Amino acid dipepetide frequency for Rubritalea profundi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.787AlaAla: 8.787 ± 0.117	1.027AlaCys: 1.027 ± 0.035	4.924AlaAsp: 4.924 ± 0.074	5.876AlaGlu: 5.876 ± 0.08	3.305AlaPhe: 3.305 ± 0.054	6.652AlaGly: 6.652 ± 0.095	1.787AlaHis: 1.787 ± 0.041	5.521AlaIle: 5.521 ± 0.076	5.547AlaLys: 5.547 ± 0.086	9.109AlaLeu: 9.109 ± 0.098	2.352AlaMet: 2.352 ± 0.047	3.078AlaAsn: 3.078 ± 0.056	3.413AlaPro: 3.413 ± 0.062	3.29AlaGln: 3.29 ± 0.054	4.07AlaArg: 4.07 ± 0.063	5.664AlaSer: 5.664 ± 0.065	4.842AlaThr: 4.842 ± 0.073	5.7AlaVal: 5.7 ± 0.085	1.178AlaTrp: 1.178 ± 0.033	2.352AlaTyr: 2.352 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.912CysAla: 0.912 ± 0.028	0.197CysCys: 0.197 ± 0.015	0.678CysAsp: 0.678 ± 0.029	0.624CysGlu: 0.624 ± 0.026	0.452CysPhe: 0.452 ± 0.023	0.96CysGly: 0.96 ± 0.029	0.396CysHis: 0.396 ± 0.022	0.636CysIle: 0.636 ± 0.026	0.443CysLys: 0.443 ± 0.024	1.031CysLeu: 1.031 ± 0.029	0.256CysMet: 0.256 ± 0.016	0.334CysAsn: 0.334 ± 0.019	0.506CysPro: 0.506 ± 0.022	0.354CysGln: 0.354 ± 0.019	0.502CysArg: 0.502 ± 0.024	0.789CysSer: 0.789 ± 0.028	0.529CysThr: 0.529 ± 0.02	0.724CysVal: 0.724 ± 0.027	0.156CysTrp: 0.156 ± 0.011	0.385CysTyr: 0.385 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.962AspAla: 4.962 ± 0.071	0.568AspCys: 0.568 ± 0.025	3.053AspAsp: 3.053 ± 0.059	3.546AspGlu: 3.546 ± 0.057	2.665AspPhe: 2.665 ± 0.048	4.76AspGly: 4.76 ± 0.081	1.286AspHis: 1.286 ± 0.037	3.216AspIle: 3.216 ± 0.058	3.148AspLys: 3.148 ± 0.063	5.601AspLeu: 5.601 ± 0.074	1.078AspMet: 1.078 ± 0.032	1.888AspAsn: 1.888 ± 0.045	2.801AspPro: 2.801 ± 0.055	1.997AspGln: 1.997 ± 0.046	2.651AspArg: 2.651 ± 0.05	3.671AspSer: 3.671 ± 0.065	2.899AspThr: 2.899 ± 0.06	3.441AspVal: 3.441 ± 0.056	1.019AspTrp: 1.019 ± 0.028	1.928AspTyr: 1.928 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.556GluAla: 5.556 ± 0.088	0.515GluCys: 0.515 ± 0.022	3.14GluAsp: 3.14 ± 0.056	4.088GluGlu: 4.088 ± 0.084	2.399GluPhe: 2.399 ± 0.053	4.033GluGly: 4.033 ± 0.063	1.437GluHis: 1.437 ± 0.036	4.112GluIle: 4.112 ± 0.064	4.412GluLys: 4.412 ± 0.073	6.786GluLeu: 6.786 ± 0.094	1.725GluMet: 1.725 ± 0.043	2.711GluAsn: 2.711 ± 0.047	2.164GluPro: 2.164 ± 0.044	2.568GluGln: 2.568 ± 0.059	3.246GluArg: 3.246 ± 0.067	3.956GluSer: 3.956 ± 0.056	3.218GluThr: 3.218 ± 0.051	4.343GluVal: 4.343 ± 0.069	0.917GluTrp: 0.917 ± 0.032	1.585GluTyr: 1.585 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.256PheAla: 3.256 ± 0.059	0.542PheCys: 0.542 ± 0.025	2.536PheAsp: 2.536 ± 0.051	2.399PheGlu: 2.399 ± 0.048	1.747PhePhe: 1.747 ± 0.052	3.216PheGly: 3.216 ± 0.062	0.927PheHis: 0.927 ± 0.029	2.411PheIle: 2.411 ± 0.05	2.079PheLys: 2.079 ± 0.045	3.916PheLeu: 3.916 ± 0.07	0.866PheMet: 0.866 ± 0.028	1.533PheAsn: 1.533 ± 0.042	1.643PhePro: 1.643 ± 0.034	1.252PheGln: 1.252 ± 0.035	1.863PheArg: 1.863 ± 0.04	3.229PheSer: 3.229 ± 0.056	2.563PheThr: 2.563 ± 0.046	2.422PheVal: 2.422 ± 0.046	0.561PheTrp: 0.561 ± 0.027	1.338PheTyr: 1.338 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	5.758GlyAla: 5.758 ± 0.088	0.864GlyCys: 0.864 ± 0.029	4.135GlyAsp: 4.135 ± 0.083	4.575GlyGlu: 4.575 ± 0.072	3.307GlyPhe: 3.307 ± 0.062	5.757GlyGly: 5.757 ± 0.105	1.695GlyHis: 1.695 ± 0.044	4.499GlyIle: 4.499 ± 0.07	5.271GlyLys: 5.271 ± 0.083	6.818GlyLeu: 6.818 ± 0.082	1.972GlyMet: 1.972 ± 0.042	2.753GlyAsn: 2.753 ± 0.056	2.223GlyPro: 2.223 ± 0.057	2.348GlyGln: 2.348 ± 0.049	3.578GlyArg: 3.578 ± 0.065	4.896GlySer: 4.896 ± 0.08	3.86GlyThr: 3.86 ± 0.065	5.226GlyVal: 5.226 ± 0.085	1.194GlyTrp: 1.194 ± 0.035	2.403GlyTyr: 2.403 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.956HisAla: 1.956 ± 0.038	0.363HisCys: 0.363 ± 0.021	1.197HisAsp: 1.197 ± 0.038	1.168HisGlu: 1.168 ± 0.032	1.121HisPhe: 1.121 ± 0.034	1.816HisGly: 1.816 ± 0.045	0.69HisHis: 0.69 ± 0.027	1.246HisIle: 1.246 ± 0.035	1.105HisLys: 1.105 ± 0.033	2.349HisLeu: 2.349 ± 0.048	0.498HisMet: 0.498 ± 0.021	0.77HisAsn: 0.77 ± 0.025	1.406HisPro: 1.406 ± 0.037	0.907HisGln: 0.907 ± 0.026	1.167HisArg: 1.167 ± 0.037	1.512HisSer: 1.512 ± 0.035	1.225HisThr: 1.225 ± 0.031	1.316HisVal: 1.316 ± 0.036	0.394HisTrp: 0.394 ± 0.023	0.785HisTyr: 0.785 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.765IleAla: 5.765 ± 0.08	0.757IleCys: 0.757 ± 0.028	4.025IleAsp: 4.025 ± 0.054	4.224IleGlu: 4.224 ± 0.065	2.221IlePhe: 2.221 ± 0.054	4.51IleGly: 4.51 ± 0.083	1.38IleHis: 1.38 ± 0.038	3.38IleIle: 3.38 ± 0.059	3.068IleLys: 3.068 ± 0.05	5.62IleLeu: 5.62 ± 0.097	1.083IleMet: 1.083 ± 0.031	2.217IleAsn: 2.217 ± 0.053	2.958IlePro: 2.958 ± 0.059	2.079IleGln: 2.079 ± 0.049	2.853IleArg: 2.853 ± 0.049	4.271IleSer: 4.271 ± 0.063	3.554IleThr: 3.554 ± 0.065	3.883IleVal: 3.883 ± 0.068	0.674IleTrp: 0.674 ± 0.024	1.798IleTyr: 1.798 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	5.299LysAla: 5.299 ± 0.083	0.418LysCys: 0.418 ± 0.019	3.212LysAsp: 3.212 ± 0.062	3.926LysGlu: 3.926 ± 0.073	1.99LysPhe: 1.99 ± 0.047	4.053LysGly: 4.053 ± 0.078	1.378LysHis: 1.378 ± 0.034	3.544LysIle: 3.544 ± 0.061	4.595LysLys: 4.595 ± 0.099	5.995LysLeu: 5.995 ± 0.088	1.712LysMet: 1.712 ± 0.042	2.66LysAsn: 2.66 ± 0.057	2.891LysPro: 2.891 ± 0.056	2.361LysGln: 2.361 ± 0.058	3.111LysArg: 3.111 ± 0.06	4.18LysSer: 4.18 ± 0.072	3.342LysThr: 3.342 ± 0.055	4.002LysVal: 4.002 ± 0.075	0.833LysTrp: 0.833 ± 0.028	1.495LysTyr: 1.495 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	9.512LeuAla: 9.512 ± 0.109	1.168LeuCys: 1.168 ± 0.034	5.678LeuAsp: 5.678 ± 0.076	6.363LeuGlu: 6.363 ± 0.081	3.703LeuPhe: 3.703 ± 0.077	6.964LeuGly: 6.964 ± 0.101	2.105LeuHis: 2.105 ± 0.049	5.9LeuIle: 5.9 ± 0.09	6.048LeuLys: 6.048 ± 0.09	9.382LeuLeu: 9.382 ± 0.14	2.171LeuMet: 2.171 ± 0.048	3.765LeuAsn: 3.765 ± 0.063	4.799LeuPro: 4.799 ± 0.068	3.249LeuGln: 3.249 ± 0.067	5.152LeuArg: 5.152 ± 0.076	7.142LeuSer: 7.142 ± 0.087	5.887LeuThr: 5.887 ± 0.087	6.378LeuVal: 6.378 ± 0.08	1.174LeuTrp: 1.174 ± 0.036	2.445LeuTyr: 2.445 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.293MetAla: 2.293 ± 0.048	0.223MetCys: 0.223 ± 0.015	1.198MetAsp: 1.198 ± 0.032	1.297MetGlu: 1.297 ± 0.036	0.74MetPhe: 0.74 ± 0.026	1.671MetGly: 1.671 ± 0.047	0.506MetHis: 0.506 ± 0.023	1.456MetIle: 1.456 ± 0.042	1.729MetLys: 1.729 ± 0.048	2.461MetLeu: 2.461 ± 0.046	0.631MetMet: 0.631 ± 0.026	1.008MetAsn: 1.008 ± 0.032	1.22MetPro: 1.22 ± 0.031	0.9MetGln: 0.9 ± 0.028	1.453MetArg: 1.453 ± 0.031	1.615MetSer: 1.615 ± 0.039	1.364MetThr: 1.364 ± 0.039	1.559MetVal: 1.559 ± 0.042	0.232MetTrp: 0.232 ± 0.017	0.423MetTyr: 0.423 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.223AsnAla: 3.223 ± 0.057	0.395AsnCys: 0.395 ± 0.02	2.089AsnAsp: 2.089 ± 0.047	2.02AsnGlu: 2.02 ± 0.048	1.603AsnPhe: 1.603 ± 0.04	3.066AsnGly: 3.066 ± 0.055	0.873AsnHis: 0.873 ± 0.029	2.259AsnIle: 2.259 ± 0.046	2.213AsnLys: 2.213 ± 0.054	3.654AsnLeu: 3.654 ± 0.051	0.811AsnMet: 0.811 ± 0.029	1.561AsnAsn: 1.561 ± 0.051	2.203AsnPro: 2.203 ± 0.051	1.491AsnGln: 1.491 ± 0.044	1.916AsnArg: 1.916 ± 0.045	2.524AsnSer: 2.524 ± 0.057	2.145AsnThr: 2.145 ± 0.055	2.231AsnVal: 2.231 ± 0.046	0.565AsnTrp: 0.565 ± 0.02	1.209AsnTyr: 1.209 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	3.962ProAla: 3.962 ± 0.064	0.394ProCys: 0.394 ± 0.018	2.767ProAsp: 2.767 ± 0.053	3.63ProGlu: 3.63 ± 0.06	1.774ProPhe: 1.774 ± 0.041	2.741ProGly: 2.741 ± 0.057	1.078ProHis: 1.078 ± 0.034	2.478ProIle: 2.478 ± 0.041	2.8ProLys: 2.8 ± 0.05	4.032ProLeu: 4.032 ± 0.073	1.032ProMet: 1.032 ± 0.032	1.877ProAsn: 1.877 ± 0.045	1.669ProPro: 1.669 ± 0.05	1.596ProGln: 1.596 ± 0.043	1.914ProArg: 1.914 ± 0.043	3.188ProSer: 3.188 ± 0.052	2.649ProThr: 2.649 ± 0.052	3.048ProVal: 3.048 ± 0.057	0.612ProTrp: 0.612 ± 0.025	1.186ProTyr: 1.186 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.401GlnAla: 3.401 ± 0.056	0.362GlnCys: 0.362 ± 0.019	1.658GlnAsp: 1.658 ± 0.049	1.901GlnGlu: 1.901 ± 0.045	1.352GlnPhe: 1.352 ± 0.034	2.36GlnGly: 2.36 ± 0.049	0.85GlnHis: 0.85 ± 0.026	2.25GlnIle: 2.25 ± 0.047	2.269GlnLys: 2.269 ± 0.054	3.986GlnLeu: 3.986 ± 0.072	0.929GlnMet: 0.929 ± 0.029	1.326GlnAsn: 1.326 ± 0.038	1.577GlnPro: 1.577 ± 0.039	1.871GlnGln: 1.871 ± 0.05	2.14GlnArg: 2.14 ± 0.05	2.48GlnSer: 2.48 ± 0.049	1.849GlnThr: 1.849 ± 0.048	2.199GlnVal: 2.199 ± 0.043	0.664GlnTrp: 0.664 ± 0.027	0.916GlnTyr: 0.916 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	3.843ArgAla: 3.843 ± 0.068	0.573ArgCys: 0.573 ± 0.023	2.815ArgAsp: 2.815 ± 0.048	3.264ArgGlu: 3.264 ± 0.057	2.266ArgPhe: 2.266 ± 0.049	3.23ArgGly: 3.23 ± 0.064	1.119ArgHis: 1.119 ± 0.033	3.118ArgIle: 3.118 ± 0.058	3.195ArgLys: 3.195 ± 0.064	4.842ArgLeu: 4.842 ± 0.058	1.404ArgMet: 1.404 ± 0.034	1.945ArgAsn: 1.945 ± 0.039	2.078ArgPro: 2.078 ± 0.052	1.805ArgGln: 1.805 ± 0.037	2.815ArgArg: 2.815 ± 0.063	3.332ArgSer: 3.332 ± 0.061	2.413ArgThr: 2.413 ± 0.048	3.391ArgVal: 3.391 ± 0.065	0.731ArgTrp: 0.731 ± 0.026	1.692ArgTyr: 1.692 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.748SerAla: 5.748 ± 0.079	0.767SerCys: 0.767 ± 0.029	3.787SerAsp: 3.787 ± 0.062	4.249SerGlu: 4.249 ± 0.058	2.881SerPhe: 2.881 ± 0.048	5.304SerGly: 5.304 ± 0.076	1.644SerHis: 1.644 ± 0.042	4.316SerIle: 4.316 ± 0.077	3.954SerLys: 3.954 ± 0.068	6.906SerLeu: 6.906 ± 0.091	1.662SerMet: 1.662 ± 0.035	2.587SerAsn: 2.587 ± 0.047	3.086SerPro: 3.086 ± 0.063	2.387SerGln: 2.387 ± 0.05	3.192SerArg: 3.192 ± 0.057	5.024SerSer: 5.024 ± 0.077	3.583SerThr: 3.583 ± 0.075	4.351SerVal: 4.351 ± 0.061	1.01SerTrp: 1.01 ± 0.035	2.147SerTyr: 2.147 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.968ThrAla: 4.968 ± 0.074	0.484ThrCys: 0.484 ± 0.02	3.005ThrAsp: 3.005 ± 0.061	3.236ThrGlu: 3.236 ± 0.052	2.246ThrPhe: 2.246 ± 0.049	4.37ThrGly: 4.37 ± 0.069	1.306ThrHis: 1.306 ± 0.034	3.497ThrIle: 3.497 ± 0.07	2.9ThrLys: 2.9 ± 0.058	5.873ThrLeu: 5.873 ± 0.082	1.201ThrMet: 1.201 ± 0.035	1.98ThrAsn: 1.98 ± 0.049	3.235ThrPro: 3.235 ± 0.053	1.952ThrGln: 1.952 ± 0.044	2.559ThrArg: 2.559 ± 0.052	3.591ThrSer: 3.591 ± 0.065	3.346ThrThr: 3.346 ± 0.092	3.605ThrVal: 3.605 ± 0.061	0.7ThrTrp: 0.7 ± 0.031	1.517ThrTyr: 1.517 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	5.917ValAla: 5.917 ± 0.089	0.769ValCys: 0.769 ± 0.028	3.839ValAsp: 3.839 ± 0.061	4.189ValGlu: 4.189 ± 0.077	2.555ValPhe: 2.555 ± 0.056	4.545ValGly: 4.545 ± 0.07	1.397ValHis: 1.397 ± 0.033	4.203ValIle: 4.203 ± 0.059	3.71ValLys: 3.71 ± 0.065	6.191ValLeu: 6.191 ± 0.075	1.579ValMet: 1.579 ± 0.047	2.283ValAsn: 2.283 ± 0.048	2.774ValPro: 2.774 ± 0.057	1.979ValGln: 1.979 ± 0.041	3.199ValArg: 3.199 ± 0.057	4.582ValSer: 4.582 ± 0.063	4.007ValThr: 4.007 ± 0.067	4.772ValVal: 4.772 ± 0.074	0.852ValTrp: 0.852 ± 0.032	1.785ValTyr: 1.785 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.992TrpAla: 0.992 ± 0.029	0.161TrpCys: 0.161 ± 0.012	0.774TrpAsp: 0.774 ± 0.028	0.697TrpGlu: 0.697 ± 0.027	0.574TrpPhe: 0.574 ± 0.025	0.959TrpGly: 0.959 ± 0.035	0.361TrpHis: 0.361 ± 0.019	0.855TrpIle: 0.855 ± 0.027	1.005TrpLys: 1.005 ± 0.035	1.585TrpLeu: 1.585 ± 0.043	0.477TrpMet: 0.477 ± 0.02	0.643TrpAsn: 0.643 ± 0.026	0.499TrpPro: 0.499 ± 0.024	0.636TrpGln: 0.636 ± 0.026	0.777TrpArg: 0.777 ± 0.03	0.932TrpSer: 0.932 ± 0.032	0.687TrpThr: 0.687 ± 0.029	0.959TrpVal: 0.959 ± 0.03	0.236TrpTrp: 0.236 ± 0.015	0.339TrpTyr: 0.339 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.363TyrAla: 2.363 ± 0.052	0.315TyrCys: 0.315 ± 0.019	1.668TyrAsp: 1.668 ± 0.04	1.638TyrGlu: 1.638 ± 0.037	1.399TyrPhe: 1.399 ± 0.033	2.167TyrGly: 2.167 ± 0.04	0.776TyrHis: 0.776 ± 0.025	1.424TyrIle: 1.424 ± 0.032	1.507TyrLys: 1.507 ± 0.041	2.849TyrLeu: 2.849 ± 0.052	0.535TyrMet: 0.535 ± 0.023	1.131TyrAsn: 1.131 ± 0.036	1.282TyrPro: 1.282 ± 0.034	1.317TyrGln: 1.317 ± 0.036	1.713TyrArg: 1.713 ± 0.043	2.01TyrSer: 2.01 ± 0.041	1.611TyrThr: 1.611 ± 0.046	1.578TyrVal: 1.578 ± 0.037	0.447TyrTrp: 0.447 ± 0.019	1.029TyrTyr: 1.029 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3389 proteins (1083921 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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