Amino acid dipepetide frequency for Aeropyrum pernix spindle-shaped virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.926AlaAla: 9.926 ± 1.29
0.609AlaCys: 0.609 ± 0.24
2.96AlaAsp: 2.96 ± 0.559
6.966AlaGlu: 6.966 ± 0.905
3.309AlaPhe: 3.309 ± 0.5
7.488AlaGly: 7.488 ± 1.144
0.958AlaHis: 0.958 ± 0.269
4.092AlaIle: 4.092 ± 0.694
2.786AlaLys: 2.786 ± 0.508
10.971AlaLeu: 10.971 ± 0.97
1.916AlaMet: 1.916 ± 0.352
1.132AlaAsn: 1.132 ± 0.311
4.092AlaPro: 4.092 ± 0.686
2.699AlaGln: 2.699 ± 0.485
7.749AlaArg: 7.749 ± 1.023
8.533AlaSer: 8.533 ± 1.155
3.135AlaThr: 3.135 ± 0.6
8.881AlaVal: 8.881 ± 1.083
1.567AlaTrp: 1.567 ± 0.418
3.396AlaTyr: 3.396 ± 0.505
0.0AlaXaa: 0.0 ± 0.0
Cys
0.348CysAla: 0.348 ± 0.146
0.087CysCys: 0.087 ± 0.085
0.435CysAsp: 0.435 ± 0.182
0.261CysGlu: 0.261 ± 0.148
0.087CysPhe: 0.087 ± 0.088
0.784CysGly: 0.784 ± 0.269
0.087CysHis: 0.087 ± 0.087
0.261CysIle: 0.261 ± 0.149
0.174CysLys: 0.174 ± 0.125
0.435CysLeu: 0.435 ± 0.198
0.174CysMet: 0.174 ± 0.128
0.087CysAsn: 0.087 ± 0.097
0.261CysPro: 0.261 ± 0.154
0.435CysGln: 0.435 ± 0.185
0.609CysArg: 0.609 ± 0.213
0.435CysSer: 0.435 ± 0.157
0.348CysThr: 0.348 ± 0.197
0.348CysVal: 0.348 ± 0.18
0.174CysTrp: 0.174 ± 0.117
0.261CysTyr: 0.261 ± 0.142
0.0CysXaa: 0.0 ± 0.0
Asp
4.092AspAla: 4.092 ± 0.635
0.348AspCys: 0.348 ± 0.21
1.828AspAsp: 1.828 ± 0.402
3.047AspGlu: 3.047 ± 0.547
1.654AspPhe: 1.654 ± 0.501
3.309AspGly: 3.309 ± 0.675
0.697AspHis: 0.697 ± 0.219
3.047AspIle: 3.047 ± 0.564
2.264AspLys: 2.264 ± 0.484
4.789AspLeu: 4.789 ± 0.497
1.045AspMet: 1.045 ± 0.254
0.871AspAsn: 0.871 ± 0.252
2.96AspPro: 2.96 ± 0.55
0.784AspGln: 0.784 ± 0.207
4.092AspArg: 4.092 ± 0.522
2.438AspSer: 2.438 ± 0.457
2.177AspThr: 2.177 ± 0.603
4.354AspVal: 4.354 ± 0.637
1.306AspTrp: 1.306 ± 0.301
2.786AspTyr: 2.786 ± 0.436
0.0AspXaa: 0.0 ± 0.0
Glu
9.665GluAla: 9.665 ± 1.13
0.348GluCys: 0.348 ± 0.164
3.483GluAsp: 3.483 ± 0.547
5.398GluGlu: 5.398 ± 0.797
2.177GluPhe: 2.177 ± 0.421
5.485GluGly: 5.485 ± 0.794
1.654GluHis: 1.654 ± 0.392
3.483GluIle: 3.483 ± 0.652
3.135GluLys: 3.135 ± 0.664
7.662GluLeu: 7.662 ± 0.964
0.958GluMet: 0.958 ± 0.25
1.219GluAsn: 1.219 ± 0.307
2.264GluPro: 2.264 ± 0.416
1.567GluGln: 1.567 ± 0.443
6.966GluArg: 6.966 ± 0.898
3.396GluSer: 3.396 ± 0.569
2.786GluThr: 2.786 ± 0.533
6.182GluVal: 6.182 ± 0.82
1.045GluTrp: 1.045 ± 0.287
3.047GluTyr: 3.047 ± 0.569
0.0GluXaa: 0.0 ± 0.0
Phe
2.177PheAla: 2.177 ± 0.511
0.087PheCys: 0.087 ± 0.088
2.09PheAsp: 2.09 ± 0.434
2.177PheGlu: 2.177 ± 0.447
1.306PhePhe: 1.306 ± 0.34
1.828PheGly: 1.828 ± 0.429
0.174PheHis: 0.174 ± 0.11
2.177PheIle: 2.177 ± 0.571
1.48PheLys: 1.48 ± 0.333
3.135PheLeu: 3.135 ± 0.607
1.219PheMet: 1.219 ± 0.329
1.045PheAsn: 1.045 ± 0.233
0.609PhePro: 0.609 ± 0.184
0.435PheGln: 0.435 ± 0.219
2.612PheArg: 2.612 ± 0.523
2.699PheSer: 2.699 ± 0.421
1.654PheThr: 1.654 ± 0.364
3.222PheVal: 3.222 ± 0.542
0.435PheTrp: 0.435 ± 0.194
1.567PheTyr: 1.567 ± 0.371
0.0PheXaa: 0.0 ± 0.0
Gly
5.921GlyAla: 5.921 ± 0.795
0.609GlyCys: 0.609 ± 0.225
3.744GlyAsp: 3.744 ± 0.619
5.747GlyGlu: 5.747 ± 0.874
4.092GlyPhe: 4.092 ± 0.766
8.01GlyGly: 8.01 ± 1.336
0.784GlyHis: 0.784 ± 0.28
3.047GlyIle: 3.047 ± 0.682
2.351GlyLys: 2.351 ± 0.523
9.316GlyLeu: 9.316 ± 1.096
1.828GlyMet: 1.828 ± 0.454
1.132GlyAsn: 1.132 ± 0.31
3.135GlyPro: 3.135 ± 0.598
1.393GlyGln: 1.393 ± 0.302
7.749GlyArg: 7.749 ± 0.764
6.269GlySer: 6.269 ± 1.317
2.525GlyThr: 2.525 ± 0.539
9.839GlyVal: 9.839 ± 1.244
2.177GlyTrp: 2.177 ± 0.489
4.092GlyTyr: 4.092 ± 0.59
0.0GlyXaa: 0.0 ± 0.0
His
2.003HisAla: 2.003 ± 0.474
0.0HisCys: 0.0 ± 0.0
0.261HisAsp: 0.261 ± 0.143
1.132HisGlu: 1.132 ± 0.304
0.697HisPhe: 0.697 ± 0.259
1.132HisGly: 1.132 ± 0.311
0.261HisHis: 0.261 ± 0.157
1.132HisIle: 1.132 ± 0.279
0.348HisLys: 0.348 ± 0.202
1.48HisLeu: 1.48 ± 0.396
0.435HisMet: 0.435 ± 0.197
0.261HisAsn: 0.261 ± 0.139
0.784HisPro: 0.784 ± 0.242
0.435HisGln: 0.435 ± 0.15
1.045HisArg: 1.045 ± 0.278
0.522HisSer: 0.522 ± 0.245
0.174HisThr: 0.174 ± 0.124
1.48HisVal: 1.48 ± 0.297
0.0HisTrp: 0.0 ± 0.0
0.522HisTyr: 0.522 ± 0.197
0.0HisXaa: 0.0 ± 0.0
Ile
3.483IleAla: 3.483 ± 0.618
0.522IleCys: 0.522 ± 0.216
2.177IleAsp: 2.177 ± 0.436
3.309IleGlu: 3.309 ± 0.732
1.393IlePhe: 1.393 ± 0.366
2.612IleGly: 2.612 ± 0.436
0.697IleHis: 0.697 ± 0.219
3.135IleIle: 3.135 ± 0.81
3.396IleLys: 3.396 ± 0.926
5.485IleLeu: 5.485 ± 0.728
0.697IleMet: 0.697 ± 0.205
1.48IleAsn: 1.48 ± 0.379
2.003IlePro: 2.003 ± 0.367
0.784IleGln: 0.784 ± 0.23
3.047IleArg: 3.047 ± 0.592
3.047IleSer: 3.047 ± 0.635
2.177IleThr: 2.177 ± 0.467
5.66IleVal: 5.66 ± 0.837
0.871IleTrp: 0.871 ± 0.279
1.828IleTyr: 1.828 ± 0.372
0.0IleXaa: 0.0 ± 0.0
Lys
3.744LysAla: 3.744 ± 0.571
0.174LysCys: 0.174 ± 0.139
1.916LysAsp: 1.916 ± 0.458
2.612LysGlu: 2.612 ± 0.475
0.871LysPhe: 0.871 ± 0.311
2.699LysGly: 2.699 ± 0.485
1.132LysHis: 1.132 ± 0.29
2.09LysIle: 2.09 ± 0.594
2.003LysLys: 2.003 ± 0.4
4.615LysLeu: 4.615 ± 0.76
0.871LysMet: 0.871 ± 0.267
1.828LysAsn: 1.828 ± 0.488
2.264LysPro: 2.264 ± 0.416
1.045LysGln: 1.045 ± 0.249
4.702LysArg: 4.702 ± 0.833
1.654LysSer: 1.654 ± 0.33
2.438LysThr: 2.438 ± 0.48
2.351LysVal: 2.351 ± 0.405
0.261LysTrp: 0.261 ± 0.146
1.567LysTyr: 1.567 ± 0.348
0.0LysXaa: 0.0 ± 0.0
Leu
14.018LeuAla: 14.018 ± 1.37
0.697LeuCys: 0.697 ± 0.219
6.966LeuAsp: 6.966 ± 0.838
8.794LeuGlu: 8.794 ± 0.991
3.483LeuPhe: 3.483 ± 0.504
11.493LeuGly: 11.493 ± 1.006
0.697LeuHis: 0.697 ± 0.236
5.05LeuIle: 5.05 ± 0.724
5.66LeuLys: 5.66 ± 0.854
13.583LeuLeu: 13.583 ± 0.942
1.654LeuMet: 1.654 ± 0.33
2.525LeuAsn: 2.525 ± 0.455
4.963LeuPro: 4.963 ± 0.487
1.741LeuGln: 1.741 ± 0.333
8.62LeuArg: 8.62 ± 0.99
7.749LeuSer: 7.749 ± 0.771
4.005LeuThr: 4.005 ± 0.612
7.923LeuVal: 7.923 ± 0.953
1.828LeuTrp: 1.828 ± 0.46
5.311LeuTyr: 5.311 ± 0.677
0.0LeuXaa: 0.0 ± 0.0
Met
2.699MetAla: 2.699 ± 0.483
0.087MetCys: 0.087 ± 0.093
1.219MetAsp: 1.219 ± 0.393
1.393MetGlu: 1.393 ± 0.329
0.871MetPhe: 0.871 ± 0.31
1.48MetGly: 1.48 ± 0.412
0.348MetHis: 0.348 ± 0.175
1.132MetIle: 1.132 ± 0.294
0.871MetLys: 0.871 ± 0.258
2.96MetLeu: 2.96 ± 0.474
0.435MetMet: 0.435 ± 0.194
0.522MetAsn: 0.522 ± 0.21
0.609MetPro: 0.609 ± 0.25
0.522MetGln: 0.522 ± 0.222
2.003MetArg: 2.003 ± 0.472
0.871MetSer: 0.871 ± 0.287
0.174MetThr: 0.174 ± 0.121
1.654MetVal: 1.654 ± 0.331
0.261MetTrp: 0.261 ± 0.137
0.261MetTyr: 0.261 ± 0.133
0.0MetXaa: 0.0 ± 0.0
Asn
2.09AsnAla: 2.09 ± 0.526
0.174AsnCys: 0.174 ± 0.128
0.784AsnAsp: 0.784 ± 0.226
0.871AsnGlu: 0.871 ± 0.267
0.174AsnPhe: 0.174 ± 0.162
1.567AsnGly: 1.567 ± 0.367
0.435AsnHis: 0.435 ± 0.224
1.393AsnIle: 1.393 ± 0.326
0.435AsnLys: 0.435 ± 0.177
2.264AsnLeu: 2.264 ± 0.507
0.871AsnMet: 0.871 ± 0.25
0.784AsnAsn: 0.784 ± 0.3
1.567AsnPro: 1.567 ± 0.392
0.522AsnGln: 0.522 ± 0.219
1.219AsnArg: 1.219 ± 0.299
1.306AsnSer: 1.306 ± 0.425
1.045AsnThr: 1.045 ± 0.375
1.741AsnVal: 1.741 ± 0.357
0.087AsnTrp: 0.087 ± 0.081
1.132AsnTyr: 1.132 ± 0.296
0.0AsnXaa: 0.0 ± 0.0
Pro
4.876ProAla: 4.876 ± 0.923
0.522ProCys: 0.522 ± 0.189
2.525ProAsp: 2.525 ± 0.472
3.135ProGlu: 3.135 ± 0.43
1.48ProPhe: 1.48 ± 0.347
4.179ProGly: 4.179 ± 0.725
0.784ProHis: 0.784 ± 0.271
1.306ProIle: 1.306 ± 0.251
1.567ProLys: 1.567 ± 0.368
4.179ProLeu: 4.179 ± 0.725
0.435ProMet: 0.435 ± 0.21
0.784ProAsn: 0.784 ± 0.212
3.396ProPro: 3.396 ± 0.774
1.393ProGln: 1.393 ± 0.409
4.702ProArg: 4.702 ± 0.875
3.135ProSer: 3.135 ± 0.476
1.654ProThr: 1.654 ± 0.351
2.438ProVal: 2.438 ± 0.451
0.348ProTrp: 0.348 ± 0.181
2.525ProTyr: 2.525 ± 0.444
0.0ProXaa: 0.0 ± 0.0
Gln
2.09GlnAla: 2.09 ± 0.43
0.0GlnCys: 0.0 ± 0.0
0.958GlnAsp: 0.958 ± 0.331
1.219GlnGlu: 1.219 ± 0.366
0.784GlnPhe: 0.784 ± 0.233
1.306GlnGly: 1.306 ± 0.331
0.435GlnHis: 0.435 ± 0.194
0.871GlnIle: 0.871 ± 0.264
0.871GlnLys: 0.871 ± 0.285
3.047GlnLeu: 3.047 ± 0.536
0.348GlnMet: 0.348 ± 0.165
0.348GlnAsn: 0.348 ± 0.197
1.48GlnPro: 1.48 ± 0.454
0.784GlnGln: 0.784 ± 0.312
1.567GlnArg: 1.567 ± 0.388
1.132GlnSer: 1.132 ± 0.289
1.219GlnThr: 1.219 ± 0.4
1.567GlnVal: 1.567 ± 0.379
0.958GlnTrp: 0.958 ± 0.241
0.697GlnTyr: 0.697 ± 0.296
0.0GlnXaa: 0.0 ± 0.0
Arg
6.008ArgAla: 6.008 ± 0.843
0.522ArgCys: 0.522 ± 0.238
3.918ArgAsp: 3.918 ± 0.588
7.749ArgGlu: 7.749 ± 0.956
1.48ArgPhe: 1.48 ± 0.281
9.229ArgGly: 9.229 ± 1.222
1.567ArgHis: 1.567 ± 0.393
4.354ArgIle: 4.354 ± 0.663
2.96ArgLys: 2.96 ± 0.566
11.667ArgLeu: 11.667 ± 1.338
1.654ArgMet: 1.654 ± 0.423
1.219ArgAsn: 1.219 ± 0.329
3.396ArgPro: 3.396 ± 0.581
1.828ArgGln: 1.828 ± 0.394
11.319ArgArg: 11.319 ± 1.958
2.96ArgSer: 2.96 ± 0.58
2.873ArgThr: 2.873 ± 0.461
6.879ArgVal: 6.879 ± 0.868
1.654ArgTrp: 1.654 ± 0.412
2.699ArgTyr: 2.699 ± 0.454
0.0ArgXaa: 0.0 ± 0.0
Ser
5.398SerAla: 5.398 ± 0.855
0.261SerCys: 0.261 ± 0.151
2.264SerAsp: 2.264 ± 0.366
3.744SerGlu: 3.744 ± 0.725
2.351SerPhe: 2.351 ± 0.403
6.008SerGly: 6.008 ± 0.786
0.958SerHis: 0.958 ± 0.346
2.525SerIle: 2.525 ± 0.419
2.264SerLys: 2.264 ± 0.419
8.01SerLeu: 8.01 ± 0.623
1.828SerMet: 1.828 ± 0.453
1.567SerAsn: 1.567 ± 0.311
3.135SerPro: 3.135 ± 0.536
1.741SerGln: 1.741 ± 0.271
5.66SerArg: 5.66 ± 0.735
3.309SerSer: 3.309 ± 0.498
4.005SerThr: 4.005 ± 0.662
3.57SerVal: 3.57 ± 0.511
1.132SerTrp: 1.132 ± 0.407
2.873SerTyr: 2.873 ± 0.493
0.0SerXaa: 0.0 ± 0.0
Thr
3.396ThrAla: 3.396 ± 0.608
0.174ThrCys: 0.174 ± 0.11
1.741ThrAsp: 1.741 ± 0.435
2.09ThrGlu: 2.09 ± 0.35
1.045ThrPhe: 1.045 ± 0.3
4.005ThrGly: 4.005 ± 0.725
0.348ThrHis: 0.348 ± 0.164
1.916ThrIle: 1.916 ± 0.428
1.306ThrLys: 1.306 ± 0.411
6.008ThrLeu: 6.008 ± 0.698
0.609ThrMet: 0.609 ± 0.262
0.784ThrAsn: 0.784 ± 0.332
2.612ThrPro: 2.612 ± 0.46
0.871ThrGln: 0.871 ± 0.274
2.264ThrArg: 2.264 ± 0.516
2.612ThrSer: 2.612 ± 0.539
2.264ThrThr: 2.264 ± 0.627
4.266ThrVal: 4.266 ± 0.792
0.697ThrTrp: 0.697 ± 0.309
1.654ThrTyr: 1.654 ± 0.301
0.0ThrXaa: 0.0 ± 0.0
Val
7.662ValAla: 7.662 ± 1.02
0.522ValCys: 0.522 ± 0.218
4.528ValAsp: 4.528 ± 0.48
7.662ValGlu: 7.662 ± 0.865
3.309ValPhe: 3.309 ± 0.478
5.572ValGly: 5.572 ± 0.806
1.306ValHis: 1.306 ± 0.333
4.266ValIle: 4.266 ± 0.742
3.57ValLys: 3.57 ± 0.771
10.535ValLeu: 10.535 ± 1.173
1.916ValMet: 1.916 ± 0.462
1.567ValAsn: 1.567 ± 0.365
3.047ValPro: 3.047 ± 0.487
1.306ValGln: 1.306 ± 0.342
5.485ValArg: 5.485 ± 0.651
4.876ValSer: 4.876 ± 0.589
2.873ValThr: 2.873 ± 0.515
8.098ValVal: 8.098 ± 0.897
2.09ValTrp: 2.09 ± 0.421
5.05ValTyr: 5.05 ± 0.686
0.0ValXaa: 0.0 ± 0.0
Trp
1.045TrpAla: 1.045 ± 0.367
0.174TrpCys: 0.174 ± 0.127
1.48TrpAsp: 1.48 ± 0.44
1.916TrpGlu: 1.916 ± 0.402
0.522TrpPhe: 0.522 ± 0.199
1.741TrpGly: 1.741 ± 0.294
0.174TrpHis: 0.174 ± 0.127
0.261TrpIle: 0.261 ± 0.131
0.435TrpLys: 0.435 ± 0.174
2.177TrpLeu: 2.177 ± 0.582
0.435TrpMet: 0.435 ± 0.193
0.609TrpAsn: 0.609 ± 0.182
0.609TrpPro: 0.609 ± 0.216
0.435TrpGln: 0.435 ± 0.198
1.132TrpArg: 1.132 ± 0.308
1.48TrpSer: 1.48 ± 0.325
0.784TrpThr: 0.784 ± 0.244
1.567TrpVal: 1.567 ± 0.429
0.784TrpTrp: 0.784 ± 0.286
1.219TrpTyr: 1.219 ± 0.535
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.612TyrAla: 2.612 ± 0.411
0.174TyrCys: 0.174 ± 0.121
2.612TyrAsp: 2.612 ± 0.515
2.699TyrGlu: 2.699 ± 0.388
1.045TyrPhe: 1.045 ± 0.267
3.831TyrGly: 3.831 ± 0.522
0.609TyrHis: 0.609 ± 0.241
2.264TyrIle: 2.264 ± 0.511
2.96TyrLys: 2.96 ± 0.636
4.441TyrLeu: 4.441 ± 0.691
0.958TyrMet: 0.958 ± 0.325
0.697TyrAsn: 0.697 ± 0.255
2.177TyrPro: 2.177 ± 0.416
0.958TyrGln: 0.958 ± 0.317
3.396TyrArg: 3.396 ± 0.517
4.179TyrSer: 4.179 ± 0.622
2.351TyrThr: 2.351 ± 0.572
3.222TyrVal: 3.222 ± 0.523
1.306TyrTrp: 1.306 ± 0.496
1.741TyrTyr: 1.741 ± 0.496
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 53 proteins (11486 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski