Amino acid dipepetide frequency for Lacipirellula limnantheis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.306AlaAla: 18.306 ± 0.164	1.258AlaCys: 1.258 ± 0.028	6.937AlaAsp: 6.937 ± 0.08	7.479AlaGlu: 7.479 ± 0.08	3.816AlaPhe: 3.816 ± 0.049	10.197AlaGly: 10.197 ± 0.111	1.923AlaHis: 1.923 ± 0.031	5.961AlaIle: 5.961 ± 0.067	4.232AlaLys: 4.232 ± 0.059	10.745AlaLeu: 10.745 ± 0.102	2.793AlaMet: 2.793 ± 0.041	3.558AlaAsn: 3.558 ± 0.054	5.769AlaPro: 5.769 ± 0.065	3.797AlaGln: 3.797 ± 0.052	6.631AlaArg: 6.631 ± 0.072	7.087AlaSer: 7.087 ± 0.072	6.989AlaThr: 6.989 ± 0.081	8.444AlaVal: 8.444 ± 0.076	1.726AlaTrp: 1.726 ± 0.036	2.402AlaTyr: 2.402 ± 0.04	0.001AlaXaa: 0.001 ± 0.001
Cys	0.923CysAla: 0.923 ± 0.025	0.247CysCys: 0.247 ± 0.016	0.679CysAsp: 0.679 ± 0.022	0.626CysGlu: 0.626 ± 0.02	0.386CysPhe: 0.386 ± 0.014	1.1CysGly: 1.1 ± 0.029	0.361CysHis: 0.361 ± 0.018	0.42CysIle: 0.42 ± 0.015	0.268CysLys: 0.268 ± 0.02	0.982CysLeu: 0.982 ± 0.025	0.191CysMet: 0.191 ± 0.009	0.279CysAsn: 0.279 ± 0.013	0.578CysPro: 0.578 ± 0.02	0.392CysGln: 0.392 ± 0.013	0.905CysArg: 0.905 ± 0.026	0.626CysSer: 0.626 ± 0.024	0.484CysThr: 0.484 ± 0.016	0.74CysVal: 0.74 ± 0.02	0.185CysTrp: 0.185 ± 0.01	0.275CysTyr: 0.275 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.117AspAla: 7.117 ± 0.064	0.537AspCys: 0.537 ± 0.019	3.759AspAsp: 3.759 ± 0.06	3.888AspGlu: 3.888 ± 0.054	2.419AspPhe: 2.419 ± 0.04	5.964AspGly: 5.964 ± 0.087	1.253AspHis: 1.253 ± 0.031	1.802AspIle: 1.802 ± 0.035	1.523AspLys: 1.523 ± 0.037	5.477AspLeu: 5.477 ± 0.06	0.92AspMet: 0.92 ± 0.022	1.506AspAsn: 1.506 ± 0.029	3.386AspPro: 3.386 ± 0.05	2.108AspGln: 2.108 ± 0.033	3.932AspArg: 3.932 ± 0.048	2.844AspSer: 2.844 ± 0.042	1.701AspThr: 1.701 ± 0.035	4.676AspVal: 4.676 ± 0.056	1.066AspTrp: 1.066 ± 0.026	1.588AspTyr: 1.588 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	6.462GluAla: 6.462 ± 0.078	0.503GluCys: 0.503 ± 0.016	2.249GluAsp: 2.249 ± 0.041	3.357GluGlu: 3.357 ± 0.058	2.35GluPhe: 2.35 ± 0.038	3.797GluGly: 3.797 ± 0.051	1.226GluHis: 1.226 ± 0.025	3.105GluIle: 3.105 ± 0.045	2.129GluLys: 2.129 ± 0.044	7.083GluLeu: 7.083 ± 0.072	1.454GluMet: 1.454 ± 0.027	1.616GluAsn: 1.616 ± 0.03	3.18GluPro: 3.18 ± 0.038	2.885GluGln: 2.885 ± 0.045	4.562GluArg: 4.562 ± 0.057	3.429GluSer: 3.429 ± 0.045	3.103GluThr: 3.103 ± 0.051	3.962GluVal: 3.962 ± 0.049	0.862GluTrp: 0.862 ± 0.024	1.325GluTyr: 1.325 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.26PheAla: 4.26 ± 0.053	0.428PheCys: 0.428 ± 0.016	2.8PheAsp: 2.8 ± 0.045	2.048PheGlu: 2.048 ± 0.034	1.34PhePhe: 1.34 ± 0.029	3.465PheGly: 3.465 ± 0.046	0.764PheHis: 0.764 ± 0.017	1.433PheIle: 1.433 ± 0.03	0.904PheLys: 0.904 ± 0.022	3.157PheLeu: 3.157 ± 0.04	0.642PheMet: 0.642 ± 0.019	1.387PheAsn: 1.387 ± 0.034	1.625PhePro: 1.625 ± 0.029	1.223PheGln: 1.223 ± 0.027	2.255PheArg: 2.255 ± 0.033	2.231PheSer: 2.231 ± 0.034	2.1PheThr: 2.1 ± 0.035	2.766PheVal: 2.766 ± 0.041	0.557PheTrp: 0.557 ± 0.02	0.919PheTyr: 0.919 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	8.979GlyAla: 8.979 ± 0.11	0.987GlyCys: 0.987 ± 0.027	5.247GlyAsp: 5.247 ± 0.066	4.936GlyGlu: 4.936 ± 0.054	3.071GlyPhe: 3.071 ± 0.043	7.989GlyGly: 7.989 ± 0.165	1.625GlyHis: 1.625 ± 0.037	3.57GlyIle: 3.57 ± 0.049	3.201GlyLys: 3.201 ± 0.047	7.219GlyLeu: 7.219 ± 0.076	1.979GlyMet: 1.979 ± 0.04	2.809GlyAsn: 2.809 ± 0.056	3.666GlyPro: 3.666 ± 0.051	3.082GlyGln: 3.082 ± 0.044	5.406GlyArg: 5.406 ± 0.066	5.244GlySer: 5.244 ± 0.078	4.505GlyThr: 4.505 ± 0.104	6.689GlyVal: 6.689 ± 0.071	1.417GlyTrp: 1.417 ± 0.025	2.182GlyTyr: 2.182 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.284HisAla: 2.284 ± 0.036	0.298HisCys: 0.298 ± 0.013	1.268HisAsp: 1.268 ± 0.029	1.224HisGlu: 1.224 ± 0.023	0.818HisPhe: 0.818 ± 0.023	1.846HisGly: 1.846 ± 0.037	0.606HisHis: 0.606 ± 0.019	0.761HisIle: 0.761 ± 0.021	0.466HisLys: 0.466 ± 0.015	1.974HisLeu: 1.974 ± 0.032	0.347HisMet: 0.347 ± 0.013	0.563HisAsn: 0.563 ± 0.018	1.288HisPro: 1.288 ± 0.029	0.741HisGln: 0.741 ± 0.022	1.532HisArg: 1.532 ± 0.029	1.083HisSer: 1.083 ± 0.026	0.828HisThr: 0.828 ± 0.025	1.442HisVal: 1.442 ± 0.03	0.421HisTrp: 0.421 ± 0.016	0.589HisTyr: 0.589 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.908IleAla: 5.908 ± 0.062	0.529IleCys: 0.529 ± 0.017	3.507IleAsp: 3.507 ± 0.047	3.307IleGlu: 3.307 ± 0.048	1.405IlePhe: 1.405 ± 0.028	4.164IleGly: 4.164 ± 0.05	0.939IleHis: 0.939 ± 0.022	1.726IleIle: 1.726 ± 0.034	1.258IleLys: 1.258 ± 0.029	3.522IleLeu: 3.522 ± 0.056	0.659IleMet: 0.659 ± 0.018	1.466IleAsn: 1.466 ± 0.035	2.18IlePro: 2.18 ± 0.037	1.325IleGln: 1.325 ± 0.028	2.947IleArg: 2.947 ± 0.045	2.573IleSer: 2.573 ± 0.044	2.324IleThr: 2.324 ± 0.04	3.87IleVal: 3.87 ± 0.053	0.611IleTrp: 0.611 ± 0.021	1.088IleTyr: 1.088 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.038LysAla: 3.038 ± 0.059	0.328LysCys: 0.328 ± 0.018	1.353LysAsp: 1.353 ± 0.035	1.689LysGlu: 1.689 ± 0.042	1.197LysPhe: 1.197 ± 0.025	1.862LysGly: 1.862 ± 0.032	0.654LysHis: 0.654 ± 0.021	1.579LysIle: 1.579 ± 0.032	1.423LysLys: 1.423 ± 0.043	3.648LysLeu: 3.648 ± 0.047	0.809LysMet: 0.809 ± 0.021	0.96LysAsn: 0.96 ± 0.026	2.06LysPro: 2.06 ± 0.043	1.39LysGln: 1.39 ± 0.027	2.165LysArg: 2.165 ± 0.036	2.055LysSer: 2.055 ± 0.036	1.738LysThr: 1.738 ± 0.037	2.131LysVal: 2.131 ± 0.045	0.492LysTrp: 0.492 ± 0.016	0.871LysTyr: 0.871 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.73LeuAla: 13.73 ± 0.105	1.028LeuCys: 1.028 ± 0.022	5.515LeuAsp: 5.515 ± 0.055	5.392LeuGlu: 5.392 ± 0.058	3.198LeuPhe: 3.198 ± 0.051	7.644LeuGly: 7.644 ± 0.072	1.963LeuHis: 1.963 ± 0.033	4.273LeuIle: 4.273 ± 0.053	3.1LeuLys: 3.1 ± 0.053	10.104LeuLeu: 10.104 ± 0.097	1.869LeuMet: 1.869 ± 0.032	2.959LeuAsn: 2.959 ± 0.046	5.654LeuPro: 5.654 ± 0.068	3.49LeuGln: 3.49 ± 0.046	6.853LeuArg: 6.853 ± 0.069	5.683LeuSer: 5.683 ± 0.052	5.674LeuThr: 5.674 ± 0.068	7.012LeuVal: 7.012 ± 0.068	1.451LeuTrp: 1.451 ± 0.036	2.117LeuTyr: 2.117 ± 0.035	0.001LeuXaa: 0.001 ± 0.001
Met	2.413MetAla: 2.413 ± 0.042	0.193MetCys: 0.193 ± 0.01	0.787MetAsp: 0.787 ± 0.02	1.034MetGlu: 1.034 ± 0.027	0.706MetPhe: 0.706 ± 0.021	1.426MetGly: 1.426 ± 0.035	0.403MetHis: 0.403 ± 0.014	1.048MetIle: 1.048 ± 0.025	0.861MetLys: 0.861 ± 0.022	2.319MetLeu: 2.319 ± 0.036	0.502MetMet: 0.502 ± 0.017	0.732MetAsn: 0.732 ± 0.02	1.342MetPro: 1.342 ± 0.026	0.768MetGln: 0.768 ± 0.019	1.447MetArg: 1.447 ± 0.028	1.494MetSer: 1.494 ± 0.027	1.406MetThr: 1.406 ± 0.024	1.373MetVal: 1.373 ± 0.031	0.238MetTrp: 0.238 ± 0.01	0.372MetTyr: 0.372 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.263AsnAla: 3.263 ± 0.049	0.324AsnCys: 0.324 ± 0.014	1.908AsnAsp: 1.908 ± 0.039	1.619AsnGlu: 1.619 ± 0.029	1.251AsnPhe: 1.251 ± 0.029	3.132AsnGly: 3.132 ± 0.068	0.657AsnHis: 0.657 ± 0.021	1.275AsnIle: 1.275 ± 0.027	0.691AsnLys: 0.691 ± 0.018	2.914AsnLeu: 2.914 ± 0.044	0.533AsnMet: 0.533 ± 0.016	1.087AsnAsn: 1.087 ± 0.036	1.947AsnPro: 1.947 ± 0.038	1.083AsnGln: 1.083 ± 0.024	2.036AsnArg: 2.036 ± 0.036	1.824AsnSer: 1.824 ± 0.043	1.299AsnThr: 1.299 ± 0.034	2.493AsnVal: 2.493 ± 0.048	0.554AsnTrp: 0.554 ± 0.019	0.886AsnTyr: 0.886 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.052ProAla: 7.052 ± 0.08	0.412ProCys: 0.412 ± 0.016	3.004ProAsp: 3.004 ± 0.052	3.624ProGlu: 3.624 ± 0.046	1.8ProPhe: 1.8 ± 0.034	4.39ProGly: 4.39 ± 0.055	1.109ProHis: 1.109 ± 0.025	2.409ProIle: 2.409 ± 0.034	1.651ProLys: 1.651 ± 0.032	5.078ProLeu: 5.078 ± 0.057	1.054ProMet: 1.054 ± 0.027	1.76ProAsn: 1.76 ± 0.034	3.297ProPro: 3.297 ± 0.048	2.077ProGln: 2.077 ± 0.035	3.152ProArg: 3.152 ± 0.047	3.43ProSer: 3.43 ± 0.046	3.416ProThr: 3.416 ± 0.049	3.614ProVal: 3.614 ± 0.047	0.818ProTrp: 0.818 ± 0.026	1.164ProTyr: 1.164 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.142GlnAla: 4.142 ± 0.047	0.362GlnCys: 0.362 ± 0.015	1.359GlnAsp: 1.359 ± 0.029	1.849GlnGlu: 1.849 ± 0.037	1.522GlnPhe: 1.522 ± 0.03	2.579GlnGly: 2.579 ± 0.046	0.782GlnHis: 0.782 ± 0.021	1.903GlnIle: 1.903 ± 0.036	1.03GlnLys: 1.03 ± 0.026	4.565GlnLeu: 4.565 ± 0.058	0.845GlnMet: 0.845 ± 0.023	0.994GlnAsn: 0.994 ± 0.024	2.129GlnPro: 2.129 ± 0.038	1.97GlnGln: 1.97 ± 0.044	3.145GlnArg: 3.145 ± 0.042	2.264GlnSer: 2.264 ± 0.033	2.038GlnThr: 2.038 ± 0.031	2.544GlnVal: 2.544 ± 0.038	0.634GlnTrp: 0.634 ± 0.019	0.858GlnTyr: 0.858 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	6.127ArgAla: 6.127 ± 0.061	0.752ArgCys: 0.752 ± 0.021	3.706ArgAsp: 3.706 ± 0.045	4.204ArgGlu: 4.204 ± 0.058	2.656ArgPhe: 2.656 ± 0.037	4.815ArgGly: 4.815 ± 0.053	1.589ArgHis: 1.589 ± 0.033	3.295ArgIle: 3.295 ± 0.054	2.02ArgLys: 2.02 ± 0.034	7.463ArgLeu: 7.463 ± 0.072	1.685ArgMet: 1.685 ± 0.032	1.809ArgAsn: 1.809 ± 0.035	3.504ArgPro: 3.504 ± 0.053	3.191ArgGln: 3.191 ± 0.044	6.496ArgArg: 6.496 ± 0.077	3.902ArgSer: 3.902 ± 0.05	3.492ArgThr: 3.492 ± 0.052	4.564ArgVal: 4.564 ± 0.052	1.277ArgTrp: 1.277 ± 0.03	1.778ArgTyr: 1.778 ± 0.032	0.001ArgXaa: 0.001 ± 0.001
Ser	6.538SerAla: 6.538 ± 0.066	0.594SerCys: 0.594 ± 0.018	3.367SerAsp: 3.367 ± 0.051	3.033SerGlu: 3.033 ± 0.041	2.267SerPhe: 2.267 ± 0.039	5.522SerGly: 5.522 ± 0.069	1.227SerHis: 1.227 ± 0.026	2.839SerIle: 2.839 ± 0.046	1.597SerLys: 1.597 ± 0.03	6.092SerLeu: 6.092 ± 0.06	1.241SerMet: 1.241 ± 0.026	1.823SerAsn: 1.823 ± 0.038	3.72SerPro: 3.72 ± 0.054	2.167SerGln: 2.167 ± 0.04	3.873SerArg: 3.873 ± 0.051	3.8SerSer: 3.8 ± 0.057	3.324SerThr: 3.324 ± 0.044	3.977SerVal: 3.977 ± 0.05	0.89SerTrp: 0.89 ± 0.024	1.382SerTyr: 1.382 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	6.357ThrAla: 6.357 ± 0.071	0.506ThrCys: 0.506 ± 0.021	2.684ThrAsp: 2.684 ± 0.044	2.486ThrGlu: 2.486 ± 0.041	2.108ThrPhe: 2.108 ± 0.041	4.921ThrGly: 4.921 ± 0.087	1.015ThrHis: 1.015 ± 0.023	2.894ThrIle: 2.894 ± 0.043	1.533ThrLys: 1.533 ± 0.031	5.927ThrLeu: 5.927 ± 0.074	1.018ThrMet: 1.018 ± 0.025	1.673ThrAsn: 1.673 ± 0.041	3.829ThrPro: 3.829 ± 0.052	1.618ThrGln: 1.618 ± 0.03	2.893ThrArg: 2.893 ± 0.041	3.194ThrSer: 3.194 ± 0.045	3.239ThrThr: 3.239 ± 0.052	4.03ThrVal: 4.03 ± 0.053	0.764ThrTrp: 0.764 ± 0.021	1.21ThrTyr: 1.21 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	9.373ValAla: 9.373 ± 0.086	0.843ValCys: 0.843 ± 0.024	4.994ValAsp: 4.994 ± 0.049	4.751ValGlu: 4.751 ± 0.053	2.328ValPhe: 2.328 ± 0.036	5.822ValGly: 5.822 ± 0.064	1.354ValHis: 1.354 ± 0.032	3.479ValIle: 3.479 ± 0.047	2.311ValLys: 2.311 ± 0.04	6.286ValLeu: 6.286 ± 0.068	1.5ValMet: 1.5 ± 0.033	2.402ValAsn: 2.402 ± 0.048	3.322ValPro: 3.322 ± 0.043	2.298ValGln: 2.298 ± 0.035	4.781ValArg: 4.781 ± 0.054	4.129ValSer: 4.129 ± 0.046	4.311ValThr: 4.311 ± 0.068	5.937ValVal: 5.937 ± 0.065	1.069ValTrp: 1.069 ± 0.028	1.559ValTyr: 1.559 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.284TrpAla: 1.284 ± 0.031	0.189TrpCys: 0.189 ± 0.01	0.802TrpAsp: 0.802 ± 0.024	0.724TrpGlu: 0.724 ± 0.023	0.566TrpPhe: 0.566 ± 0.018	1.047TrpGly: 1.047 ± 0.029	0.382TrpHis: 0.382 ± 0.015	0.74TrpIle: 0.74 ± 0.022	0.65TrpLys: 0.65 ± 0.021	1.774TrpLeu: 1.774 ± 0.035	0.401TrpMet: 0.401 ± 0.015	0.65TrpAsn: 0.65 ± 0.021	0.74TrpPro: 0.74 ± 0.02	0.919TrpGln: 0.919 ± 0.023	1.38TrpArg: 1.38 ± 0.03	1.05TrpSer: 1.05 ± 0.026	0.909TrpThr: 0.909 ± 0.029	0.909TrpVal: 0.909 ± 0.022	0.291TrpTrp: 0.291 ± 0.013	0.375TrpTyr: 0.375 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.495TyrAla: 2.495 ± 0.04	0.334TyrCys: 0.334 ± 0.013	1.54TyrAsp: 1.54 ± 0.03	1.369TyrGlu: 1.369 ± 0.025	1.103TyrPhe: 1.103 ± 0.029	2.121TyrGly: 2.121 ± 0.038	0.548TyrHis: 0.548 ± 0.018	0.792TyrIle: 0.792 ± 0.02	0.591TyrLys: 0.591 ± 0.02	2.38TyrLeu: 2.38 ± 0.044	0.421TyrMet: 0.421 ± 0.016	0.741TyrAsn: 0.741 ± 0.023	1.094TyrPro: 1.094 ± 0.027	0.988TyrGln: 0.988 ± 0.022	1.938TyrArg: 1.938 ± 0.028	1.329TyrSer: 1.329 ± 0.028	1.019TyrThr: 1.019 ± 0.025	1.676TyrVal: 1.676 ± 0.029	0.46TyrTrp: 0.46 ± 0.018	0.706TyrTyr: 0.706 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 5493 proteins (1881987 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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