Amino acid dipepetide frequency for Jannaschia rubra

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.815AlaAla: 18.815 ± 0.187	1.189AlaCys: 1.189 ± 0.033	7.873AlaAsp: 7.873 ± 0.09	8.356AlaGlu: 8.356 ± 0.124	4.592AlaPhe: 4.592 ± 0.066	11.779AlaGly: 11.779 ± 0.125	2.319AlaHis: 2.319 ± 0.048	5.934AlaIle: 5.934 ± 0.083	2.701AlaLys: 2.701 ± 0.066	14.102AlaLeu: 14.102 ± 0.144	4.133AlaMet: 4.133 ± 0.061	2.408AlaAsn: 2.408 ± 0.053	6.642AlaPro: 6.642 ± 0.101	4.13AlaGln: 4.13 ± 0.066	11.041AlaArg: 11.041 ± 0.146	5.422AlaSer: 5.422 ± 0.082	6.77AlaThr: 6.77 ± 0.081	9.394AlaVal: 9.394 ± 0.1	1.729AlaTrp: 1.729 ± 0.045	2.308AlaTyr: 2.308 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.117CysAla: 1.117 ± 0.035	0.098CysCys: 0.098 ± 0.009	0.659CysAsp: 0.659 ± 0.026	0.394CysGlu: 0.394 ± 0.019	0.302CysPhe: 0.302 ± 0.016	0.896CysGly: 0.896 ± 0.032	0.251CysHis: 0.251 ± 0.015	0.389CysIle: 0.389 ± 0.018	0.141CysLys: 0.141 ± 0.012	0.819CysLeu: 0.819 ± 0.028	0.162CysMet: 0.162 ± 0.011	0.187CysAsn: 0.187 ± 0.013	0.494CysPro: 0.494 ± 0.022	0.173CysGln: 0.173 ± 0.012	0.604CysArg: 0.604 ± 0.024	0.402CysSer: 0.402 ± 0.022	0.437CysThr: 0.437 ± 0.024	0.63CysVal: 0.63 ± 0.024	0.095CysTrp: 0.095 ± 0.01	0.179CysTyr: 0.179 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	9.035AspAla: 9.035 ± 0.109	0.534AspCys: 0.534 ± 0.023	4.441AspAsp: 4.441 ± 0.085	3.388AspGlu: 3.388 ± 0.064	2.264AspPhe: 2.264 ± 0.042	6.755AspGly: 6.755 ± 0.098	1.502AspHis: 1.502 ± 0.037	2.945AspIle: 2.945 ± 0.058	1.2AspLys: 1.2 ± 0.036	7.334AspLeu: 7.334 ± 0.1	1.743AspMet: 1.743 ± 0.045	1.098AspAsn: 1.098 ± 0.035	4.264AspPro: 4.264 ± 0.064	1.462AspGln: 1.462 ± 0.041	6.167AspArg: 6.167 ± 0.081	1.909AspSer: 1.909 ± 0.044	3.16AspThr: 3.16 ± 0.064	4.778AspVal: 4.778 ± 0.069	1.378AspTrp: 1.378 ± 0.041	1.459AspTyr: 1.459 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	8.204GluAla: 8.204 ± 0.099	0.304GluCys: 0.304 ± 0.017	3.209GluAsp: 3.209 ± 0.057	3.421GluGlu: 3.421 ± 0.078	1.489GluPhe: 1.489 ± 0.036	5.173GluGly: 5.173 ± 0.069	1.016GluHis: 1.016 ± 0.033	2.936GluIle: 2.936 ± 0.051	1.485GluLys: 1.485 ± 0.047	4.281GluLeu: 4.281 ± 0.07	1.804GluMet: 1.804 ± 0.043	1.304GluAsn: 1.304 ± 0.041	2.48GluPro: 2.48 ± 0.053	1.688GluGln: 1.688 ± 0.045	4.651GluArg: 4.651 ± 0.075	1.943GluSer: 1.943 ± 0.048	3.706GluThr: 3.706 ± 0.064	4.513GluVal: 4.513 ± 0.065	0.756GluTrp: 0.756 ± 0.03	0.891GluTyr: 0.891 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.558PheAla: 4.558 ± 0.068	0.398PheCys: 0.398 ± 0.019	3.052PheAsp: 3.052 ± 0.058	1.878PheGlu: 1.878 ± 0.047	1.234PhePhe: 1.234 ± 0.04	3.617PheGly: 3.617 ± 0.061	0.781PheHis: 0.781 ± 0.03	1.419PheIle: 1.419 ± 0.038	0.662PheLys: 0.662 ± 0.027	3.42PheLeu: 3.42 ± 0.062	0.759PheMet: 0.759 ± 0.025	0.796PheAsn: 0.796 ± 0.026	1.56PhePro: 1.56 ± 0.045	0.845PheGln: 0.845 ± 0.027	2.437PheArg: 2.437 ± 0.044	1.667PheSer: 1.667 ± 0.037	1.881PheThr: 1.881 ± 0.045	2.716PheVal: 2.716 ± 0.054	0.535PheTrp: 0.535 ± 0.022	0.779PheTyr: 0.779 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.698GlyAla: 10.698 ± 0.129	0.86GlyCys: 0.86 ± 0.032	5.611GlyAsp: 5.611 ± 0.096	4.678GlyGlu: 4.678 ± 0.076	3.61GlyPhe: 3.61 ± 0.057	8.3GlyGly: 8.3 ± 0.137	2.041GlyHis: 2.041 ± 0.047	4.497GlyIle: 4.497 ± 0.07	2.493GlyLys: 2.493 ± 0.053	9.535GlyLeu: 9.535 ± 0.103	2.701GlyMet: 2.701 ± 0.055	1.966GlyAsn: 1.966 ± 0.05	4.317GlyPro: 4.317 ± 0.065	2.965GlyGln: 2.965 ± 0.055	7.281GlyArg: 7.281 ± 0.092	4.117GlySer: 4.117 ± 0.067	5.369GlyThr: 5.369 ± 0.082	6.653GlyVal: 6.653 ± 0.083	1.612GlyTrp: 1.612 ± 0.045	2.093GlyTyr: 2.093 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.529HisAla: 2.529 ± 0.05	0.22HisCys: 0.22 ± 0.013	1.514HisAsp: 1.514 ± 0.04	0.976HisGlu: 0.976 ± 0.031	0.736HisPhe: 0.736 ± 0.027	2.038HisGly: 2.038 ± 0.049	0.574HisHis: 0.574 ± 0.024	0.815HisIle: 0.815 ± 0.029	0.337HisLys: 0.337 ± 0.016	2.169HisLeu: 2.169 ± 0.045	0.485HisMet: 0.485 ± 0.021	0.397HisAsn: 0.397 ± 0.019	1.438HisPro: 1.438 ± 0.036	0.465HisGln: 0.465 ± 0.018	1.59HisArg: 1.59 ± 0.044	0.783HisSer: 0.783 ± 0.031	0.735HisThr: 0.735 ± 0.028	1.695HisVal: 1.695 ± 0.041	0.338HisTrp: 0.338 ± 0.02	0.466HisTyr: 0.466 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.858IleAla: 6.858 ± 0.079	0.514IleCys: 0.514 ± 0.022	3.816IleAsp: 3.816 ± 0.059	3.132IleGlu: 3.132 ± 0.07	1.52IlePhe: 1.52 ± 0.043	4.612IleGly: 4.612 ± 0.077	0.937IleHis: 0.937 ± 0.026	1.615IleIle: 1.615 ± 0.045	0.865IleLys: 0.865 ± 0.025	4.741IleLeu: 4.741 ± 0.08	0.914IleMet: 0.914 ± 0.031	0.943IleAsn: 0.943 ± 0.03	2.18IlePro: 2.18 ± 0.047	0.969IleGln: 0.969 ± 0.029	3.268IleArg: 3.268 ± 0.047	2.06IleSer: 2.06 ± 0.045	2.365IleThr: 2.365 ± 0.053	4.099IleVal: 4.099 ± 0.076	0.621IleTrp: 0.621 ± 0.023	1.008IleTyr: 1.008 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	2.949LysAla: 2.949 ± 0.063	0.13LysCys: 0.13 ± 0.01	1.296LysAsp: 1.296 ± 0.04	1.07LysGlu: 1.07 ± 0.037	0.626LysPhe: 0.626 ± 0.025	2.082LysGly: 2.082 ± 0.053	0.431LysHis: 0.431 ± 0.022	1.073LysIle: 1.073 ± 0.035	0.771LysLys: 0.771 ± 0.038	2.104LysLeu: 2.104 ± 0.055	0.641LysMet: 0.641 ± 0.026	0.494LysAsn: 0.494 ± 0.023	1.346LysPro: 1.346 ± 0.036	0.565LysGln: 0.565 ± 0.025	1.77LysArg: 1.77 ± 0.043	1.278LysSer: 1.278 ± 0.033	1.381LysThr: 1.381 ± 0.038	1.868LysVal: 1.868 ± 0.045	0.293LysTrp: 0.293 ± 0.016	0.435LysTyr: 0.435 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.642LeuAla: 13.642 ± 0.132	0.838LeuCys: 0.838 ± 0.027	6.84LeuAsp: 6.84 ± 0.097	4.62LeuGlu: 4.62 ± 0.063	3.395LeuPhe: 3.395 ± 0.059	8.635LeuGly: 8.635 ± 0.102	1.948LeuHis: 1.948 ± 0.036	4.903LeuIle: 4.903 ± 0.078	2.298LeuLys: 2.298 ± 0.054	9.16LeuLeu: 9.16 ± 0.125	2.603LeuMet: 2.603 ± 0.052	2.295LeuAsn: 2.295 ± 0.052	5.903LeuPro: 5.903 ± 0.088	2.318LeuGln: 2.318 ± 0.043	8.299LeuArg: 8.299 ± 0.1	6.463LeuSer: 6.463 ± 0.08	6.448LeuThr: 6.448 ± 0.082	6.861LeuVal: 6.861 ± 0.081	1.375LeuTrp: 1.375 ± 0.035	1.708LeuTyr: 1.708 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.806MetAla: 3.806 ± 0.062	0.167MetCys: 0.167 ± 0.011	1.497MetAsp: 1.497 ± 0.038	1.409MetGlu: 1.409 ± 0.04	0.775MetPhe: 0.775 ± 0.028	2.431MetGly: 2.431 ± 0.045	0.45MetHis: 0.45 ± 0.022	1.4MetIle: 1.4 ± 0.035	0.884MetLys: 0.884 ± 0.027	2.555MetLeu: 2.555 ± 0.051	0.719MetMet: 0.719 ± 0.027	0.745MetAsn: 0.745 ± 0.026	1.54MetPro: 1.54 ± 0.041	0.851MetGln: 0.851 ± 0.027	2.023MetArg: 2.023 ± 0.036	1.494MetSer: 1.494 ± 0.038	2.317MetThr: 2.317 ± 0.046	1.862MetVal: 1.862 ± 0.038	0.23MetTrp: 0.23 ± 0.014	0.322MetTyr: 0.322 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.718AsnAla: 2.718 ± 0.051	0.205AsnCys: 0.205 ± 0.013	1.278AsnAsp: 1.278 ± 0.042	0.927AsnGlu: 0.927 ± 0.03	0.787AsnPhe: 0.787 ± 0.027	1.949AsnGly: 1.949 ± 0.044	0.435AsnHis: 0.435 ± 0.022	1.052AsnIle: 1.052 ± 0.033	0.398AsnLys: 0.398 ± 0.02	2.211AsnLeu: 2.211 ± 0.051	0.549AsnMet: 0.549 ± 0.024	0.485AsnAsn: 0.485 ± 0.023	1.681AsnPro: 1.681 ± 0.04	0.52AsnGln: 0.52 ± 0.023	1.675AsnArg: 1.675 ± 0.037	0.849AsnSer: 0.849 ± 0.032	1.082AsnThr: 1.082 ± 0.033	1.705AsnVal: 1.705 ± 0.034	0.388AsnTrp: 0.388 ± 0.017	0.495AsnTyr: 0.495 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.733ProAla: 6.733 ± 0.088	0.379ProCys: 0.379 ± 0.019	4.752ProAsp: 4.752 ± 0.074	4.193ProGlu: 4.193 ± 0.064	2.008ProPhe: 2.008 ± 0.039	5.16ProGly: 5.16 ± 0.07	1.081ProHis: 1.081 ± 0.032	2.085ProIle: 2.085 ± 0.043	1.222ProLys: 1.222 ± 0.039	4.841ProLeu: 4.841 ± 0.073	1.405ProMet: 1.405 ± 0.038	1.067ProAsn: 1.067 ± 0.033	2.831ProPro: 2.831 ± 0.066	1.515ProGln: 1.515 ± 0.039	3.579ProArg: 3.579 ± 0.061	2.472ProSer: 2.472 ± 0.042	2.527ProThr: 2.527 ± 0.046	4.631ProVal: 4.631 ± 0.072	0.755ProTrp: 0.755 ± 0.028	0.978ProTyr: 0.978 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.928GlnAla: 3.928 ± 0.063	0.162GlnCys: 0.162 ± 0.013	1.661GlnAsp: 1.661 ± 0.039	1.328GlnGlu: 1.328 ± 0.04	0.85GlnPhe: 0.85 ± 0.028	2.51GlnGly: 2.51 ± 0.048	0.43GlnHis: 0.43 ± 0.019	1.553GlnIle: 1.553 ± 0.043	0.767GlnLys: 0.767 ± 0.028	2.206GlnLeu: 2.206 ± 0.05	0.922GlnMet: 0.922 ± 0.033	0.666GlnAsn: 0.666 ± 0.026	1.442GlnPro: 1.442 ± 0.039	0.823GlnGln: 0.823 ± 0.035	1.969GlnArg: 1.969 ± 0.042	1.386GlnSer: 1.386 ± 0.039	1.615GlnThr: 1.615 ± 0.04	2.336GlnVal: 2.336 ± 0.054	0.346GlnTrp: 0.346 ± 0.019	0.469GlnTyr: 0.469 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.928ArgAla: 9.928 ± 0.131	0.543ArgCys: 0.543 ± 0.023	5.661ArgAsp: 5.661 ± 0.076	3.888ArgGlu: 3.888 ± 0.07	2.716ArgPhe: 2.716 ± 0.051	5.754ArgGly: 5.754 ± 0.068	1.861ArgHis: 1.861 ± 0.046	4.383ArgIle: 4.383 ± 0.062	1.886ArgLys: 1.886 ± 0.049	8.543ArgLeu: 8.543 ± 0.104	2.358ArgMet: 2.358 ± 0.045	1.732ArgAsn: 1.732 ± 0.039	4.225ArgPro: 4.225 ± 0.068	2.481ArgGln: 2.481 ± 0.052	6.728ArgArg: 6.728 ± 0.099	3.488ArgSer: 3.488 ± 0.066	4.077ArgThr: 4.077 ± 0.06	5.59ArgVal: 5.59 ± 0.074	1.097ArgTrp: 1.097 ± 0.031	1.532ArgTyr: 1.532 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.369SerAla: 5.369 ± 0.083	0.364SerCys: 0.364 ± 0.02	3.275SerAsp: 3.275 ± 0.056	2.393SerGlu: 2.393 ± 0.044	1.825SerPhe: 1.825 ± 0.038	5.031SerGly: 5.031 ± 0.079	0.95SerHis: 0.95 ± 0.029	2.128SerIle: 2.128 ± 0.05	1.094SerLys: 1.094 ± 0.033	4.468SerLeu: 4.468 ± 0.073	1.236SerMet: 1.236 ± 0.033	1.093SerAsn: 1.093 ± 0.034	2.363SerPro: 2.363 ± 0.046	1.289SerGln: 1.289 ± 0.034	3.365SerArg: 3.365 ± 0.06	2.173SerSer: 2.173 ± 0.053	2.249SerThr: 2.249 ± 0.049	3.637SerVal: 3.637 ± 0.055	0.622SerTrp: 0.622 ± 0.025	1.095SerTyr: 1.095 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.661ThrAla: 6.661 ± 0.085	0.518ThrCys: 0.518 ± 0.025	3.506ThrAsp: 3.506 ± 0.064	2.882ThrGlu: 2.882 ± 0.054	2.121ThrPhe: 2.121 ± 0.043	5.923ThrGly: 5.923 ± 0.079	1.113ThrHis: 1.113 ± 0.035	2.623ThrIle: 2.623 ± 0.051	1.07ThrLys: 1.07 ± 0.033	6.327ThrLeu: 6.327 ± 0.078	1.415ThrMet: 1.415 ± 0.039	1.053ThrAsn: 1.053 ± 0.028	3.592ThrPro: 3.592 ± 0.053	1.396ThrGln: 1.396 ± 0.038	4.012ThrArg: 4.012 ± 0.06	2.547ThrSer: 2.547 ± 0.049	2.867ThrThr: 2.867 ± 0.058	4.602ThrVal: 4.602 ± 0.063	0.72ThrTrp: 0.72 ± 0.025	1.115ThrTyr: 1.115 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	10.348ValAla: 10.348 ± 0.122	0.673ValCys: 0.673 ± 0.024	4.493ValAsp: 4.493 ± 0.069	4.671ValGlu: 4.671 ± 0.066	2.796ValPhe: 2.796 ± 0.054	5.705ValGly: 5.705 ± 0.08	1.402ValHis: 1.402 ± 0.037	3.869ValIle: 3.869 ± 0.068	1.567ValLys: 1.567 ± 0.048	7.966ValLeu: 7.966 ± 0.103	2.096ValMet: 2.096 ± 0.046	1.784ValAsn: 1.784 ± 0.042	4.165ValPro: 4.165 ± 0.065	1.882ValGln: 1.882 ± 0.041	5.151ValArg: 5.151 ± 0.066	3.818ValSer: 3.818 ± 0.06	5.194ValThr: 5.194 ± 0.079	6.009ValVal: 6.009 ± 0.101	1.062ValTrp: 1.062 ± 0.032	1.354ValTyr: 1.354 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.377TrpAla: 1.377 ± 0.037	0.136TrpCys: 0.136 ± 0.012	0.824TrpAsp: 0.824 ± 0.029	0.613TrpGlu: 0.613 ± 0.025	0.583TrpPhe: 0.583 ± 0.024	1.06TrpGly: 1.06 ± 0.038	0.328TrpHis: 0.328 ± 0.018	0.738TrpIle: 0.738 ± 0.029	0.407TrpLys: 0.407 ± 0.021	1.781TrpLeu: 1.781 ± 0.042	0.423TrpMet: 0.423 ± 0.019	0.416TrpAsn: 0.416 ± 0.021	0.792TrpPro: 0.792 ± 0.027	0.523TrpGln: 0.523 ± 0.023	1.3TrpArg: 1.3 ± 0.033	0.812TrpSer: 0.812 ± 0.027	0.97TrpThr: 0.97 ± 0.03	0.944TrpVal: 0.944 ± 0.029	0.302TrpTrp: 0.302 ± 0.018	0.235TrpTyr: 0.235 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.364TyrAla: 2.364 ± 0.047	0.196TyrCys: 0.196 ± 0.013	1.556TyrAsp: 1.556 ± 0.037	1.036TyrGlu: 1.036 ± 0.031	0.763TyrPhe: 0.763 ± 0.027	1.989TyrGly: 1.989 ± 0.044	0.453TyrHis: 0.453 ± 0.021	0.68TyrIle: 0.68 ± 0.024	0.353TyrLys: 0.353 ± 0.018	1.989TyrLeu: 1.989 ± 0.037	0.407TyrMet: 0.407 ± 0.02	0.461TyrAsn: 0.461 ± 0.02	0.96TyrPro: 0.96 ± 0.029	0.51TyrGln: 0.51 ± 0.021	1.564TyrArg: 1.564 ± 0.036	0.934TyrSer: 0.934 ± 0.03	0.912TyrThr: 0.912 ± 0.029	1.484TyrVal: 1.484 ± 0.041	0.313TyrTrp: 0.313 ± 0.018	0.483TyrTyr: 0.483 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3629 proteins (1106816 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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