Amino acid dipepetide frequency for Paracoccus sp. J56

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.743AlaAla: 17.743 ± 0.204	1.069AlaCys: 1.069 ± 0.034	6.792AlaAsp: 6.792 ± 0.091	9.15AlaGlu: 9.15 ± 0.125	3.911AlaPhe: 3.911 ± 0.063	11.42AlaGly: 11.42 ± 0.125	2.354AlaHis: 2.354 ± 0.054	6.149AlaIle: 6.149 ± 0.084	3.119AlaLys: 3.119 ± 0.059	14.55AlaLeu: 14.55 ± 0.144	3.911AlaMet: 3.911 ± 0.067	2.564AlaAsn: 2.564 ± 0.045	6.178AlaPro: 6.178 ± 0.086	4.604AlaGln: 4.604 ± 0.066	10.378AlaArg: 10.378 ± 0.119	5.652AlaSer: 5.652 ± 0.064	5.745AlaThr: 5.745 ± 0.073	8.632AlaVal: 8.632 ± 0.099	1.428AlaTrp: 1.428 ± 0.039	2.273AlaTyr: 2.273 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.007CysAla: 1.007 ± 0.036	0.118CysCys: 0.118 ± 0.01	0.579CysAsp: 0.579 ± 0.022	0.413CysGlu: 0.413 ± 0.022	0.335CysPhe: 0.335 ± 0.015	0.971CysGly: 0.971 ± 0.031	0.262CysHis: 0.262 ± 0.016	0.427CysIle: 0.427 ± 0.02	0.191CysLys: 0.191 ± 0.012	0.838CysLeu: 0.838 ± 0.023	0.169CysMet: 0.169 ± 0.012	0.193CysAsn: 0.193 ± 0.013	0.513CysPro: 0.513 ± 0.024	0.24CysGln: 0.24 ± 0.013	0.634CysArg: 0.634 ± 0.026	0.465CysSer: 0.465 ± 0.023	0.408CysThr: 0.408 ± 0.021	0.535CysVal: 0.535 ± 0.024	0.118CysTrp: 0.118 ± 0.009	0.206CysTyr: 0.206 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.514AspAla: 6.514 ± 0.086	0.496AspCys: 0.496 ± 0.021	2.837AspAsp: 2.837 ± 0.057	3.584AspGlu: 3.584 ± 0.062	2.13AspPhe: 2.13 ± 0.046	4.895AspGly: 4.895 ± 0.087	1.365AspHis: 1.365 ± 0.035	2.707AspIle: 2.707 ± 0.051	1.53AspLys: 1.53 ± 0.04	6.375AspLeu: 6.375 ± 0.078	1.43AspMet: 1.43 ± 0.033	1.106AspAsn: 1.106 ± 0.031	3.867AspPro: 3.867 ± 0.063	1.877AspGln: 1.877 ± 0.042	4.572AspArg: 4.572 ± 0.072	2.245AspSer: 2.245 ± 0.042	2.398AspThr: 2.398 ± 0.054	3.404AspVal: 3.404 ± 0.061	1.227AspTrp: 1.227 ± 0.035	1.496AspTyr: 1.496 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	8.378GluAla: 8.378 ± 0.116	0.366GluCys: 0.366 ± 0.02	2.943GluAsp: 2.943 ± 0.054	3.124GluGlu: 3.124 ± 0.062	1.883GluPhe: 1.883 ± 0.037	4.79GluGly: 4.79 ± 0.066	1.169GluHis: 1.169 ± 0.034	3.69GluIle: 3.69 ± 0.059	1.979GluLys: 1.979 ± 0.047	5.58GluLeu: 5.58 ± 0.076	1.696GluMet: 1.696 ± 0.039	1.633GluAsn: 1.633 ± 0.041	2.881GluPro: 2.881 ± 0.057	1.947GluGln: 1.947 ± 0.048	4.547GluArg: 4.547 ± 0.069	2.261GluSer: 2.261 ± 0.046	3.475GluThr: 3.475 ± 0.059	4.256GluVal: 4.256 ± 0.064	0.772GluTrp: 0.772 ± 0.028	1.082GluTyr: 1.082 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.336PheAla: 4.336 ± 0.064	0.387PheCys: 0.387 ± 0.017	2.504PheAsp: 2.504 ± 0.041	1.759PheGlu: 1.759 ± 0.039	1.289PhePhe: 1.289 ± 0.038	3.541PheGly: 3.541 ± 0.057	0.795PheHis: 0.795 ± 0.028	1.657PheIle: 1.657 ± 0.042	0.675PheLys: 0.675 ± 0.027	3.437PheLeu: 3.437 ± 0.061	0.816PheMet: 0.816 ± 0.028	0.882PheAsn: 0.882 ± 0.027	1.591PhePro: 1.591 ± 0.034	1.02PheGln: 1.02 ± 0.031	2.389PheArg: 2.389 ± 0.046	2.075PheSer: 2.075 ± 0.045	1.82PheThr: 1.82 ± 0.044	2.401PheVal: 2.401 ± 0.054	0.593PheTrp: 0.593 ± 0.023	0.847PheTyr: 0.847 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	10.143GlyAla: 10.143 ± 0.112	0.871GlyCys: 0.871 ± 0.029	4.412GlyAsp: 4.412 ± 0.071	4.777GlyGlu: 4.777 ± 0.066	3.656GlyPhe: 3.656 ± 0.054	7.495GlyGly: 7.495 ± 0.116	2.009GlyHis: 2.009 ± 0.043	4.838GlyIle: 4.838 ± 0.066	3.061GlyLys: 3.061 ± 0.055	9.633GlyLeu: 9.633 ± 0.121	2.619GlyMet: 2.619 ± 0.053	2.212GlyAsn: 2.212 ± 0.078	4.081GlyPro: 4.081 ± 0.066	3.519GlyGln: 3.519 ± 0.054	6.797GlyArg: 6.797 ± 0.087	4.139GlySer: 4.139 ± 0.071	4.563GlyThr: 4.563 ± 0.075	6.217GlyVal: 6.217 ± 0.068	1.655GlyTrp: 1.655 ± 0.043	2.189GlyTyr: 2.189 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.364HisAla: 2.364 ± 0.053	0.209HisCys: 0.209 ± 0.014	1.422HisAsp: 1.422 ± 0.037	1.151HisGlu: 1.151 ± 0.032	0.802HisPhe: 0.802 ± 0.026	2.117HisGly: 2.117 ± 0.046	0.582HisHis: 0.582 ± 0.025	0.957HisIle: 0.957 ± 0.036	0.459HisLys: 0.459 ± 0.017	2.209HisLeu: 2.209 ± 0.048	0.547HisMet: 0.547 ± 0.023	0.44HisAsn: 0.44 ± 0.021	1.525HisPro: 1.525 ± 0.041	0.569HisGln: 0.569 ± 0.024	1.55HisArg: 1.55 ± 0.035	0.898HisSer: 0.898 ± 0.027	0.715HisThr: 0.715 ± 0.027	1.544HisVal: 1.544 ± 0.037	0.369HisTrp: 0.369 ± 0.019	0.546HisTyr: 0.546 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.482IleAla: 7.482 ± 0.084	0.656IleCys: 0.656 ± 0.026	3.232IleAsp: 3.232 ± 0.057	3.544IleGlu: 3.544 ± 0.068	1.761IlePhe: 1.761 ± 0.044	5.082IleGly: 5.082 ± 0.08	0.992IleHis: 0.992 ± 0.027	2.31IleIle: 2.31 ± 0.052	1.195IleLys: 1.195 ± 0.033	4.9IleLeu: 4.9 ± 0.074	1.142IleMet: 1.142 ± 0.031	1.267IleAsn: 1.267 ± 0.034	2.496IlePro: 2.496 ± 0.046	1.185IleGln: 1.185 ± 0.033	4.021IleArg: 4.021 ± 0.059	3.088IleSer: 3.088 ± 0.051	2.8IleThr: 2.8 ± 0.048	3.622IleVal: 3.622 ± 0.058	0.79IleTrp: 0.79 ± 0.026	1.102IleTyr: 1.102 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.494LysAla: 3.494 ± 0.061	0.148LysCys: 0.148 ± 0.01	1.417LysAsp: 1.417 ± 0.04	1.377LysGlu: 1.377 ± 0.043	0.757LysPhe: 0.757 ± 0.028	2.52LysGly: 2.52 ± 0.048	0.496LysHis: 0.496 ± 0.021	1.405LysIle: 1.405 ± 0.038	0.903LysLys: 0.903 ± 0.035	2.759LysLeu: 2.759 ± 0.05	0.706LysMet: 0.706 ± 0.031	0.628LysAsn: 0.628 ± 0.023	1.697LysPro: 1.697 ± 0.045	0.819LysGln: 0.819 ± 0.026	1.853LysArg: 1.853 ± 0.043	1.489LysSer: 1.489 ± 0.036	1.538LysThr: 1.538 ± 0.038	2.062LysVal: 2.062 ± 0.044	0.376LysTrp: 0.376 ± 0.018	0.548LysTyr: 0.548 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.644LeuAla: 14.644 ± 0.161	0.963LeuCys: 0.963 ± 0.029	5.895LeuAsp: 5.895 ± 0.076	5.019LeuGlu: 5.019 ± 0.069	3.379LeuPhe: 3.379 ± 0.066	8.889LeuGly: 8.889 ± 0.099	2.04LeuHis: 2.04 ± 0.045	5.868LeuIle: 5.868 ± 0.08	2.809LeuLys: 2.809 ± 0.054	9.115LeuLeu: 9.115 ± 0.142	2.657LeuMet: 2.657 ± 0.046	2.607LeuAsn: 2.607 ± 0.047	6.351LeuPro: 6.351 ± 0.081	2.749LeuGln: 2.749 ± 0.052	8.143LeuArg: 8.143 ± 0.093	6.372LeuSer: 6.372 ± 0.078	6.359LeuThr: 6.359 ± 0.077	7.054LeuVal: 7.054 ± 0.095	1.37LeuTrp: 1.37 ± 0.042	1.923LeuTyr: 1.923 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.578MetAla: 3.578 ± 0.063	0.162MetCys: 0.162 ± 0.012	1.299MetAsp: 1.299 ± 0.034	1.174MetGlu: 1.174 ± 0.031	0.77MetPhe: 0.77 ± 0.027	2.225MetGly: 2.225 ± 0.051	0.423MetHis: 0.423 ± 0.019	1.576MetIle: 1.576 ± 0.036	0.905MetLys: 0.905 ± 0.027	2.705MetLeu: 2.705 ± 0.05	0.712MetMet: 0.712 ± 0.027	0.859MetAsn: 0.859 ± 0.031	1.517MetPro: 1.517 ± 0.035	1.005MetGln: 1.005 ± 0.031	2.122MetArg: 2.122 ± 0.042	1.548MetSer: 1.548 ± 0.038	2.065MetThr: 2.065 ± 0.042	1.848MetVal: 1.848 ± 0.038	0.209MetTrp: 0.209 ± 0.013	0.282MetTyr: 0.282 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.892AsnAla: 2.892 ± 0.053	0.241AsnCys: 0.241 ± 0.015	1.381AsnAsp: 1.381 ± 0.063	1.165AsnGlu: 1.165 ± 0.031	0.844AsnPhe: 0.844 ± 0.027	2.211AsnGly: 2.211 ± 0.046	0.511AsnHis: 0.511 ± 0.019	1.325AsnIle: 1.325 ± 0.04	0.535AsnLys: 0.535 ± 0.02	2.512AsnLeu: 2.512 ± 0.045	0.654AsnMet: 0.654 ± 0.023	0.537AsnAsn: 0.537 ± 0.02	1.87AsnPro: 1.87 ± 0.038	0.71AsnGln: 0.71 ± 0.025	1.867AsnArg: 1.867 ± 0.038	1.14AsnSer: 1.14 ± 0.032	1.087AsnThr: 1.087 ± 0.031	1.612AsnVal: 1.612 ± 0.039	0.42AsnTrp: 0.42 ± 0.019	0.562AsnTyr: 0.562 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.003ProAla: 7.003 ± 0.086	0.384ProCys: 0.384 ± 0.018	3.897ProAsp: 3.897 ± 0.055	4.653ProGlu: 4.653 ± 0.071	1.922ProPhe: 1.922 ± 0.048	5.35ProGly: 5.35 ± 0.079	1.132ProHis: 1.132 ± 0.033	2.184ProIle: 2.184 ± 0.04	1.355ProLys: 1.355 ± 0.035	5.075ProLeu: 5.075 ± 0.068	1.368ProMet: 1.368 ± 0.029	1.172ProAsn: 1.172 ± 0.035	2.61ProPro: 2.61 ± 0.054	2.029ProGln: 2.029 ± 0.045	3.48ProArg: 3.48 ± 0.06	2.516ProSer: 2.516 ± 0.047	2.288ProThr: 2.288 ± 0.048	4.678ProVal: 4.678 ± 0.067	0.753ProTrp: 0.753 ± 0.028	1.044ProTyr: 1.044 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.306GlnAla: 4.306 ± 0.067	0.185GlnCys: 0.185 ± 0.014	1.602GlnAsp: 1.602 ± 0.038	1.631GlnGlu: 1.631 ± 0.042	1.014GlnPhe: 1.014 ± 0.031	3.119GlnGly: 3.119 ± 0.058	0.629GlnHis: 0.629 ± 0.025	2.125GlnIle: 2.125 ± 0.047	1.024GlnLys: 1.024 ± 0.035	2.894GlnLeu: 2.894 ± 0.051	1.046GlnMet: 1.046 ± 0.028	0.927GlnAsn: 0.927 ± 0.034	2.111GlnPro: 2.111 ± 0.046	1.184GlnGln: 1.184 ± 0.038	2.461GlnArg: 2.461 ± 0.055	1.668GlnSer: 1.668 ± 0.043	1.654GlnThr: 1.654 ± 0.04	2.461GlnVal: 2.461 ± 0.045	0.349GlnTrp: 0.349 ± 0.019	0.557GlnTyr: 0.557 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	9.183ArgAla: 9.183 ± 0.107	0.531ArgCys: 0.531 ± 0.022	4.506ArgAsp: 4.506 ± 0.068	4.462ArgGlu: 4.462 ± 0.066	2.741ArgPhe: 2.741 ± 0.053	5.321ArgGly: 5.321 ± 0.065	1.875ArgHis: 1.875 ± 0.05	4.668ArgIle: 4.668 ± 0.062	2.283ArgLys: 2.283 ± 0.046	8.874ArgLeu: 8.874 ± 0.1	2.162ArgMet: 2.162 ± 0.042	1.968ArgAsn: 1.968 ± 0.044	4.105ArgPro: 4.105 ± 0.071	2.795ArgGln: 2.795 ± 0.055	6.245ArgArg: 6.245 ± 0.099	3.404ArgSer: 3.404 ± 0.056	3.087ArgThr: 3.087 ± 0.056	4.995ArgVal: 4.995 ± 0.058	1.073ArgTrp: 1.073 ± 0.029	1.557ArgTyr: 1.557 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.915SerAla: 5.915 ± 0.072	0.471SerCys: 0.471 ± 0.02	2.958SerAsp: 2.958 ± 0.053	2.554SerGlu: 2.554 ± 0.046	2.088SerPhe: 2.088 ± 0.044	5.465SerGly: 5.465 ± 0.073	1.093SerHis: 1.093 ± 0.031	2.371SerIle: 2.371 ± 0.045	1.125SerLys: 1.125 ± 0.034	4.896SerLeu: 4.896 ± 0.069	1.266SerMet: 1.266 ± 0.035	1.133SerAsn: 1.133 ± 0.035	2.696SerPro: 2.696 ± 0.051	1.634SerGln: 1.634 ± 0.037	3.721SerArg: 3.721 ± 0.058	2.406SerSer: 2.406 ± 0.049	2.377SerThr: 2.377 ± 0.049	3.452SerVal: 3.452 ± 0.057	0.743SerTrp: 0.743 ± 0.026	1.17SerTyr: 1.17 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.029ThrAla: 6.029 ± 0.074	0.453ThrCys: 0.453 ± 0.021	2.695ThrAsp: 2.695 ± 0.046	2.921ThrGlu: 2.921 ± 0.055	1.705ThrPhe: 1.705 ± 0.041	5.35ThrGly: 5.35 ± 0.078	1.082ThrHis: 1.082 ± 0.033	2.581ThrIle: 2.581 ± 0.044	1.095ThrLys: 1.095 ± 0.031	5.689ThrLeu: 5.689 ± 0.064	1.208ThrMet: 1.208 ± 0.029	1.102ThrAsn: 1.102 ± 0.029	3.322ThrPro: 3.322 ± 0.059	1.503ThrGln: 1.503 ± 0.037	3.835ThrArg: 3.835 ± 0.063	2.442ThrSer: 2.442 ± 0.05	2.529ThrThr: 2.529 ± 0.056	4.015ThrVal: 4.015 ± 0.065	0.603ThrTrp: 0.603 ± 0.026	1.01ThrTyr: 1.01 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	8.885ValAla: 8.885 ± 0.097	0.565ValCys: 0.565 ± 0.025	3.544ValAsp: 3.544 ± 0.057	4.239ValGlu: 4.239 ± 0.062	2.502ValPhe: 2.502 ± 0.053	5.093ValGly: 5.093 ± 0.074	1.307ValHis: 1.307 ± 0.038	4.288ValIle: 4.288 ± 0.069	1.846ValLys: 1.846 ± 0.046	7.986ValLeu: 7.986 ± 0.093	2.088ValMet: 2.088 ± 0.041	1.871ValAsn: 1.871 ± 0.039	3.675ValPro: 3.675 ± 0.053	2.169ValGln: 2.169 ± 0.041	4.346ValArg: 4.346 ± 0.063	3.904ValSer: 3.904 ± 0.063	4.558ValThr: 4.558 ± 0.064	5.397ValVal: 5.397 ± 0.088	0.965ValTrp: 0.965 ± 0.032	1.246ValTyr: 1.246 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.398TrpAla: 1.398 ± 0.033	0.123TrpCys: 0.123 ± 0.01	0.69TrpAsp: 0.69 ± 0.025	0.595TrpGlu: 0.595 ± 0.023	0.565TrpPhe: 0.565 ± 0.023	1.019TrpGly: 1.019 ± 0.036	0.36TrpHis: 0.36 ± 0.016	0.703TrpIle: 0.703 ± 0.023	0.442TrpLys: 0.442 ± 0.021	1.984TrpLeu: 1.984 ± 0.053	0.37TrpMet: 0.37 ± 0.018	0.414TrpAsn: 0.414 ± 0.017	0.745TrpPro: 0.745 ± 0.03	0.751TrpGln: 0.751 ± 0.026	1.321TrpArg: 1.321 ± 0.036	0.801TrpSer: 0.801 ± 0.026	0.756TrpThr: 0.756 ± 0.027	0.863TrpVal: 0.863 ± 0.033	0.232TrpTrp: 0.232 ± 0.013	0.252TrpTyr: 0.252 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.326TyrAla: 2.326 ± 0.044	0.223TyrCys: 0.223 ± 0.014	1.451TyrAsp: 1.451 ± 0.042	1.162TyrGlu: 1.162 ± 0.034	0.759TyrPhe: 0.759 ± 0.027	2.012TyrGly: 2.012 ± 0.046	0.499TyrHis: 0.499 ± 0.021	0.84TyrIle: 0.84 ± 0.031	0.461TyrLys: 0.461 ± 0.018	2.196TyrLeu: 2.196 ± 0.039	0.417TyrMet: 0.417 ± 0.019	0.564TyrAsn: 0.564 ± 0.025	1.061TyrPro: 1.061 ± 0.031	0.637TyrGln: 0.637 ± 0.028	1.554TyrArg: 1.554 ± 0.035	1.022TyrSer: 1.022 ± 0.03	0.945TyrThr: 0.945 ± 0.029	1.423TyrVal: 1.423 ± 0.036	0.34TyrTrp: 0.34 ± 0.018	0.514TyrTyr: 0.514 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3752 proteins (1148692 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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