Amino acid dipepetide frequency for Muricauda ruestringensis (strain DSM 13258 / CIP 107369 / LMG 19739 / B1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.299AlaAla: 4.299 ± 0.081	0.556AlaCys: 0.556 ± 0.027	3.492AlaAsp: 3.492 ± 0.062	4.256AlaGlu: 4.256 ± 0.065	3.239AlaPhe: 3.239 ± 0.056	4.24AlaGly: 4.24 ± 0.072	1.211AlaHis: 1.211 ± 0.039	5.127AlaIle: 5.127 ± 0.075	4.517AlaLys: 4.517 ± 0.075	6.55AlaLeu: 6.55 ± 0.086	1.685AlaMet: 1.685 ± 0.038	3.194AlaAsn: 3.194 ± 0.061	2.139AlaPro: 2.139 ± 0.055	2.65AlaGln: 2.65 ± 0.051	2.135AlaArg: 2.135 ± 0.042	4.278AlaSer: 4.278 ± 0.068	3.591AlaThr: 3.591 ± 0.071	4.171AlaVal: 4.171 ± 0.077	0.66AlaTrp: 0.66 ± 0.024	2.511AlaTyr: 2.511 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.427CysAla: 0.427 ± 0.022	0.097CysCys: 0.097 ± 0.011	0.428CysAsp: 0.428 ± 0.024	0.452CysGlu: 0.452 ± 0.023	0.395CysPhe: 0.395 ± 0.02	0.587CysGly: 0.587 ± 0.023	0.199CysHis: 0.199 ± 0.014	0.494CysIle: 0.494 ± 0.022	0.451CysLys: 0.451 ± 0.019	0.667CysLeu: 0.667 ± 0.023	0.167CysMet: 0.167 ± 0.012	0.391CysAsn: 0.391 ± 0.019	0.319CysPro: 0.319 ± 0.023	0.204CysGln: 0.204 ± 0.014	0.211CysArg: 0.211 ± 0.014	0.523CysSer: 0.523 ± 0.024	0.449CysThr: 0.449 ± 0.026	0.429CysVal: 0.429 ± 0.02	0.069CysTrp: 0.069 ± 0.009	0.298CysTyr: 0.298 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.788AspAla: 3.788 ± 0.065	0.444AspCys: 0.444 ± 0.02	3.342AspAsp: 3.342 ± 0.081	4.192AspGlu: 4.192 ± 0.061	3.783AspPhe: 3.783 ± 0.072	4.518AspGly: 4.518 ± 0.108	1.03AspHis: 1.03 ± 0.031	4.333AspIle: 4.333 ± 0.063	3.956AspLys: 3.956 ± 0.071	5.256AspLeu: 5.256 ± 0.069	1.408AspMet: 1.408 ± 0.033	3.029AspAsn: 3.029 ± 0.065	2.029AspPro: 2.029 ± 0.063	1.658AspGln: 1.658 ± 0.04	2.171AspArg: 2.171 ± 0.046	3.464AspSer: 3.464 ± 0.064	2.923AspThr: 2.923 ± 0.051	3.79AspVal: 3.79 ± 0.065	0.854AspTrp: 0.854 ± 0.026	2.829AspTyr: 2.829 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	4.657GluAla: 4.657 ± 0.077	0.36GluCys: 0.36 ± 0.019	3.933GluAsp: 3.933 ± 0.062	5.703GluGlu: 5.703 ± 0.09	2.922GluPhe: 2.922 ± 0.051	4.291GluGly: 4.291 ± 0.072	1.388GluHis: 1.388 ± 0.041	5.013GluIle: 5.013 ± 0.068	5.733GluLys: 5.733 ± 0.081	6.621GluLeu: 6.621 ± 0.087	1.741GluMet: 1.741 ± 0.04	4.255GluAsn: 4.255 ± 0.066	1.925GluPro: 1.925 ± 0.048	2.597GluGln: 2.597 ± 0.052	3.024GluArg: 3.024 ± 0.049	3.553GluSer: 3.553 ± 0.053	3.803GluThr: 3.803 ± 0.059	4.908GluVal: 4.908 ± 0.073	0.722GluTrp: 0.722 ± 0.024	2.406GluTyr: 2.406 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	3.024PheAla: 3.024 ± 0.05	0.413PheCys: 0.413 ± 0.022	3.406PheAsp: 3.406 ± 0.064	3.496PheGlu: 3.496 ± 0.057	2.722PhePhe: 2.722 ± 0.064	3.887PheGly: 3.887 ± 0.059	0.849PheHis: 0.849 ± 0.027	3.272PheIle: 3.272 ± 0.059	3.419PheLys: 3.419 ± 0.062	4.751PheLeu: 4.751 ± 0.074	1.23PheMet: 1.23 ± 0.037	2.834PheAsn: 2.834 ± 0.062	1.802PhePro: 1.802 ± 0.044	1.605PheGln: 1.605 ± 0.041	1.699PheArg: 1.699 ± 0.041	3.679PheSer: 3.679 ± 0.059	2.862PheThr: 2.862 ± 0.052	3.142PheVal: 3.142 ± 0.054	0.61PheTrp: 0.61 ± 0.024	2.077PheTyr: 2.077 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.442GlyAla: 4.442 ± 0.08	0.616GlyCys: 0.616 ± 0.035	3.889GlyAsp: 3.889 ± 0.073	4.249GlyGlu: 4.249 ± 0.06	3.792GlyPhe: 3.792 ± 0.067	5.072GlyGly: 5.072 ± 0.102	1.297GlyHis: 1.297 ± 0.039	5.456GlyIle: 5.456 ± 0.085	5.11GlyLys: 5.11 ± 0.077	6.368GlyLeu: 6.368 ± 0.082	1.854GlyMet: 1.854 ± 0.048	3.759GlyAsn: 3.759 ± 0.069	1.674GlyPro: 1.674 ± 0.046	2.144GlyGln: 2.144 ± 0.047	2.36GlyArg: 2.36 ± 0.046	4.238GlySer: 4.238 ± 0.083	4.425GlyThr: 4.425 ± 0.084	4.705GlyVal: 4.705 ± 0.076	0.877GlyTrp: 0.877 ± 0.029	2.971GlyTyr: 2.971 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	0.988HisAla: 0.988 ± 0.031	0.165HisCys: 0.165 ± 0.012	0.876HisAsp: 0.876 ± 0.028	1.03HisGlu: 1.03 ± 0.034	1.165HisPhe: 1.165 ± 0.031	1.226HisGly: 1.226 ± 0.035	0.49HisHis: 0.49 ± 0.026	1.428HisIle: 1.428 ± 0.034	1.185HisLys: 1.185 ± 0.029	1.87HisLeu: 1.87 ± 0.043	0.376HisMet: 0.376 ± 0.017	0.922HisAsn: 0.922 ± 0.03	0.975HisPro: 0.975 ± 0.034	0.82HisGln: 0.82 ± 0.029	0.778HisArg: 0.778 ± 0.029	1.067HisSer: 1.067 ± 0.03	0.995HisThr: 0.995 ± 0.033	1.074HisVal: 1.074 ± 0.031	0.272HisTrp: 0.272 ± 0.017	0.824HisTyr: 0.824 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.209IleAla: 5.209 ± 0.076	0.555IleCys: 0.555 ± 0.02	4.306IleAsp: 4.306 ± 0.069	4.736IleGlu: 4.736 ± 0.065	3.391IlePhe: 3.391 ± 0.063	4.919IleGly: 4.919 ± 0.078	1.297IleHis: 1.297 ± 0.037	4.725IleIle: 4.725 ± 0.076	5.026IleLys: 5.026 ± 0.073	6.649IleLeu: 6.649 ± 0.089	1.44IleMet: 1.44 ± 0.037	3.963IleAsn: 3.963 ± 0.061	3.14IlePro: 3.14 ± 0.051	2.439IleGln: 2.439 ± 0.051	2.564IleArg: 2.564 ± 0.052	5.093IleSer: 5.093 ± 0.07	4.217IleThr: 4.217 ± 0.077	4.532IleVal: 4.532 ± 0.077	0.725IleTrp: 0.725 ± 0.028	2.585IleTyr: 2.585 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	4.733LysAla: 4.733 ± 0.079	0.34LysCys: 0.34 ± 0.02	4.284LysAsp: 4.284 ± 0.062	6.129LysGlu: 6.129 ± 0.089	2.576LysPhe: 2.576 ± 0.043	4.647LysGly: 4.647 ± 0.073	1.362LysHis: 1.362 ± 0.035	5.178LysIle: 5.178 ± 0.07	6.652LysLys: 6.652 ± 0.099	6.173LysLeu: 6.173 ± 0.089	1.974LysMet: 1.974 ± 0.047	4.465LysAsn: 4.465 ± 0.071	2.368LysPro: 2.368 ± 0.057	2.444LysGln: 2.444 ± 0.049	3.016LysArg: 3.016 ± 0.055	4.24LysSer: 4.24 ± 0.075	4.173LysThr: 4.173 ± 0.061	4.816LysVal: 4.816 ± 0.069	0.76LysTrp: 0.76 ± 0.026	2.689LysTyr: 2.689 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	6.173LeuAla: 6.173 ± 0.089	0.693LeuCys: 0.693 ± 0.023	5.818LeuAsp: 5.818 ± 0.066	6.835LeuGlu: 6.835 ± 0.087	4.835LeuPhe: 4.835 ± 0.079	6.506LeuGly: 6.506 ± 0.086	1.567LeuHis: 1.567 ± 0.04	6.024LeuIle: 6.024 ± 0.086	7.168LeuLys: 7.168 ± 0.087	8.833LeuLeu: 8.833 ± 0.126	2.421LeuMet: 2.421 ± 0.045	5.042LeuAsn: 5.042 ± 0.074	3.705LeuPro: 3.705 ± 0.06	3.232LeuGln: 3.232 ± 0.056	3.47LeuArg: 3.47 ± 0.057	6.569LeuSer: 6.569 ± 0.088	4.98LeuThr: 4.98 ± 0.073	6.03LeuVal: 6.03 ± 0.08	0.902LeuTrp: 0.902 ± 0.034	3.153LeuTyr: 3.153 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.066MetAla: 2.066 ± 0.041	0.128MetCys: 0.128 ± 0.011	1.669MetAsp: 1.669 ± 0.037	1.964MetGlu: 1.964 ± 0.048	0.945MetPhe: 0.945 ± 0.03	1.876MetGly: 1.876 ± 0.043	0.439MetHis: 0.439 ± 0.018	1.418MetIle: 1.418 ± 0.038	2.045MetLys: 2.045 ± 0.041	2.15MetLeu: 2.15 ± 0.043	0.633MetMet: 0.633 ± 0.025	1.227MetAsn: 1.227 ± 0.034	0.937MetPro: 0.937 ± 0.029	0.871MetGln: 0.871 ± 0.031	0.97MetArg: 0.97 ± 0.03	1.35MetSer: 1.35 ± 0.035	1.176MetThr: 1.176 ± 0.035	1.737MetVal: 1.737 ± 0.041	0.177MetTrp: 0.177 ± 0.012	0.727MetTyr: 0.727 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.523AsnAla: 3.523 ± 0.058	0.404AsnCys: 0.404 ± 0.022	2.984AsnAsp: 2.984 ± 0.067	3.28AsnGlu: 3.28 ± 0.058	2.794AsnPhe: 2.794 ± 0.054	4.127AsnGly: 4.127 ± 0.072	1.036AsnHis: 1.036 ± 0.033	4.049AsnIle: 4.049 ± 0.059	3.547AsnLys: 3.547 ± 0.053	4.974AsnLeu: 4.974 ± 0.076	1.295AsnMet: 1.295 ± 0.031	3.119AsnAsn: 3.119 ± 0.066	2.695AsnPro: 2.695 ± 0.052	2.176AsnGln: 2.176 ± 0.047	2.249AsnArg: 2.249 ± 0.051	3.264AsnSer: 3.264 ± 0.055	3.26AsnThr: 3.26 ± 0.057	3.397AsnVal: 3.397 ± 0.065	0.67AsnTrp: 0.67 ± 0.025	2.456AsnTyr: 2.456 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	1.925ProAla: 1.925 ± 0.048	0.217ProCys: 0.217 ± 0.014	2.354ProAsp: 2.354 ± 0.055	3.107ProGlu: 3.107 ± 0.048	1.926ProPhe: 1.926 ± 0.038	2.207ProGly: 2.207 ± 0.05	0.657ProHis: 0.657 ± 0.022	2.695ProIle: 2.695 ± 0.049	2.806ProLys: 2.806 ± 0.058	3.227ProLeu: 3.227 ± 0.057	0.91ProMet: 0.91 ± 0.031	2.249ProAsn: 2.249 ± 0.047	1.007ProPro: 1.007 ± 0.035	1.179ProGln: 1.179 ± 0.033	1.05ProArg: 1.05 ± 0.029	2.363ProSer: 2.363 ± 0.05	2.103ProThr: 2.103 ± 0.051	2.424ProVal: 2.424 ± 0.051	0.39ProTrp: 0.39 ± 0.019	1.493ProTyr: 1.493 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.057GlnAla: 2.057 ± 0.045	0.173GlnCys: 0.173 ± 0.013	1.771GlnAsp: 1.771 ± 0.044	2.533GlnGlu: 2.533 ± 0.046	1.7GlnPhe: 1.7 ± 0.038	2.069GlnGly: 2.069 ± 0.047	0.621GlnHis: 0.621 ± 0.023	2.571GlnIle: 2.571 ± 0.054	2.801GlnLys: 2.801 ± 0.06	3.585GlnLeu: 3.585 ± 0.059	0.992GlnMet: 0.992 ± 0.031	2.092GlnAsn: 2.092 ± 0.051	1.142GlnPro: 1.142 ± 0.031	1.499GlnGln: 1.499 ± 0.039	1.447GlnArg: 1.447 ± 0.04	1.975GlnSer: 1.975 ± 0.042	1.84GlnThr: 1.84 ± 0.046	2.089GlnVal: 2.089 ± 0.037	0.435GlnTrp: 0.435 ± 0.019	1.357GlnTyr: 1.357 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.247ArgAla: 2.247 ± 0.037	0.209ArgCys: 0.209 ± 0.013	2.01ArgAsp: 2.01 ± 0.047	2.557ArgGlu: 2.557 ± 0.049	2.043ArgPhe: 2.043 ± 0.047	2.204ArgGly: 2.204 ± 0.053	0.691ArgHis: 0.691 ± 0.023	2.912ArgIle: 2.912 ± 0.059	2.887ArgLys: 2.887 ± 0.052	3.563ArgLeu: 3.563 ± 0.061	0.999ArgMet: 0.999 ± 0.029	2.12ArgAsn: 2.12 ± 0.048	1.332ArgPro: 1.332 ± 0.033	1.202ArgGln: 1.202 ± 0.042	1.454ArgArg: 1.454 ± 0.036	2.165ArgSer: 2.165 ± 0.047	2.053ArgThr: 2.053 ± 0.042	2.179ArgVal: 2.179 ± 0.039	0.426ArgTrp: 0.426 ± 0.023	1.657ArgTyr: 1.657 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	3.633SerAla: 3.633 ± 0.054	0.597SerCys: 0.597 ± 0.024	3.641SerAsp: 3.641 ± 0.072	4.081SerGlu: 4.081 ± 0.054	3.459SerPhe: 3.459 ± 0.057	4.757SerGly: 4.757 ± 0.08	1.148SerHis: 1.148 ± 0.034	4.888SerIle: 4.888 ± 0.073	4.645SerLys: 4.645 ± 0.073	5.983SerLeu: 5.983 ± 0.084	1.445SerMet: 1.445 ± 0.034	3.496SerAsn: 3.496 ± 0.067	2.236SerPro: 2.236 ± 0.048	2.06SerGln: 2.06 ± 0.046	2.185SerArg: 2.185 ± 0.045	4.03SerSer: 4.03 ± 0.07	3.567SerThr: 3.567 ± 0.063	3.97SerVal: 3.97 ± 0.058	0.713SerTrp: 0.713 ± 0.026	2.624SerTyr: 2.624 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	3.647ThrAla: 3.647 ± 0.076	0.361ThrCys: 0.361 ± 0.021	3.384ThrAsp: 3.384 ± 0.08	3.47ThrGlu: 3.47 ± 0.057	2.881ThrPhe: 2.881 ± 0.054	4.149ThrGly: 4.149 ± 0.068	0.979ThrHis: 0.979 ± 0.029	4.449ThrIle: 4.449 ± 0.074	3.529ThrLys: 3.529 ± 0.061	5.343ThrLeu: 5.343 ± 0.064	1.172ThrMet: 1.172 ± 0.033	2.884ThrAsn: 2.884 ± 0.061	2.426ThrPro: 2.426 ± 0.049	1.907ThrGln: 1.907 ± 0.042	1.715ThrArg: 1.715 ± 0.041	3.628ThrSer: 3.628 ± 0.064	3.175ThrThr: 3.175 ± 0.067	3.923ThrVal: 3.923 ± 0.07	0.646ThrTrp: 0.646 ± 0.027	2.404ThrTyr: 2.404 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	4.476ValAla: 4.476 ± 0.07	0.531ValCys: 0.531 ± 0.027	4.129ValAsp: 4.129 ± 0.072	4.357ValGlu: 4.357 ± 0.061	3.333ValPhe: 3.333 ± 0.054	4.316ValGly: 4.316 ± 0.068	1.179ValHis: 1.179 ± 0.031	4.272ValIle: 4.272 ± 0.064	4.205ValLys: 4.205 ± 0.069	6.562ValLeu: 6.562 ± 0.089	1.567ValMet: 1.567 ± 0.045	3.256ValAsn: 3.256 ± 0.062	2.604ValPro: 2.604 ± 0.047	2.09ValGln: 2.09 ± 0.04	2.237ValArg: 2.237 ± 0.044	4.58ValSer: 4.58 ± 0.055	3.572ValThr: 3.572 ± 0.081	4.685ValVal: 4.685 ± 0.077	0.669ValTrp: 0.669 ± 0.023	2.377ValTyr: 2.377 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.67TrpAla: 0.67 ± 0.025	0.091TrpCys: 0.091 ± 0.007	0.728TrpAsp: 0.728 ± 0.024	0.808TrpGlu: 0.808 ± 0.029	0.576TrpPhe: 0.576 ± 0.022	0.791TrpGly: 0.791 ± 0.032	0.236TrpHis: 0.236 ± 0.013	0.696TrpIle: 0.696 ± 0.024	0.783TrpLys: 0.783 ± 0.026	1.014TrpLeu: 1.014 ± 0.029	0.362TrpMet: 0.362 ± 0.022	0.718TrpAsn: 0.718 ± 0.028	0.332TrpPro: 0.332 ± 0.02	0.411TrpGln: 0.411 ± 0.021	0.44TrpArg: 0.44 ± 0.02	0.651TrpSer: 0.651 ± 0.027	0.593TrpThr: 0.593 ± 0.025	0.73TrpVal: 0.73 ± 0.028	0.176TrpTrp: 0.176 ± 0.013	0.45TrpTyr: 0.45 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.518TyrAla: 2.518 ± 0.055	0.305TyrCys: 0.305 ± 0.015	2.354TyrAsp: 2.354 ± 0.052	2.319TyrGlu: 2.319 ± 0.045	2.301TyrPhe: 2.301 ± 0.051	2.908TyrGly: 2.908 ± 0.055	0.854TyrHis: 0.854 ± 0.028	2.505TyrIle: 2.505 ± 0.041	2.554TyrLys: 2.554 ± 0.042	3.818TyrLeu: 3.818 ± 0.069	0.836TyrMet: 0.836 ± 0.029	2.284TyrAsn: 2.284 ± 0.051	1.5TyrPro: 1.5 ± 0.037	1.561TyrGln: 1.561 ± 0.043	1.736TyrArg: 1.736 ± 0.042	2.449TyrSer: 2.449 ± 0.048	2.315TyrThr: 2.315 ± 0.052	2.269TyrVal: 2.269 ± 0.046	0.502TyrTrp: 0.502 ± 0.022	1.673TyrTyr: 1.673 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3425 proteins (1152300 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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