Amino acid dipepetide frequency for Candidatus Tokpelaia hoelldoblerii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.685AlaAla: 14.685 ± 0.285
1.091AlaCys: 1.091 ± 0.054
6.451AlaAsp: 6.451 ± 0.117
6.667AlaGlu: 6.667 ± 0.136
4.404AlaPhe: 4.404 ± 0.103
10.549AlaGly: 10.549 ± 0.23
2.193AlaHis: 2.193 ± 0.058
6.115AlaIle: 6.115 ± 0.11
3.87AlaLys: 3.87 ± 0.086
12.505AlaLeu: 12.505 ± 0.21
3.056AlaMet: 3.056 ± 0.09
3.011AlaAsn: 3.011 ± 0.081
4.49AlaPro: 4.49 ± 0.098
4.745AlaGln: 4.745 ± 0.108
7.873AlaArg: 7.873 ± 0.154
5.123AlaSer: 5.123 ± 0.103
5.033AlaThr: 5.033 ± 0.102
8.556AlaVal: 8.556 ± 0.163
1.073AlaTrp: 1.073 ± 0.044
2.657AlaTyr: 2.657 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.879CysAla: 0.879 ± 0.049
0.11CysCys: 0.11 ± 0.015
0.471CysAsp: 0.471 ± 0.031
0.394CysGlu: 0.394 ± 0.024
0.39CysPhe: 0.39 ± 0.024
0.881CysGly: 0.881 ± 0.047
0.228CysHis: 0.228 ± 0.021
0.455CysIle: 0.455 ± 0.033
0.293CysLys: 0.293 ± 0.023
0.942CysLeu: 0.942 ± 0.049
0.183CysMet: 0.183 ± 0.017
0.248CysAsn: 0.248 ± 0.021
0.437CysPro: 0.437 ± 0.033
0.288CysGln: 0.288 ± 0.019
0.593CysArg: 0.593 ± 0.034
0.51CysSer: 0.51 ± 0.026
0.433CysThr: 0.433 ± 0.028
0.572CysVal: 0.572 ± 0.036
0.102CysTrp: 0.102 ± 0.013
0.201CysTyr: 0.201 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.986AspAla: 4.986 ± 0.128
0.518AspCys: 0.518 ± 0.033
2.907AspAsp: 2.907 ± 0.118
3.618AspGlu: 3.618 ± 0.108
2.371AspPhe: 2.371 ± 0.074
4.814AspGly: 4.814 ± 0.223
1.154AspHis: 1.154 ± 0.043
4.242AspIle: 4.242 ± 0.096
2.691AspLys: 2.691 ± 0.083
4.896AspLeu: 4.896 ± 0.109
1.85AspMet: 1.85 ± 0.061
1.972AspAsn: 1.972 ± 0.09
2.285AspPro: 2.285 ± 0.071
1.136AspGln: 1.136 ± 0.048
3.169AspArg: 3.169 ± 0.078
2.574AspSer: 2.574 ± 0.073
2.89AspThr: 2.89 ± 0.122
3.854AspVal: 3.854 ± 0.085
0.811AspTrp: 0.811 ± 0.039
1.869AspTyr: 1.869 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
6.719GluAla: 6.719 ± 0.133
0.304GluCys: 0.304 ± 0.023
3.009GluAsp: 3.009 ± 0.104
3.895GluGlu: 3.895 ± 0.117
1.594GluPhe: 1.594 ± 0.056
4.118GluGly: 4.118 ± 0.103
1.242GluHis: 1.242 ± 0.066
3.714GluIle: 3.714 ± 0.097
4.046GluLys: 4.046 ± 0.108
4.72GluLeu: 4.72 ± 0.114
1.65GluMet: 1.65 ± 0.063
2.391GluAsn: 2.391 ± 0.071
2.161GluPro: 2.161 ± 0.072
2.68GluGln: 2.68 ± 0.088
4.025GluArg: 4.025 ± 0.091
2.175GluSer: 2.175 ± 0.06
3.85GluThr: 3.85 ± 0.101
3.241GluVal: 3.241 ± 0.087
0.62GluTrp: 0.62 ± 0.041
1.113GluTyr: 1.113 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
4.488PheAla: 4.488 ± 0.112
0.473PheCys: 0.473 ± 0.031
2.5PheAsp: 2.5 ± 0.07
2.09PheGlu: 2.09 ± 0.065
1.815PhePhe: 1.815 ± 0.077
3.467PheGly: 3.467 ± 0.1
0.886PheHis: 0.886 ± 0.05
2.493PheIle: 2.493 ± 0.078
1.19PheLys: 1.19 ± 0.054
3.719PheLeu: 3.719 ± 0.105
1.021PheMet: 1.021 ± 0.051
1.416PheAsn: 1.416 ± 0.05
1.481PhePro: 1.481 ± 0.06
1.086PheGln: 1.086 ± 0.044
2.026PheArg: 2.026 ± 0.056
2.96PheSer: 2.96 ± 0.081
2.236PheThr: 2.236 ± 0.06
2.854PheVal: 2.854 ± 0.085
0.514PheTrp: 0.514 ± 0.035
1.141PheTyr: 1.141 ± 0.053
0.0PheXaa: 0.0 ± 0.0
Gly
8.556GlyAla: 8.556 ± 0.161
0.742GlyCys: 0.742 ± 0.041
4.082GlyAsp: 4.082 ± 0.136
4.715GlyGlu: 4.715 ± 0.133
3.8GlyPhe: 3.8 ± 0.1
7.05GlyGly: 7.05 ± 0.221
1.841GlyHis: 1.841 ± 0.066
4.907GlyIle: 4.907 ± 0.109
4.691GlyLys: 4.691 ± 0.116
8.094GlyLeu: 8.094 ± 0.138
2.303GlyMet: 2.303 ± 0.069
2.799GlyAsn: 2.799 ± 0.153
2.033GlyPro: 2.033 ± 0.063
3.031GlyGln: 3.031 ± 0.078
5.516GlyArg: 5.516 ± 0.12
4.3GlySer: 4.3 ± 0.132
4.283GlyThr: 4.283 ± 0.149
5.718GlyVal: 5.718 ± 0.121
1.132GlyTrp: 1.132 ± 0.049
2.358GlyTyr: 2.358 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
2.051HisAla: 2.051 ± 0.064
0.214HisCys: 0.214 ± 0.019
1.247HisAsp: 1.247 ± 0.053
1.244HisGlu: 1.244 ± 0.049
0.96HisPhe: 0.96 ± 0.044
1.869HisGly: 1.869 ± 0.063
0.593HisHis: 0.593 ± 0.039
1.585HisIle: 1.585 ± 0.052
0.888HisLys: 0.888 ± 0.044
1.948HisLeu: 1.948 ± 0.062
0.672HisMet: 0.672 ± 0.036
0.803HisAsn: 0.803 ± 0.038
1.123HisPro: 1.123 ± 0.043
0.638HisGln: 0.638 ± 0.033
1.194HisArg: 1.194 ± 0.054
1.091HisSer: 1.091 ± 0.045
1.01HisThr: 1.01 ± 0.05
1.33HisVal: 1.33 ± 0.05
0.324HisTrp: 0.324 ± 0.021
0.809HisTyr: 0.809 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
7.806IleAla: 7.806 ± 0.124
0.618IleCys: 0.618 ± 0.036
3.525IleAsp: 3.525 ± 0.099
3.5IleGlu: 3.5 ± 0.091
2.168IlePhe: 2.168 ± 0.073
5.164IleGly: 5.164 ± 0.111
1.143IleHis: 1.143 ± 0.046
3.76IleIle: 3.76 ± 0.102
2.125IleLys: 2.125 ± 0.062
5.033IleLeu: 5.033 ± 0.121
1.377IleMet: 1.377 ± 0.059
1.957IleAsn: 1.957 ± 0.064
2.538IlePro: 2.538 ± 0.07
1.278IleGln: 1.278 ± 0.046
3.78IleArg: 3.78 ± 0.088
3.555IleSer: 3.555 ± 0.099
3.525IleThr: 3.525 ± 0.114
4.384IleVal: 4.384 ± 0.105
0.536IleTrp: 0.536 ± 0.033
1.391IleTyr: 1.391 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
5.085LysAla: 5.085 ± 0.128
0.2LysCys: 0.2 ± 0.02
2.27LysAsp: 2.27 ± 0.084
2.166LysGlu: 2.166 ± 0.07
1.016LysPhe: 1.016 ± 0.046
3.225LysGly: 3.225 ± 0.079
0.865LysHis: 0.865 ± 0.041
2.768LysIle: 2.768 ± 0.077
2.587LysLys: 2.587 ± 0.087
3.971LysLeu: 3.971 ± 0.102
1.147LysMet: 1.147 ± 0.053
1.819LysAsn: 1.819 ± 0.06
2.504LysPro: 2.504 ± 0.071
1.774LysGln: 1.774 ± 0.058
3.0LysArg: 3.0 ± 0.092
2.299LysSer: 2.299 ± 0.067
2.942LysThr: 2.942 ± 0.072
2.484LysVal: 2.484 ± 0.077
0.442LysTrp: 0.442 ± 0.032
0.911LysTyr: 0.911 ± 0.042
0.0LysXaa: 0.0 ± 0.0
Leu
12.302LeuAla: 12.302 ± 0.198
1.037LeuCys: 1.037 ± 0.051
5.533LeuAsp: 5.533 ± 0.112
5.349LeuGlu: 5.349 ± 0.119
4.048LeuPhe: 4.048 ± 0.115
7.303LeuGly: 7.303 ± 0.128
2.128LeuHis: 2.128 ± 0.064
4.86LeuIle: 4.86 ± 0.124
4.318LeuLys: 4.318 ± 0.102
9.692LeuLeu: 9.692 ± 0.194
2.25LeuMet: 2.25 ± 0.066
2.982LeuAsn: 2.982 ± 0.078
5.317LeuPro: 5.317 ± 0.131
3.76LeuGln: 3.76 ± 0.099
5.941LeuArg: 5.941 ± 0.114
6.223LeuSer: 6.223 ± 0.11
4.934LeuThr: 4.934 ± 0.115
7.67LeuVal: 7.67 ± 0.142
1.071LeuTrp: 1.071 ± 0.054
2.518LeuTyr: 2.518 ± 0.084
0.0LeuXaa: 0.0 ± 0.0
Met
3.169MetAla: 3.169 ± 0.086
0.147MetCys: 0.147 ± 0.02
1.278MetAsp: 1.278 ± 0.045
1.438MetGlu: 1.438 ± 0.051
0.768MetPhe: 0.768 ± 0.037
1.72MetGly: 1.72 ± 0.065
0.442MetHis: 0.442 ± 0.024
1.526MetIle: 1.526 ± 0.057
1.352MetLys: 1.352 ± 0.056
2.596MetLeu: 2.596 ± 0.077
0.848MetMet: 0.848 ± 0.045
0.919MetAsn: 0.919 ± 0.042
1.487MetPro: 1.487 ± 0.053
1.176MetGln: 1.176 ± 0.049
1.869MetArg: 1.869 ± 0.062
1.503MetSer: 1.503 ± 0.056
1.864MetThr: 1.864 ± 0.06
1.911MetVal: 1.911 ± 0.058
0.201MetTrp: 0.201 ± 0.021
0.334MetTyr: 0.334 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.466AsnAla: 3.466 ± 0.096
0.234AsnCys: 0.234 ± 0.021
1.621AsnAsp: 1.621 ± 0.061
1.487AsnGlu: 1.487 ± 0.067
1.21AsnPhe: 1.21 ± 0.049
3.023AsnGly: 3.023 ± 0.126
0.735AsnHis: 0.735 ± 0.039
2.155AsnIle: 2.155 ± 0.07
1.264AsnLys: 1.264 ± 0.053
2.863AsnLeu: 2.863 ± 0.073
0.845AsnMet: 0.845 ± 0.036
1.19AsnAsn: 1.19 ± 0.06
2.114AsnPro: 2.114 ± 0.069
0.949AsnGln: 0.949 ± 0.044
2.369AsnArg: 2.369 ± 0.074
1.718AsnSer: 1.718 ± 0.062
1.814AsnThr: 1.814 ± 0.076
2.164AsnVal: 2.164 ± 0.077
0.46AsnTrp: 0.46 ± 0.028
0.848AsnTyr: 0.848 ± 0.039
0.0AsnXaa: 0.0 ± 0.0
Pro
5.502ProAla: 5.502 ± 0.106
0.354ProCys: 0.354 ± 0.025
3.221ProAsp: 3.221 ± 0.09
3.235ProGlu: 3.235 ± 0.081
1.966ProPhe: 1.966 ± 0.058
3.216ProGly: 3.216 ± 0.085
1.05ProHis: 1.05 ± 0.04
1.616ProIle: 1.616 ± 0.056
1.495ProLys: 1.495 ± 0.053
4.486ProLeu: 4.486 ± 0.11
0.922ProMet: 0.922 ± 0.038
1.003ProAsn: 1.003 ± 0.046
1.952ProPro: 1.952 ± 0.07
2.182ProGln: 2.182 ± 0.073
2.353ProArg: 2.353 ± 0.061
1.905ProSer: 1.905 ± 0.059
1.67ProThr: 1.67 ± 0.06
4.81ProVal: 4.81 ± 0.106
0.532ProTrp: 0.532 ± 0.035
1.217ProTyr: 1.217 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
4.718GlnAla: 4.718 ± 0.114
0.221GlnCys: 0.221 ± 0.02
1.738GlnAsp: 1.738 ± 0.058
2.182GlnGlu: 2.182 ± 0.079
1.188GlnPhe: 1.188 ± 0.047
2.811GlnGly: 2.811 ± 0.072
0.748GlnHis: 0.748 ± 0.042
2.179GlnIle: 2.179 ± 0.07
1.992GlnLys: 1.992 ± 0.069
3.431GlnLeu: 3.431 ± 0.094
1.075GlnMet: 1.075 ± 0.046
1.271GlnAsn: 1.271 ± 0.049
1.711GlnPro: 1.711 ± 0.063
1.718GlnGln: 1.718 ± 0.065
2.24GlnArg: 2.24 ± 0.07
1.868GlnSer: 1.868 ± 0.06
2.263GlnThr: 2.263 ± 0.067
2.378GlnVal: 2.378 ± 0.074
0.451GlnTrp: 0.451 ± 0.027
0.771GlnTyr: 0.771 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
6.388ArgAla: 6.388 ± 0.136
0.397ArgCys: 0.397 ± 0.029
3.439ArgAsp: 3.439 ± 0.085
3.992ArgGlu: 3.992 ± 0.104
2.883ArgPhe: 2.883 ± 0.081
4.059ArgGly: 4.059 ± 0.101
1.744ArgHis: 1.744 ± 0.055
4.143ArgIle: 4.143 ± 0.09
3.02ArgLys: 3.02 ± 0.082
7.278ArgLeu: 7.278 ± 0.15
1.781ArgMet: 1.781 ± 0.063
2.294ArgAsn: 2.294 ± 0.06
2.781ArgPro: 2.781 ± 0.08
3.045ArgGln: 3.045 ± 0.085
4.6ArgArg: 4.6 ± 0.119
3.005ArgSer: 3.005 ± 0.086
2.989ArgThr: 2.989 ± 0.082
4.059ArgVal: 4.059 ± 0.084
0.696ArgTrp: 0.696 ± 0.036
1.871ArgTyr: 1.871 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
5.849SerAla: 5.849 ± 0.113
0.482SerCys: 0.482 ± 0.034
2.653SerAsp: 2.653 ± 0.084
2.477SerGlu: 2.477 ± 0.079
2.376SerPhe: 2.376 ± 0.062
5.705SerGly: 5.705 ± 0.143
1.213SerHis: 1.213 ± 0.043
2.739SerIle: 2.739 ± 0.076
1.792SerLys: 1.792 ± 0.063
5.423SerLeu: 5.423 ± 0.128
1.343SerMet: 1.343 ± 0.051
1.539SerAsn: 1.539 ± 0.055
2.346SerPro: 2.346 ± 0.066
1.699SerGln: 1.699 ± 0.06
3.44SerArg: 3.44 ± 0.078
2.88SerSer: 2.88 ± 0.087
2.491SerThr: 2.491 ± 0.07
3.96SerVal: 3.96 ± 0.091
0.735SerTrp: 0.735 ± 0.042
1.451SerTyr: 1.451 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
6.192ThrAla: 6.192 ± 0.107
0.451ThrCys: 0.451 ± 0.03
2.669ThrAsp: 2.669 ± 0.097
2.382ThrGlu: 2.382 ± 0.07
2.049ThrPhe: 2.049 ± 0.072
5.389ThrGly: 5.389 ± 0.135
1.046ThrHis: 1.046 ± 0.042
3.3ThrIle: 3.3 ± 0.099
1.429ThrLys: 1.429 ± 0.055
5.959ThrLeu: 5.959 ± 0.104
1.242ThrMet: 1.242 ± 0.052
1.343ThrAsn: 1.343 ± 0.067
2.989ThrPro: 2.989 ± 0.088
1.738ThrGln: 1.738 ± 0.059
3.255ThrArg: 3.255 ± 0.086
2.608ThrSer: 2.608 ± 0.086
2.718ThrThr: 2.718 ± 0.071
4.609ThrVal: 4.609 ± 0.129
0.566ThrTrp: 0.566 ± 0.035
1.167ThrTyr: 1.167 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
7.817ValAla: 7.817 ± 0.141
0.647ValCys: 0.647 ± 0.037
3.908ValAsp: 3.908 ± 0.116
4.544ValGlu: 4.544 ± 0.097
3.234ValPhe: 3.234 ± 0.095
4.598ValGly: 4.598 ± 0.104
1.366ValHis: 1.366 ± 0.054
4.652ValIle: 4.652 ± 0.113
2.887ValLys: 2.887 ± 0.075
7.623ValLeu: 7.623 ± 0.148
2.046ValMet: 2.046 ± 0.068
2.216ValAsn: 2.216 ± 0.071
3.313ValPro: 3.313 ± 0.089
2.308ValGln: 2.308 ± 0.067
4.513ValArg: 4.513 ± 0.103
4.318ValSer: 4.318 ± 0.096
4.219ValThr: 4.219 ± 0.107
5.394ValVal: 5.394 ± 0.114
0.836ValTrp: 0.836 ± 0.042
1.724ValTyr: 1.724 ± 0.053
0.0ValXaa: 0.0 ± 0.0
Trp
0.94TrpAla: 0.94 ± 0.047
0.137TrpCys: 0.137 ± 0.016
0.51TrpAsp: 0.51 ± 0.043
0.455TrpGlu: 0.455 ± 0.036
0.528TrpPhe: 0.528 ± 0.032
0.751TrpGly: 0.751 ± 0.044
0.32TrpHis: 0.32 ± 0.023
0.546TrpIle: 0.546 ± 0.035
0.532TrpLys: 0.532 ± 0.031
1.646TrpLeu: 1.646 ± 0.066
0.302TrpMet: 0.302 ± 0.022
0.413TrpAsn: 0.413 ± 0.026
0.527TrpPro: 0.527 ± 0.031
0.748TrpGln: 0.748 ± 0.037
0.98TrpArg: 0.98 ± 0.04
0.591TrpSer: 0.591 ± 0.031
0.536TrpThr: 0.536 ± 0.035
0.658TrpVal: 0.658 ± 0.04
0.217TrpTrp: 0.217 ± 0.022
0.302TrpTyr: 0.302 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.547TyrAla: 2.547 ± 0.076
0.234TyrCys: 0.234 ± 0.019
1.573TyrAsp: 1.573 ± 0.055
1.436TyrGlu: 1.436 ± 0.051
1.091TyrPhe: 1.091 ± 0.05
2.24TyrGly: 2.24 ± 0.073
0.658TyrHis: 0.658 ± 0.033
1.407TyrIle: 1.407 ± 0.051
1.014TyrLys: 1.014 ± 0.046
2.41TyrLeu: 2.41 ± 0.074
0.633TyrMet: 0.633 ± 0.037
0.944TyrAsn: 0.944 ± 0.048
1.102TyrPro: 1.102 ± 0.05
0.976TyrGln: 0.976 ± 0.048
1.727TyrArg: 1.727 ± 0.058
1.386TyrSer: 1.386 ± 0.055
1.4TyrThr: 1.4 ± 0.049
1.557TyrVal: 1.557 ± 0.055
0.32TyrTrp: 0.32 ± 0.027
0.764TyrTyr: 0.764 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1683 proteins (556338 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski