Amino acid dipepetide frequency for Streptococcus phage Javan288

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.83AlaAla: 2.83 ± 0.651
0.257AlaCys: 0.257 ± 0.139
4.46AlaAsp: 4.46 ± 0.483
4.889AlaGlu: 4.889 ± 0.695
3.002AlaPhe: 3.002 ± 0.61
3.602AlaGly: 3.602 ± 0.977
0.772AlaHis: 0.772 ± 0.26
5.318AlaIle: 5.318 ± 0.976
6.69AlaLys: 6.69 ± 1.375
5.489AlaLeu: 5.489 ± 0.718
2.23AlaMet: 2.23 ± 0.568
5.146AlaAsn: 5.146 ± 0.674
1.372AlaPro: 1.372 ± 0.51
2.487AlaGln: 2.487 ± 0.447
2.402AlaArg: 2.402 ± 0.413
4.803AlaSer: 4.803 ± 0.91
5.06AlaThr: 5.06 ± 0.744
5.146AlaVal: 5.146 ± 0.664
1.029AlaTrp: 1.029 ± 0.3
3.088AlaTyr: 3.088 ± 0.738
0.0AlaXaa: 0.0 ± 0.0
Cys
0.086CysAla: 0.086 ± 0.075
0.0CysCys: 0.0 ± 0.0
0.515CysAsp: 0.515 ± 0.255
0.6CysGlu: 0.6 ± 0.295
0.429CysPhe: 0.429 ± 0.246
0.429CysGly: 0.429 ± 0.317
0.172CysHis: 0.172 ± 0.128
0.172CysIle: 0.172 ± 0.145
0.515CysLys: 0.515 ± 0.342
0.343CysLeu: 0.343 ± 0.168
0.257CysMet: 0.257 ± 0.152
0.515CysAsn: 0.515 ± 0.224
0.172CysPro: 0.172 ± 0.12
0.172CysGln: 0.172 ± 0.127
0.515CysArg: 0.515 ± 0.254
0.343CysSer: 0.343 ± 0.175
0.257CysThr: 0.257 ± 0.142
0.172CysVal: 0.172 ± 0.095
0.086CysTrp: 0.086 ± 0.083
0.086CysTyr: 0.086 ± 0.087
0.0CysXaa: 0.0 ± 0.0
Asp
3.517AspAla: 3.517 ± 0.678
0.686AspCys: 0.686 ± 0.298
4.632AspAsp: 4.632 ± 0.724
5.489AspGlu: 5.489 ± 0.789
3.602AspPhe: 3.602 ± 0.581
5.747AspGly: 5.747 ± 1.061
0.429AspHis: 0.429 ± 0.233
3.602AspIle: 3.602 ± 0.543
5.832AspLys: 5.832 ± 0.77
4.46AspLeu: 4.46 ± 0.673
1.801AspMet: 1.801 ± 0.374
4.289AspAsn: 4.289 ± 0.595
2.23AspPro: 2.23 ± 0.388
1.372AspGln: 1.372 ± 0.292
1.715AspArg: 1.715 ± 0.507
3.945AspSer: 3.945 ± 0.66
3.774AspThr: 3.774 ± 0.58
4.203AspVal: 4.203 ± 0.743
1.201AspTrp: 1.201 ± 0.295
3.088AspTyr: 3.088 ± 0.579
0.0AspXaa: 0.0 ± 0.0
Glu
4.717GluAla: 4.717 ± 0.732
0.6GluCys: 0.6 ± 0.301
4.031GluAsp: 4.031 ± 0.674
5.232GluGlu: 5.232 ± 1.102
2.316GluPhe: 2.316 ± 0.485
2.316GluGly: 2.316 ± 0.436
1.287GluHis: 1.287 ± 0.363
5.575GluIle: 5.575 ± 0.644
4.975GluLys: 4.975 ± 0.74
7.033GluLeu: 7.033 ± 1.07
2.058GluMet: 2.058 ± 0.389
3.002GluAsn: 3.002 ± 0.586
2.058GluPro: 2.058 ± 0.384
3.174GluGln: 3.174 ± 0.674
3.517GluArg: 3.517 ± 0.544
3.431GluSer: 3.431 ± 0.761
4.289GluThr: 4.289 ± 0.486
4.975GluVal: 4.975 ± 0.714
0.772GluTrp: 0.772 ± 0.304
3.431GluTyr: 3.431 ± 0.493
0.0GluXaa: 0.0 ± 0.0
Phe
2.23PheAla: 2.23 ± 0.552
0.257PheCys: 0.257 ± 0.126
3.688PheAsp: 3.688 ± 0.526
3.002PheGlu: 3.002 ± 0.7
1.715PhePhe: 1.715 ± 0.342
3.602PheGly: 3.602 ± 0.664
0.172PheHis: 0.172 ± 0.117
2.402PheIle: 2.402 ± 0.567
4.031PheLys: 4.031 ± 0.491
2.487PheLeu: 2.487 ± 0.543
1.115PheMet: 1.115 ± 0.301
2.316PheAsn: 2.316 ± 0.445
1.115PhePro: 1.115 ± 0.326
1.287PheGln: 1.287 ± 0.35
1.63PheArg: 1.63 ± 0.359
3.259PheSer: 3.259 ± 0.481
1.973PheThr: 1.973 ± 0.417
2.745PheVal: 2.745 ± 0.61
0.257PheTrp: 0.257 ± 0.129
1.544PheTyr: 1.544 ± 0.454
0.0PheXaa: 0.0 ± 0.0
Gly
3.174GlyAla: 3.174 ± 0.697
0.172GlyCys: 0.172 ± 0.11
3.431GlyAsp: 3.431 ± 0.593
4.374GlyGlu: 4.374 ± 0.708
3.945GlyPhe: 3.945 ± 0.646
5.404GlyGly: 5.404 ± 0.867
0.772GlyHis: 0.772 ± 0.224
4.374GlyIle: 4.374 ± 1.0
5.232GlyLys: 5.232 ± 0.616
6.433GlyLeu: 6.433 ± 0.793
2.487GlyMet: 2.487 ± 0.365
4.717GlyAsn: 4.717 ± 0.832
0.686GlyPro: 0.686 ± 0.223
2.916GlyGln: 2.916 ± 0.41
2.058GlyArg: 2.058 ± 0.449
3.945GlySer: 3.945 ± 0.861
4.975GlyThr: 4.975 ± 1.095
3.688GlyVal: 3.688 ± 0.509
1.115GlyTrp: 1.115 ± 0.317
2.745GlyTyr: 2.745 ± 0.446
0.0GlyXaa: 0.0 ± 0.0
His
0.6HisAla: 0.6 ± 0.293
0.086HisCys: 0.086 ± 0.071
1.029HisAsp: 1.029 ± 0.291
0.858HisGlu: 0.858 ± 0.282
0.686HisPhe: 0.686 ± 0.248
0.6HisGly: 0.6 ± 0.25
0.343HisHis: 0.343 ± 0.15
0.686HisIle: 0.686 ± 0.259
1.201HisLys: 1.201 ± 0.337
1.029HisLeu: 1.029 ± 0.268
0.343HisMet: 0.343 ± 0.161
1.029HisAsn: 1.029 ± 0.376
0.6HisPro: 0.6 ± 0.198
0.515HisGln: 0.515 ± 0.25
0.6HisArg: 0.6 ± 0.184
0.686HisSer: 0.686 ± 0.275
0.772HisThr: 0.772 ± 0.257
1.115HisVal: 1.115 ± 0.285
0.086HisTrp: 0.086 ± 0.074
0.6HisTyr: 0.6 ± 0.225
0.0HisXaa: 0.0 ± 0.0
Ile
5.661IleAla: 5.661 ± 0.656
0.515IleCys: 0.515 ± 0.222
4.717IleAsp: 4.717 ± 0.676
5.06IleGlu: 5.06 ± 0.824
1.287IlePhe: 1.287 ± 0.353
4.546IleGly: 4.546 ± 0.698
1.029IleHis: 1.029 ± 0.285
3.602IleIle: 3.602 ± 0.452
6.776IleLys: 6.776 ± 0.763
4.289IleLeu: 4.289 ± 0.646
1.544IleMet: 1.544 ± 0.448
3.259IleAsn: 3.259 ± 0.378
2.144IlePro: 2.144 ± 0.392
2.316IleGln: 2.316 ± 0.514
2.058IleArg: 2.058 ± 0.549
4.717IleSer: 4.717 ± 0.57
4.289IleThr: 4.289 ± 0.554
4.031IleVal: 4.031 ± 0.829
0.772IleTrp: 0.772 ± 0.222
2.659IleTyr: 2.659 ± 0.543
0.0IleXaa: 0.0 ± 0.0
Lys
5.661LysAla: 5.661 ± 0.625
0.343LysCys: 0.343 ± 0.316
4.975LysAsp: 4.975 ± 0.584
5.747LysGlu: 5.747 ± 0.802
3.86LysPhe: 3.86 ± 0.898
6.175LysGly: 6.175 ± 0.664
1.715LysHis: 1.715 ± 0.54
7.119LysIle: 7.119 ± 0.706
6.604LysLys: 6.604 ± 1.026
6.09LysLeu: 6.09 ± 0.589
2.487LysMet: 2.487 ± 0.408
6.261LysAsn: 6.261 ± 0.632
2.144LysPro: 2.144 ± 0.515
3.602LysGln: 3.602 ± 0.617
3.774LysArg: 3.774 ± 0.645
5.146LysSer: 5.146 ± 0.547
5.832LysThr: 5.832 ± 0.659
4.717LysVal: 4.717 ± 0.64
1.458LysTrp: 1.458 ± 0.289
2.058LysTyr: 2.058 ± 0.362
0.0LysXaa: 0.0 ± 0.0
Leu
7.719LeuAla: 7.719 ± 0.869
0.429LeuCys: 0.429 ± 0.218
5.489LeuAsp: 5.489 ± 1.022
5.832LeuGlu: 5.832 ± 0.811
1.715LeuPhe: 1.715 ± 0.341
5.146LeuGly: 5.146 ± 0.812
0.943LeuHis: 0.943 ± 0.268
4.546LeuIle: 4.546 ± 0.514
8.234LeuLys: 8.234 ± 0.878
5.661LeuLeu: 5.661 ± 0.651
2.316LeuMet: 2.316 ± 0.521
4.374LeuAsn: 4.374 ± 0.712
2.916LeuPro: 2.916 ± 0.414
3.002LeuGln: 3.002 ± 0.437
2.916LeuArg: 2.916 ± 0.675
4.803LeuSer: 4.803 ± 0.686
4.889LeuThr: 4.889 ± 0.723
3.945LeuVal: 3.945 ± 0.568
0.686LeuTrp: 0.686 ± 0.268
1.973LeuTyr: 1.973 ± 0.464
0.0LeuXaa: 0.0 ± 0.0
Met
2.745MetAla: 2.745 ± 0.531
0.172MetCys: 0.172 ± 0.148
1.029MetAsp: 1.029 ± 0.247
1.63MetGlu: 1.63 ± 0.417
1.372MetPhe: 1.372 ± 0.305
0.515MetGly: 0.515 ± 0.22
0.172MetHis: 0.172 ± 0.103
1.458MetIle: 1.458 ± 0.358
2.745MetLys: 2.745 ± 0.438
2.573MetLeu: 2.573 ± 0.439
0.6MetMet: 0.6 ± 0.212
1.287MetAsn: 1.287 ± 0.342
1.115MetPro: 1.115 ± 0.259
0.858MetGln: 0.858 ± 0.256
1.029MetArg: 1.029 ± 0.337
1.973MetSer: 1.973 ± 0.369
1.63MetThr: 1.63 ± 0.43
2.144MetVal: 2.144 ± 0.377
0.515MetTrp: 0.515 ± 0.206
1.287MetTyr: 1.287 ± 0.376
0.0MetXaa: 0.0 ± 0.0
Asn
5.575AsnAla: 5.575 ± 0.79
0.257AsnCys: 0.257 ± 0.145
3.945AsnAsp: 3.945 ± 0.654
3.088AsnGlu: 3.088 ± 0.587
1.801AsnPhe: 1.801 ± 0.368
6.519AsnGly: 6.519 ± 0.903
0.772AsnHis: 0.772 ± 0.234
3.259AsnIle: 3.259 ± 0.537
4.203AsnLys: 4.203 ± 0.652
3.517AsnLeu: 3.517 ± 0.55
2.659AsnMet: 2.659 ± 0.415
3.945AsnAsn: 3.945 ± 0.562
2.316AsnPro: 2.316 ± 0.43
2.573AsnGln: 2.573 ± 0.397
2.573AsnArg: 2.573 ± 0.531
4.632AsnSer: 4.632 ± 0.841
3.86AsnThr: 3.86 ± 0.932
4.031AsnVal: 4.031 ± 0.525
1.201AsnTrp: 1.201 ± 0.33
2.058AsnTyr: 2.058 ± 0.324
0.0AsnXaa: 0.0 ± 0.0
Pro
2.058ProAla: 2.058 ± 0.427
0.086ProCys: 0.086 ± 0.086
1.201ProAsp: 1.201 ± 0.416
2.23ProGlu: 2.23 ± 0.364
1.458ProPhe: 1.458 ± 0.249
0.858ProGly: 0.858 ± 0.358
0.515ProHis: 0.515 ± 0.185
1.887ProIle: 1.887 ± 0.325
2.487ProLys: 2.487 ± 0.467
2.316ProLeu: 2.316 ± 0.471
0.515ProMet: 0.515 ± 0.178
2.402ProAsn: 2.402 ± 0.332
0.6ProPro: 0.6 ± 0.268
0.943ProGln: 0.943 ± 0.206
0.686ProArg: 0.686 ± 0.201
2.058ProSer: 2.058 ± 0.39
2.316ProThr: 2.316 ± 0.396
1.63ProVal: 1.63 ± 0.365
0.257ProTrp: 0.257 ± 0.132
1.115ProTyr: 1.115 ± 0.311
0.0ProXaa: 0.0 ± 0.0
Gln
3.945GlnAla: 3.945 ± 0.651
0.086GlnCys: 0.086 ± 0.098
2.058GlnAsp: 2.058 ± 0.326
2.573GlnGlu: 2.573 ± 0.435
1.63GlnPhe: 1.63 ± 0.24
2.83GlnGly: 2.83 ± 0.675
0.686GlnHis: 0.686 ± 0.216
2.659GlnIle: 2.659 ± 0.588
3.602GlnLys: 3.602 ± 0.439
3.431GlnLeu: 3.431 ± 0.47
1.201GlnMet: 1.201 ± 0.325
1.715GlnAsn: 1.715 ± 0.452
0.686GlnPro: 0.686 ± 0.254
2.23GlnGln: 2.23 ± 0.462
2.144GlnArg: 2.144 ± 0.459
2.23GlnSer: 2.23 ± 0.466
2.144GlnThr: 2.144 ± 0.411
2.144GlnVal: 2.144 ± 0.525
0.343GlnTrp: 0.343 ± 0.133
2.23GlnTyr: 2.23 ± 0.403
0.0GlnXaa: 0.0 ± 0.0
Arg
2.402ArgAla: 2.402 ± 0.519
0.343ArgCys: 0.343 ± 0.212
2.487ArgAsp: 2.487 ± 0.573
2.83ArgGlu: 2.83 ± 0.591
1.201ArgPhe: 1.201 ± 0.364
1.63ArgGly: 1.63 ± 0.344
0.686ArgHis: 0.686 ± 0.293
2.316ArgIle: 2.316 ± 0.526
4.289ArgLys: 4.289 ± 0.778
2.83ArgLeu: 2.83 ± 0.514
0.772ArgMet: 0.772 ± 0.278
3.259ArgAsn: 3.259 ± 0.526
1.029ArgPro: 1.029 ± 0.363
2.487ArgGln: 2.487 ± 0.42
1.372ArgArg: 1.372 ± 0.407
1.544ArgSer: 1.544 ± 0.255
2.659ArgThr: 2.659 ± 0.566
1.715ArgVal: 1.715 ± 0.351
0.6ArgTrp: 0.6 ± 0.159
1.715ArgTyr: 1.715 ± 0.5
0.0ArgXaa: 0.0 ± 0.0
Ser
3.259SerAla: 3.259 ± 0.559
0.343SerCys: 0.343 ± 0.197
4.546SerAsp: 4.546 ± 0.606
4.889SerGlu: 4.889 ± 0.593
3.259SerPhe: 3.259 ± 0.521
4.803SerGly: 4.803 ± 0.849
0.6SerHis: 0.6 ± 0.178
3.945SerIle: 3.945 ± 0.613
4.975SerLys: 4.975 ± 0.782
4.889SerLeu: 4.889 ± 0.55
1.801SerMet: 1.801 ± 0.391
4.117SerAsn: 4.117 ± 0.669
1.801SerPro: 1.801 ± 0.322
3.002SerGln: 3.002 ± 0.53
2.316SerArg: 2.316 ± 0.611
4.031SerSer: 4.031 ± 0.763
4.203SerThr: 4.203 ± 0.572
4.374SerVal: 4.374 ± 0.589
0.6SerTrp: 0.6 ± 0.215
1.887SerTyr: 1.887 ± 0.354
0.0SerXaa: 0.0 ± 0.0
Thr
5.575ThrAla: 5.575 ± 0.802
0.515ThrCys: 0.515 ± 0.251
4.975ThrAsp: 4.975 ± 0.651
3.002ThrGlu: 3.002 ± 0.571
2.659ThrPhe: 2.659 ± 0.508
4.546ThrGly: 4.546 ± 0.578
0.943ThrHis: 0.943 ± 0.309
4.889ThrIle: 4.889 ± 0.748
4.632ThrLys: 4.632 ± 0.666
5.146ThrLeu: 5.146 ± 0.733
1.029ThrMet: 1.029 ± 0.292
4.289ThrAsn: 4.289 ± 0.846
1.544ThrPro: 1.544 ± 0.43
2.573ThrGln: 2.573 ± 0.465
1.887ThrArg: 1.887 ± 0.374
3.688ThrSer: 3.688 ± 0.596
3.431ThrThr: 3.431 ± 0.651
3.517ThrVal: 3.517 ± 0.851
1.458ThrTrp: 1.458 ± 0.322
3.688ThrTyr: 3.688 ± 0.58
0.0ThrXaa: 0.0 ± 0.0
Val
4.889ValAla: 4.889 ± 0.67
0.172ValCys: 0.172 ± 0.111
4.975ValAsp: 4.975 ± 0.648
3.774ValGlu: 3.774 ± 0.531
2.23ValPhe: 2.23 ± 0.426
3.86ValGly: 3.86 ± 0.525
0.515ValHis: 0.515 ± 0.198
4.717ValIle: 4.717 ± 0.723
4.975ValLys: 4.975 ± 0.684
4.975ValLeu: 4.975 ± 0.72
0.772ValMet: 0.772 ± 0.288
3.688ValAsn: 3.688 ± 0.938
1.973ValPro: 1.973 ± 0.429
1.887ValGln: 1.887 ± 0.481
2.144ValArg: 2.144 ± 0.504
5.575ValSer: 5.575 ± 0.655
4.203ValThr: 4.203 ± 0.716
3.945ValVal: 3.945 ± 0.672
0.858ValTrp: 0.858 ± 0.296
2.316ValTyr: 2.316 ± 0.47
0.0ValXaa: 0.0 ± 0.0
Trp
0.515TrpAla: 0.515 ± 0.163
0.0TrpCys: 0.0 ± 0.0
1.115TrpAsp: 1.115 ± 0.424
1.458TrpGlu: 1.458 ± 0.368
0.515TrpPhe: 0.515 ± 0.187
0.772TrpGly: 0.772 ± 0.18
0.257TrpHis: 0.257 ± 0.137
0.686TrpIle: 0.686 ± 0.305
0.943TrpLys: 0.943 ± 0.275
1.287TrpLeu: 1.287 ± 0.313
0.172TrpMet: 0.172 ± 0.125
1.115TrpAsn: 1.115 ± 0.312
0.086TrpPro: 0.086 ± 0.108
0.6TrpGln: 0.6 ± 0.241
0.858TrpArg: 0.858 ± 0.226
1.115TrpSer: 1.115 ± 0.289
1.115TrpThr: 1.115 ± 0.34
0.858TrpVal: 0.858 ± 0.226
0.257TrpTrp: 0.257 ± 0.18
0.343TrpTyr: 0.343 ± 0.149
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.916TyrAla: 2.916 ± 0.4
0.515TyrCys: 0.515 ± 0.236
2.316TyrAsp: 2.316 ± 0.501
2.23TyrGlu: 2.23 ± 0.452
2.23TyrPhe: 2.23 ± 0.388
2.745TyrGly: 2.745 ± 0.612
0.686TyrHis: 0.686 ± 0.217
2.058TyrIle: 2.058 ± 0.596
2.83TyrLys: 2.83 ± 0.567
3.259TyrLeu: 3.259 ± 0.572
0.6TyrMet: 0.6 ± 0.244
2.058TyrAsn: 2.058 ± 0.516
1.029TyrPro: 1.029 ± 0.29
2.573TyrGln: 2.573 ± 0.461
1.973TyrArg: 1.973 ± 0.392
1.715TyrSer: 1.715 ± 0.433
2.316TyrThr: 2.316 ± 0.782
3.345TyrVal: 3.345 ± 0.46
0.515TyrTrp: 0.515 ± 0.229
2.144TyrTyr: 2.144 ± 0.585
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 51 proteins (11660 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski