Amino acid dipepetide frequency for Lactobacillus kimchicus JCM 15530

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.375AlaAla: 9.375 ± 0.228
0.382AlaCys: 0.382 ± 0.022
5.742AlaAsp: 5.742 ± 0.09
4.64AlaGlu: 4.64 ± 0.09
3.822AlaPhe: 3.822 ± 0.081
7.009AlaGly: 7.009 ± 0.108
1.852AlaHis: 1.852 ± 0.048
6.331AlaIle: 6.331 ± 0.108
5.302AlaLys: 5.302 ± 0.095
8.981AlaLeu: 8.981 ± 0.139
2.481AlaMet: 2.481 ± 0.068
4.038AlaAsn: 4.038 ± 0.08
2.875AlaPro: 2.875 ± 0.066
3.954AlaGln: 3.954 ± 0.077
3.156AlaArg: 3.156 ± 0.068
5.255AlaSer: 5.255 ± 0.251
6.55AlaThr: 6.55 ± 0.113
7.121AlaVal: 7.121 ± 0.113
0.786AlaTrp: 0.786 ± 0.033
2.829AlaTyr: 2.829 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.302CysAla: 0.302 ± 0.019
0.038CysCys: 0.038 ± 0.007
0.227CysAsp: 0.227 ± 0.016
0.174CysGlu: 0.174 ± 0.015
0.196CysPhe: 0.196 ± 0.017
0.396CysGly: 0.396 ± 0.021
0.115CysHis: 0.115 ± 0.013
0.213CysIle: 0.213 ± 0.016
0.077CysLys: 0.077 ± 0.01
0.425CysLeu: 0.425 ± 0.024
0.082CysMet: 0.082 ± 0.01
0.127CysAsn: 0.127 ± 0.011
0.171CysPro: 0.171 ± 0.019
0.155CysGln: 0.155 ± 0.019
0.166CysArg: 0.166 ± 0.016
0.197CysSer: 0.197 ± 0.017
0.19CysThr: 0.19 ± 0.013
0.271CysVal: 0.271 ± 0.021
0.058CysTrp: 0.058 ± 0.01
0.165CysTyr: 0.165 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
4.849AspAla: 4.849 ± 0.075
0.229AspCys: 0.229 ± 0.02
3.823AspAsp: 3.823 ± 0.101
3.591AspGlu: 3.591 ± 0.08
2.585AspPhe: 2.585 ± 0.051
4.031AspGly: 4.031 ± 0.095
1.585AspHis: 1.585 ± 0.052
3.24AspIle: 3.24 ± 0.071
2.783AspLys: 2.783 ± 0.064
5.606AspLeu: 5.606 ± 0.1
1.489AspMet: 1.489 ± 0.052
2.295AspAsn: 2.295 ± 0.058
2.453AspPro: 2.453 ± 0.064
3.309AspGln: 3.309 ± 0.077
2.869AspArg: 2.869 ± 0.061
2.982AspSer: 2.982 ± 0.067
2.968AspThr: 2.968 ± 0.058
4.226AspVal: 4.226 ± 0.078
0.836AspTrp: 0.836 ± 0.035
2.469AspTyr: 2.469 ± 0.057
0.0AspXaa: 0.0 ± 0.0
Glu
4.946GluAla: 4.946 ± 0.094
0.127GluCys: 0.127 ± 0.012
2.486GluAsp: 2.486 ± 0.067
2.57GluGlu: 2.57 ± 0.07
1.795GluPhe: 1.795 ± 0.053
2.62GluGly: 2.62 ± 0.064
0.952GluHis: 0.952 ± 0.039
3.396GluIle: 3.396 ± 0.07
3.242GluLys: 3.242 ± 0.073
5.174GluLeu: 5.174 ± 0.073
1.656GluMet: 1.656 ± 0.05
2.389GluAsn: 2.389 ± 0.057
1.801GluPro: 1.801 ± 0.056
2.341GluGln: 2.341 ± 0.06
2.489GluArg: 2.489 ± 0.056
2.646GluSer: 2.646 ± 0.065
3.726GluThr: 3.726 ± 0.07
3.465GluVal: 3.465 ± 0.084
0.517GluTrp: 0.517 ± 0.027
1.315GluTyr: 1.315 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
3.299PheAla: 3.299 ± 0.076
0.209PheCys: 0.209 ± 0.017
3.003PheAsp: 3.003 ± 0.064
2.277PheGlu: 2.277 ± 0.059
1.848PhePhe: 1.848 ± 0.061
3.442PheGly: 3.442 ± 0.079
0.795PheHis: 0.795 ± 0.034
2.613PheIle: 2.613 ± 0.058
2.373PheLys: 2.373 ± 0.054
3.799PheLeu: 3.799 ± 0.109
1.049PheMet: 1.049 ± 0.039
2.165PheAsn: 2.165 ± 0.054
1.446PhePro: 1.446 ± 0.048
1.489PheGln: 1.489 ± 0.048
1.423PheArg: 1.423 ± 0.045
3.018PheSer: 3.018 ± 0.065
2.461PheThr: 2.461 ± 0.059
3.149PheVal: 3.149 ± 0.072
0.586PheTrp: 0.586 ± 0.027
1.535PheTyr: 1.535 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
5.763GlyAla: 5.763 ± 0.11
0.321GlyCys: 0.321 ± 0.02
3.878GlyAsp: 3.878 ± 0.075
3.31GlyGlu: 3.31 ± 0.07
3.379GlyPhe: 3.379 ± 0.07
4.931GlyGly: 4.931 ± 0.097
1.833GlyHis: 1.833 ± 0.048
5.067GlyIle: 5.067 ± 0.088
3.741GlyLys: 3.741 ± 0.075
7.809GlyLeu: 7.809 ± 0.193
1.93GlyMet: 1.93 ± 0.053
2.839GlyAsn: 2.839 ± 0.074
1.959GlyPro: 1.959 ± 0.052
3.469GlyGln: 3.469 ± 0.081
3.124GlyArg: 3.124 ± 0.069
4.006GlySer: 4.006 ± 0.088
4.652GlyThr: 4.652 ± 0.087
5.563GlyVal: 5.563 ± 0.088
0.904GlyTrp: 0.904 ± 0.038
2.744GlyTyr: 2.744 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
1.533HisAla: 1.533 ± 0.049
0.104HisCys: 0.104 ± 0.012
1.363HisAsp: 1.363 ± 0.045
1.126HisGlu: 1.126 ± 0.041
1.145HisPhe: 1.145 ± 0.042
1.623HisGly: 1.623 ± 0.046
0.775HisHis: 0.775 ± 0.038
1.127HisIle: 1.127 ± 0.044
0.78HisLys: 0.78 ± 0.03
2.206HisLeu: 2.206 ± 0.056
0.536HisMet: 0.536 ± 0.025
0.802HisAsn: 0.802 ± 0.034
1.149HisPro: 1.149 ± 0.042
1.253HisGln: 1.253 ± 0.045
1.119HisArg: 1.119 ± 0.04
1.085HisSer: 1.085 ± 0.044
1.076HisThr: 1.076 ± 0.04
1.658HisVal: 1.658 ± 0.048
0.279HisTrp: 0.279 ± 0.021
0.977HisTyr: 0.977 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
6.153IleAla: 6.153 ± 0.11
0.332IleCys: 0.332 ± 0.021
3.939IleAsp: 3.939 ± 0.079
3.475IleGlu: 3.475 ± 0.085
2.551IlePhe: 2.551 ± 0.077
5.278IleGly: 5.278 ± 0.102
1.219IleHis: 1.219 ± 0.037
4.025IleIle: 4.025 ± 0.082
3.488IleLys: 3.488 ± 0.069
5.648IleLeu: 5.648 ± 0.111
1.497IleMet: 1.497 ± 0.047
2.971IleAsn: 2.971 ± 0.069
2.553IlePro: 2.553 ± 0.059
2.477IleGln: 2.477 ± 0.057
2.511IleArg: 2.511 ± 0.06
4.278IleSer: 4.278 ± 0.077
3.884IleThr: 3.884 ± 0.077
4.838IleVal: 4.838 ± 0.088
0.678IleTrp: 0.678 ± 0.032
1.77IleTyr: 1.77 ± 0.05
0.0IleXaa: 0.0 ± 0.0
Lys
5.055LysAla: 5.055 ± 0.101
0.108LysCys: 0.108 ± 0.013
2.809LysAsp: 2.809 ± 0.068
2.503LysGlu: 2.503 ± 0.061
1.559LysPhe: 1.559 ± 0.045
3.079LysGly: 3.079 ± 0.078
1.064LysHis: 1.064 ± 0.037
3.194LysIle: 3.194 ± 0.077
3.665LysLys: 3.665 ± 0.094
4.945LysLeu: 4.945 ± 0.091
1.905LysMet: 1.905 ± 0.047
2.515LysAsn: 2.515 ± 0.065
2.179LysPro: 2.179 ± 0.069
2.947LysGln: 2.947 ± 0.074
2.941LysArg: 2.941 ± 0.07
2.909LysSer: 2.909 ± 0.075
4.093LysThr: 4.093 ± 0.075
3.755LysVal: 3.755 ± 0.075
0.606LysTrp: 0.606 ± 0.031
1.736LysTyr: 1.736 ± 0.048
0.0LysXaa: 0.0 ± 0.0
Leu
9.984LeuAla: 9.984 ± 0.156
0.393LeuCys: 0.393 ± 0.022
5.316LeuAsp: 5.316 ± 0.086
4.052LeuGlu: 4.052 ± 0.074
4.209LeuPhe: 4.209 ± 0.097
7.262LeuGly: 7.262 ± 0.187
1.721LeuHis: 1.721 ± 0.044
6.706LeuIle: 6.706 ± 0.103
5.713LeuLys: 5.713 ± 0.086
9.621LeuLeu: 9.621 ± 0.389
2.778LeuMet: 2.778 ± 0.062
4.555LeuAsn: 4.555 ± 0.089
4.421LeuPro: 4.421 ± 0.18
3.592LeuGln: 3.592 ± 0.068
3.782LeuArg: 3.782 ± 0.077
6.521LeuSer: 6.521 ± 0.101
7.793LeuThr: 7.793 ± 0.102
7.125LeuVal: 7.125 ± 0.095
0.841LeuTrp: 0.841 ± 0.038
2.588LeuTyr: 2.588 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
3.02MetAla: 3.02 ± 0.071
0.088MetCys: 0.088 ± 0.012
1.285MetAsp: 1.285 ± 0.043
0.984MetGlu: 0.984 ± 0.038
0.949MetPhe: 0.949 ± 0.034
1.971MetGly: 1.971 ± 0.053
0.432MetHis: 0.432 ± 0.026
1.826MetIle: 1.826 ± 0.053
1.651MetLys: 1.651 ± 0.043
2.242MetLeu: 2.242 ± 0.057
0.96MetMet: 0.96 ± 0.043
1.251MetAsn: 1.251 ± 0.039
1.103MetPro: 1.103 ± 0.042
1.068MetGln: 1.068 ± 0.042
1.089MetArg: 1.089 ± 0.032
1.602MetSer: 1.602 ± 0.051
2.416MetThr: 2.416 ± 0.058
2.144MetVal: 2.144 ± 0.061
0.204MetTrp: 0.204 ± 0.017
0.582MetTyr: 0.582 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.793AsnAla: 3.793 ± 0.068
0.157AsnCys: 0.157 ± 0.015
2.585AsnAsp: 2.585 ± 0.068
2.214AsnGlu: 2.214 ± 0.065
1.741AsnPhe: 1.741 ± 0.046
3.535AsnGly: 3.535 ± 0.075
1.218AsnHis: 1.218 ± 0.04
2.277AsnIle: 2.277 ± 0.066
2.036AsnLys: 2.036 ± 0.058
3.93AsnLeu: 3.93 ± 0.076
1.15AsnMet: 1.15 ± 0.036
1.814AsnAsn: 1.814 ± 0.055
2.141AsnPro: 2.141 ± 0.057
2.609AsnGln: 2.609 ± 0.065
2.311AsnArg: 2.311 ± 0.06
2.196AsnSer: 2.196 ± 0.066
2.295AsnThr: 2.295 ± 0.063
3.153AsnVal: 3.153 ± 0.068
0.594AsnTrp: 0.594 ± 0.031
1.573AsnTyr: 1.573 ± 0.052
0.0AsnXaa: 0.0 ± 0.0
Pro
3.639ProAla: 3.639 ± 0.074
0.088ProCys: 0.088 ± 0.012
2.542ProAsp: 2.542 ± 0.064
2.735ProGlu: 2.735 ± 0.061
1.758ProPhe: 1.758 ± 0.055
2.474ProGly: 2.474 ± 0.055
0.725ProHis: 0.725 ± 0.036
2.661ProIle: 2.661 ± 0.053
2.242ProLys: 2.242 ± 0.056
3.715ProLeu: 3.715 ± 0.144
0.857ProMet: 0.857 ± 0.032
1.755ProAsn: 1.755 ± 0.048
0.686ProPro: 0.686 ± 0.036
1.544ProGln: 1.544 ± 0.044
1.262ProArg: 1.262 ± 0.045
2.179ProSer: 2.179 ± 0.061
2.945ProThr: 2.945 ± 0.072
3.311ProVal: 3.311 ± 0.071
0.371ProTrp: 0.371 ± 0.022
1.266ProTyr: 1.266 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
4.626GlnAla: 4.626 ± 0.094
0.108GlnCys: 0.108 ± 0.013
2.099GlnAsp: 2.099 ± 0.053
2.103GlnGlu: 2.103 ± 0.049
1.998GlnPhe: 1.998 ± 0.052
2.261GlnGly: 2.261 ± 0.055
1.022GlnHis: 1.022 ± 0.038
2.785GlnIle: 2.785 ± 0.065
2.461GlnLys: 2.461 ± 0.066
5.73GlnLeu: 5.73 ± 0.109
1.174GlnMet: 1.174 ± 0.046
1.921GlnAsn: 1.921 ± 0.052
1.961GlnPro: 1.961 ± 0.045
2.659GlnGln: 2.659 ± 0.076
2.327GlnArg: 2.327 ± 0.063
2.794GlnSer: 2.794 ± 0.064
3.217GlnThr: 3.217 ± 0.079
3.403GlnVal: 3.403 ± 0.073
0.467GlnTrp: 0.467 ± 0.023
1.538GlnTyr: 1.538 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
3.306ArgAla: 3.306 ± 0.08
0.126ArgCys: 0.126 ± 0.014
2.454ArgAsp: 2.454 ± 0.066
2.369ArgGlu: 2.369 ± 0.061
2.141ArgPhe: 2.141 ± 0.056
2.558ArgGly: 2.558 ± 0.06
1.172ArgHis: 1.172 ± 0.038
2.734ArgIle: 2.734 ± 0.074
1.98ArgLys: 1.98 ± 0.051
4.779ArgLeu: 4.779 ± 0.078
1.173ArgMet: 1.173 ± 0.039
1.693ArgAsn: 1.693 ± 0.044
1.737ArgPro: 1.737 ± 0.042
2.777ArgGln: 2.777 ± 0.068
2.329ArgArg: 2.329 ± 0.055
2.191ArgSer: 2.191 ± 0.065
2.238ArgThr: 2.238 ± 0.058
3.195ArgVal: 3.195 ± 0.069
0.432ArgTrp: 0.432 ± 0.026
1.759ArgTyr: 1.759 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
5.175SerAla: 5.175 ± 0.135
0.193SerCys: 0.193 ± 0.017
3.63SerAsp: 3.63 ± 0.077
3.021SerGlu: 3.021 ± 0.07
2.584SerPhe: 2.584 ± 0.061
4.924SerGly: 4.924 ± 0.087
1.339SerHis: 1.339 ± 0.04
3.329SerIle: 3.329 ± 0.081
2.971SerLys: 2.971 ± 0.07
5.657SerLeu: 5.657 ± 0.092
1.533SerMet: 1.533 ± 0.046
2.331SerAsn: 2.331 ± 0.066
2.038SerPro: 2.038 ± 0.054
2.96SerGln: 2.96 ± 0.07
2.667SerArg: 2.667 ± 0.067
3.626SerSer: 3.626 ± 0.117
3.708SerThr: 3.708 ± 0.1
4.39SerVal: 4.39 ± 0.086
0.611SerTrp: 0.611 ± 0.029
1.92SerTyr: 1.92 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
6.408ThrAla: 6.408 ± 0.122
0.223ThrCys: 0.223 ± 0.019
4.023ThrAsp: 4.023 ± 0.081
3.045ThrGlu: 3.045 ± 0.066
2.717ThrPhe: 2.717 ± 0.056
5.22ThrGly: 5.22 ± 0.09
1.432ThrHis: 1.432 ± 0.043
4.672ThrIle: 4.672 ± 0.087
3.319ThrLys: 3.319 ± 0.072
6.562ThrLeu: 6.562 ± 0.1
1.565ThrMet: 1.565 ± 0.046
2.747ThrAsn: 2.747 ± 0.067
3.283ThrPro: 3.283 ± 0.078
2.715ThrGln: 2.715 ± 0.06
2.393ThrArg: 2.393 ± 0.06
3.766ThrSer: 3.766 ± 0.08
5.193ThrThr: 5.193 ± 0.136
5.809ThrVal: 5.809 ± 0.1
0.675ThrTrp: 0.675 ± 0.031
2.099ThrTyr: 2.099 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
7.875ValAla: 7.875 ± 0.126
0.354ValCys: 0.354 ± 0.021
4.46ValAsp: 4.46 ± 0.077
3.422ValGlu: 3.422 ± 0.075
2.866ValPhe: 2.866 ± 0.072
5.485ValGly: 5.485 ± 0.084
1.299ValHis: 1.299 ± 0.043
5.113ValIle: 5.113 ± 0.096
4.079ValLys: 4.079 ± 0.073
7.063ValLeu: 7.063 ± 0.112
2.056ValMet: 2.056 ± 0.061
3.294ValAsn: 3.294 ± 0.063
3.101ValPro: 3.101 ± 0.064
2.609ValGln: 2.609 ± 0.066
2.719ValArg: 2.719 ± 0.062
4.916ValSer: 4.916 ± 0.072
5.979ValThr: 5.979 ± 0.103
6.331ValVal: 6.331 ± 0.091
0.692ValTrp: 0.692 ± 0.032
2.261ValTyr: 2.261 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.775TrpAla: 0.775 ± 0.036
0.042TrpCys: 0.042 ± 0.008
0.533TrpAsp: 0.533 ± 0.029
0.409TrpGlu: 0.409 ± 0.023
0.531TrpPhe: 0.531 ± 0.031
0.698TrpGly: 0.698 ± 0.031
0.321TrpHis: 0.321 ± 0.021
0.664TrpIle: 0.664 ± 0.031
0.309TrpLys: 0.309 ± 0.021
1.565TrpLeu: 1.565 ± 0.054
0.258TrpMet: 0.258 ± 0.018
0.42TrpAsn: 0.42 ± 0.025
0.396TrpPro: 0.396 ± 0.024
0.73TrpGln: 0.73 ± 0.036
0.633TrpArg: 0.633 ± 0.031
0.63TrpSer: 0.63 ± 0.03
0.576TrpThr: 0.576 ± 0.03
0.757TrpVal: 0.757 ± 0.037
0.209TrpTrp: 0.209 ± 0.017
0.367TrpTyr: 0.367 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.603TyrAla: 2.603 ± 0.064
0.126TyrCys: 0.126 ± 0.014
2.018TyrAsp: 2.018 ± 0.064
1.635TyrGlu: 1.635 ± 0.046
1.608TyrPhe: 1.608 ± 0.051
2.426TyrGly: 2.426 ± 0.061
0.846TyrHis: 0.846 ± 0.038
1.589TyrIle: 1.589 ± 0.047
1.353TyrLys: 1.353 ± 0.046
3.518TyrLeu: 3.518 ± 0.064
0.736TyrMet: 0.736 ± 0.03
1.401TyrAsn: 1.401 ± 0.044
1.304TyrPro: 1.304 ± 0.04
1.998TyrGln: 1.998 ± 0.058
1.832TyrArg: 1.832 ± 0.052
1.81TyrSer: 1.81 ± 0.05
1.906TyrThr: 1.906 ± 0.05
2.308TyrVal: 2.308 ± 0.053
0.477TyrTrp: 0.477 ± 0.027
1.381TyrTyr: 1.381 ± 0.055
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2470 proteins (740804 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski