Amino acid dipepetide frequency for Halomonas subglaciescola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.138AlaAla: 13.138 ± 0.158	1.235AlaCys: 1.235 ± 0.045	6.617AlaAsp: 6.617 ± 0.078	7.152AlaGlu: 7.152 ± 0.118	4.232AlaPhe: 4.232 ± 0.07	9.355AlaGly: 9.355 ± 0.113	2.442AlaHis: 2.442 ± 0.064	5.2AlaIle: 5.2 ± 0.082	3.12AlaLys: 3.12 ± 0.064	15.026AlaLeu: 15.026 ± 0.179	3.238AlaMet: 3.238 ± 0.068	2.918AlaAsn: 2.918 ± 0.053	5.279AlaPro: 5.279 ± 0.088	4.401AlaGln: 4.401 ± 0.09	7.882AlaArg: 7.882 ± 0.111	6.395AlaSer: 6.395 ± 0.093	5.747AlaThr: 5.747 ± 0.084	7.812AlaVal: 7.812 ± 0.111	1.719AlaTrp: 1.719 ± 0.047	2.498AlaTyr: 2.498 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.998CysAla: 0.998 ± 0.034	0.124CysCys: 0.124 ± 0.013	0.56CysAsp: 0.56 ± 0.026	0.527CysGlu: 0.527 ± 0.024	0.305CysPhe: 0.305 ± 0.02	0.912CysGly: 0.912 ± 0.039	0.375CysHis: 0.375 ± 0.022	0.378CysIle: 0.378 ± 0.022	0.216CysLys: 0.216 ± 0.017	0.956CysLeu: 0.956 ± 0.036	0.194CysMet: 0.194 ± 0.013	0.218CysAsn: 0.218 ± 0.018	0.529CysPro: 0.529 ± 0.029	0.406CysGln: 0.406 ± 0.022	0.717CysArg: 0.717 ± 0.03	0.456CysSer: 0.456 ± 0.024	0.414CysThr: 0.414 ± 0.022	0.652CysVal: 0.652 ± 0.026	0.15CysTrp: 0.15 ± 0.014	0.263CysTyr: 0.263 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	7.705AspAla: 7.705 ± 0.109	0.445AspCys: 0.445 ± 0.023	4.377AspAsp: 4.377 ± 0.083	3.897AspGlu: 3.897 ± 0.077	2.051AspPhe: 2.051 ± 0.052	4.681AspGly: 4.681 ± 0.091	1.299AspHis: 1.299 ± 0.041	3.111AspIle: 3.111 ± 0.065	1.889AspLys: 1.889 ± 0.05	4.698AspLeu: 4.698 ± 0.078	1.476AspMet: 1.476 ± 0.043	1.92AspAsn: 1.92 ± 0.052	2.675AspPro: 2.675 ± 0.058	2.009AspGln: 2.009 ± 0.046	3.072AspArg: 3.072 ± 0.069	2.93AspSer: 2.93 ± 0.058	3.498AspThr: 3.498 ± 0.065	4.507AspVal: 4.507 ± 0.076	0.942AspTrp: 0.942 ± 0.042	1.862AspTyr: 1.862 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	7.384GluAla: 7.384 ± 0.108	0.43GluCys: 0.43 ± 0.021	2.91GluAsp: 2.91 ± 0.075	3.164GluGlu: 3.164 ± 0.08	1.622GluPhe: 1.622 ± 0.048	4.232GluGly: 4.232 ± 0.077	1.903GluHis: 1.903 ± 0.047	2.706GluIle: 2.706 ± 0.054	2.227GluLys: 2.227 ± 0.06	6.321GluLeu: 6.321 ± 0.082	1.421GluMet: 1.421 ± 0.041	1.705GluAsn: 1.705 ± 0.047	2.714GluPro: 2.714 ± 0.07	3.467GluGln: 3.467 ± 0.069	5.726GluArg: 5.726 ± 0.084	3.054GluSer: 3.054 ± 0.058	3.124GluThr: 3.124 ± 0.064	4.074GluVal: 4.074 ± 0.087	0.855GluTrp: 0.855 ± 0.027	1.17GluTyr: 1.17 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.843PheAla: 3.843 ± 0.075	0.408PheCys: 0.408 ± 0.019	2.597PheAsp: 2.597 ± 0.06	1.983PheGlu: 1.983 ± 0.047	1.374PhePhe: 1.374 ± 0.048	3.047PheGly: 3.047 ± 0.057	0.792PheHis: 0.792 ± 0.03	1.856PheIle: 1.856 ± 0.053	1.0PheLys: 1.0 ± 0.03	3.017PheLeu: 3.017 ± 0.066	0.909PheMet: 0.909 ± 0.035	1.2PheAsn: 1.2 ± 0.037	1.351PhePro: 1.351 ± 0.039	1.156PheGln: 1.156 ± 0.034	1.829PheArg: 1.829 ± 0.051	2.448PheSer: 2.448 ± 0.059	2.08PheThr: 2.08 ± 0.056	2.367PheVal: 2.367 ± 0.055	0.517PheTrp: 0.517 ± 0.024	1.031PheTyr: 1.031 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	7.606GlyAla: 7.606 ± 0.111	0.94GlyCys: 0.94 ± 0.034	4.518GlyAsp: 4.518 ± 0.068	5.374GlyGlu: 5.374 ± 0.076	3.275GlyPhe: 3.275 ± 0.066	6.226GlyGly: 6.226 ± 0.105	1.996GlyHis: 1.996 ± 0.051	4.301GlyIle: 4.301 ± 0.075	2.967GlyLys: 2.967 ± 0.062	8.742GlyLeu: 8.742 ± 0.107	2.519GlyMet: 2.519 ± 0.056	2.253GlyAsn: 2.253 ± 0.055	2.334GlyPro: 2.334 ± 0.055	3.227GlyGln: 3.227 ± 0.065	5.112GlyArg: 5.112 ± 0.093	4.215GlySer: 4.215 ± 0.072	3.73GlyThr: 3.73 ± 0.063	6.175GlyVal: 6.175 ± 0.1	1.353GlyTrp: 1.353 ± 0.047	2.351GlyTyr: 2.351 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.761HisAla: 2.761 ± 0.067	0.303HisCys: 0.303 ± 0.02	1.449HisAsp: 1.449 ± 0.042	1.304HisGlu: 1.304 ± 0.042	1.029HisPhe: 1.029 ± 0.035	2.121HisGly: 2.121 ± 0.049	0.738HisHis: 0.738 ± 0.033	1.005HisIle: 1.005 ± 0.032	0.692HisLys: 0.692 ± 0.025	2.597HisLeu: 2.597 ± 0.062	0.565HisMet: 0.565 ± 0.025	0.68HisAsn: 0.68 ± 0.026	1.475HisPro: 1.475 ± 0.039	1.033HisGln: 1.033 ± 0.04	1.756HisArg: 1.756 ± 0.043	1.267HisSer: 1.267 ± 0.037	1.201HisThr: 1.201 ± 0.037	1.47HisVal: 1.47 ± 0.043	0.435HisTrp: 0.435 ± 0.021	0.832HisTyr: 0.832 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.781IleAla: 5.781 ± 0.082	0.387IleCys: 0.387 ± 0.02	3.392IleAsp: 3.392 ± 0.065	3.39IleGlu: 3.39 ± 0.066	1.443IlePhe: 1.443 ± 0.046	4.1IleGly: 4.1 ± 0.073	1.027IleHis: 1.027 ± 0.036	2.207IleIle: 2.207 ± 0.062	1.571IleLys: 1.571 ± 0.045	3.49IleLeu: 3.49 ± 0.071	1.023IleMet: 1.023 ± 0.036	1.703IleAsn: 1.703 ± 0.049	2.048IlePro: 2.048 ± 0.048	1.429IleGln: 1.429 ± 0.04	2.688IleArg: 2.688 ± 0.056	2.805IleSer: 2.805 ± 0.064	2.731IleThr: 2.731 ± 0.059	3.269IleVal: 3.269 ± 0.066	0.502IleTrp: 0.502 ± 0.025	1.083IleTyr: 1.083 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.826LysAla: 3.826 ± 0.088	0.159LysCys: 0.159 ± 0.014	1.525LysAsp: 1.525 ± 0.04	1.554LysGlu: 1.554 ± 0.045	0.682LysPhe: 0.682 ± 0.031	2.31LysGly: 2.31 ± 0.06	0.698LysHis: 0.698 ± 0.032	1.275LysIle: 1.275 ± 0.047	1.294LysLys: 1.294 ± 0.049	3.023LysLeu: 3.023 ± 0.063	0.692LysMet: 0.692 ± 0.03	0.929LysAsn: 0.929 ± 0.035	1.706LysPro: 1.706 ± 0.053	1.344LysGln: 1.344 ± 0.039	2.866LysArg: 2.866 ± 0.054	1.643LysSer: 1.643 ± 0.05	1.806LysThr: 1.806 ± 0.05	2.188LysVal: 2.188 ± 0.049	0.308LysTrp: 0.308 ± 0.018	0.569LysTyr: 0.569 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	14.255LeuAla: 14.255 ± 0.18	1.132LeuCys: 1.132 ± 0.038	7.177LeuAsp: 7.177 ± 0.109	7.016LeuGlu: 7.016 ± 0.114	3.655LeuPhe: 3.655 ± 0.08	9.084LeuGly: 9.084 ± 0.128	2.354LeuHis: 2.354 ± 0.061	5.139LeuIle: 5.139 ± 0.084	3.745LeuLys: 3.745 ± 0.066	11.981LeuLeu: 11.981 ± 0.174	2.843LeuMet: 2.843 ± 0.057	3.266LeuAsn: 3.266 ± 0.066	5.969LeuPro: 5.969 ± 0.082	3.147LeuGln: 3.147 ± 0.06	6.521LeuArg: 6.521 ± 0.09	7.006LeuSer: 7.006 ± 0.109	6.282LeuThr: 6.282 ± 0.089	7.51LeuVal: 7.51 ± 0.117	1.508LeuTrp: 1.508 ± 0.046	2.477LeuTyr: 2.477 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	3.216MetAla: 3.216 ± 0.065	0.177MetCys: 0.177 ± 0.016	1.185MetAsp: 1.185 ± 0.035	1.167MetGlu: 1.167 ± 0.038	0.641MetPhe: 0.641 ± 0.028	1.874MetGly: 1.874 ± 0.051	0.59MetHis: 0.59 ± 0.024	1.248MetIle: 1.248 ± 0.04	0.778MetLys: 0.778 ± 0.032	2.956MetLeu: 2.956 ± 0.07	0.671MetMet: 0.671 ± 0.029	0.803MetAsn: 0.803 ± 0.033	1.5MetPro: 1.5 ± 0.045	1.134MetGln: 1.134 ± 0.043	1.663MetArg: 1.663 ± 0.045	1.79MetSer: 1.79 ± 0.049	1.709MetThr: 1.709 ± 0.048	1.703MetVal: 1.703 ± 0.041	0.208MetTrp: 0.208 ± 0.016	0.352MetTyr: 0.352 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.771AsnAla: 3.771 ± 0.064	0.221AsnCys: 0.221 ± 0.018	1.668AsnAsp: 1.668 ± 0.046	1.52AsnGlu: 1.52 ± 0.039	0.836AsnPhe: 0.836 ± 0.029	2.394AsnGly: 2.394 ± 0.051	0.658AsnHis: 0.658 ± 0.029	1.375AsnIle: 1.375 ± 0.044	0.729AsnLys: 0.729 ± 0.03	2.673AsnLeu: 2.673 ± 0.064	0.613AsnMet: 0.613 ± 0.026	0.83AsnAsn: 0.83 ± 0.031	1.696AsnPro: 1.696 ± 0.047	1.076AsnGln: 1.076 ± 0.036	1.988AsnArg: 1.988 ± 0.048	1.222AsnSer: 1.222 ± 0.037	1.537AsnThr: 1.537 ± 0.044	2.135AsnVal: 2.135 ± 0.053	0.337AsnTrp: 0.337 ± 0.024	0.672AsnTyr: 0.672 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	5.546ProAla: 5.546 ± 0.093	0.351ProCys: 0.351 ± 0.022	3.459ProAsp: 3.459 ± 0.071	3.892ProGlu: 3.892 ± 0.093	1.712ProPhe: 1.712 ± 0.044	3.943ProGly: 3.943 ± 0.067	1.176ProHis: 1.176 ± 0.038	1.835ProIle: 1.835 ± 0.043	1.312ProLys: 1.312 ± 0.037	5.666ProLeu: 5.666 ± 0.092	1.159ProMet: 1.159 ± 0.035	1.231ProAsn: 1.231 ± 0.038	2.258ProPro: 2.258 ± 0.056	1.822ProGln: 1.822 ± 0.046	2.874ProArg: 2.874 ± 0.064	2.485ProSer: 2.485 ± 0.046	2.306ProThr: 2.306 ± 0.047	3.697ProVal: 3.697 ± 0.073	0.804ProTrp: 0.804 ± 0.033	1.072ProTyr: 1.072 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	5.429GlnAla: 5.429 ± 0.102	0.338GlnCys: 0.338 ± 0.02	1.78GlnAsp: 1.78 ± 0.048	1.932GlnGlu: 1.932 ± 0.062	1.103GlnPhe: 1.103 ± 0.033	3.096GlnGly: 3.096 ± 0.058	1.136GlnHis: 1.136 ± 0.038	1.523GlnIle: 1.523 ± 0.041	1.198GlnLys: 1.198 ± 0.038	4.412GlnLeu: 4.412 ± 0.081	0.91GlnMet: 0.91 ± 0.033	0.963GlnAsn: 0.963 ± 0.032	2.051GlnPro: 2.051 ± 0.064	2.452GlnGln: 2.452 ± 0.074	3.695GlnArg: 3.695 ± 0.072	2.167GlnSer: 2.167 ± 0.057	2.118GlnThr: 2.118 ± 0.046	2.843GlnVal: 2.843 ± 0.065	0.655GlnTrp: 0.655 ± 0.029	0.697GlnTyr: 0.697 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	6.41ArgAla: 6.41 ± 0.097	0.646ArgCys: 0.646 ± 0.027	4.065ArgAsp: 4.065 ± 0.076	4.771ArgGlu: 4.771 ± 0.088	3.028ArgPhe: 3.028 ± 0.07	4.314ArgGly: 4.314 ± 0.066	2.284ArgHis: 2.284 ± 0.059	3.206ArgIle: 3.206 ± 0.057	1.97ArgLys: 1.97 ± 0.054	9.182ArgLeu: 9.182 ± 0.138	1.741ArgMet: 1.741 ± 0.045	1.665ArgAsn: 1.665 ± 0.044	2.954ArgPro: 2.954 ± 0.063	3.458ArgGln: 3.458 ± 0.084	5.53ArgArg: 5.53 ± 0.098	2.956ArgSer: 2.956 ± 0.058	2.87ArgThr: 2.87 ± 0.059	4.683ArgVal: 4.683 ± 0.081	1.18ArgTrp: 1.18 ± 0.04	2.301ArgTyr: 2.301 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	6.213SerAla: 6.213 ± 0.09	0.433SerCys: 0.433 ± 0.02	3.1SerAsp: 3.1 ± 0.058	2.933SerGlu: 2.933 ± 0.064	1.939SerPhe: 1.939 ± 0.052	5.139SerGly: 5.139 ± 0.079	1.362SerHis: 1.362 ± 0.04	2.423SerIle: 2.423 ± 0.053	1.363SerLys: 1.363 ± 0.048	6.222SerLeu: 6.222 ± 0.083	1.435SerMet: 1.435 ± 0.043	1.361SerAsn: 1.361 ± 0.042	2.837SerPro: 2.837 ± 0.062	2.255SerGln: 2.255 ± 0.049	4.006SerArg: 4.006 ± 0.063	2.963SerSer: 2.963 ± 0.069	2.771SerThr: 2.771 ± 0.056	4.061SerVal: 4.061 ± 0.072	0.736SerTrp: 0.736 ± 0.031	1.266SerTyr: 1.266 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.51ThrAla: 5.51 ± 0.09	0.456ThrCys: 0.456 ± 0.024	2.545ThrAsp: 2.545 ± 0.057	2.335ThrGlu: 2.335 ± 0.06	1.923ThrPhe: 1.923 ± 0.05	4.357ThrGly: 4.357 ± 0.078	1.337ThrHis: 1.337 ± 0.036	1.86ThrIle: 1.86 ± 0.044	1.057ThrLys: 1.057 ± 0.038	8.225ThrLeu: 8.225 ± 0.112	1.014ThrMet: 1.014 ± 0.032	1.16ThrAsn: 1.16 ± 0.038	3.927ThrPro: 3.927 ± 0.068	2.193ThrGln: 2.193 ± 0.05	3.839ThrArg: 3.839 ± 0.084	2.715ThrSer: 2.715 ± 0.063	2.772ThrThr: 2.772 ± 0.06	3.604ThrVal: 3.604 ± 0.067	0.611ThrTrp: 0.611 ± 0.029	1.169ThrTyr: 1.169 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	8.179ValAla: 8.179 ± 0.12	0.677ValCys: 0.677 ± 0.027	4.256ValAsp: 4.256 ± 0.077	4.615ValGlu: 4.615 ± 0.073	2.503ValPhe: 2.503 ± 0.061	5.171ValGly: 5.171 ± 0.091	1.436ValHis: 1.436 ± 0.039	3.926ValIle: 3.926 ± 0.077	2.318ValLys: 2.318 ± 0.062	7.599ValLeu: 7.599 ± 0.108	2.057ValMet: 2.057 ± 0.048	2.132ValAsn: 2.132 ± 0.052	3.254ValPro: 3.254 ± 0.058	2.151ValGln: 2.151 ± 0.055	4.163ValArg: 4.163 ± 0.077	4.27ValSer: 4.27 ± 0.07	4.114ValThr: 4.114 ± 0.061	5.657ValVal: 5.657 ± 0.109	0.879ValTrp: 0.879 ± 0.034	1.618ValTyr: 1.618 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.158TrpAla: 1.158 ± 0.04	0.207TrpCys: 0.207 ± 0.015	0.602TrpAsp: 0.602 ± 0.028	0.655TrpGlu: 0.655 ± 0.029	0.493TrpPhe: 0.493 ± 0.027	0.878TrpGly: 0.878 ± 0.042	0.45TrpHis: 0.45 ± 0.019	0.579TrpIle: 0.579 ± 0.028	0.35TrpLys: 0.35 ± 0.021	2.511TrpLeu: 2.511 ± 0.069	0.419TrpMet: 0.419 ± 0.022	0.359TrpAsn: 0.359 ± 0.023	0.724TrpPro: 0.724 ± 0.028	1.143TrpGln: 1.143 ± 0.039	1.11TrpArg: 1.11 ± 0.04	0.662TrpSer: 0.662 ± 0.025	0.539TrpThr: 0.539 ± 0.026	0.933TrpVal: 0.933 ± 0.032	0.278TrpTrp: 0.278 ± 0.02	0.318TrpTyr: 0.318 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.677TyrAla: 2.677 ± 0.047	0.282TyrCys: 0.282 ± 0.019	1.26TyrAsp: 1.26 ± 0.037	1.029TyrGlu: 1.029 ± 0.04	0.957TyrPhe: 0.957 ± 0.04	1.983TyrGly: 1.983 ± 0.049	0.658TyrHis: 0.658 ± 0.022	0.918TyrIle: 0.918 ± 0.031	0.601TyrLys: 0.601 ± 0.028	2.769TyrLeu: 2.769 ± 0.064	0.463TyrMet: 0.463 ± 0.024	0.657TyrAsn: 0.657 ± 0.033	1.318TyrPro: 1.318 ± 0.042	1.194TyrGln: 1.194 ± 0.036	2.174TyrArg: 2.174 ± 0.051	1.37TyrSer: 1.37 ± 0.041	1.261TyrThr: 1.261 ± 0.033	1.636TyrVal: 1.636 ± 0.038	0.393TyrTrp: 0.393 ± 0.021	0.732TyrTyr: 0.732 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2724 proteins (880880 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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