Amino acid dipepetide frequency for Aerococcus sanguinicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.183AlaAla: 7.183 ± 0.157
0.901AlaCys: 0.901 ± 0.047
5.909AlaAsp: 5.909 ± 0.123
5.909AlaGlu: 5.909 ± 0.12
3.752AlaPhe: 3.752 ± 0.099
6.509AlaGly: 6.509 ± 0.125
1.514AlaHis: 1.514 ± 0.058
6.062AlaIle: 6.062 ± 0.137
5.31AlaLys: 5.31 ± 0.109
9.603AlaLeu: 9.603 ± 0.193
2.278AlaMet: 2.278 ± 0.072
3.397AlaAsn: 3.397 ± 0.085
2.781AlaPro: 2.781 ± 0.08
4.257AlaGln: 4.257 ± 0.118
3.29AlaArg: 3.29 ± 0.099
5.494AlaSer: 5.494 ± 0.117
3.592AlaThr: 3.592 ± 0.085
5.355AlaVal: 5.355 ± 0.105
0.786AlaTrp: 0.786 ± 0.034
3.804AlaTyr: 3.804 ± 0.088
0.0AlaXaa: 0.0 ± 0.0
Cys
0.502CysAla: 0.502 ± 0.03
0.072CysCys: 0.072 ± 0.012
0.444CysAsp: 0.444 ± 0.033
0.315CysGlu: 0.315 ± 0.021
0.361CysPhe: 0.361 ± 0.027
0.572CysGly: 0.572 ± 0.036
0.176CysHis: 0.176 ± 0.019
0.338CysIle: 0.338 ± 0.026
0.201CysLys: 0.201 ± 0.017
0.96CysLeu: 0.96 ± 0.046
0.133CysMet: 0.133 ± 0.016
0.209CysAsn: 0.209 ± 0.021
0.291CysPro: 0.291 ± 0.024
0.618CysGln: 0.618 ± 0.038
0.338CysArg: 0.338 ± 0.024
0.395CysSer: 0.395 ± 0.026
0.232CysThr: 0.232 ± 0.025
0.372CysVal: 0.372 ± 0.026
0.043CysTrp: 0.043 ± 0.008
0.275CysTyr: 0.275 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
4.102AspAla: 4.102 ± 0.107
0.469AspCys: 0.469 ± 0.03
3.473AspAsp: 3.473 ± 0.111
4.307AspGlu: 4.307 ± 0.104
3.194AspPhe: 3.194 ± 0.082
4.535AspGly: 4.535 ± 0.41
1.726AspHis: 1.726 ± 0.07
3.868AspIle: 3.868 ± 0.091
3.859AspLys: 3.859 ± 0.113
7.602AspLeu: 7.602 ± 0.161
1.612AspMet: 1.612 ± 0.055
2.112AspAsn: 2.112 ± 0.063
2.962AspPro: 2.962 ± 0.169
5.513AspGln: 5.513 ± 0.14
3.572AspArg: 3.572 ± 0.091
2.909AspSer: 2.909 ± 0.075
2.509AspThr: 2.509 ± 0.078
3.487AspVal: 3.487 ± 0.087
0.884AspTrp: 0.884 ± 0.043
3.158AspTyr: 3.158 ± 0.083
0.0AspXaa: 0.0 ± 0.0
Glu
8.039GluAla: 8.039 ± 0.147
0.266GluCys: 0.266 ± 0.026
5.538GluAsp: 5.538 ± 0.135
7.169GluGlu: 7.169 ± 0.151
1.963GluPhe: 1.963 ± 0.069
4.907GluGly: 4.907 ± 0.108
0.992GluHis: 0.992 ± 0.046
4.967GluIle: 4.967 ± 0.114
4.329GluLys: 4.329 ± 0.137
5.963GluLeu: 5.963 ± 0.13
1.913GluMet: 1.913 ± 0.064
2.847GluAsn: 2.847 ± 0.083
1.801GluPro: 1.801 ± 0.074
2.27GluGln: 2.27 ± 0.075
3.302GluArg: 3.302 ± 0.115
3.52GluSer: 3.52 ± 0.083
3.554GluThr: 3.554 ± 0.124
5.172GluVal: 5.172 ± 0.138
0.582GluTrp: 0.582 ± 0.028
1.555GluTyr: 1.555 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
3.117PheAla: 3.117 ± 0.069
0.309PheCys: 0.309 ± 0.024
2.837PheAsp: 2.837 ± 0.069
2.536PheGlu: 2.536 ± 0.074
1.907PhePhe: 1.907 ± 0.067
2.867PheGly: 2.867 ± 0.091
0.732PheHis: 0.732 ± 0.042
2.918PheIle: 2.918 ± 0.091
2.172PheLys: 2.172 ± 0.061
4.025PheLeu: 4.025 ± 0.108
1.034PheMet: 1.034 ± 0.039
1.834PheAsn: 1.834 ± 0.061
1.47PhePro: 1.47 ± 0.059
1.787PheGln: 1.787 ± 0.052
1.584PheArg: 1.584 ± 0.053
2.671PheSer: 2.671 ± 0.079
2.154PheThr: 2.154 ± 0.06
2.718PheVal: 2.718 ± 0.085
0.351PheTrp: 0.351 ± 0.027
1.681PheTyr: 1.681 ± 0.072
0.0PheXaa: 0.0 ± 0.0
Gly
5.416GlyAla: 5.416 ± 0.13
0.462GlyCys: 0.462 ± 0.034
3.996GlyAsp: 3.996 ± 0.094
4.406GlyGlu: 4.406 ± 0.159
2.953GlyPhe: 2.953 ± 0.089
4.447GlyGly: 4.447 ± 0.122
1.496GlyHis: 1.496 ± 0.056
5.085GlyIle: 5.085 ± 0.119
4.604GlyLys: 4.604 ± 0.243
7.367GlyLeu: 7.367 ± 0.139
1.819GlyMet: 1.819 ± 0.063
2.369GlyAsn: 2.369 ± 0.069
2.073GlyPro: 2.073 ± 0.078
4.6GlyGln: 4.6 ± 0.148
3.378GlyArg: 3.378 ± 0.09
3.806GlySer: 3.806 ± 0.092
3.694GlyThr: 3.694 ± 0.174
4.532GlyVal: 4.532 ± 0.097
0.617GlyTrp: 0.617 ± 0.038
2.738GlyTyr: 2.738 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
1.3HisAla: 1.3 ± 0.051
0.189HisCys: 0.189 ± 0.017
1.188HisAsp: 1.188 ± 0.054
1.199HisGlu: 1.199 ± 0.05
1.15HisPhe: 1.15 ± 0.053
1.294HisGly: 1.294 ± 0.051
0.521HisHis: 0.521 ± 0.033
1.242HisIle: 1.242 ± 0.044
0.893HisLys: 0.893 ± 0.035
2.188HisLeu: 2.188 ± 0.061
0.41HisMet: 0.41 ± 0.027
0.676HisAsn: 0.676 ± 0.034
1.246HisPro: 1.246 ± 0.049
1.055HisGln: 1.055 ± 0.043
0.811HisArg: 0.811 ± 0.037
1.017HisSer: 1.017 ± 0.039
0.868HisThr: 0.868 ± 0.05
1.177HisVal: 1.177 ± 0.046
0.207HisTrp: 0.207 ± 0.021
1.145HisTyr: 1.145 ± 0.05
0.0HisXaa: 0.0 ± 0.0
Ile
5.6IleAla: 5.6 ± 0.116
0.633IleCys: 0.633 ± 0.036
4.368IleAsp: 4.368 ± 0.103
4.41IleGlu: 4.41 ± 0.116
2.856IlePhe: 2.856 ± 0.107
4.539IleGly: 4.539 ± 0.12
1.357IleHis: 1.357 ± 0.053
4.393IleIle: 4.393 ± 0.118
3.362IleLys: 3.362 ± 0.095
6.32IleLeu: 6.32 ± 0.125
1.415IleMet: 1.415 ± 0.056
2.572IleAsn: 2.572 ± 0.064
2.695IlePro: 2.695 ± 0.071
3.363IleGln: 3.363 ± 0.08
2.961IleArg: 2.961 ± 0.073
4.018IleSer: 4.018 ± 0.095
3.052IleThr: 3.052 ± 0.085
4.413IleVal: 4.413 ± 0.115
0.582IleTrp: 0.582 ± 0.036
2.475IleTyr: 2.475 ± 0.074
0.0IleXaa: 0.0 ± 0.0
Lys
5.328LysAla: 5.328 ± 0.108
0.183LysCys: 0.183 ± 0.018
4.401LysAsp: 4.401 ± 0.234
5.163LysGlu: 5.163 ± 0.106
1.612LysPhe: 1.612 ± 0.07
3.694LysGly: 3.694 ± 0.127
1.034LysHis: 1.034 ± 0.042
3.245LysIle: 3.245 ± 0.089
3.601LysLys: 3.601 ± 0.11
4.695LysLeu: 4.695 ± 0.096
1.409LysMet: 1.409 ± 0.051
2.323LysAsn: 2.323 ± 0.081
1.821LysPro: 1.821 ± 0.092
2.646LysGln: 2.646 ± 0.077
2.82LysArg: 2.82 ± 0.082
2.776LysSer: 2.776 ± 0.095
3.069LysThr: 3.069 ± 0.095
3.728LysVal: 3.728 ± 0.124
0.453LysTrp: 0.453 ± 0.028
1.582LysTyr: 1.582 ± 0.06
0.0LysXaa: 0.0 ± 0.0
Leu
10.773LeuAla: 10.773 ± 0.213
0.705LeuCys: 0.705 ± 0.035
6.917LeuAsp: 6.917 ± 0.131
6.791LeuGlu: 6.791 ± 0.128
3.824LeuPhe: 3.824 ± 0.112
6.987LeuGly: 6.987 ± 0.149
1.573LeuHis: 1.573 ± 0.057
6.32LeuIle: 6.32 ± 0.155
5.553LeuLys: 5.553 ± 0.135
9.75LeuLeu: 9.75 ± 0.224
2.445LeuMet: 2.445 ± 0.086
3.948LeuAsn: 3.948 ± 0.089
4.179LeuPro: 4.179 ± 0.097
3.489LeuGln: 3.489 ± 0.102
3.834LeuArg: 3.834 ± 0.089
6.883LeuSer: 6.883 ± 0.128
5.621LeuThr: 5.621 ± 0.106
7.106LeuVal: 7.106 ± 0.163
0.705LeuTrp: 0.705 ± 0.041
3.239LeuTyr: 3.239 ± 0.096
0.0LeuXaa: 0.0 ± 0.0
Met
2.529MetAla: 2.529 ± 0.071
0.088MetCys: 0.088 ± 0.014
1.472MetAsp: 1.472 ± 0.059
1.384MetGlu: 1.384 ± 0.052
0.697MetPhe: 0.697 ± 0.035
1.794MetGly: 1.794 ± 0.062
0.361MetHis: 0.361 ± 0.026
1.661MetIle: 1.661 ± 0.062
1.514MetLys: 1.514 ± 0.049
2.017MetLeu: 2.017 ± 0.069
0.627MetMet: 0.627 ± 0.037
1.034MetAsn: 1.034 ± 0.043
1.055MetPro: 1.055 ± 0.041
0.906MetGln: 0.906 ± 0.037
1.107MetArg: 1.107 ± 0.049
1.461MetSer: 1.461 ± 0.056
1.914MetThr: 1.914 ± 0.063
1.749MetVal: 1.749 ± 0.057
0.135MetTrp: 0.135 ± 0.015
0.573MetTyr: 0.573 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
2.612AsnAla: 2.612 ± 0.067
0.25AsnCys: 0.25 ± 0.022
2.181AsnAsp: 2.181 ± 0.062
2.371AsnGlu: 2.371 ± 0.075
1.839AsnPhe: 1.839 ± 0.056
2.698AsnGly: 2.698 ± 0.106
0.958AsnHis: 0.958 ± 0.037
2.54AsnIle: 2.54 ± 0.065
1.85AsnLys: 1.85 ± 0.069
3.827AsnLeu: 3.827 ± 0.087
0.942AsnMet: 0.942 ± 0.045
1.648AsnAsn: 1.648 ± 0.104
2.211AsnPro: 2.211 ± 0.083
2.252AsnGln: 2.252 ± 0.066
1.981AsnArg: 1.981 ± 0.078
1.88AsnSer: 1.88 ± 0.073
1.71AsnThr: 1.71 ± 0.063
2.38AsnVal: 2.38 ± 0.064
0.5AsnTrp: 0.5 ± 0.027
1.74AsnTyr: 1.74 ± 0.064
0.0AsnXaa: 0.0 ± 0.0
Pro
3.268ProAla: 3.268 ± 0.118
0.21ProCys: 0.21 ± 0.018
2.684ProAsp: 2.684 ± 0.069
3.381ProGlu: 3.381 ± 0.108
1.602ProPhe: 1.602 ± 0.067
2.846ProGly: 2.846 ± 0.147
0.759ProHis: 0.759 ± 0.037
2.391ProIle: 2.391 ± 0.067
2.085ProLys: 2.085 ± 0.092
3.496ProLeu: 3.496 ± 0.086
0.773ProMet: 0.773 ± 0.034
1.686ProAsn: 1.686 ± 0.088
0.608ProPro: 0.608 ± 0.036
1.803ProGln: 1.803 ± 0.07
1.239ProArg: 1.239 ± 0.047
2.572ProSer: 2.572 ± 0.073
1.738ProThr: 1.738 ± 0.064
2.838ProVal: 2.838 ± 0.133
0.316ProTrp: 0.316 ± 0.029
1.562ProTyr: 1.562 ± 0.065
0.0ProXaa: 0.0 ± 0.0
Gln
7.485GlnAla: 7.485 ± 0.165
0.214GlnCys: 0.214 ± 0.019
3.162GlnAsp: 3.162 ± 0.101
4.23GlnGlu: 4.23 ± 0.101
1.541GlnPhe: 1.541 ± 0.054
3.629GlnGly: 3.629 ± 0.101
0.845GlnHis: 0.845 ± 0.041
2.993GlnIle: 2.993 ± 0.08
2.527GlnLys: 2.527 ± 0.073
4.758GlnLeu: 4.758 ± 0.113
1.163GlnMet: 1.163 ± 0.047
1.666GlnAsn: 1.666 ± 0.051
1.611GlnPro: 1.611 ± 0.073
1.839GlnGln: 1.839 ± 0.072
2.163GlnArg: 2.163 ± 0.069
2.909GlnSer: 2.909 ± 0.081
2.517GlnThr: 2.517 ± 0.063
4.451GlnVal: 4.451 ± 0.095
0.439GlnTrp: 0.439 ± 0.03
1.282GlnTyr: 1.282 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
3.13ArgAla: 3.13 ± 0.08
0.288ArgCys: 0.288 ± 0.024
2.813ArgAsp: 2.813 ± 0.085
3.121ArgGlu: 3.121 ± 0.096
1.931ArgPhe: 1.931 ± 0.06
2.583ArgGly: 2.583 ± 0.078
1.007ArgHis: 1.007 ± 0.042
3.022ArgIle: 3.022 ± 0.081
2.328ArgLys: 2.328 ± 0.07
5.069ArgLeu: 5.069 ± 0.11
1.113ArgMet: 1.113 ± 0.052
1.503ArgAsn: 1.503 ± 0.049
1.767ArgPro: 1.767 ± 0.056
3.034ArgGln: 3.034 ± 0.081
2.4ArgArg: 2.4 ± 0.08
2.303ArgSer: 2.303 ± 0.069
1.945ArgThr: 1.945 ± 0.059
2.937ArgVal: 2.937 ± 0.076
0.352ArgTrp: 0.352 ± 0.024
2.067ArgTyr: 2.067 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
4.108SerAla: 4.108 ± 0.084
0.329SerCys: 0.329 ± 0.027
3.437SerAsp: 3.437 ± 0.085
3.446SerGlu: 3.446 ± 0.107
2.758SerPhe: 2.758 ± 0.077
4.307SerGly: 4.307 ± 0.099
1.318SerHis: 1.318 ± 0.051
3.455SerIle: 3.455 ± 0.083
2.948SerLys: 2.948 ± 0.078
6.675SerLeu: 6.675 ± 0.154
1.296SerMet: 1.296 ± 0.05
2.145SerAsn: 2.145 ± 0.071
2.258SerPro: 2.258 ± 0.071
4.127SerGln: 4.127 ± 0.11
2.614SerArg: 2.614 ± 0.077
3.572SerSer: 3.572 ± 0.095
2.607SerThr: 2.607 ± 0.074
3.433SerVal: 3.433 ± 0.085
0.563SerTrp: 0.563 ± 0.039
2.367SerTyr: 2.367 ± 0.066
0.0SerXaa: 0.0 ± 0.0
Thr
4.251ThrAla: 4.251 ± 0.089
0.379ThrCys: 0.379 ± 0.031
3.25ThrAsp: 3.25 ± 0.097
2.968ThrGlu: 2.968 ± 0.09
1.927ThrPhe: 1.927 ± 0.066
4.07ThrGly: 4.07 ± 0.11
0.951ThrHis: 0.951 ± 0.038
3.669ThrIle: 3.669 ± 0.098
2.554ThrLys: 2.554 ± 0.096
4.485ThrLeu: 4.485 ± 0.094
1.075ThrMet: 1.075 ± 0.048
1.843ThrAsn: 1.843 ± 0.066
2.348ThrPro: 2.348 ± 0.112
1.756ThrGln: 1.756 ± 0.064
1.914ThrArg: 1.914 ± 0.059
2.923ThrSer: 2.923 ± 0.086
2.713ThrThr: 2.713 ± 0.155
3.593ThrVal: 3.593 ± 0.126
0.557ThrTrp: 0.557 ± 0.038
2.069ThrTyr: 2.069 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
5.456ValAla: 5.456 ± 0.094
0.511ValCys: 0.511 ± 0.029
4.805ValAsp: 4.805 ± 0.107
4.703ValGlu: 4.703 ± 0.129
2.623ValPhe: 2.623 ± 0.075
4.345ValGly: 4.345 ± 0.104
1.283ValHis: 1.283 ± 0.054
4.534ValIle: 4.534 ± 0.103
3.989ValLys: 3.989 ± 0.135
6.54ValLeu: 6.54 ± 0.137
1.589ValMet: 1.589 ± 0.056
2.939ValAsn: 2.939 ± 0.07
2.599ValPro: 2.599 ± 0.089
2.713ValGln: 2.713 ± 0.073
2.743ValArg: 2.743 ± 0.071
4.221ValSer: 4.221 ± 0.081
3.698ValThr: 3.698 ± 0.11
4.672ValVal: 4.672 ± 0.128
0.563ValTrp: 0.563 ± 0.028
2.33ValTyr: 2.33 ± 0.064
0.0ValXaa: 0.0 ± 0.0
Trp
0.671TrpAla: 0.671 ± 0.036
0.043TrpCys: 0.043 ± 0.008
0.52TrpAsp: 0.52 ± 0.032
0.55TrpGlu: 0.55 ± 0.036
0.316TrpPhe: 0.316 ± 0.024
0.611TrpGly: 0.611 ± 0.039
0.209TrpHis: 0.209 ± 0.02
0.593TrpIle: 0.593 ± 0.042
0.388TrpLys: 0.388 ± 0.027
1.15TrpLeu: 1.15 ± 0.048
0.243TrpMet: 0.243 ± 0.022
0.318TrpAsn: 0.318 ± 0.031
0.351TrpPro: 0.351 ± 0.027
0.654TrpGln: 0.654 ± 0.037
0.523TrpArg: 0.523 ± 0.033
0.494TrpSer: 0.494 ± 0.032
0.476TrpThr: 0.476 ± 0.028
0.564TrpVal: 0.564 ± 0.041
0.086TrpTrp: 0.086 ± 0.012
0.279TrpTyr: 0.279 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.813TyrAla: 2.813 ± 0.06
0.347TyrCys: 0.347 ± 0.023
2.463TyrAsp: 2.463 ± 0.073
2.292TyrGlu: 2.292 ± 0.065
1.895TyrPhe: 1.895 ± 0.056
2.621TyrGly: 2.621 ± 0.069
0.967TyrHis: 0.967 ± 0.041
2.089TyrIle: 2.089 ± 0.063
1.517TyrLys: 1.517 ± 0.052
4.152TyrLeu: 4.152 ± 0.102
0.791TyrMet: 0.791 ± 0.039
1.301TyrAsn: 1.301 ± 0.054
1.731TyrPro: 1.731 ± 0.06
2.738TyrGln: 2.738 ± 0.09
2.139TyrArg: 2.139 ± 0.074
1.938TyrSer: 1.938 ± 0.065
1.634TyrThr: 1.634 ± 0.057
2.173TyrVal: 2.173 ± 0.06
0.32TyrTrp: 0.32 ± 0.027
1.702TyrTyr: 1.702 ± 0.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1731 proteins (556294 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski