Amino acid dipepetide frequency for Bifidobacterium phage BadAargau2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.242AlaAla: 6.242 ± 1.131
1.181AlaCys: 1.181 ± 0.373
6.579AlaAsp: 6.579 ± 0.995
3.711AlaGlu: 3.711 ± 0.803
2.699AlaPhe: 2.699 ± 0.583
5.735AlaGly: 5.735 ± 0.755
1.012AlaHis: 1.012 ± 0.28
4.723AlaIle: 4.723 ± 1.074
5.061AlaLys: 5.061 ± 0.759
4.723AlaLeu: 4.723 ± 0.936
2.868AlaMet: 2.868 ± 0.83
4.892AlaAsn: 4.892 ± 1.309
3.036AlaPro: 3.036 ± 0.781
4.049AlaGln: 4.049 ± 0.901
4.386AlaArg: 4.386 ± 1.184
4.386AlaSer: 4.386 ± 0.864
5.904AlaThr: 5.904 ± 1.261
3.711AlaVal: 3.711 ± 0.813
1.35AlaTrp: 1.35 ± 0.344
4.723AlaTyr: 4.723 ± 0.703
0.0AlaXaa: 0.0 ± 0.0
Cys
0.506CysAla: 0.506 ± 0.332
0.0CysCys: 0.0 ± 0.0
0.843CysAsp: 0.843 ± 0.303
0.169CysGlu: 0.169 ± 0.154
0.0CysPhe: 0.0 ± 0.0
0.506CysGly: 0.506 ± 0.303
0.169CysHis: 0.169 ± 0.147
0.675CysIle: 0.675 ± 0.371
0.506CysLys: 0.506 ± 0.245
1.012CysLeu: 1.012 ± 0.445
0.0CysMet: 0.0 ± 0.0
0.843CysAsn: 0.843 ± 0.353
0.506CysPro: 0.506 ± 0.235
0.337CysGln: 0.337 ± 0.308
0.506CysArg: 0.506 ± 0.206
1.35CysSer: 1.35 ± 0.466
0.506CysThr: 0.506 ± 0.266
0.675CysVal: 0.675 ± 0.348
0.0CysTrp: 0.0 ± 0.0
0.675CysTyr: 0.675 ± 0.259
0.0CysXaa: 0.0 ± 0.0
Asp
5.229AspAla: 5.229 ± 0.715
0.843AspCys: 0.843 ± 0.284
6.916AspAsp: 6.916 ± 1.581
3.711AspGlu: 3.711 ± 0.709
2.362AspPhe: 2.362 ± 0.649
4.386AspGly: 4.386 ± 0.85
1.181AspHis: 1.181 ± 0.533
6.41AspIle: 6.41 ± 0.842
4.892AspLys: 4.892 ± 0.778
3.88AspLeu: 3.88 ± 0.836
3.543AspMet: 3.543 ± 0.862
5.398AspAsn: 5.398 ± 1.268
2.362AspPro: 2.362 ± 0.885
1.181AspGln: 1.181 ± 0.351
4.217AspArg: 4.217 ± 0.586
5.398AspSer: 5.398 ± 1.068
5.229AspThr: 5.229 ± 1.161
4.386AspVal: 4.386 ± 0.994
0.506AspTrp: 0.506 ± 0.291
3.88AspTyr: 3.88 ± 0.858
0.0AspXaa: 0.0 ± 0.0
Glu
2.362GluAla: 2.362 ± 0.793
0.675GluCys: 0.675 ± 0.436
4.217GluAsp: 4.217 ± 0.859
2.362GluGlu: 2.362 ± 0.627
2.193GluPhe: 2.193 ± 0.582
1.687GluGly: 1.687 ± 0.458
1.518GluHis: 1.518 ± 0.532
3.88GluIle: 3.88 ± 0.817
2.53GluLys: 2.53 ± 0.607
3.88GluLeu: 3.88 ± 0.733
1.012GluMet: 1.012 ± 0.294
3.205GluAsn: 3.205 ± 0.757
1.518GluPro: 1.518 ± 0.551
2.193GluGln: 2.193 ± 0.69
3.205GluArg: 3.205 ± 1.152
2.362GluSer: 2.362 ± 0.719
3.374GluThr: 3.374 ± 0.667
3.374GluVal: 3.374 ± 1.027
1.35GluTrp: 1.35 ± 0.453
2.868GluTyr: 2.868 ± 0.618
0.0GluXaa: 0.0 ± 0.0
Phe
2.868PheAla: 2.868 ± 0.531
0.169PheCys: 0.169 ± 0.159
3.543PheAsp: 3.543 ± 0.903
2.024PheGlu: 2.024 ± 0.555
0.843PhePhe: 0.843 ± 0.32
4.217PheGly: 4.217 ± 0.66
0.506PheHis: 0.506 ± 0.244
2.53PheIle: 2.53 ± 0.637
0.843PheLys: 0.843 ± 0.3
2.362PheLeu: 2.362 ± 0.633
1.181PheMet: 1.181 ± 0.342
1.856PheAsn: 1.856 ± 0.606
2.024PhePro: 2.024 ± 0.592
2.024PheGln: 2.024 ± 0.586
1.518PheArg: 1.518 ± 0.594
2.53PheSer: 2.53 ± 0.519
1.012PheThr: 1.012 ± 0.351
1.687PheVal: 1.687 ± 0.53
0.506PheTrp: 0.506 ± 0.336
1.181PheTyr: 1.181 ± 0.371
0.0PheXaa: 0.0 ± 0.0
Gly
4.217GlyAla: 4.217 ± 0.919
0.843GlyCys: 0.843 ± 0.48
4.386GlyAsp: 4.386 ± 0.955
3.88GlyGlu: 3.88 ± 0.658
2.193GlyPhe: 2.193 ± 0.466
5.567GlyGly: 5.567 ± 1.342
1.181GlyHis: 1.181 ± 0.395
4.892GlyIle: 4.892 ± 0.864
3.711GlyLys: 3.711 ± 0.886
4.049GlyLeu: 4.049 ± 0.603
1.856GlyMet: 1.856 ± 0.642
6.073GlyAsn: 6.073 ± 1.089
1.181GlyPro: 1.181 ± 0.419
3.205GlyGln: 3.205 ± 0.74
3.205GlyArg: 3.205 ± 0.75
3.88GlySer: 3.88 ± 0.739
4.892GlyThr: 4.892 ± 0.869
3.711GlyVal: 3.711 ± 0.765
0.675GlyTrp: 0.675 ± 0.256
4.723GlyTyr: 4.723 ± 0.785
0.0GlyXaa: 0.0 ± 0.0
His
1.35HisAla: 1.35 ± 0.44
0.169HisCys: 0.169 ± 0.159
1.012HisAsp: 1.012 ± 0.399
0.506HisGlu: 0.506 ± 0.258
0.506HisPhe: 0.506 ± 0.297
1.687HisGly: 1.687 ± 0.603
0.337HisHis: 0.337 ± 0.21
1.181HisIle: 1.181 ± 0.344
0.506HisLys: 0.506 ± 0.27
2.193HisLeu: 2.193 ± 0.422
0.506HisMet: 0.506 ± 0.311
1.012HisAsn: 1.012 ± 0.438
0.843HisPro: 0.843 ± 0.371
0.843HisGln: 0.843 ± 0.368
0.506HisArg: 0.506 ± 0.24
1.181HisSer: 1.181 ± 0.485
1.012HisThr: 1.012 ± 0.322
0.675HisVal: 0.675 ± 0.324
0.506HisTrp: 0.506 ± 0.463
0.843HisTyr: 0.843 ± 0.377
0.0HisXaa: 0.0 ± 0.0
Ile
5.735IleAla: 5.735 ± 0.91
0.337IleCys: 0.337 ± 0.209
3.543IleAsp: 3.543 ± 0.815
3.036IleGlu: 3.036 ± 0.815
2.868IlePhe: 2.868 ± 0.778
5.229IleGly: 5.229 ± 0.811
1.012IleHis: 1.012 ± 0.418
4.049IleIle: 4.049 ± 0.939
2.53IleLys: 2.53 ± 0.543
3.036IleLeu: 3.036 ± 0.688
2.193IleMet: 2.193 ± 0.419
3.036IleAsn: 3.036 ± 0.451
2.193IlePro: 2.193 ± 0.629
2.699IleGln: 2.699 ± 0.756
3.205IleArg: 3.205 ± 0.886
3.205IleSer: 3.205 ± 0.646
3.374IleThr: 3.374 ± 0.544
4.049IleVal: 4.049 ± 0.699
0.843IleTrp: 0.843 ± 0.291
1.518IleTyr: 1.518 ± 0.671
0.0IleXaa: 0.0 ± 0.0
Lys
3.711LysAla: 3.711 ± 0.787
0.169LysCys: 0.169 ± 0.216
3.711LysAsp: 3.711 ± 0.655
2.024LysGlu: 2.024 ± 0.634
2.024LysPhe: 2.024 ± 0.452
4.386LysGly: 4.386 ± 0.769
1.012LysHis: 1.012 ± 0.438
1.856LysIle: 1.856 ± 0.467
2.53LysLys: 2.53 ± 0.531
6.41LysLeu: 6.41 ± 1.203
2.362LysMet: 2.362 ± 0.56
3.374LysAsn: 3.374 ± 0.885
2.024LysPro: 2.024 ± 0.709
1.856LysGln: 1.856 ± 0.533
3.205LysArg: 3.205 ± 0.963
3.711LysSer: 3.711 ± 0.563
4.049LysThr: 4.049 ± 0.671
2.868LysVal: 2.868 ± 0.692
0.843LysTrp: 0.843 ± 0.429
1.35LysTyr: 1.35 ± 0.295
0.0LysXaa: 0.0 ± 0.0
Leu
5.398LeuAla: 5.398 ± 0.682
1.181LeuCys: 1.181 ± 0.486
4.386LeuAsp: 4.386 ± 0.726
4.217LeuGlu: 4.217 ± 1.156
2.699LeuPhe: 2.699 ± 0.585
4.555LeuGly: 4.555 ± 1.054
0.843LeuHis: 0.843 ± 0.353
3.88LeuIle: 3.88 ± 0.797
4.217LeuLys: 4.217 ± 0.903
3.543LeuLeu: 3.543 ± 0.521
2.193LeuMet: 2.193 ± 0.632
4.049LeuAsn: 4.049 ± 0.718
2.53LeuPro: 2.53 ± 0.846
3.374LeuGln: 3.374 ± 0.969
4.723LeuArg: 4.723 ± 0.97
4.386LeuSer: 4.386 ± 0.973
3.036LeuThr: 3.036 ± 0.749
4.049LeuVal: 4.049 ± 0.724
0.675LeuTrp: 0.675 ± 0.317
2.193LeuTyr: 2.193 ± 0.515
0.0LeuXaa: 0.0 ± 0.0
Met
3.711MetAla: 3.711 ± 0.595
0.337MetCys: 0.337 ± 0.234
2.53MetAsp: 2.53 ± 0.654
1.181MetGlu: 1.181 ± 0.316
1.856MetPhe: 1.856 ± 0.467
2.193MetGly: 2.193 ± 0.664
0.506MetHis: 0.506 ± 0.268
1.518MetIle: 1.518 ± 0.503
1.012MetLys: 1.012 ± 0.49
1.856MetLeu: 1.856 ± 0.449
0.843MetMet: 0.843 ± 0.321
1.35MetAsn: 1.35 ± 0.396
2.024MetPro: 2.024 ± 0.538
0.506MetGln: 0.506 ± 0.24
1.35MetArg: 1.35 ± 0.492
2.868MetSer: 2.868 ± 0.549
1.687MetThr: 1.687 ± 0.529
1.35MetVal: 1.35 ± 0.546
0.843MetTrp: 0.843 ± 0.341
2.024MetTyr: 2.024 ± 0.6
0.0MetXaa: 0.0 ± 0.0
Asn
7.928AsnAla: 7.928 ± 1.234
0.675AsnCys: 0.675 ± 0.359
5.061AsnAsp: 5.061 ± 1.299
2.362AsnGlu: 2.362 ± 0.49
2.024AsnPhe: 2.024 ± 0.714
4.049AsnGly: 4.049 ± 0.561
1.181AsnHis: 1.181 ± 0.509
4.217AsnIle: 4.217 ± 0.967
4.049AsnLys: 4.049 ± 0.998
5.229AsnLeu: 5.229 ± 0.828
1.687AsnMet: 1.687 ± 0.616
3.711AsnAsn: 3.711 ± 0.713
3.036AsnPro: 3.036 ± 0.765
2.53AsnGln: 2.53 ± 0.783
2.53AsnArg: 2.53 ± 0.483
4.217AsnSer: 4.217 ± 0.9
4.217AsnThr: 4.217 ± 0.92
3.205AsnVal: 3.205 ± 0.546
0.506AsnTrp: 0.506 ± 0.24
1.687AsnTyr: 1.687 ± 0.639
0.0AsnXaa: 0.0 ± 0.0
Pro
2.193ProAla: 2.193 ± 0.674
0.169ProCys: 0.169 ± 0.153
4.049ProAsp: 4.049 ± 0.745
2.868ProGlu: 2.868 ± 0.746
1.181ProPhe: 1.181 ± 0.408
2.024ProGly: 2.024 ± 0.641
0.337ProHis: 0.337 ± 0.187
1.181ProIle: 1.181 ± 0.387
2.699ProLys: 2.699 ± 0.596
1.518ProLeu: 1.518 ± 0.526
0.675ProMet: 0.675 ± 0.219
3.036ProAsn: 3.036 ± 0.757
1.687ProPro: 1.687 ± 0.431
2.193ProGln: 2.193 ± 0.666
1.518ProArg: 1.518 ± 0.47
2.193ProSer: 2.193 ± 0.521
3.205ProThr: 3.205 ± 0.488
1.518ProVal: 1.518 ± 0.559
1.181ProTrp: 1.181 ± 0.368
3.036ProTyr: 3.036 ± 0.591
0.0ProXaa: 0.0 ± 0.0
Gln
4.723GlnAla: 4.723 ± 0.725
0.0GlnCys: 0.0 ± 0.0
2.362GlnAsp: 2.362 ± 0.542
1.518GlnGlu: 1.518 ± 0.751
1.518GlnPhe: 1.518 ± 0.631
2.024GlnGly: 2.024 ± 0.599
0.0GlnHis: 0.0 ± 0.0
2.193GlnIle: 2.193 ± 0.669
2.362GlnLys: 2.362 ± 0.671
2.699GlnLeu: 2.699 ± 0.58
1.687GlnMet: 1.687 ± 0.502
2.53GlnAsn: 2.53 ± 1.067
1.518GlnPro: 1.518 ± 0.538
3.374GlnGln: 3.374 ± 0.942
2.699GlnArg: 2.699 ± 0.585
3.543GlnSer: 3.543 ± 0.705
3.374GlnThr: 3.374 ± 0.759
2.53GlnVal: 2.53 ± 0.592
0.843GlnTrp: 0.843 ± 0.376
1.35GlnTyr: 1.35 ± 0.409
0.0GlnXaa: 0.0 ± 0.0
Arg
2.868ArgAla: 2.868 ± 0.651
0.675ArgCys: 0.675 ± 0.255
3.205ArgAsp: 3.205 ± 0.716
2.362ArgGlu: 2.362 ± 0.471
2.193ArgPhe: 2.193 ± 0.724
2.193ArgGly: 2.193 ± 0.5
1.012ArgHis: 1.012 ± 0.444
3.374ArgIle: 3.374 ± 0.788
3.543ArgLys: 3.543 ± 1.274
4.386ArgLeu: 4.386 ± 1.083
1.518ArgMet: 1.518 ± 0.631
3.374ArgAsn: 3.374 ± 1.192
2.024ArgPro: 2.024 ± 0.672
2.362ArgGln: 2.362 ± 0.805
3.036ArgArg: 3.036 ± 0.759
2.699ArgSer: 2.699 ± 0.903
3.374ArgThr: 3.374 ± 0.924
4.049ArgVal: 4.049 ± 0.979
0.506ArgTrp: 0.506 ± 0.264
4.892ArgTyr: 4.892 ± 0.628
0.0ArgXaa: 0.0 ± 0.0
Ser
6.41SerAla: 6.41 ± 0.961
0.337SerCys: 0.337 ± 0.316
6.242SerAsp: 6.242 ± 1.301
3.543SerGlu: 3.543 ± 0.441
2.362SerPhe: 2.362 ± 0.506
4.892SerGly: 4.892 ± 0.987
1.35SerHis: 1.35 ± 0.416
2.868SerIle: 2.868 ± 0.669
3.711SerLys: 3.711 ± 0.719
3.88SerLeu: 3.88 ± 0.763
1.35SerMet: 1.35 ± 0.425
4.723SerAsn: 4.723 ± 0.886
1.856SerPro: 1.856 ± 0.377
3.374SerGln: 3.374 ± 0.784
3.374SerArg: 3.374 ± 0.762
5.398SerSer: 5.398 ± 1.47
3.374SerThr: 3.374 ± 0.638
4.723SerVal: 4.723 ± 0.59
1.35SerTrp: 1.35 ± 0.49
3.036SerTyr: 3.036 ± 0.802
0.0SerXaa: 0.0 ± 0.0
Thr
6.073ThrAla: 6.073 ± 1.075
0.675ThrCys: 0.675 ± 0.309
6.41ThrAsp: 6.41 ± 0.88
3.374ThrGlu: 3.374 ± 0.693
2.699ThrPhe: 2.699 ± 0.59
5.735ThrGly: 5.735 ± 1.056
0.843ThrHis: 0.843 ± 0.315
3.205ThrIle: 3.205 ± 0.723
2.193ThrLys: 2.193 ± 0.825
3.711ThrLeu: 3.711 ± 0.831
2.362ThrMet: 2.362 ± 0.674
3.205ThrAsn: 3.205 ± 0.856
2.699ThrPro: 2.699 ± 0.597
3.205ThrGln: 3.205 ± 0.627
3.036ThrArg: 3.036 ± 0.689
4.723ThrSer: 4.723 ± 0.814
5.061ThrThr: 5.061 ± 0.863
3.543ThrVal: 3.543 ± 0.75
1.518ThrTrp: 1.518 ± 0.764
1.856ThrTyr: 1.856 ± 0.54
0.0ThrXaa: 0.0 ± 0.0
Val
3.374ValAla: 3.374 ± 0.672
1.012ValCys: 1.012 ± 0.404
2.699ValAsp: 2.699 ± 0.563
3.711ValGlu: 3.711 ± 0.889
1.012ValPhe: 1.012 ± 0.401
3.205ValGly: 3.205 ± 0.583
1.35ValHis: 1.35 ± 0.503
2.193ValIle: 2.193 ± 0.436
3.543ValLys: 3.543 ± 0.998
3.711ValLeu: 3.711 ± 1.137
2.024ValMet: 2.024 ± 0.506
3.543ValAsn: 3.543 ± 0.802
2.53ValPro: 2.53 ± 0.644
1.687ValGln: 1.687 ± 0.535
3.205ValArg: 3.205 ± 0.784
5.229ValSer: 5.229 ± 1.072
5.904ValThr: 5.904 ± 0.911
2.53ValVal: 2.53 ± 0.859
1.518ValTrp: 1.518 ± 0.483
2.53ValTyr: 2.53 ± 0.608
0.0ValXaa: 0.0 ± 0.0
Trp
1.856TrpAla: 1.856 ± 0.523
0.0TrpCys: 0.0 ± 0.0
1.181TrpAsp: 1.181 ± 0.398
0.506TrpGlu: 0.506 ± 0.249
0.169TrpPhe: 0.169 ± 0.173
0.337TrpGly: 0.337 ± 0.2
0.169TrpHis: 0.169 ± 0.146
1.012TrpIle: 1.012 ± 0.446
1.181TrpLys: 1.181 ± 0.285
0.506TrpLeu: 0.506 ± 0.249
0.506TrpMet: 0.506 ± 0.231
1.518TrpAsn: 1.518 ± 0.667
0.843TrpPro: 0.843 ± 0.264
1.012TrpGln: 1.012 ± 0.402
0.675TrpArg: 0.675 ± 0.265
2.193TrpSer: 2.193 ± 0.641
1.012TrpThr: 1.012 ± 0.38
0.675TrpVal: 0.675 ± 0.335
0.169TrpTrp: 0.169 ± 0.154
0.843TrpTyr: 0.843 ± 0.283
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.217TyrAla: 4.217 ± 0.711
0.337TyrCys: 0.337 ± 0.221
3.036TyrAsp: 3.036 ± 0.69
2.868TyrGlu: 2.868 ± 0.617
2.024TyrPhe: 2.024 ± 0.615
3.711TyrGly: 3.711 ± 0.838
1.856TyrHis: 1.856 ± 0.434
1.856TyrIle: 1.856 ± 0.541
1.856TyrLys: 1.856 ± 0.633
3.543TyrLeu: 3.543 ± 0.72
1.012TyrMet: 1.012 ± 0.407
3.374TyrAsn: 3.374 ± 0.582
2.024TyrPro: 2.024 ± 0.348
0.843TyrGln: 0.843 ± 0.267
3.543TyrArg: 3.543 ± 0.613
2.699TyrSer: 2.699 ± 0.784
2.53TyrThr: 2.53 ± 0.435
3.205TyrVal: 3.205 ± 0.725
0.675TyrTrp: 0.675 ± 0.255
2.193TyrTyr: 2.193 ± 0.527
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 23 proteins (5929 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski