Amino acid dipepetide frequency for Roseibaca ekhonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.869AlaAla: 16.869 ± 0.187
1.256AlaCys: 1.256 ± 0.033
7.45AlaAsp: 7.45 ± 0.091
8.204AlaGlu: 8.204 ± 0.092
4.394AlaPhe: 4.394 ± 0.061
10.383AlaGly: 10.383 ± 0.108
2.699AlaHis: 2.699 ± 0.055
5.736AlaIle: 5.736 ± 0.078
3.585AlaLys: 3.585 ± 0.057
15.134AlaLeu: 15.134 ± 0.156
3.974AlaMet: 3.974 ± 0.058
2.765AlaAsn: 2.765 ± 0.054
6.496AlaPro: 6.496 ± 0.102
5.657AlaGln: 5.657 ± 0.074
10.473AlaArg: 10.473 ± 0.126
5.669AlaSer: 5.669 ± 0.072
6.529AlaThr: 6.529 ± 0.087
8.37AlaVal: 8.37 ± 0.091
1.602AlaTrp: 1.602 ± 0.043
2.476AlaTyr: 2.476 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
1.259CysAla: 1.259 ± 0.035
0.122CysCys: 0.122 ± 0.012
0.683CysAsp: 0.683 ± 0.027
0.424CysGlu: 0.424 ± 0.019
0.329CysPhe: 0.329 ± 0.016
0.941CysGly: 0.941 ± 0.031
0.274CysHis: 0.274 ± 0.018
0.375CysIle: 0.375 ± 0.018
0.211CysLys: 0.211 ± 0.014
0.829CysLeu: 0.829 ± 0.024
0.187CysMet: 0.187 ± 0.013
0.233CysAsn: 0.233 ± 0.015
0.585CysPro: 0.585 ± 0.022
0.233CysGln: 0.233 ± 0.014
0.61CysArg: 0.61 ± 0.024
0.435CysSer: 0.435 ± 0.021
0.479CysThr: 0.479 ± 0.02
0.628CysVal: 0.628 ± 0.029
0.15CysTrp: 0.15 ± 0.012
0.222CysTyr: 0.222 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
8.246AspAla: 8.246 ± 0.109
0.529AspCys: 0.529 ± 0.022
3.618AspAsp: 3.618 ± 0.072
3.233AspGlu: 3.233 ± 0.068
2.168AspPhe: 2.168 ± 0.043
5.842AspGly: 5.842 ± 0.08
1.473AspHis: 1.473 ± 0.039
3.087AspIle: 3.087 ± 0.051
1.625AspLys: 1.625 ± 0.042
6.706AspLeu: 6.706 ± 0.078
1.988AspMet: 1.988 ± 0.044
1.273AspAsn: 1.273 ± 0.032
3.779AspPro: 3.779 ± 0.065
1.938AspGln: 1.938 ± 0.044
4.556AspArg: 4.556 ± 0.061
2.55AspSer: 2.55 ± 0.044
3.372AspThr: 3.372 ± 0.059
4.032AspVal: 4.032 ± 0.057
1.393AspTrp: 1.393 ± 0.035
1.478AspTyr: 1.478 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
7.243GluAla: 7.243 ± 0.091
0.422GluCys: 0.422 ± 0.017
3.227GluAsp: 3.227 ± 0.061
2.897GluGlu: 2.897 ± 0.062
1.924GluPhe: 1.924 ± 0.041
4.371GluGly: 4.371 ± 0.069
1.183GluHis: 1.183 ± 0.03
3.327GluIle: 3.327 ± 0.056
1.697GluLys: 1.697 ± 0.044
5.13GluLeu: 5.13 ± 0.08
1.737GluMet: 1.737 ± 0.041
1.538GluAsn: 1.538 ± 0.039
2.277GluPro: 2.277 ± 0.062
2.046GluGln: 2.046 ± 0.046
4.42GluArg: 4.42 ± 0.077
2.231GluSer: 2.231 ± 0.038
3.311GluThr: 3.311 ± 0.061
3.927GluVal: 3.927 ± 0.081
0.694GluTrp: 0.694 ± 0.027
1.018GluTyr: 1.018 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
4.719PheAla: 4.719 ± 0.069
0.44PheCys: 0.44 ± 0.018
2.812PheAsp: 2.812 ± 0.051
2.084PheGlu: 2.084 ± 0.046
1.346PhePhe: 1.346 ± 0.035
3.631PheGly: 3.631 ± 0.064
0.723PheHis: 0.723 ± 0.025
1.603PheIle: 1.603 ± 0.037
0.888PheLys: 0.888 ± 0.029
3.434PheLeu: 3.434 ± 0.059
0.878PheMet: 0.878 ± 0.027
1.036PheAsn: 1.036 ± 0.032
1.504PhePro: 1.504 ± 0.04
1.074PheGln: 1.074 ± 0.035
2.241PheArg: 2.241 ± 0.04
1.877PheSer: 1.877 ± 0.046
2.049PheThr: 2.049 ± 0.049
2.563PheVal: 2.563 ± 0.054
0.598PheTrp: 0.598 ± 0.025
0.886PheTyr: 0.886 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
10.631GlyAla: 10.631 ± 0.114
0.888GlyCys: 0.888 ± 0.033
4.565GlyAsp: 4.565 ± 0.064
4.075GlyGlu: 4.075 ± 0.068
3.705GlyPhe: 3.705 ± 0.062
7.072GlyGly: 7.072 ± 0.115
2.059GlyHis: 2.059 ± 0.048
3.992GlyIle: 3.992 ± 0.06
2.666GlyLys: 2.666 ± 0.057
9.68GlyLeu: 9.68 ± 0.111
2.641GlyMet: 2.641 ± 0.047
1.986GlyAsn: 1.986 ± 0.048
3.72GlyPro: 3.72 ± 0.058
3.538GlyGln: 3.538 ± 0.065
5.906GlyArg: 5.906 ± 0.077
3.856GlySer: 3.856 ± 0.06
4.642GlyThr: 4.642 ± 0.063
6.258GlyVal: 6.258 ± 0.079
1.516GlyTrp: 1.516 ± 0.038
2.172GlyTyr: 2.172 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
2.718HisAla: 2.718 ± 0.062
0.242HisCys: 0.242 ± 0.014
1.509HisAsp: 1.509 ± 0.039
0.994HisGlu: 0.994 ± 0.026
0.827HisPhe: 0.827 ± 0.028
2.062HisGly: 2.062 ± 0.046
0.579HisHis: 0.579 ± 0.024
1.046HisIle: 1.046 ± 0.028
0.524HisLys: 0.524 ± 0.02
2.187HisLeu: 2.187 ± 0.045
0.575HisMet: 0.575 ± 0.024
0.467HisAsn: 0.467 ± 0.023
1.388HisPro: 1.388 ± 0.037
0.574HisGln: 0.574 ± 0.023
1.432HisArg: 1.432 ± 0.037
0.941HisSer: 0.941 ± 0.03
0.858HisThr: 0.858 ± 0.027
1.631HisVal: 1.631 ± 0.04
0.381HisTrp: 0.381 ± 0.02
0.522HisTyr: 0.522 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
6.903IleAla: 6.903 ± 0.086
0.6IleCys: 0.6 ± 0.024
3.411IleAsp: 3.411 ± 0.055
2.936IleGlu: 2.936 ± 0.058
1.56IlePhe: 1.56 ± 0.041
4.577IleGly: 4.577 ± 0.063
0.832IleHis: 0.832 ± 0.029
2.08IleIle: 2.08 ± 0.04
1.166IleLys: 1.166 ± 0.037
4.363IleLeu: 4.363 ± 0.061
1.129IleMet: 1.129 ± 0.03
1.229IleAsn: 1.229 ± 0.031
2.139IlePro: 2.139 ± 0.045
1.086IleGln: 1.086 ± 0.037
3.125IleArg: 3.125 ± 0.058
2.697IleSer: 2.697 ± 0.049
2.802IleThr: 2.802 ± 0.049
3.526IleVal: 3.526 ± 0.063
0.752IleTrp: 0.752 ± 0.023
1.056IleTyr: 1.056 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
3.443LysAla: 3.443 ± 0.06
0.171LysCys: 0.171 ± 0.012
1.49LysAsp: 1.49 ± 0.041
1.127LysGlu: 1.127 ± 0.039
0.811LysPhe: 0.811 ± 0.027
2.379LysGly: 2.379 ± 0.046
0.624LysHis: 0.624 ± 0.026
1.445LysIle: 1.445 ± 0.04
0.984LysLys: 0.984 ± 0.044
3.063LysLeu: 3.063 ± 0.06
0.746LysMet: 0.746 ± 0.03
0.638LysAsn: 0.638 ± 0.027
1.757LysPro: 1.757 ± 0.046
0.83LysGln: 0.83 ± 0.03
2.216LysArg: 2.216 ± 0.053
1.619LysSer: 1.619 ± 0.043
1.782LysThr: 1.782 ± 0.042
1.928LysVal: 1.928 ± 0.048
0.317LysTrp: 0.317 ± 0.018
0.532LysTyr: 0.532 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
13.887LeuAla: 13.887 ± 0.14
0.981LeuCys: 0.981 ± 0.03
6.692LeuAsp: 6.692 ± 0.081
5.359LeuGlu: 5.359 ± 0.071
3.533LeuPhe: 3.533 ± 0.066
8.925LeuGly: 8.925 ± 0.102
2.118LeuHis: 2.118 ± 0.045
4.517LeuIle: 4.517 ± 0.067
2.729LeuLys: 2.729 ± 0.06
9.007LeuLeu: 9.007 ± 0.117
2.632LeuMet: 2.632 ± 0.053
2.551LeuAsn: 2.551 ± 0.047
5.87LeuPro: 5.87 ± 0.078
2.986LeuGln: 2.986 ± 0.049
8.342LeuArg: 8.342 ± 0.1
6.46LeuSer: 6.46 ± 0.073
5.892LeuThr: 5.892 ± 0.08
7.291LeuVal: 7.291 ± 0.085
1.436LeuTrp: 1.436 ± 0.041
1.862LeuTyr: 1.862 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
3.851MetAla: 3.851 ± 0.049
0.181MetCys: 0.181 ± 0.011
1.527MetAsp: 1.527 ± 0.038
1.266MetGlu: 1.266 ± 0.035
0.813MetPhe: 0.813 ± 0.028
2.381MetGly: 2.381 ± 0.05
0.491MetHis: 0.491 ± 0.023
1.42MetIle: 1.42 ± 0.038
0.887MetLys: 0.887 ± 0.027
2.724MetLeu: 2.724 ± 0.049
0.77MetMet: 0.77 ± 0.025
0.784MetAsn: 0.784 ± 0.026
1.624MetPro: 1.624 ± 0.038
1.036MetGln: 1.036 ± 0.033
2.039MetArg: 2.039 ± 0.041
1.762MetSer: 1.762 ± 0.043
2.056MetThr: 2.056 ± 0.041
1.936MetVal: 1.936 ± 0.045
0.257MetTrp: 0.257 ± 0.017
0.326MetTyr: 0.326 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.157AsnAla: 3.157 ± 0.05
0.257AsnCys: 0.257 ± 0.015
1.378AsnAsp: 1.378 ± 0.042
1.047AsnGlu: 1.047 ± 0.034
0.905AsnPhe: 0.905 ± 0.028
2.152AsnGly: 2.152 ± 0.043
0.481AsnHis: 0.481 ± 0.021
1.287AsnIle: 1.287 ± 0.038
0.606AsnLys: 0.606 ± 0.026
2.44AsnLeu: 2.44 ± 0.046
0.661AsnMet: 0.661 ± 0.023
0.629AsnAsn: 0.629 ± 0.025
1.831AsnPro: 1.831 ± 0.042
0.64AsnGln: 0.64 ± 0.023
1.726AsnArg: 1.726 ± 0.044
1.139AsnSer: 1.139 ± 0.032
1.39AsnThr: 1.39 ± 0.036
1.605AsnVal: 1.605 ± 0.041
0.427AsnTrp: 0.427 ± 0.02
0.599AsnTyr: 0.599 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
6.254ProAla: 6.254 ± 0.088
0.433ProCys: 0.433 ± 0.019
4.634ProAsp: 4.634 ± 0.081
4.017ProGlu: 4.017 ± 0.073
1.937ProPhe: 1.937 ± 0.039
4.182ProGly: 4.182 ± 0.062
1.132ProHis: 1.132 ± 0.03
2.116ProIle: 2.116 ± 0.047
1.598ProLys: 1.598 ± 0.038
4.693ProLeu: 4.693 ± 0.068
1.395ProMet: 1.395 ± 0.032
1.254ProAsn: 1.254 ± 0.032
2.533ProPro: 2.533 ± 0.057
1.819ProGln: 1.819 ± 0.043
3.172ProArg: 3.172 ± 0.053
2.607ProSer: 2.607 ± 0.048
2.404ProThr: 2.404 ± 0.049
4.093ProVal: 4.093 ± 0.063
0.68ProTrp: 0.68 ± 0.026
1.114ProTyr: 1.114 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.708GlnAla: 4.708 ± 0.068
0.228GlnCys: 0.228 ± 0.014
1.968GlnAsp: 1.968 ± 0.041
1.514GlnGlu: 1.514 ± 0.04
1.165GlnPhe: 1.165 ± 0.036
2.936GlnGly: 2.936 ± 0.048
0.663GlnHis: 0.663 ± 0.023
2.144GlnIle: 2.144 ± 0.047
0.967GlnLys: 0.967 ± 0.031
2.902GlnLeu: 2.902 ± 0.051
1.083GlnMet: 1.083 ± 0.034
0.926GlnAsn: 0.926 ± 0.03
1.802GlnPro: 1.802 ± 0.037
1.033GlnGln: 1.033 ± 0.034
2.325GlnArg: 2.325 ± 0.052
1.967GlnSer: 1.967 ± 0.049
2.127GlnThr: 2.127 ± 0.044
2.546GlnVal: 2.546 ± 0.048
0.41GlnTrp: 0.41 ± 0.018
0.631GlnTyr: 0.631 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
10.204ArgAla: 10.204 ± 0.126
0.516ArgCys: 0.516 ± 0.022
4.873ArgAsp: 4.873 ± 0.071
3.832ArgGlu: 3.832 ± 0.061
2.853ArgPhe: 2.853 ± 0.057
5.013ArgGly: 5.013 ± 0.073
1.726ArgHis: 1.726 ± 0.039
3.658ArgIle: 3.658 ± 0.063
2.348ArgLys: 2.348 ± 0.059
7.898ArgLeu: 7.898 ± 0.096
2.142ArgMet: 2.142 ± 0.043
1.832ArgAsn: 1.832 ± 0.035
3.561ArgPro: 3.561 ± 0.056
2.369ArgGln: 2.369 ± 0.048
5.254ArgArg: 5.254 ± 0.078
3.367ArgSer: 3.367 ± 0.059
2.992ArgThr: 2.992 ± 0.051
5.043ArgVal: 5.043 ± 0.07
0.952ArgTrp: 0.952 ± 0.031
1.624ArgTyr: 1.624 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
6.102SerAla: 6.102 ± 0.067
0.425SerCys: 0.425 ± 0.021
3.434SerAsp: 3.434 ± 0.058
2.836SerGlu: 2.836 ± 0.045
2.106SerPhe: 2.106 ± 0.045
5.172SerGly: 5.172 ± 0.074
1.059SerHis: 1.059 ± 0.032
2.266SerIle: 2.266 ± 0.044
1.307SerLys: 1.307 ± 0.038
4.901SerLeu: 4.901 ± 0.072
1.319SerMet: 1.319 ± 0.037
1.258SerAsn: 1.258 ± 0.036
2.385SerPro: 2.385 ± 0.042
1.64SerGln: 1.64 ± 0.04
3.221SerArg: 3.221 ± 0.06
2.376SerSer: 2.376 ± 0.053
2.465SerThr: 2.465 ± 0.056
3.614SerVal: 3.614 ± 0.06
0.659SerTrp: 0.659 ± 0.027
1.268SerTyr: 1.268 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
6.256ThrAla: 6.256 ± 0.083
0.528ThrCys: 0.528 ± 0.022
3.3ThrAsp: 3.3 ± 0.051
2.93ThrGlu: 2.93 ± 0.056
1.751ThrPhe: 1.751 ± 0.038
5.421ThrGly: 5.421 ± 0.074
1.15ThrHis: 1.15 ± 0.031
2.564ThrIle: 2.564 ± 0.049
1.381ThrLys: 1.381 ± 0.034
6.167ThrLeu: 6.167 ± 0.078
1.262ThrMet: 1.262 ± 0.031
1.213ThrAsn: 1.213 ± 0.032
3.589ThrPro: 3.589 ± 0.059
1.738ThrGln: 1.738 ± 0.035
3.99ThrArg: 3.99 ± 0.063
2.542ThrSer: 2.542 ± 0.052
2.864ThrThr: 2.864 ± 0.059
3.985ThrVal: 3.985 ± 0.065
0.694ThrTrp: 0.694 ± 0.026
1.13ThrTyr: 1.13 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
9.228ValAla: 9.228 ± 0.095
0.623ValCys: 0.623 ± 0.022
3.933ValAsp: 3.933 ± 0.068
4.129ValGlu: 4.129 ± 0.061
2.836ValPhe: 2.836 ± 0.05
5.182ValGly: 5.182 ± 0.07
1.319ValHis: 1.319 ± 0.037
3.797ValIle: 3.797 ± 0.052
1.797ValLys: 1.797 ± 0.05
7.748ValLeu: 7.748 ± 0.089
2.126ValMet: 2.126 ± 0.043
1.785ValAsn: 1.785 ± 0.043
3.437ValPro: 3.437 ± 0.059
2.408ValGln: 2.408 ± 0.043
4.154ValArg: 4.154 ± 0.062
3.891ValSer: 3.891 ± 0.056
4.523ValThr: 4.523 ± 0.06
5.444ValVal: 5.444 ± 0.07
0.992ValTrp: 0.992 ± 0.028
1.396ValTyr: 1.396 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
1.53TrpAla: 1.53 ± 0.044
0.143TrpCys: 0.143 ± 0.011
0.839TrpAsp: 0.839 ± 0.026
0.598TrpGlu: 0.598 ± 0.023
0.559TrpPhe: 0.559 ± 0.023
1.017TrpGly: 1.017 ± 0.029
0.371TrpHis: 0.371 ± 0.017
0.615TrpIle: 0.615 ± 0.022
0.399TrpLys: 0.399 ± 0.02
1.811TrpLeu: 1.811 ± 0.044
0.403TrpMet: 0.403 ± 0.021
0.428TrpAsn: 0.428 ± 0.018
0.782TrpPro: 0.782 ± 0.028
0.728TrpGln: 0.728 ± 0.029
1.271TrpArg: 1.271 ± 0.04
0.738TrpSer: 0.738 ± 0.023
0.798TrpThr: 0.798 ± 0.031
0.957TrpVal: 0.957 ± 0.03
0.248TrpTrp: 0.248 ± 0.015
0.249TrpTyr: 0.249 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.514TyrAla: 2.514 ± 0.051
0.223TyrCys: 0.223 ± 0.015
1.543TyrAsp: 1.543 ± 0.034
1.116TyrGlu: 1.116 ± 0.031
0.861TyrPhe: 0.861 ± 0.025
1.928TyrGly: 1.928 ± 0.043
0.502TyrHis: 0.502 ± 0.019
0.893TyrIle: 0.893 ± 0.028
0.537TyrLys: 0.537 ± 0.024
2.254TyrLeu: 2.254 ± 0.048
0.483TyrMet: 0.483 ± 0.021
0.535TyrAsn: 0.535 ± 0.022
1.009TyrPro: 1.009 ± 0.028
0.674TyrGln: 0.674 ± 0.023
1.584TyrArg: 1.584 ± 0.036
1.089TyrSer: 1.089 ± 0.035
1.122TyrThr: 1.122 ± 0.028
1.371TyrVal: 1.371 ± 0.036
0.324TyrTrp: 0.324 ± 0.017
0.492TyrTyr: 0.492 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3887 proteins (1169467 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski