Amino acid dipepetide frequency for Arthrobacter phage Abba

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.798AlaAla: 16.798 ± 1.399
0.739AlaCys: 0.739 ± 0.263
10.751AlaAsp: 10.751 ± 1.285
9.272AlaGlu: 9.272 ± 1.234
3.695AlaPhe: 3.695 ± 0.581
10.616AlaGly: 10.616 ± 1.232
2.083AlaHis: 2.083 ± 0.305
4.367AlaIle: 4.367 ± 0.487
4.233AlaLys: 4.233 ± 0.463
10.549AlaLeu: 10.549 ± 0.906
2.755AlaMet: 2.755 ± 0.456
3.36AlaAsn: 3.36 ± 0.452
9.138AlaPro: 9.138 ± 1.231
4.905AlaGln: 4.905 ± 0.627
8.063AlaArg: 8.063 ± 0.648
6.182AlaSer: 6.182 ± 0.793
9.138AlaThr: 9.138 ± 0.951
9.071AlaVal: 9.071 ± 0.725
1.881AlaTrp: 1.881 ± 0.458
2.889AlaTyr: 2.889 ± 0.413
0.0AlaXaa: 0.0 ± 0.0
Cys
0.538CysAla: 0.538 ± 0.188
0.0CysCys: 0.0 ± 0.0
0.269CysAsp: 0.269 ± 0.123
0.202CysGlu: 0.202 ± 0.132
0.067CysPhe: 0.067 ± 0.057
0.47CysGly: 0.47 ± 0.194
0.134CysHis: 0.134 ± 0.085
0.067CysIle: 0.067 ± 0.067
0.202CysLys: 0.202 ± 0.118
0.47CysLeu: 0.47 ± 0.167
0.134CysMet: 0.134 ± 0.089
0.067CysAsn: 0.067 ± 0.064
0.739CysPro: 0.739 ± 0.271
0.269CysGln: 0.269 ± 0.131
0.202CysArg: 0.202 ± 0.108
0.269CysSer: 0.269 ± 0.136
0.134CysThr: 0.134 ± 0.088
0.47CysVal: 0.47 ± 0.176
0.067CysTrp: 0.067 ± 0.069
0.269CysTyr: 0.269 ± 0.155
0.0CysXaa: 0.0 ± 0.0
Asp
9.944AspAla: 9.944 ± 0.992
0.403AspCys: 0.403 ± 0.176
4.233AspAsp: 4.233 ± 0.555
5.308AspGlu: 5.308 ± 0.767
2.016AspPhe: 2.016 ± 0.375
5.98AspGly: 5.98 ± 0.625
0.941AspHis: 0.941 ± 0.247
1.545AspIle: 1.545 ± 0.384
2.016AspLys: 2.016 ± 0.297
6.114AspLeu: 6.114 ± 0.696
1.008AspMet: 1.008 ± 0.222
2.016AspAsn: 2.016 ± 0.41
3.897AspPro: 3.897 ± 0.502
1.209AspGln: 1.209 ± 0.292
4.166AspArg: 4.166 ± 0.642
2.419AspSer: 2.419 ± 0.43
3.225AspThr: 3.225 ± 0.569
5.711AspVal: 5.711 ± 0.578
1.814AspTrp: 1.814 ± 0.369
1.68AspTyr: 1.68 ± 0.359
0.0AspXaa: 0.0 ± 0.0
Glu
6.719GluAla: 6.719 ± 0.752
0.134GluCys: 0.134 ± 0.108
2.486GluAsp: 2.486 ± 0.54
3.292GluGlu: 3.292 ± 0.591
1.277GluPhe: 1.277 ± 0.299
3.628GluGly: 3.628 ± 0.489
1.545GluHis: 1.545 ± 0.416
3.225GluIle: 3.225 ± 0.468
1.881GluLys: 1.881 ± 0.426
7.929GluLeu: 7.929 ± 0.809
1.344GluMet: 1.344 ± 0.383
0.941GluAsn: 0.941 ± 0.226
3.897GluPro: 3.897 ± 0.489
2.688GluGln: 2.688 ± 0.444
3.964GluArg: 3.964 ± 0.65
3.695GluSer: 3.695 ± 0.447
3.024GluThr: 3.024 ± 0.431
3.158GluVal: 3.158 ± 0.485
0.941GluTrp: 0.941 ± 0.268
1.478GluTyr: 1.478 ± 0.284
0.0GluXaa: 0.0 ± 0.0
Phe
4.636PheAla: 4.636 ± 0.649
0.134PheCys: 0.134 ± 0.102
1.949PheAsp: 1.949 ± 0.397
2.352PheGlu: 2.352 ± 0.357
1.142PhePhe: 1.142 ± 0.251
3.225PheGly: 3.225 ± 0.413
0.336PheHis: 0.336 ± 0.138
1.68PheIle: 1.68 ± 0.368
1.344PheLys: 1.344 ± 0.294
1.008PheLeu: 1.008 ± 0.261
0.672PheMet: 0.672 ± 0.231
1.142PheAsn: 1.142 ± 0.311
1.344PhePro: 1.344 ± 0.345
0.605PheGln: 0.605 ± 0.168
1.545PheArg: 1.545 ± 0.372
2.284PheSer: 2.284 ± 0.419
2.62PheThr: 2.62 ± 0.464
2.688PheVal: 2.688 ± 0.424
0.739PheTrp: 0.739 ± 0.223
0.806PheTyr: 0.806 ± 0.24
0.0PheXaa: 0.0 ± 0.0
Gly
10.818GlyAla: 10.818 ± 0.808
0.067GlyCys: 0.067 ± 0.058
5.98GlyAsp: 5.98 ± 0.693
3.83GlyGlu: 3.83 ± 0.596
3.36GlyPhe: 3.36 ± 0.502
9.071GlyGly: 9.071 ± 1.521
1.68GlyHis: 1.68 ± 0.344
3.36GlyIle: 3.36 ± 0.531
5.174GlyLys: 5.174 ± 0.599
6.45GlyLeu: 6.45 ± 0.859
2.016GlyMet: 2.016 ± 0.473
2.755GlyAsn: 2.755 ± 0.408
2.688GlyPro: 2.688 ± 0.426
2.62GlyGln: 2.62 ± 0.517
5.241GlyArg: 5.241 ± 0.644
3.897GlySer: 3.897 ± 0.578
5.913GlyThr: 5.913 ± 0.662
6.652GlyVal: 6.652 ± 0.929
0.739GlyTrp: 0.739 ± 0.222
2.62GlyTyr: 2.62 ± 0.41
0.0GlyXaa: 0.0 ± 0.0
His
2.553HisAla: 2.553 ± 0.53
0.202HisCys: 0.202 ± 0.124
1.075HisAsp: 1.075 ± 0.305
2.016HisGlu: 2.016 ± 0.44
0.538HisPhe: 0.538 ± 0.167
0.806HisGly: 0.806 ± 0.31
0.202HisHis: 0.202 ± 0.154
0.134HisIle: 0.134 ± 0.089
0.605HisLys: 0.605 ± 0.225
1.613HisLeu: 1.613 ± 0.373
0.269HisMet: 0.269 ± 0.129
0.605HisAsn: 0.605 ± 0.19
0.941HisPro: 0.941 ± 0.277
0.403HisGln: 0.403 ± 0.187
1.075HisArg: 1.075 ± 0.27
0.739HisSer: 0.739 ± 0.222
1.344HisThr: 1.344 ± 0.344
1.545HisVal: 1.545 ± 0.361
0.605HisTrp: 0.605 ± 0.188
0.202HisTyr: 0.202 ± 0.113
0.0HisXaa: 0.0 ± 0.0
Ile
5.51IleAla: 5.51 ± 0.666
0.067IleCys: 0.067 ± 0.069
4.367IleAsp: 4.367 ± 0.512
3.897IleGlu: 3.897 ± 0.471
1.008IlePhe: 1.008 ± 0.287
3.897IleGly: 3.897 ± 0.648
0.672IleHis: 0.672 ± 0.195
2.755IleIle: 2.755 ± 0.486
2.083IleLys: 2.083 ± 0.337
1.68IleLeu: 1.68 ± 0.299
0.739IleMet: 0.739 ± 0.215
1.344IleAsn: 1.344 ± 0.259
1.68IlePro: 1.68 ± 0.338
1.344IleGln: 1.344 ± 0.324
2.016IleArg: 2.016 ± 0.346
2.15IleSer: 2.15 ± 0.409
2.822IleThr: 2.822 ± 0.488
4.166IleVal: 4.166 ± 0.46
0.202IleTrp: 0.202 ± 0.129
0.605IleTyr: 0.605 ± 0.215
0.0IleXaa: 0.0 ± 0.0
Lys
5.174LysAla: 5.174 ± 0.587
0.202LysCys: 0.202 ± 0.122
1.613LysAsp: 1.613 ± 0.384
1.613LysGlu: 1.613 ± 0.325
1.142LysPhe: 1.142 ± 0.251
3.158LysGly: 3.158 ± 0.517
0.806LysHis: 0.806 ± 0.211
1.949LysIle: 1.949 ± 0.348
2.284LysLys: 2.284 ± 0.46
4.771LysLeu: 4.771 ± 0.486
0.941LysMet: 0.941 ± 0.23
0.538LysAsn: 0.538 ± 0.201
3.964LysPro: 3.964 ± 0.64
1.545LysGln: 1.545 ± 0.282
3.091LysArg: 3.091 ± 0.526
2.553LysSer: 2.553 ± 0.44
3.158LysThr: 3.158 ± 0.442
2.553LysVal: 2.553 ± 0.384
0.873LysTrp: 0.873 ± 0.262
0.672LysTyr: 0.672 ± 0.196
0.0LysXaa: 0.0 ± 0.0
Leu
12.229LeuAla: 12.229 ± 1.194
0.269LeuCys: 0.269 ± 0.113
5.039LeuAsp: 5.039 ± 0.594
3.628LeuGlu: 3.628 ± 0.465
1.814LeuPhe: 1.814 ± 0.315
7.391LeuGly: 7.391 ± 0.563
1.008LeuHis: 1.008 ± 0.254
4.569LeuIle: 4.569 ± 0.601
2.688LeuLys: 2.688 ± 0.374
5.913LeuLeu: 5.913 ± 0.659
2.352LeuMet: 2.352 ± 0.443
2.822LeuAsn: 2.822 ± 0.494
4.166LeuPro: 4.166 ± 0.73
2.15LeuGln: 2.15 ± 0.418
4.905LeuArg: 4.905 ± 0.628
5.442LeuSer: 5.442 ± 0.618
6.786LeuThr: 6.786 ± 0.633
7.391LeuVal: 7.391 ± 0.931
1.142LeuTrp: 1.142 ± 0.294
1.478LeuTyr: 1.478 ± 0.29
0.0LeuXaa: 0.0 ± 0.0
Met
2.083MetAla: 2.083 ± 0.386
0.134MetCys: 0.134 ± 0.093
0.269MetAsp: 0.269 ± 0.117
0.202MetGlu: 0.202 ± 0.126
0.806MetPhe: 0.806 ± 0.217
1.142MetGly: 1.142 ± 0.292
0.269MetHis: 0.269 ± 0.135
0.538MetIle: 0.538 ± 0.167
1.478MetLys: 1.478 ± 0.368
1.881MetLeu: 1.881 ± 0.314
0.202MetMet: 0.202 ± 0.094
0.538MetAsn: 0.538 ± 0.2
1.747MetPro: 1.747 ± 0.373
0.403MetGln: 0.403 ± 0.149
2.553MetArg: 2.553 ± 0.395
2.352MetSer: 2.352 ± 0.379
3.561MetThr: 3.561 ± 0.488
0.605MetVal: 0.605 ± 0.188
0.134MetTrp: 0.134 ± 0.093
0.336MetTyr: 0.336 ± 0.149
0.0MetXaa: 0.0 ± 0.0
Asn
3.561AsnAla: 3.561 ± 0.524
0.269AsnCys: 0.269 ± 0.123
1.613AsnAsp: 1.613 ± 0.395
1.68AsnGlu: 1.68 ± 0.306
1.209AsnPhe: 1.209 ± 0.299
3.091AsnGly: 3.091 ± 0.566
0.403AsnHis: 0.403 ± 0.192
1.478AsnIle: 1.478 ± 0.368
1.277AsnLys: 1.277 ± 0.31
2.956AsnLeu: 2.956 ± 0.347
0.336AsnMet: 0.336 ± 0.129
1.209AsnAsn: 1.209 ± 0.322
2.284AsnPro: 2.284 ± 0.393
0.605AsnGln: 0.605 ± 0.158
1.68AsnArg: 1.68 ± 0.322
1.411AsnSer: 1.411 ± 0.299
1.209AsnThr: 1.209 ± 0.272
2.486AsnVal: 2.486 ± 0.399
0.806AsnTrp: 0.806 ± 0.242
0.672AsnTyr: 0.672 ± 0.216
0.0AsnXaa: 0.0 ± 0.0
Pro
8.197ProAla: 8.197 ± 1.045
0.47ProCys: 0.47 ± 0.22
3.964ProAsp: 3.964 ± 0.622
3.763ProGlu: 3.763 ± 0.496
1.478ProPhe: 1.478 ± 0.298
5.577ProGly: 5.577 ± 0.705
1.277ProHis: 1.277 ± 0.338
1.949ProIle: 1.949 ± 0.276
2.889ProLys: 2.889 ± 0.648
3.897ProLeu: 3.897 ± 0.536
0.605ProMet: 0.605 ± 0.202
1.881ProAsn: 1.881 ± 0.328
2.083ProPro: 2.083 ± 0.709
1.075ProGln: 1.075 ± 0.225
2.755ProArg: 2.755 ± 0.589
3.427ProSer: 3.427 ± 0.556
4.233ProThr: 4.233 ± 0.709
3.695ProVal: 3.695 ± 0.511
0.605ProTrp: 0.605 ± 0.193
1.411ProTyr: 1.411 ± 0.348
0.0ProXaa: 0.0 ± 0.0
Gln
5.241GlnAla: 5.241 ± 0.86
0.067GlnCys: 0.067 ± 0.069
1.209GlnAsp: 1.209 ± 0.255
0.941GlnGlu: 0.941 ± 0.276
1.008GlnPhe: 1.008 ± 0.274
2.755GlnGly: 2.755 ± 0.509
1.008GlnHis: 1.008 ± 0.277
2.15GlnIle: 2.15 ± 0.435
1.411GlnLys: 1.411 ± 0.377
2.083GlnLeu: 2.083 ± 0.298
1.209GlnMet: 1.209 ± 0.276
0.403GlnAsn: 0.403 ± 0.146
1.344GlnPro: 1.344 ± 0.35
1.209GlnGln: 1.209 ± 0.335
2.15GlnArg: 2.15 ± 0.448
1.68GlnSer: 1.68 ± 0.381
1.747GlnThr: 1.747 ± 0.295
2.419GlnVal: 2.419 ± 0.369
0.269GlnTrp: 0.269 ± 0.115
0.538GlnTyr: 0.538 ± 0.176
0.0GlnXaa: 0.0 ± 0.0
Arg
8.13ArgAla: 8.13 ± 0.806
0.672ArgCys: 0.672 ± 0.247
3.763ArgAsp: 3.763 ± 0.484
3.628ArgGlu: 3.628 ± 0.657
2.352ArgPhe: 2.352 ± 0.398
3.494ArgGly: 3.494 ± 0.494
1.209ArgHis: 1.209 ± 0.438
2.217ArgIle: 2.217 ± 0.377
2.956ArgLys: 2.956 ± 0.565
5.913ArgLeu: 5.913 ± 0.596
1.209ArgMet: 1.209 ± 0.318
1.949ArgAsn: 1.949 ± 0.416
3.628ArgPro: 3.628 ± 0.591
2.62ArgGln: 2.62 ± 0.427
4.905ArgArg: 4.905 ± 0.739
3.225ArgSer: 3.225 ± 0.438
3.225ArgThr: 3.225 ± 0.405
4.905ArgVal: 4.905 ± 0.548
1.277ArgTrp: 1.277 ± 0.33
1.881ArgTyr: 1.881 ± 0.423
0.0ArgXaa: 0.0 ± 0.0
Ser
6.585SerAla: 6.585 ± 0.903
0.336SerCys: 0.336 ± 0.184
3.292SerAsp: 3.292 ± 0.457
2.352SerGlu: 2.352 ± 0.339
1.747SerPhe: 1.747 ± 0.359
5.241SerGly: 5.241 ± 0.827
1.142SerHis: 1.142 ± 0.274
2.419SerIle: 2.419 ± 0.401
2.822SerLys: 2.822 ± 0.455
5.106SerLeu: 5.106 ± 0.572
1.881SerMet: 1.881 ± 0.389
2.016SerAsn: 2.016 ± 0.355
2.755SerPro: 2.755 ± 0.522
1.075SerGln: 1.075 ± 0.237
3.024SerArg: 3.024 ± 0.467
3.427SerSer: 3.427 ± 0.594
3.763SerThr: 3.763 ± 0.545
3.897SerVal: 3.897 ± 0.612
1.008SerTrp: 1.008 ± 0.284
1.545SerTyr: 1.545 ± 0.307
0.0SerXaa: 0.0 ± 0.0
Thr
8.264ThrAla: 8.264 ± 0.678
0.336ThrCys: 0.336 ± 0.157
4.166ThrAsp: 4.166 ± 0.682
2.688ThrGlu: 2.688 ± 0.513
3.158ThrPhe: 3.158 ± 0.588
5.375ThrGly: 5.375 ± 0.604
1.075ThrHis: 1.075 ± 0.322
3.091ThrIle: 3.091 ± 0.456
2.284ThrLys: 2.284 ± 0.416
6.047ThrLeu: 6.047 ± 0.413
1.209ThrMet: 1.209 ± 0.258
1.747ThrAsn: 1.747 ± 0.316
4.233ThrPro: 4.233 ± 0.414
2.688ThrGln: 2.688 ± 0.403
4.636ThrArg: 4.636 ± 0.579
3.091ThrSer: 3.091 ± 0.582
4.233ThrThr: 4.233 ± 0.514
6.182ThrVal: 6.182 ± 0.809
1.142ThrTrp: 1.142 ± 0.268
1.747ThrTyr: 1.747 ± 0.287
0.0ThrXaa: 0.0 ± 0.0
Val
9.071ValAla: 9.071 ± 0.891
0.403ValCys: 0.403 ± 0.14
7.122ValAsp: 7.122 ± 0.769
5.174ValGlu: 5.174 ± 0.549
3.427ValPhe: 3.427 ± 0.463
6.182ValGly: 6.182 ± 0.727
1.075ValHis: 1.075 ± 0.28
3.897ValIle: 3.897 ± 0.51
3.494ValLys: 3.494 ± 0.438
4.838ValLeu: 4.838 ± 0.671
1.68ValMet: 1.68 ± 0.316
2.688ValAsn: 2.688 ± 0.435
2.755ValPro: 2.755 ± 0.417
1.881ValGln: 1.881 ± 0.372
4.3ValArg: 4.3 ± 0.6
4.838ValSer: 4.838 ± 0.693
5.442ValThr: 5.442 ± 0.691
6.316ValVal: 6.316 ± 0.761
0.873ValTrp: 0.873 ± 0.191
1.008ValTyr: 1.008 ± 0.274
0.0ValXaa: 0.0 ± 0.0
Trp
1.949TrpAla: 1.949 ± 0.274
0.067TrpCys: 0.067 ± 0.057
0.941TrpAsp: 0.941 ± 0.221
0.269TrpGlu: 0.269 ± 0.132
0.336TrpPhe: 0.336 ± 0.194
1.344TrpGly: 1.344 ± 0.358
0.336TrpHis: 0.336 ± 0.158
0.873TrpIle: 0.873 ± 0.345
0.672TrpLys: 0.672 ± 0.211
1.949TrpLeu: 1.949 ± 0.327
0.336TrpMet: 0.336 ± 0.147
0.941TrpAsn: 0.941 ± 0.46
0.403TrpPro: 0.403 ± 0.155
0.806TrpGln: 0.806 ± 0.204
1.411TrpArg: 1.411 ± 0.297
0.739TrpSer: 0.739 ± 0.28
0.672TrpThr: 0.672 ± 0.191
1.142TrpVal: 1.142 ± 0.263
0.47TrpTrp: 0.47 ± 0.139
0.202TrpTyr: 0.202 ± 0.12
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.486TyrAla: 2.486 ± 0.374
0.067TyrCys: 0.067 ± 0.062
1.545TyrAsp: 1.545 ± 0.407
1.142TyrGlu: 1.142 ± 0.307
0.672TyrPhe: 0.672 ± 0.249
2.486TyrGly: 2.486 ± 0.41
0.269TyrHis: 0.269 ± 0.139
0.739TyrIle: 0.739 ± 0.225
0.806TyrLys: 0.806 ± 0.186
2.016TyrLeu: 2.016 ± 0.315
0.269TyrMet: 0.269 ± 0.123
1.277TyrAsn: 1.277 ± 0.264
1.545TyrPro: 1.545 ± 0.291
0.739TyrGln: 0.739 ± 0.256
1.478TyrArg: 1.478 ± 0.34
1.68TyrSer: 1.68 ± 0.359
1.142TyrThr: 1.142 ± 0.234
1.411TyrVal: 1.411 ± 0.283
0.269TyrTrp: 0.269 ± 0.156
0.269TyrTyr: 0.269 ± 0.118
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 71 proteins (14884 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski