 0.241 ± 0.017	0.401TrpGln: 0.401 ± 0.019	0.402TrpArg: 0.402 ± 0.019	0.681TrpSer: 0.681 ± 0.029	0.579TrpThr: 0.579 ± 0.023	0.661TrpVal: 0.661 ± 0.023	0.169TrpTrp: 0.169 ± 0.012	0.482TrpTyr: 0.482 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.427TyrAla: 2.427 ± 0.048	0.342TyrCys: 0.342 ± 0.019	2.259TyrAsp: 2.259 ± 0.05	2.169TyrGlu: 2.169 ± 0.048	2.496TyrPhe: 2.496 ± 0.05	2.607TyrGly: 2.607 ± 0.051	0.812TyrHis: 0.812 ± 0.031	3.019TyrIle: 3.019 ± 0.053	3.673TyrLys: 3.673 ± 0.065	3.776TyrLeu: 3.776 ± 0.061	0.72TyrMet: 0.72 ± 0.024	3.201TyrAsn: 3.201 ± 0.06	1.443TyrPro: 1.443 ± 0.038	1.413TyrGln: 1.413 ± 0.034	1.54TyrArg: 1.54 ± 0.035	2.787TyrSer: 2.787 ± 0.06	2.473TyrThr: 2.473 ± 0.054	2.17TyrVal: 2.17 ± 0.043	0.518TyrTrp: 0.518 ± 0.025	1.923TyrTyr: 1.923 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3344 proteins (1180465 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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