Amino acid dipepetide frequency for Lysinibacillus antri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.267AlaAla: 5.267 ± 0.081
0.556AlaCys: 0.556 ± 0.025
3.142AlaAsp: 3.142 ± 0.054
4.517AlaGlu: 4.517 ± 0.067
3.256AlaPhe: 3.256 ± 0.063
4.726AlaGly: 4.726 ± 0.075
1.281AlaHis: 1.281 ± 0.031
6.539AlaIle: 6.539 ± 0.081
4.889AlaLys: 4.889 ± 0.079
7.046AlaLeu: 7.046 ± 0.082
1.978AlaMet: 1.978 ± 0.043
3.187AlaAsn: 3.187 ± 0.056
1.939AlaPro: 1.939 ± 0.037
2.47AlaGln: 2.47 ± 0.054
2.474AlaArg: 2.474 ± 0.051
4.036AlaSer: 4.036 ± 0.059
3.985AlaThr: 3.985 ± 0.069
4.742AlaVal: 4.742 ± 0.074
0.535AlaTrp: 0.535 ± 0.023
2.253AlaTyr: 2.253 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.465CysAla: 0.465 ± 0.022
0.101CysCys: 0.101 ± 0.009
0.389CysAsp: 0.389 ± 0.02
0.471CysGlu: 0.471 ± 0.024
0.302CysPhe: 0.302 ± 0.017
0.644CysGly: 0.644 ± 0.029
0.186CysHis: 0.186 ± 0.015
0.601CysIle: 0.601 ± 0.026
0.354CysLys: 0.354 ± 0.019
0.647CysLeu: 0.647 ± 0.024
0.161CysMet: 0.161 ± 0.011
0.298CysAsn: 0.298 ± 0.015
0.295CysPro: 0.295 ± 0.019
0.205CysGln: 0.205 ± 0.014
0.228CysArg: 0.228 ± 0.015
0.495CysSer: 0.495 ± 0.02
0.4CysThr: 0.4 ± 0.019
0.394CysVal: 0.394 ± 0.017
0.066CysTrp: 0.066 ± 0.007
0.248CysTyr: 0.248 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
3.422AspAla: 3.422 ± 0.059
0.387AspCys: 0.387 ± 0.019
2.439AspAsp: 2.439 ± 0.051
4.515AspGlu: 4.515 ± 0.081
2.477AspPhe: 2.477 ± 0.047
3.368AspGly: 3.368 ± 0.06
1.088AspHis: 1.088 ± 0.03
4.234AspIle: 4.234 ± 0.066
2.803AspLys: 2.803 ± 0.05
4.791AspLeu: 4.791 ± 0.072
1.235AspMet: 1.235 ± 0.032
1.906AspAsn: 1.906 ± 0.05
1.693AspPro: 1.693 ± 0.042
1.874AspGln: 1.874 ± 0.043
1.933AspArg: 1.933 ± 0.038
2.566AspSer: 2.566 ± 0.054
2.462AspThr: 2.462 ± 0.047
3.891AspVal: 3.891 ± 0.059
0.538AspTrp: 0.538 ± 0.022
2.185AspTyr: 2.185 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
5.236GluAla: 5.236 ± 0.081
0.364GluCys: 0.364 ± 0.02
3.782GluAsp: 3.782 ± 0.059
7.26GluGlu: 7.26 ± 0.1
2.696GluPhe: 2.696 ± 0.048
4.077GluGly: 4.077 ± 0.067
1.554GluHis: 1.554 ± 0.04
6.141GluIle: 6.141 ± 0.074
6.354GluLys: 6.354 ± 0.09
7.24GluLeu: 7.24 ± 0.094
2.289GluMet: 2.289 ± 0.042
3.936GluAsn: 3.936 ± 0.063
1.933GluPro: 1.933 ± 0.047
3.94GluGln: 3.94 ± 0.086
3.367GluArg: 3.367 ± 0.061
3.672GluSer: 3.672 ± 0.063
3.982GluThr: 3.982 ± 0.068
5.5GluVal: 5.5 ± 0.073
0.74GluTrp: 0.74 ± 0.023
2.227GluTyr: 2.227 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.114PheAla: 3.114 ± 0.065
0.367PheCys: 0.367 ± 0.017
2.424PheAsp: 2.424 ± 0.051
3.276PheGlu: 3.276 ± 0.062
2.246PhePhe: 2.246 ± 0.052
3.257PheGly: 3.257 ± 0.057
1.004PheHis: 1.004 ± 0.033
4.295PheIle: 4.295 ± 0.081
2.595PheLys: 2.595 ± 0.05
4.312PheLeu: 4.312 ± 0.077
1.128PheMet: 1.128 ± 0.034
2.204PheAsn: 2.204 ± 0.046
1.523PhePro: 1.523 ± 0.037
1.564PheGln: 1.564 ± 0.042
1.456PheArg: 1.456 ± 0.034
3.179PheSer: 3.179 ± 0.06
2.792PheThr: 2.792 ± 0.055
3.284PheVal: 3.284 ± 0.058
0.463PheTrp: 0.463 ± 0.021
1.748PheTyr: 1.748 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
4.576GlyAla: 4.576 ± 0.082
0.514GlyCys: 0.514 ± 0.024
3.095GlyAsp: 3.095 ± 0.049
4.44GlyGlu: 4.44 ± 0.081
3.207GlyPhe: 3.207 ± 0.057
4.384GlyGly: 4.384 ± 0.084
1.3GlyHis: 1.3 ± 0.04
5.694GlyIle: 5.694 ± 0.08
4.679GlyLys: 4.679 ± 0.072
6.157GlyLeu: 6.157 ± 0.087
1.839GlyMet: 1.839 ± 0.044
2.862GlyAsn: 2.862 ± 0.053
1.538GlyPro: 1.538 ± 0.038
2.185GlyGln: 2.185 ± 0.051
2.395GlyArg: 2.395 ± 0.051
3.679GlySer: 3.679 ± 0.051
3.855GlyThr: 3.855 ± 0.066
4.898GlyVal: 4.898 ± 0.077
0.698GlyTrp: 0.698 ± 0.025
2.649GlyTyr: 2.649 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.277HisAla: 1.277 ± 0.035
0.189HisCys: 0.189 ± 0.014
0.953HisAsp: 0.953 ± 0.032
1.359HisGlu: 1.359 ± 0.035
1.06HisPhe: 1.06 ± 0.03
1.317HisGly: 1.317 ± 0.031
0.653HisHis: 0.653 ± 0.029
1.646HisIle: 1.646 ± 0.039
1.003HisLys: 1.003 ± 0.032
2.083HisLeu: 2.083 ± 0.047
0.492HisMet: 0.492 ± 0.02
0.863HisAsn: 0.863 ± 0.028
1.106HisPro: 1.106 ± 0.037
0.829HisGln: 0.829 ± 0.027
0.756HisArg: 0.756 ± 0.029
1.2HisSer: 1.2 ± 0.034
1.064HisThr: 1.064 ± 0.03
1.388HisVal: 1.388 ± 0.038
0.21HisTrp: 0.21 ± 0.016
0.877HisTyr: 0.877 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.467IleAla: 6.467 ± 0.081
0.636IleCys: 0.636 ± 0.022
4.708IleAsp: 4.708 ± 0.073
6.665IleGlu: 6.665 ± 0.079
3.617IlePhe: 3.617 ± 0.069
5.964IleGly: 5.964 ± 0.081
1.804IleHis: 1.804 ± 0.04
6.506IleIle: 6.506 ± 0.087
4.649IleLys: 4.649 ± 0.067
7.532IleLeu: 7.532 ± 0.105
1.798IleMet: 1.798 ± 0.047
3.645IleAsn: 3.645 ± 0.065
3.285IlePro: 3.285 ± 0.047
3.419IleGln: 3.419 ± 0.069
3.094IleArg: 3.094 ± 0.049
5.371IleSer: 5.371 ± 0.077
4.809IleThr: 4.809 ± 0.077
6.267IleVal: 6.267 ± 0.09
0.658IleTrp: 0.658 ± 0.025
2.652IleTyr: 2.652 ± 0.052
0.0IleXaa: 0.0 ± 0.0
Lys
4.323LysAla: 4.323 ± 0.067
0.36LysCys: 0.36 ± 0.02
3.544LysAsp: 3.544 ± 0.064
6.544LysGlu: 6.544 ± 0.081
2.29LysPhe: 2.29 ± 0.047
4.118LysGly: 4.118 ± 0.063
1.27LysHis: 1.27 ± 0.038
5.025LysIle: 5.025 ± 0.066
5.441LysLys: 5.441 ± 0.076
6.103LysLeu: 6.103 ± 0.085
2.178LysMet: 2.178 ± 0.039
3.609LysAsn: 3.609 ± 0.064
2.108LysPro: 2.108 ± 0.044
3.101LysGln: 3.101 ± 0.053
3.122LysArg: 3.122 ± 0.051
3.73LysSer: 3.73 ± 0.059
3.551LysThr: 3.551 ± 0.06
4.688LysVal: 4.688 ± 0.062
0.803LysTrp: 0.803 ± 0.024
2.213LysTyr: 2.213 ± 0.046
0.0LysXaa: 0.0 ± 0.0
Leu
7.245LeuAla: 7.245 ± 0.093
0.653LeuCys: 0.653 ± 0.027
4.648LeuAsp: 4.648 ± 0.071
6.68LeuGlu: 6.68 ± 0.095
4.881LeuPhe: 4.881 ± 0.087
5.916LeuGly: 5.916 ± 0.08
1.949LeuHis: 1.949 ± 0.046
7.458LeuIle: 7.458 ± 0.108
6.736LeuLys: 6.736 ± 0.089
10.091LeuLeu: 10.091 ± 0.128
2.426LeuMet: 2.426 ± 0.046
4.679LeuAsn: 4.679 ± 0.062
3.748LeuPro: 3.748 ± 0.056
3.847LeuGln: 3.847 ± 0.066
3.458LeuArg: 3.458 ± 0.058
6.629LeuSer: 6.629 ± 0.082
5.791LeuThr: 5.791 ± 0.074
6.324LeuVal: 6.324 ± 0.08
0.723LeuTrp: 0.723 ± 0.026
3.132LeuTyr: 3.132 ± 0.058
0.0LeuXaa: 0.0 ± 0.0
Met
1.81MetAla: 1.81 ± 0.044
0.166MetCys: 0.166 ± 0.019
1.457MetAsp: 1.457 ± 0.036
1.879MetGlu: 1.879 ± 0.044
1.064MetPhe: 1.064 ± 0.031
1.601MetGly: 1.601 ± 0.04
0.446MetHis: 0.446 ± 0.021
2.06MetIle: 2.06 ± 0.039
2.39MetLys: 2.39 ± 0.046
2.443MetLeu: 2.443 ± 0.048
0.811MetMet: 0.811 ± 0.03
1.569MetAsn: 1.569 ± 0.037
0.962MetPro: 0.962 ± 0.034
0.969MetGln: 0.969 ± 0.028
1.09MetArg: 1.09 ± 0.032
1.616MetSer: 1.616 ± 0.034
1.686MetThr: 1.686 ± 0.04
1.608MetVal: 1.608 ± 0.04
0.179MetTrp: 0.179 ± 0.012
0.768MetTyr: 0.768 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.279AsnAla: 3.279 ± 0.055
0.345AsnCys: 0.345 ± 0.019
2.394AsnAsp: 2.394 ± 0.048
4.078AsnGlu: 4.078 ± 0.066
1.964AsnPhe: 1.964 ± 0.047
3.486AsnGly: 3.486 ± 0.061
1.02AsnHis: 1.02 ± 0.028
3.82AsnIle: 3.82 ± 0.063
3.149AsnLys: 3.149 ± 0.056
4.365AsnLeu: 4.365 ± 0.065
1.234AsnMet: 1.234 ± 0.034
2.463AsnAsn: 2.463 ± 0.068
2.116AsnPro: 2.116 ± 0.05
1.976AsnGln: 1.976 ± 0.048
2.081AsnArg: 2.081 ± 0.049
2.648AsnSer: 2.648 ± 0.057
2.451AsnThr: 2.451 ± 0.049
3.318AsnVal: 3.318 ± 0.059
0.503AsnTrp: 0.503 ± 0.02
1.848AsnTyr: 1.848 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
1.994ProAla: 1.994 ± 0.044
0.201ProCys: 0.201 ± 0.015
1.674ProAsp: 1.674 ± 0.041
2.637ProGlu: 2.637 ± 0.049
1.977ProPhe: 1.977 ± 0.044
1.963ProGly: 1.963 ± 0.049
0.76ProHis: 0.76 ± 0.03
3.181ProIle: 3.181 ± 0.054
2.213ProLys: 2.213 ± 0.047
3.259ProLeu: 3.259 ± 0.055
0.763ProMet: 0.763 ± 0.026
1.823ProAsn: 1.823 ± 0.044
0.946ProPro: 0.946 ± 0.035
1.159ProGln: 1.159 ± 0.033
0.955ProArg: 0.955 ± 0.03
2.18ProSer: 2.18 ± 0.05
2.241ProThr: 2.241 ± 0.045
2.51ProVal: 2.51 ± 0.048
0.323ProTrp: 0.323 ± 0.018
1.35ProTyr: 1.35 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
2.638GlnAla: 2.638 ± 0.053
0.21GlnCys: 0.21 ± 0.017
1.643GlnAsp: 1.643 ± 0.042
2.79GlnGlu: 2.79 ± 0.057
1.926GlnPhe: 1.926 ± 0.043
2.011GlnGly: 2.011 ± 0.044
0.858GlnHis: 0.858 ± 0.025
3.033GlnIle: 3.033 ± 0.06
2.62GlnLys: 2.62 ± 0.051
4.533GlnLeu: 4.533 ± 0.083
1.19GlnMet: 1.19 ± 0.036
1.948GlnAsn: 1.948 ± 0.041
1.218GlnPro: 1.218 ± 0.033
2.121GlnGln: 2.121 ± 0.062
1.332GlnArg: 1.332 ± 0.038
2.379GlnSer: 2.379 ± 0.049
2.211GlnThr: 2.211 ± 0.046
2.545GlnVal: 2.545 ± 0.05
0.401GlnTrp: 0.401 ± 0.019
1.546GlnTyr: 1.546 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
2.461ArgAla: 2.461 ± 0.055
0.235ArgCys: 0.235 ± 0.015
1.933ArgAsp: 1.933 ± 0.043
2.978ArgGlu: 2.978 ± 0.056
1.863ArgPhe: 1.863 ± 0.037
2.165ArgGly: 2.165 ± 0.047
0.739ArgHis: 0.739 ± 0.024
3.042ArgIle: 3.042 ± 0.06
3.03ArgLys: 3.03 ± 0.053
3.67ArgLeu: 3.67 ± 0.064
1.136ArgMet: 1.136 ± 0.031
2.006ArgAsn: 2.006 ± 0.041
1.224ArgPro: 1.224 ± 0.038
1.488ArgGln: 1.488 ± 0.038
1.615ArgArg: 1.615 ± 0.043
2.03ArgSer: 2.03 ± 0.04
1.951ArgThr: 1.951 ± 0.048
2.505ArgVal: 2.505 ± 0.054
0.372ArgTrp: 0.372 ± 0.017
1.407ArgTyr: 1.407 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
3.612SerAla: 3.612 ± 0.058
0.364SerCys: 0.364 ± 0.02
2.682SerAsp: 2.682 ± 0.046
3.927SerGlu: 3.927 ± 0.073
3.26SerPhe: 3.26 ± 0.06
3.999SerGly: 3.999 ± 0.054
1.122SerHis: 1.122 ± 0.032
5.66SerIle: 5.66 ± 0.08
4.119SerLys: 4.119 ± 0.062
5.978SerLeu: 5.978 ± 0.086
1.671SerMet: 1.671 ± 0.034
3.081SerAsn: 3.081 ± 0.055
2.022SerPro: 2.022 ± 0.044
2.061SerGln: 2.061 ± 0.046
2.097SerArg: 2.097 ± 0.044
4.026SerSer: 4.026 ± 0.084
3.553SerThr: 3.553 ± 0.072
3.989SerVal: 3.989 ± 0.06
0.552SerTrp: 0.552 ± 0.026
2.241SerTyr: 2.241 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
3.703ThrAla: 3.703 ± 0.068
0.348ThrCys: 0.348 ± 0.019
2.781ThrAsp: 2.781 ± 0.052
3.716ThrGlu: 3.716 ± 0.07
2.783ThrPhe: 2.783 ± 0.057
3.955ThrGly: 3.955 ± 0.073
1.027ThrHis: 1.027 ± 0.03
5.272ThrIle: 5.272 ± 0.074
3.729ThrLys: 3.729 ± 0.069
5.374ThrLeu: 5.374 ± 0.07
1.357ThrMet: 1.357 ± 0.037
2.947ThrAsn: 2.947 ± 0.049
2.354ThrPro: 2.354 ± 0.049
1.682ThrGln: 1.682 ± 0.039
1.836ThrArg: 1.836 ± 0.043
3.436ThrSer: 3.436 ± 0.059
3.488ThrThr: 3.488 ± 0.068
4.395ThrVal: 4.395 ± 0.067
0.5ThrTrp: 0.5 ± 0.021
2.056ThrTyr: 2.056 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
5.212ValAla: 5.212 ± 0.073
0.574ValCys: 0.574 ± 0.022
3.679ValAsp: 3.679 ± 0.063
5.285ValGlu: 5.285 ± 0.071
2.99ValPhe: 2.99 ± 0.058
4.685ValGly: 4.685 ± 0.07
1.327ValHis: 1.327 ± 0.035
5.805ValIle: 5.805 ± 0.072
4.646ValLys: 4.646 ± 0.069
6.805ValLeu: 6.805 ± 0.086
1.772ValMet: 1.772 ± 0.042
3.357ValAsn: 3.357 ± 0.059
2.547ValPro: 2.547 ± 0.056
2.504ValGln: 2.504 ± 0.052
2.692ValArg: 2.692 ± 0.052
4.447ValSer: 4.447 ± 0.065
4.151ValThr: 4.151 ± 0.079
5.435ValVal: 5.435 ± 0.091
0.564ValTrp: 0.564 ± 0.023
2.173ValTyr: 2.173 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
0.537TrpAla: 0.537 ± 0.02
0.084TrpCys: 0.084 ± 0.009
0.468TrpAsp: 0.468 ± 0.022
0.594TrpGlu: 0.594 ± 0.026
0.451TrpPhe: 0.451 ± 0.021
0.67TrpGly: 0.67 ± 0.028
0.196TrpHis: 0.196 ± 0.012
0.812TrpIle: 0.812 ± 0.029
0.615TrpLys: 0.615 ± 0.027
1.041TrpLeu: 1.041 ± 0.033
0.285TrpMet: 0.285 ± 0.015
0.507TrpAsn: 0.507 ± 0.021
0.23TrpPro: 0.23 ± 0.015
0.381TrpGln: 0.381 ± 0.016
0.339TrpArg: 0.339 ± 0.016
0.55TrpSer: 0.55 ± 0.02
0.468TrpThr: 0.468 ± 0.023
0.625TrpVal: 0.625 ± 0.026
0.121TrpTrp: 0.121 ± 0.011
0.323TrpTyr: 0.323 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.179TyrAla: 2.179 ± 0.044
0.297TyrCys: 0.297 ± 0.018
1.972TyrAsp: 1.972 ± 0.052
2.68TyrGlu: 2.68 ± 0.051
1.92TyrPhe: 1.92 ± 0.044
2.338TyrGly: 2.338 ± 0.047
0.742TyrHis: 0.742 ± 0.026
2.723TyrIle: 2.723 ± 0.047
2.108TyrLys: 2.108 ± 0.048
3.544TyrLeu: 3.544 ± 0.062
0.829TyrMet: 0.829 ± 0.028
1.65TyrAsn: 1.65 ± 0.038
1.321TyrPro: 1.321 ± 0.031
1.379TyrGln: 1.379 ± 0.036
1.528TyrArg: 1.528 ± 0.037
2.15TyrSer: 2.15 ± 0.049
1.846TyrThr: 1.846 ± 0.041
2.344TyrVal: 2.344 ± 0.045
0.347TyrTrp: 0.347 ± 0.017
1.429TyrTyr: 1.429 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3826 proteins (1143930 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski