Amino acid dipepetide frequency for Sulfurisoma sediminicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.553AlaAla: 19.553 ± 0.256
1.418AlaCys: 1.418 ± 0.042
6.944AlaAsp: 6.944 ± 0.104
7.864AlaGlu: 7.864 ± 0.156
4.059AlaPhe: 4.059 ± 0.072
11.549AlaGly: 11.549 ± 0.165
2.574AlaHis: 2.574 ± 0.06
6.007AlaIle: 6.007 ± 0.09
4.574AlaLys: 4.574 ± 0.118
13.883AlaLeu: 13.883 ± 0.19
3.306AlaMet: 3.306 ± 0.064
3.047AlaAsn: 3.047 ± 0.075
5.745AlaPro: 5.745 ± 0.113
4.28AlaGln: 4.28 ± 0.075
9.025AlaArg: 9.025 ± 0.152
5.567AlaSer: 5.567 ± 0.108
6.34AlaThr: 6.34 ± 0.115
8.878AlaVal: 8.878 ± 0.109
1.93AlaTrp: 1.93 ± 0.06
2.522AlaTyr: 2.522 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
1.123CysAla: 1.123 ± 0.037
0.121CysCys: 0.121 ± 0.013
0.582CysAsp: 0.582 ± 0.028
0.512CysGlu: 0.512 ± 0.022
0.339CysPhe: 0.339 ± 0.017
1.107CysGly: 1.107 ± 0.037
0.422CysHis: 0.422 ± 0.027
0.415CysIle: 0.415 ± 0.024
0.302CysLys: 0.302 ± 0.018
0.889CysLeu: 0.889 ± 0.032
0.202CysMet: 0.202 ± 0.016
0.26CysAsn: 0.26 ± 0.017
0.631CysPro: 0.631 ± 0.028
0.259CysGln: 0.259 ± 0.019
0.696CysArg: 0.696 ± 0.027
0.505CysSer: 0.505 ± 0.027
0.487CysThr: 0.487 ± 0.028
0.732CysVal: 0.732 ± 0.032
0.148CysTrp: 0.148 ± 0.014
0.235CysTyr: 0.235 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
7.197AspAla: 7.197 ± 0.099
0.52AspCys: 0.52 ± 0.026
2.999AspAsp: 2.999 ± 0.085
3.418AspGlu: 3.418 ± 0.064
2.46AspPhe: 2.46 ± 0.071
4.904AspGly: 4.904 ± 0.115
1.11AspHis: 1.11 ± 0.038
2.885AspIle: 2.885 ± 0.058
2.054AspLys: 2.054 ± 0.061
5.43AspLeu: 5.43 ± 0.081
1.228AspMet: 1.228 ± 0.036
1.336AspAsn: 1.336 ± 0.049
3.015AspPro: 3.015 ± 0.062
1.386AspGln: 1.386 ± 0.036
3.395AspArg: 3.395 ± 0.062
2.2AspSer: 2.2 ± 0.057
2.583AspThr: 2.583 ± 0.08
3.933AspVal: 3.933 ± 0.072
0.969AspTrp: 0.969 ± 0.037
1.703AspTyr: 1.703 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
7.483GluAla: 7.483 ± 0.14
0.501GluCys: 0.501 ± 0.026
2.472GluAsp: 2.472 ± 0.061
3.105GluGlu: 3.105 ± 0.08
2.161GluPhe: 2.161 ± 0.052
3.949GluGly: 3.949 ± 0.073
1.397GluHis: 1.397 ± 0.046
3.376GluIle: 3.376 ± 0.073
2.673GluLys: 2.673 ± 0.068
6.311GluLeu: 6.311 ± 0.098
1.518GluMet: 1.518 ± 0.043
1.507GluAsn: 1.507 ± 0.045
2.525GluPro: 2.525 ± 0.058
2.259GluGln: 2.259 ± 0.051
5.042GluArg: 5.042 ± 0.1
2.562GluSer: 2.562 ± 0.058
2.807GluThr: 2.807 ± 0.056
4.33GluVal: 4.33 ± 0.089
0.842GluTrp: 0.842 ± 0.028
1.215GluTyr: 1.215 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
4.769PheAla: 4.769 ± 0.084
0.398PheCys: 0.398 ± 0.022
2.607PheAsp: 2.607 ± 0.053
2.266PheGlu: 2.266 ± 0.053
1.485PhePhe: 1.485 ± 0.057
3.57PheGly: 3.57 ± 0.062
0.812PheHis: 0.812 ± 0.034
1.605PheIle: 1.605 ± 0.042
1.2PheLys: 1.2 ± 0.041
3.48PheLeu: 3.48 ± 0.084
0.85PheMet: 0.85 ± 0.033
1.127PheAsn: 1.127 ± 0.046
1.652PhePro: 1.652 ± 0.044
0.913PheGln: 0.913 ± 0.032
2.212PheArg: 2.212 ± 0.055
2.035PheSer: 2.035 ± 0.049
1.716PheThr: 1.716 ± 0.06
3.07PheVal: 3.07 ± 0.063
0.531PheTrp: 0.531 ± 0.025
0.895PheTyr: 0.895 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
8.972GlyAla: 8.972 ± 0.149
1.038GlyCys: 1.038 ± 0.037
4.654GlyAsp: 4.654 ± 0.105
5.029GlyGlu: 5.029 ± 0.081
3.374GlyPhe: 3.374 ± 0.064
7.513GlyGly: 7.513 ± 0.185
2.038GlyHis: 2.038 ± 0.058
4.719GlyIle: 4.719 ± 0.072
3.856GlyLys: 3.856 ± 0.085
8.445GlyLeu: 8.445 ± 0.108
2.543GlyMet: 2.543 ± 0.067
2.465GlyAsn: 2.465 ± 0.123
2.665GlyPro: 2.665 ± 0.053
2.755GlyGln: 2.755 ± 0.064
5.956GlyArg: 5.956 ± 0.093
4.409GlySer: 4.409 ± 0.13
4.417GlyThr: 4.417 ± 0.146
6.182GlyVal: 6.182 ± 0.075
1.427GlyTrp: 1.427 ± 0.049
2.291GlyTyr: 2.291 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
2.727HisAla: 2.727 ± 0.059
0.313HisCys: 0.313 ± 0.02
1.329HisAsp: 1.329 ± 0.034
1.221HisGlu: 1.221 ± 0.041
0.993HisPhe: 0.993 ± 0.034
2.165HisGly: 2.165 ± 0.057
0.685HisHis: 0.685 ± 0.028
1.025HisIle: 1.025 ± 0.036
0.636HisLys: 0.636 ± 0.031
2.383HisLeu: 2.383 ± 0.057
0.491HisMet: 0.491 ± 0.025
0.494HisAsn: 0.494 ± 0.024
1.497HisPro: 1.497 ± 0.045
0.65HisGln: 0.65 ± 0.025
1.562HisArg: 1.562 ± 0.044
0.928HisSer: 0.928 ± 0.031
0.888HisThr: 0.888 ± 0.031
1.577HisVal: 1.577 ± 0.048
0.355HisTrp: 0.355 ± 0.022
0.678HisTyr: 0.678 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.679IleAla: 6.679 ± 0.094
0.435IleCys: 0.435 ± 0.024
3.282IleAsp: 3.282 ± 0.061
3.634IleGlu: 3.634 ± 0.061
1.547IlePhe: 1.547 ± 0.043
4.522IleGly: 4.522 ± 0.082
1.1IleHis: 1.1 ± 0.031
1.717IleIle: 1.717 ± 0.045
1.714IleLys: 1.714 ± 0.047
4.158IleLeu: 4.158 ± 0.076
0.836IleMet: 0.836 ± 0.032
1.392IleAsn: 1.392 ± 0.045
2.212IlePro: 2.212 ± 0.046
1.193IleGln: 1.193 ± 0.037
2.998IleArg: 2.998 ± 0.057
2.384IleSer: 2.384 ± 0.052
2.389IleThr: 2.389 ± 0.057
3.997IleVal: 3.997 ± 0.072
0.478IleTrp: 0.478 ± 0.023
1.111IleTyr: 1.111 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
4.376LysAla: 4.376 ± 0.111
0.259LysCys: 0.259 ± 0.016
1.965LysAsp: 1.965 ± 0.055
1.98LysGlu: 1.98 ± 0.052
1.16LysPhe: 1.16 ± 0.041
2.882LysGly: 2.882 ± 0.074
0.748LysHis: 0.748 ± 0.027
1.812LysIle: 1.812 ± 0.043
1.899LysLys: 1.899 ± 0.072
3.872LysLeu: 3.872 ± 0.079
1.005LysMet: 1.005 ± 0.036
1.059LysAsn: 1.059 ± 0.04
2.302LysPro: 2.302 ± 0.056
1.324LysGln: 1.324 ± 0.043
2.523LysArg: 2.523 ± 0.063
1.979LysSer: 1.979 ± 0.058
1.874LysThr: 1.874 ± 0.053
2.931LysVal: 2.931 ± 0.064
0.406LysTrp: 0.406 ± 0.019
0.823LysTyr: 0.823 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
15.903LeuAla: 15.903 ± 0.223
0.962LeuCys: 0.962 ± 0.031
6.138LeuAsp: 6.138 ± 0.092
5.824LeuGlu: 5.824 ± 0.082
3.703LeuPhe: 3.703 ± 0.08
8.771LeuGly: 8.771 ± 0.119
2.214LeuHis: 2.214 ± 0.06
4.653LeuIle: 4.653 ± 0.087
4.034LeuLys: 4.034 ± 0.075
11.856LeuLeu: 11.856 ± 0.225
2.316LeuMet: 2.316 ± 0.053
2.553LeuAsn: 2.553 ± 0.055
6.343LeuPro: 6.343 ± 0.1
3.114LeuGln: 3.114 ± 0.07
7.565LeuArg: 7.565 ± 0.121
5.208LeuSer: 5.208 ± 0.089
5.266LeuThr: 5.266 ± 0.075
7.562LeuVal: 7.562 ± 0.109
1.344LeuTrp: 1.344 ± 0.046
2.124LeuTyr: 2.124 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
2.986MetAla: 2.986 ± 0.056
0.167MetCys: 0.167 ± 0.016
1.084MetAsp: 1.084 ± 0.036
1.146MetGlu: 1.146 ± 0.041
0.73MetPhe: 0.73 ± 0.025
1.756MetGly: 1.756 ± 0.053
0.523MetHis: 0.523 ± 0.026
1.133MetIle: 1.133 ± 0.036
1.238MetLys: 1.238 ± 0.041
2.662MetLeu: 2.662 ± 0.064
0.597MetMet: 0.597 ± 0.028
0.863MetAsn: 0.863 ± 0.031
1.411MetPro: 1.411 ± 0.036
0.916MetGln: 0.916 ± 0.037
1.724MetArg: 1.724 ± 0.044
1.548MetSer: 1.548 ± 0.046
1.473MetThr: 1.473 ± 0.043
1.651MetVal: 1.651 ± 0.05
0.206MetTrp: 0.206 ± 0.014
0.357MetTyr: 0.357 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.03AsnAla: 3.03 ± 0.071
0.29AsnCys: 0.29 ± 0.017
1.421AsnAsp: 1.421 ± 0.084
1.305AsnGlu: 1.305 ± 0.041
1.062AsnPhe: 1.062 ± 0.035
2.085AsnGly: 2.085 ± 0.061
0.512AsnHis: 0.512 ± 0.027
1.307AsnIle: 1.307 ± 0.039
0.892AsnLys: 0.892 ± 0.036
2.771AsnLeu: 2.771 ± 0.064
0.608AsnMet: 0.608 ± 0.027
0.673AsnAsn: 0.673 ± 0.036
1.865AsnPro: 1.865 ± 0.043
0.751AsnGln: 0.751 ± 0.028
1.786AsnArg: 1.786 ± 0.046
1.1AsnSer: 1.1 ± 0.042
1.219AsnThr: 1.219 ± 0.052
2.039AsnVal: 2.039 ± 0.071
0.382AsnTrp: 0.382 ± 0.026
0.712AsnTyr: 0.712 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
7.037ProAla: 7.037 ± 0.135
0.421ProCys: 0.421 ± 0.023
3.062ProAsp: 3.062 ± 0.063
3.502ProGlu: 3.502 ± 0.063
1.758ProPhe: 1.758 ± 0.047
4.44ProGly: 4.44 ± 0.075
1.108ProHis: 1.108 ± 0.035
1.9ProIle: 1.9 ± 0.051
1.71ProLys: 1.71 ± 0.05
5.369ProLeu: 5.369 ± 0.096
1.163ProMet: 1.163 ± 0.031
1.216ProAsn: 1.216 ± 0.038
2.795ProPro: 2.795 ± 0.079
1.883ProGln: 1.883 ± 0.047
2.992ProArg: 2.992 ± 0.071
2.149ProSer: 2.149 ± 0.057
2.416ProThr: 2.416 ± 0.055
3.82ProVal: 3.82 ± 0.067
0.737ProTrp: 0.737 ± 0.031
1.189ProTyr: 1.189 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
4.243GlnAla: 4.243 ± 0.075
0.285GlnCys: 0.285 ± 0.02
1.412GlnAsp: 1.412 ± 0.037
1.612GlnGlu: 1.612 ± 0.043
1.123GlnPhe: 1.123 ± 0.036
2.423GlnGly: 2.423 ± 0.048
0.757GlnHis: 0.757 ± 0.032
1.553GlnIle: 1.553 ± 0.039
1.268GlnLys: 1.268 ± 0.046
3.574GlnLeu: 3.574 ± 0.064
0.88GlnMet: 0.88 ± 0.032
0.742GlnAsn: 0.742 ± 0.027
1.902GlnPro: 1.902 ± 0.056
1.366GlnGln: 1.366 ± 0.049
2.594GlnArg: 2.594 ± 0.067
1.517GlnSer: 1.517 ± 0.04
1.475GlnThr: 1.475 ± 0.057
2.457GlnVal: 2.457 ± 0.059
0.477GlnTrp: 0.477 ± 0.021
0.677GlnTyr: 0.677 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
7.419ArgAla: 7.419 ± 0.119
0.624ArgCys: 0.624 ± 0.027
4.037ArgAsp: 4.037 ± 0.07
4.753ArgGlu: 4.753 ± 0.104
2.984ArgPhe: 2.984 ± 0.071
4.795ArgGly: 4.795 ± 0.084
2.056ArgHis: 2.056 ± 0.047
3.886ArgIle: 3.886 ± 0.06
2.232ArgLys: 2.232 ± 0.055
8.587ArgLeu: 8.587 ± 0.147
1.831ArgMet: 1.831 ± 0.052
1.732ArgAsn: 1.732 ± 0.046
3.106ArgPro: 3.106 ± 0.068
2.739ArgGln: 2.739 ± 0.064
5.612ArgArg: 5.612 ± 0.125
3.026ArgSer: 3.026 ± 0.062
2.894ArgThr: 2.894 ± 0.057
4.87ArgVal: 4.87 ± 0.072
1.085ArgTrp: 1.085 ± 0.035
1.994ArgTyr: 1.994 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
5.375SerAla: 5.375 ± 0.102
0.556SerCys: 0.556 ± 0.029
2.363SerAsp: 2.363 ± 0.064
2.348SerGlu: 2.348 ± 0.052
1.913SerPhe: 1.913 ± 0.051
5.158SerGly: 5.158 ± 0.127
1.14SerHis: 1.14 ± 0.036
2.216SerIle: 2.216 ± 0.066
1.486SerLys: 1.486 ± 0.046
5.181SerLeu: 5.181 ± 0.094
1.135SerMet: 1.135 ± 0.039
1.242SerAsn: 1.242 ± 0.054
2.475SerPro: 2.475 ± 0.052
1.472SerGln: 1.472 ± 0.047
3.426SerArg: 3.426 ± 0.062
2.458SerSer: 2.458 ± 0.078
2.266SerThr: 2.266 ± 0.077
3.308SerVal: 3.308 ± 0.104
0.723SerTrp: 0.723 ± 0.029
1.163SerTyr: 1.163 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
6.052ThrAla: 6.052 ± 0.113
0.439ThrCys: 0.439 ± 0.026
2.501ThrAsp: 2.501 ± 0.063
2.35ThrGlu: 2.35 ± 0.046
1.853ThrPhe: 1.853 ± 0.066
4.423ThrGly: 4.423 ± 0.12
1.091ThrHis: 1.091 ± 0.037
2.224ThrIle: 2.224 ± 0.057
1.37ThrLys: 1.37 ± 0.042
6.297ThrLeu: 6.297 ± 0.109
1.006ThrMet: 1.006 ± 0.034
1.095ThrAsn: 1.095 ± 0.048
3.008ThrPro: 3.008 ± 0.068
1.538ThrGln: 1.538 ± 0.045
3.1ThrArg: 3.1 ± 0.064
2.227ThrSer: 2.227 ± 0.073
2.587ThrThr: 2.587 ± 0.104
4.055ThrVal: 4.055 ± 0.103
0.625ThrTrp: 0.625 ± 0.026
1.068ThrTyr: 1.068 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
10.156ValAla: 10.156 ± 0.132
0.722ValCys: 0.722 ± 0.031
3.931ValAsp: 3.931 ± 0.07
4.413ValGlu: 4.413 ± 0.073
2.908ValPhe: 2.908 ± 0.059
5.819ValGly: 5.819 ± 0.086
1.423ValHis: 1.423 ± 0.036
3.744ValIle: 3.744 ± 0.067
2.83ValLys: 2.83 ± 0.066
7.701ValLeu: 7.701 ± 0.111
1.879ValMet: 1.879 ± 0.052
1.927ValAsn: 1.927 ± 0.057
3.668ValPro: 3.668 ± 0.062
2.008ValGln: 2.008 ± 0.05
4.897ValArg: 4.897 ± 0.071
3.772ValSer: 3.772 ± 0.093
4.072ValThr: 4.072 ± 0.11
6.156ValVal: 6.156 ± 0.105
0.895ValTrp: 0.895 ± 0.032
1.396ValTyr: 1.396 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.284TrpAla: 1.284 ± 0.039
0.191TrpCys: 0.191 ± 0.016
0.604TrpAsp: 0.604 ± 0.032
0.613TrpGlu: 0.613 ± 0.026
0.597TrpPhe: 0.597 ± 0.028
0.917TrpGly: 0.917 ± 0.036
0.366TrpHis: 0.366 ± 0.019
0.69TrpIle: 0.69 ± 0.027
0.506TrpLys: 0.506 ± 0.022
2.147TrpLeu: 2.147 ± 0.066
0.322TrpMet: 0.322 ± 0.019
0.483TrpAsn: 0.483 ± 0.023
0.675TrpPro: 0.675 ± 0.03
0.749TrpGln: 0.749 ± 0.033
1.249TrpArg: 1.249 ± 0.042
0.659TrpSer: 0.659 ± 0.029
0.613TrpThr: 0.613 ± 0.031
0.941TrpVal: 0.941 ± 0.035
0.275TrpTrp: 0.275 ± 0.019
0.329TrpTyr: 0.329 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.7TyrAla: 2.7 ± 0.067
0.306TyrCys: 0.306 ± 0.018
1.34TyrAsp: 1.34 ± 0.042
1.14TyrGlu: 1.14 ± 0.035
0.983TyrPhe: 0.983 ± 0.036
1.997TyrGly: 1.997 ± 0.055
0.523TyrHis: 0.523 ± 0.026
0.908TyrIle: 0.908 ± 0.036
0.707TyrLys: 0.707 ± 0.031
2.459TyrLeu: 2.459 ± 0.05
0.454TyrMet: 0.454 ± 0.024
0.598TyrAsn: 0.598 ± 0.034
1.175TyrPro: 1.175 ± 0.044
0.784TyrGln: 0.784 ± 0.032
1.908TyrArg: 1.908 ± 0.046
1.169TyrSer: 1.169 ± 0.04
1.127TyrThr: 1.127 ± 0.042
1.829TyrVal: 1.829 ± 0.059
0.375TyrTrp: 0.375 ± 0.019
0.694TyrTyr: 0.694 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2823 proteins (922662 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski