Amino acid dipepetide frequency for Angomonas deanei

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.398AlaAla: 8.398 ± 0.124	1.202AlaCys: 1.202 ± 0.025	4.069AlaAsp: 4.069 ± 0.096	5.734AlaGlu: 5.734 ± 0.093	2.681AlaPhe: 2.681 ± 0.034	4.104AlaGly: 4.104 ± 0.045	1.593AlaHis: 1.593 ± 0.024	2.983AlaIle: 2.983 ± 0.033	4.214AlaLys: 4.214 ± 0.051	7.998AlaLeu: 7.998 ± 0.092	1.7AlaMet: 1.7 ± 0.025	2.865AlaAsn: 2.865 ± 0.07	4.194AlaPro: 4.194 ± 0.046	3.081AlaGln: 3.081 ± 0.05	4.01AlaArg: 4.01 ± 0.046	5.625AlaSer: 5.625 ± 0.054	4.612AlaThr: 4.612 ± 0.05	6.005AlaVal: 6.005 ± 0.054	0.627AlaTrp: 0.627 ± 0.016	1.94AlaTyr: 1.94 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	1.488CysAla: 1.488 ± 0.031	0.579CysCys: 0.579 ± 0.017	1.001CysAsp: 1.001 ± 0.059	1.085CysGlu: 1.085 ± 0.034	0.811CysPhe: 0.811 ± 0.016	1.433CysGly: 1.433 ± 0.026	0.421CysHis: 0.421 ± 0.01	0.905CysIle: 0.905 ± 0.017	0.861CysLys: 0.861 ± 0.021	1.628CysLeu: 1.628 ± 0.021	0.38CysMet: 0.38 ± 0.01	0.654CysAsn: 0.654 ± 0.018	0.935CysPro: 0.935 ± 0.022	0.601CysGln: 0.601 ± 0.013	1.038CysArg: 1.038 ± 0.015	1.466CysSer: 1.466 ± 0.032	1.309CysThr: 1.309 ± 0.05	1.827CysVal: 1.827 ± 0.051	0.188CysTrp: 0.188 ± 0.007	0.562CysTyr: 0.562 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.602AspAla: 4.602 ± 0.071	0.873AspCys: 0.873 ± 0.02	3.773AspAsp: 3.773 ± 0.063	4.284AspGlu: 4.284 ± 0.075	1.991AspPhe: 1.991 ± 0.026	3.796AspGly: 3.796 ± 0.054	1.151AspHis: 1.151 ± 0.019	2.414AspIle: 2.414 ± 0.027	2.463AspLys: 2.463 ± 0.053	4.461AspLeu: 4.461 ± 0.056	1.166AspMet: 1.166 ± 0.019	2.098AspAsn: 2.098 ± 0.029	2.731AspPro: 2.731 ± 0.046	1.485AspGln: 1.485 ± 0.045	2.735AspArg: 2.735 ± 0.038	3.689AspSer: 3.689 ± 0.038	3.143AspThr: 3.143 ± 0.039	4.066AspVal: 4.066 ± 0.039	0.541AspTrp: 0.541 ± 0.013	1.637AspTyr: 1.637 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	5.97GluAla: 5.97 ± 0.094	1.025GluCys: 1.025 ± 0.017	4.441GluAsp: 4.441 ± 0.055	10.004GluGlu: 10.004 ± 0.147	1.88GluPhe: 1.88 ± 0.027	4.288GluGly: 4.288 ± 0.035	1.455GluHis: 1.455 ± 0.021	2.65GluIle: 2.65 ± 0.033	5.598GluLys: 5.598 ± 0.073	6.288GluLeu: 6.288 ± 0.087	1.853GluMet: 1.853 ± 0.023	3.259GluAsn: 3.259 ± 0.045	2.312GluPro: 2.312 ± 0.039	2.915GluGln: 2.915 ± 0.072	4.672GluArg: 4.672 ± 0.061	4.492GluSer: 4.492 ± 0.044	3.82GluThr: 3.82 ± 0.037	4.954GluVal: 4.954 ± 0.041	0.76GluTrp: 0.76 ± 0.017	1.872GluTyr: 1.872 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	2.571PheAla: 2.571 ± 0.031	0.819PheCys: 0.819 ± 0.016	2.054PheAsp: 2.054 ± 0.025	1.96PheGlu: 1.96 ± 0.028	2.07PhePhe: 2.07 ± 0.03	2.201PheGly: 2.201 ± 0.03	0.993PheHis: 0.993 ± 0.015	1.835PheIle: 1.835 ± 0.023	1.473PheLys: 1.473 ± 0.021	4.034PheLeu: 4.034 ± 0.035	0.863PheMet: 0.863 ± 0.019	1.566PheAsn: 1.566 ± 0.026	1.85PhePro: 1.85 ± 0.023	1.333PheGln: 1.333 ± 0.017	1.988PheArg: 1.988 ± 0.023	3.511PheSer: 3.511 ± 0.05	2.268PheThr: 2.268 ± 0.024	2.752PheVal: 2.752 ± 0.027	0.362PheTrp: 0.362 ± 0.011	1.409PheTyr: 1.409 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	4.431GlyAla: 4.431 ± 0.054	1.307GlyCys: 1.307 ± 0.031	3.431GlyAsp: 3.431 ± 0.041	4.301GlyGlu: 4.301 ± 0.043	2.067GlyPhe: 2.067 ± 0.048	4.862GlyGly: 4.862 ± 0.054	1.11GlyHis: 1.11 ± 0.018	2.438GlyIle: 2.438 ± 0.031	3.645GlyLys: 3.645 ± 0.049	4.772GlyLeu: 4.772 ± 0.073	1.305GlyMet: 1.305 ± 0.02	2.364GlyAsn: 2.364 ± 0.03	1.98GlyPro: 1.98 ± 0.024	1.782GlyGln: 1.782 ± 0.025	3.336GlyArg: 3.336 ± 0.036	4.536GlySer: 4.536 ± 0.045	3.518GlyThr: 3.518 ± 0.036	4.332GlyVal: 4.332 ± 0.038	0.615GlyTrp: 0.615 ± 0.014	1.752GlyTyr: 1.752 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.548HisAla: 1.548 ± 0.022	0.574HisCys: 0.574 ± 0.016	1.034HisAsp: 1.034 ± 0.021	1.185HisGlu: 1.185 ± 0.024	1.083HisPhe: 1.083 ± 0.018	1.281HisGly: 1.281 ± 0.021	0.999HisHis: 0.999 ± 0.019	1.052HisIle: 1.052 ± 0.016	1.02HisLys: 1.02 ± 0.015	2.306HisLeu: 2.306 ± 0.027	0.488HisMet: 0.488 ± 0.01	1.167HisAsn: 1.167 ± 0.019	1.386HisPro: 1.386 ± 0.022	0.965HisGln: 0.965 ± 0.016	1.517HisArg: 1.517 ± 0.023	1.8HisSer: 1.8 ± 0.024	1.519HisThr: 1.519 ± 0.022	1.597HisVal: 1.597 ± 0.021	0.265HisTrp: 0.265 ± 0.009	0.941HisTyr: 0.941 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	3.272IleAla: 3.272 ± 0.038	0.732IleCys: 0.732 ± 0.015	2.204IleAsp: 2.204 ± 0.026	2.615IleGlu: 2.615 ± 0.033	1.594IlePhe: 1.594 ± 0.021	2.269IleGly: 2.269 ± 0.026	1.087IleHis: 1.087 ± 0.017	1.991IleIle: 1.991 ± 0.028	2.075IleLys: 2.075 ± 0.027	3.922IleLeu: 3.922 ± 0.037	0.82IleMet: 0.82 ± 0.014	1.616IleAsn: 1.616 ± 0.024	2.475IlePro: 2.475 ± 0.024	1.782IleGln: 1.782 ± 0.023	2.435IleArg: 2.435 ± 0.027	2.999IleSer: 2.999 ± 0.031	2.528IleThr: 2.528 ± 0.03	3.076IleVal: 3.076 ± 0.031	0.292IleTrp: 0.292 ± 0.008	1.08IleTyr: 1.08 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.897LysAla: 3.897 ± 0.052	0.952LysCys: 0.952 ± 0.046	3.144LysAsp: 3.144 ± 0.053	5.626LysGlu: 5.626 ± 0.07	1.395LysPhe: 1.395 ± 0.02	3.233LysGly: 3.233 ± 0.053	1.093LysHis: 1.093 ± 0.015	2.062LysIle: 2.062 ± 0.025	5.143LysLys: 5.143 ± 0.063	4.42LysLeu: 4.42 ± 0.046	1.406LysMet: 1.406 ± 0.021	2.551LysAsn: 2.551 ± 0.034	2.254LysPro: 2.254 ± 0.029	2.284LysGln: 2.284 ± 0.036	3.732LysArg: 3.732 ± 0.04	3.707LysSer: 3.707 ± 0.035	3.227LysThr: 3.227 ± 0.034	3.453LysVal: 3.453 ± 0.038	0.534LysTrp: 0.534 ± 0.012	1.52LysTyr: 1.52 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	6.465LeuAla: 6.465 ± 0.065	1.921LeuCys: 1.921 ± 0.026	4.53LeuAsp: 4.53 ± 0.058	6.63LeuGlu: 6.63 ± 0.109	4.204LeuPhe: 4.204 ± 0.042	4.46LeuGly: 4.46 ± 0.066	2.586LeuHis: 2.586 ± 0.029	3.382LeuIle: 3.382 ± 0.028	5.027LeuLys: 5.027 ± 0.056	10.48LeuLeu: 10.48 ± 0.084	1.937LeuMet: 1.937 ± 0.026	3.547LeuAsn: 3.547 ± 0.037	5.108LeuPro: 5.108 ± 0.044	4.924LeuGln: 4.924 ± 0.055	6.343LeuArg: 6.343 ± 0.064	8.055LeuSer: 8.055 ± 0.059	5.483LeuThr: 5.483 ± 0.053	5.625LeuVal: 5.625 ± 0.041	1.002LeuTrp: 1.002 ± 0.015	3.006LeuTyr: 3.006 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	1.53MetAla: 1.53 ± 0.021	0.398MetCys: 0.398 ± 0.01	1.247MetAsp: 1.247 ± 0.019	1.774MetGlu: 1.774 ± 0.023	0.783MetPhe: 0.783 ± 0.014	1.234MetGly: 1.234 ± 0.024	0.461MetHis: 0.461 ± 0.01	0.931MetIle: 0.931 ± 0.015	1.378MetLys: 1.378 ± 0.02	1.93MetLeu: 1.93 ± 0.024	0.645MetMet: 0.645 ± 0.015	1.098MetAsn: 1.098 ± 0.023	0.893MetPro: 0.893 ± 0.018	0.928MetGln: 0.928 ± 0.015	1.402MetArg: 1.402 ± 0.022	1.758MetSer: 1.758 ± 0.022	1.401MetThr: 1.401 ± 0.023	1.292MetVal: 1.292 ± 0.02	0.272MetTrp: 0.272 ± 0.008	0.64MetTyr: 0.64 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.358AsnAla: 3.358 ± 0.054	0.844AsnCys: 0.844 ± 0.04	2.301AsnAsp: 2.301 ± 0.044	2.814AsnGlu: 2.814 ± 0.04	1.509AsnPhe: 1.509 ± 0.02	2.443AsnGly: 2.443 ± 0.033	1.056AsnHis: 1.056 ± 0.019	1.945AsnIle: 1.945 ± 0.025	2.256AsnLys: 2.256 ± 0.027	3.188AsnLeu: 3.188 ± 0.036	0.907AsnMet: 0.907 ± 0.016	4.461AsnAsn: 4.461 ± 0.125	2.216AsnPro: 2.216 ± 0.031	1.386AsnGln: 1.386 ± 0.025	2.152AsnArg: 2.152 ± 0.026	3.291AsnSer: 3.291 ± 0.035	2.888AsnThr: 2.888 ± 0.039	2.852AsnVal: 2.852 ± 0.027	0.337AsnTrp: 0.337 ± 0.01	1.356AsnTyr: 1.356 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	3.81ProAla: 3.81 ± 0.043	0.647ProCys: 0.647 ± 0.014	2.205ProAsp: 2.205 ± 0.028	3.019ProGlu: 3.019 ± 0.042	2.119ProPhe: 2.119 ± 0.025	2.137ProGly: 2.137 ± 0.027	1.265ProHis: 1.265 ± 0.018	1.946ProIle: 1.946 ± 0.022	2.444ProLys: 2.444 ± 0.033	4.969ProLeu: 4.969 ± 0.047	0.888ProMet: 0.888 ± 0.016	2.059ProAsn: 2.059 ± 0.025	4.208ProPro: 4.208 ± 0.055	2.1ProGln: 2.1 ± 0.033	2.624ProArg: 2.624 ± 0.034	4.928ProSer: 4.928 ± 0.049	3.5ProThr: 3.5 ± 0.037	3.563ProVal: 3.563 ± 0.045	0.437ProTrp: 0.437 ± 0.011	1.459ProTyr: 1.459 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	2.538GlnAla: 2.538 ± 0.053	0.894GlnCys: 0.894 ± 0.03	1.577GlnAsp: 1.577 ± 0.023	2.927GlnGlu: 2.927 ± 0.06	1.365GlnPhe: 1.365 ± 0.019	1.804GlnGly: 1.804 ± 0.024	1.113GlnHis: 1.113 ± 0.018	1.417GlnIle: 1.417 ± 0.02	2.498GlnLys: 2.498 ± 0.038	4.508GlnLeu: 4.508 ± 0.06	0.979GlnMet: 0.979 ± 0.019	1.665GlnAsn: 1.665 ± 0.025	1.759GlnPro: 1.759 ± 0.027	2.815GlnGln: 2.815 ± 0.075	2.995GlnArg: 2.995 ± 0.049	2.865GlnSer: 2.865 ± 0.049	2.143GlnThr: 2.143 ± 0.026	2.234GlnVal: 2.234 ± 0.025	0.528GlnTrp: 0.528 ± 0.012	1.382GlnTyr: 1.382 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	4.237ArgAla: 4.237 ± 0.057	1.165ArgCys: 1.165 ± 0.022	3.066ArgAsp: 3.066 ± 0.041	4.644ArgGlu: 4.644 ± 0.062	2.078ArgPhe: 2.078 ± 0.026	3.501ArgGly: 3.501 ± 0.036	1.64ArgHis: 1.64 ± 0.023	2.388ArgIle: 2.388 ± 0.026	3.356ArgLys: 3.356 ± 0.038	5.664ArgLeu: 5.664 ± 0.052	1.3ArgMet: 1.3 ± 0.018	2.256ArgAsn: 2.256 ± 0.025	2.616ArgPro: 2.616 ± 0.031	2.914ArgGln: 2.914 ± 0.04	5.252ArgArg: 5.252 ± 0.053	4.333ArgSer: 4.333 ± 0.052	3.144ArgThr: 3.144 ± 0.036	3.88ArgVal: 3.88 ± 0.036	0.747ArgTrp: 0.747 ± 0.016	1.868ArgTyr: 1.868 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	6.212SerAla: 6.212 ± 0.064	1.399SerCys: 1.399 ± 0.03	3.897SerAsp: 3.897 ± 0.041	4.481SerGlu: 4.481 ± 0.053	3.314SerPhe: 3.314 ± 0.03	5.083SerGly: 5.083 ± 0.062	1.758SerHis: 1.758 ± 0.024	3.411SerIle: 3.411 ± 0.034	3.638SerLys: 3.638 ± 0.04	7.658SerLeu: 7.658 ± 0.069	1.628SerMet: 1.628 ± 0.022	3.071SerAsn: 3.071 ± 0.037	4.433SerPro: 4.433 ± 0.045	2.634SerGln: 2.634 ± 0.027	4.163SerArg: 4.163 ± 0.045	7.706SerSer: 7.706 ± 0.079	5.021SerThr: 5.021 ± 0.057	5.853SerVal: 5.853 ± 0.06	0.705SerTrp: 0.705 ± 0.014	2.045SerTyr: 2.045 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	5.216ThrAla: 5.216 ± 0.05	1.346ThrCys: 1.346 ± 0.066	2.947ThrAsp: 2.947 ± 0.032	3.882ThrGlu: 3.882 ± 0.042	2.277ThrPhe: 2.277 ± 0.026	3.485ThrGly: 3.485 ± 0.044	1.285ThrHis: 1.285 ± 0.019	2.633ThrIle: 2.633 ± 0.045	2.879ThrLys: 2.879 ± 0.033	5.726ThrLeu: 5.726 ± 0.05	1.181ThrMet: 1.181 ± 0.023	2.585ThrAsn: 2.585 ± 0.033	3.702ThrPro: 3.702 ± 0.043	2.001ThrGln: 2.001 ± 0.023	3.02ThrArg: 3.02 ± 0.032	4.938ThrSer: 4.938 ± 0.066	4.554ThrThr: 4.554 ± 0.086	4.783ThrVal: 4.783 ± 0.039	0.481ThrTrp: 0.481 ± 0.012	1.578ThrTyr: 1.578 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	5.361ValAla: 5.361 ± 0.044	1.536ValCys: 1.536 ± 0.052	3.975ValAsp: 3.975 ± 0.04	5.165ValGlu: 5.165 ± 0.05	2.875ValPhe: 2.875 ± 0.033	3.832ValGly: 3.832 ± 0.039	1.656ValHis: 1.656 ± 0.021	2.689ValIle: 2.689 ± 0.029	3.618ValLys: 3.618 ± 0.036	7.053ValLeu: 7.053 ± 0.048	1.544ValMet: 1.544 ± 0.024	2.732ValAsn: 2.732 ± 0.031	3.652ValPro: 3.652 ± 0.041	2.693ValGln: 2.693 ± 0.027	4.122ValArg: 4.122 ± 0.039	5.505ValSer: 5.505 ± 0.052	3.991ValThr: 3.991 ± 0.056	5.618ValVal: 5.618 ± 0.049	0.743ValTrp: 0.743 ± 0.016	2.132ValTyr: 2.132 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.64TrpAla: 0.64 ± 0.018	0.265TrpCys: 0.265 ± 0.008	0.533TrpAsp: 0.533 ± 0.011	0.655TrpGlu: 0.655 ± 0.015	0.372TrpPhe: 0.372 ± 0.009	0.601TrpGly: 0.601 ± 0.014	0.207TrpHis: 0.207 ± 0.008	0.411TrpIle: 0.411 ± 0.011	0.612TrpLys: 0.612 ± 0.014	0.885TrpLeu: 0.885 ± 0.015	0.307TrpMet: 0.307 ± 0.008	0.436TrpAsn: 0.436 ± 0.01	0.332TrpPro: 0.332 ± 0.008	0.353TrpGln: 0.353 ± 0.01	0.776TrpArg: 0.776 ± 0.016	0.85TrpSer: 0.85 ± 0.019	0.551TrpThr: 0.551 ± 0.013	0.635TrpVal: 0.635 ± 0.013	0.207TrpTrp: 0.207 ± 0.008	0.318TrpTyr: 0.318 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.093TyrAla: 2.093 ± 0.042	0.695TyrCys: 0.695 ± 0.015	1.668TyrAsp: 1.668 ± 0.025	1.725TyrGlu: 1.725 ± 0.024	1.446TyrPhe: 1.446 ± 0.022	1.837TyrGly: 1.837 ± 0.023	0.797TyrHis: 0.797 ± 0.015	1.379TyrIle: 1.379 ± 0.02	1.436TyrLys: 1.436 ± 0.031	2.826TyrLeu: 2.826 ± 0.031	0.698TyrMet: 0.698 ± 0.013	1.509TyrAsn: 1.509 ± 0.024	1.291TyrPro: 1.291 ± 0.02	1.032TyrGln: 1.032 ± 0.016	1.737TyrArg: 1.737 ± 0.025	2.058TyrSer: 2.058 ± 0.025	1.879TyrThr: 1.879 ± 0.023	2.091TyrVal: 2.091 ± 0.024	0.301TyrTrp: 0.301 ± 0.007	1.369TyrTyr: 1.369 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10115 proteins (4218491 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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