Amino acid dipepetide frequency for Weissella soli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.097AlaAla: 10.097 ± 0.235
0.093AlaCys: 0.093 ± 0.016
6.082AlaAsp: 6.082 ± 0.128
5.997AlaGlu: 5.997 ± 0.153
3.648AlaPhe: 3.648 ± 0.096
7.251AlaGly: 7.251 ± 0.148
1.928AlaHis: 1.928 ± 0.067
6.832AlaIle: 6.832 ± 0.127
5.651AlaLys: 5.651 ± 0.132
9.612AlaLeu: 9.612 ± 0.177
2.479AlaMet: 2.479 ± 0.071
3.982AlaAsn: 3.982 ± 0.104
2.827AlaPro: 2.827 ± 0.081
4.527AlaGln: 4.527 ± 0.112
3.774AlaArg: 3.774 ± 0.089
4.786AlaSer: 4.786 ± 0.128
6.579AlaThr: 6.579 ± 0.135
7.201AlaVal: 7.201 ± 0.136
1.013AlaTrp: 1.013 ± 0.039
2.99AlaTyr: 2.99 ± 0.084
0.0AlaXaa: 0.0 ± 0.0
Cys
0.091CysAla: 0.091 ± 0.015
0.014CysCys: 0.014 ± 0.006
0.062CysAsp: 0.062 ± 0.011
0.052CysGlu: 0.052 ± 0.011
0.045CysPhe: 0.045 ± 0.009
0.155CysGly: 0.155 ± 0.023
0.037CysHis: 0.037 ± 0.009
0.049CysIle: 0.049 ± 0.011
0.031CysLys: 0.031 ± 0.008
0.101CysLeu: 0.101 ± 0.016
0.027CysMet: 0.027 ± 0.007
0.045CysAsn: 0.045 ± 0.009
0.068CysPro: 0.068 ± 0.012
0.043CysGln: 0.043 ± 0.011
0.041CysArg: 0.041 ± 0.011
0.074CysSer: 0.074 ± 0.015
0.072CysThr: 0.072 ± 0.014
0.068CysVal: 0.068 ± 0.012
0.014CysTrp: 0.014 ± 0.005
0.041CysTyr: 0.041 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
5.537AspAla: 5.537 ± 0.135
0.054AspCys: 0.054 ± 0.011
3.409AspAsp: 3.409 ± 0.107
4.25AspGlu: 4.25 ± 0.118
2.796AspPhe: 2.796 ± 0.078
3.846AspGly: 3.846 ± 0.09
1.233AspHis: 1.233 ± 0.06
3.949AspIle: 3.949 ± 0.101
2.842AspLys: 2.842 ± 0.074
5.665AspLeu: 5.665 ± 0.12
1.576AspMet: 1.576 ± 0.064
2.167AspAsn: 2.167 ± 0.073
2.017AspPro: 2.017 ± 0.079
2.425AspGln: 2.425 ± 0.07
2.427AspArg: 2.427 ± 0.086
2.475AspSer: 2.475 ± 0.08
3.17AspThr: 3.17 ± 0.092
4.403AspVal: 4.403 ± 0.109
0.813AspTrp: 0.813 ± 0.05
2.304AspTyr: 2.304 ± 0.072
0.0AspXaa: 0.0 ± 0.0
Glu
5.539GluAla: 5.539 ± 0.119
0.049GluCys: 0.049 ± 0.012
2.774GluAsp: 2.774 ± 0.093
3.366GluGlu: 3.366 ± 0.098
2.448GluPhe: 2.448 ± 0.076
2.856GluGly: 2.856 ± 0.09
1.266GluHis: 1.266 ± 0.055
4.219GluIle: 4.219 ± 0.109
3.465GluLys: 3.465 ± 0.099
6.084GluLeu: 6.084 ± 0.124
1.86GluMet: 1.86 ± 0.066
2.77GluAsn: 2.77 ± 0.085
1.767GluPro: 1.767 ± 0.06
2.937GluGln: 2.937 ± 0.082
2.904GluArg: 2.904 ± 0.091
2.516GluSer: 2.516 ± 0.075
3.514GluThr: 3.514 ± 0.092
4.304GluVal: 4.304 ± 0.103
0.59GluTrp: 0.59 ± 0.034
1.79GluTyr: 1.79 ± 0.065
0.0GluXaa: 0.0 ± 0.0
Phe
3.939PheAla: 3.939 ± 0.108
0.049PheCys: 0.049 ± 0.011
3.058PheAsp: 3.058 ± 0.079
2.687PheGlu: 2.687 ± 0.067
1.91PhePhe: 1.91 ± 0.075
3.774PheGly: 3.774 ± 0.092
0.732PheHis: 0.732 ± 0.041
2.91PheIle: 2.91 ± 0.086
2.155PheLys: 2.155 ± 0.072
3.559PheLeu: 3.559 ± 0.093
1.227PheMet: 1.227 ± 0.052
2.056PheAsn: 2.056 ± 0.062
1.404PhePro: 1.404 ± 0.045
1.349PheGln: 1.349 ± 0.054
1.361PheArg: 1.361 ± 0.05
2.551PheSer: 2.551 ± 0.078
2.568PheThr: 2.568 ± 0.073
3.312PheVal: 3.312 ± 0.1
0.546PheTrp: 0.546 ± 0.039
1.423PheTyr: 1.423 ± 0.058
0.0PheXaa: 0.0 ± 0.0
Gly
6.018GlyAla: 6.018 ± 0.134
0.097GlyCys: 0.097 ± 0.014
3.747GlyAsp: 3.747 ± 0.093
3.724GlyGlu: 3.724 ± 0.088
3.221GlyPhe: 3.221 ± 0.085
4.685GlyGly: 4.685 ± 0.123
1.567GlyHis: 1.567 ± 0.061
5.168GlyIle: 5.168 ± 0.118
3.772GlyLys: 3.772 ± 0.093
7.282GlyLeu: 7.282 ± 0.115
2.184GlyMet: 2.184 ± 0.083
2.627GlyAsn: 2.627 ± 0.086
1.53GlyPro: 1.53 ± 0.052
3.095GlyGln: 3.095 ± 0.088
2.963GlyArg: 2.963 ± 0.079
3.749GlySer: 3.749 ± 0.1
4.504GlyThr: 4.504 ± 0.118
5.925GlyVal: 5.925 ± 0.122
0.926GlyTrp: 0.926 ± 0.052
2.677GlyTyr: 2.677 ± 0.081
0.0GlyXaa: 0.0 ± 0.0
His
1.914HisAla: 1.914 ± 0.07
0.033HisCys: 0.033 ± 0.009
1.326HisAsp: 1.326 ± 0.054
1.324HisGlu: 1.324 ± 0.05
0.99HisPhe: 0.99 ± 0.047
1.646HisGly: 1.646 ± 0.059
0.643HisHis: 0.643 ± 0.04
1.429HisIle: 1.429 ± 0.068
0.786HisLys: 0.786 ± 0.041
1.988HisLeu: 1.988 ± 0.067
0.549HisMet: 0.549 ± 0.035
0.829HisAsn: 0.829 ± 0.039
1.091HisPro: 1.091 ± 0.053
1.021HisGln: 1.021 ± 0.05
0.905HisArg: 0.905 ± 0.042
0.905HisSer: 0.905 ± 0.038
1.124HisThr: 1.124 ± 0.046
1.516HisVal: 1.516 ± 0.062
0.301HisTrp: 0.301 ± 0.026
0.903HisTyr: 0.903 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
7.067IleAla: 7.067 ± 0.132
0.095IleCys: 0.095 ± 0.017
4.31IleAsp: 4.31 ± 0.104
4.16IleGlu: 4.16 ± 0.1
2.988IlePhe: 2.988 ± 0.1
5.415IleGly: 5.415 ± 0.122
1.157IleHis: 1.157 ± 0.048
4.786IleIle: 4.786 ± 0.115
3.597IleLys: 3.597 ± 0.097
6.296IleLeu: 6.296 ± 0.135
1.701IleMet: 1.701 ± 0.062
3.211IleAsn: 3.211 ± 0.092
2.53IlePro: 2.53 ± 0.074
2.51IleGln: 2.51 ± 0.091
2.582IleArg: 2.582 ± 0.077
3.962IleSer: 3.962 ± 0.102
4.459IleThr: 4.459 ± 0.097
5.341IleVal: 5.341 ± 0.1
0.794IleTrp: 0.794 ± 0.046
2.056IleTyr: 2.056 ± 0.073
0.0IleXaa: 0.0 ± 0.0
Lys
4.593LysAla: 4.593 ± 0.12
0.031LysCys: 0.031 ± 0.007
2.588LysAsp: 2.588 ± 0.075
2.875LysGlu: 2.875 ± 0.086
1.92LysPhe: 1.92 ± 0.067
2.827LysGly: 2.827 ± 0.079
1.064LysHis: 1.064 ± 0.05
3.724LysIle: 3.724 ± 0.101
3.234LysLys: 3.234 ± 0.091
4.951LysLeu: 4.951 ± 0.119
1.916LysMet: 1.916 ± 0.064
2.658LysAsn: 2.658 ± 0.081
1.8LysPro: 1.8 ± 0.065
2.757LysGln: 2.757 ± 0.083
2.561LysArg: 2.561 ± 0.07
2.834LysSer: 2.834 ± 0.09
3.613LysThr: 3.613 ± 0.1
3.877LysVal: 3.877 ± 0.095
0.598LysTrp: 0.598 ± 0.038
1.967LysTyr: 1.967 ± 0.066
0.0LysXaa: 0.0 ± 0.0
Leu
10.538LeuAla: 10.538 ± 0.172
0.095LeuCys: 0.095 ± 0.017
5.343LeuAsp: 5.343 ± 0.133
4.778LeuGlu: 4.778 ± 0.124
3.869LeuPhe: 3.869 ± 0.11
6.739LeuGly: 6.739 ± 0.128
1.963LeuHis: 1.963 ± 0.066
6.496LeuIle: 6.496 ± 0.135
4.844LeuLys: 4.844 ± 0.109
9.15LeuLeu: 9.15 ± 0.201
2.681LeuMet: 2.681 ± 0.078
4.393LeuAsn: 4.393 ± 0.092
4.162LeuPro: 4.162 ± 0.103
4.211LeuGln: 4.211 ± 0.106
4.044LeuArg: 4.044 ± 0.1
5.96LeuSer: 5.96 ± 0.139
7.032LeuThr: 7.032 ± 0.146
7.455LeuVal: 7.455 ± 0.137
0.924LeuTrp: 0.924 ± 0.05
2.671LeuTyr: 2.671 ± 0.073
0.0LeuXaa: 0.0 ± 0.0
Met
3.178MetAla: 3.178 ± 0.095
0.029MetCys: 0.029 ± 0.007
1.386MetAsp: 1.386 ± 0.064
1.089MetGlu: 1.089 ± 0.048
0.988MetPhe: 0.988 ± 0.043
1.833MetGly: 1.833 ± 0.059
0.557MetHis: 0.557 ± 0.033
1.947MetIle: 1.947 ± 0.067
1.425MetLys: 1.425 ± 0.053
2.609MetLeu: 2.609 ± 0.082
0.963MetMet: 0.963 ± 0.051
1.299MetAsn: 1.299 ± 0.057
1.163MetPro: 1.163 ± 0.048
1.384MetGln: 1.384 ± 0.055
1.26MetArg: 1.26 ± 0.048
1.551MetSer: 1.551 ± 0.054
2.163MetThr: 2.163 ± 0.07
2.112MetVal: 2.112 ± 0.063
0.235MetTrp: 0.235 ± 0.023
0.711MetTyr: 0.711 ± 0.038
0.0MetXaa: 0.0 ± 0.0
Asn
3.718AsnAla: 3.718 ± 0.101
0.058AsnCys: 0.058 ± 0.012
2.506AsnAsp: 2.506 ± 0.079
2.553AsnGlu: 2.553 ± 0.069
1.84AsnPhe: 1.84 ± 0.057
3.335AsnGly: 3.335 ± 0.091
1.087AsnHis: 1.087 ± 0.049
2.774AsnIle: 2.774 ± 0.084
2.134AsnLys: 2.134 ± 0.073
3.881AsnLeu: 3.881 ± 0.103
1.198AsnMet: 1.198 ± 0.053
1.868AsnAsn: 1.868 ± 0.076
2.145AsnPro: 2.145 ± 0.058
2.091AsnGln: 2.091 ± 0.079
1.722AsnArg: 1.722 ± 0.058
2.029AsnSer: 2.029 ± 0.075
2.506AsnThr: 2.506 ± 0.08
3.271AsnVal: 3.271 ± 0.085
0.596AsnTrp: 0.596 ± 0.032
1.637AsnTyr: 1.637 ± 0.061
0.0AsnXaa: 0.0 ± 0.0
Pro
3.543ProAla: 3.543 ± 0.081
0.039ProCys: 0.039 ± 0.01
2.062ProAsp: 2.062 ± 0.061
2.706ProGlu: 2.706 ± 0.076
1.697ProPhe: 1.697 ± 0.067
2.273ProGly: 2.273 ± 0.073
0.693ProHis: 0.693 ± 0.038
2.398ProIle: 2.398 ± 0.068
2.073ProLys: 2.073 ± 0.068
3.089ProLeu: 3.089 ± 0.084
0.996ProMet: 0.996 ± 0.045
1.646ProAsn: 1.646 ± 0.06
0.439ProPro: 0.439 ± 0.033
1.299ProGln: 1.299 ± 0.046
1.25ProArg: 1.25 ± 0.046
1.852ProSer: 1.852 ± 0.061
2.537ProThr: 2.537 ± 0.075
3.238ProVal: 3.238 ± 0.086
0.388ProTrp: 0.388 ± 0.027
1.264ProTyr: 1.264 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
4.846GlnAla: 4.846 ± 0.133
0.035GlnCys: 0.035 ± 0.01
2.058GlnAsp: 2.058 ± 0.069
1.959GlnGlu: 1.959 ± 0.062
1.827GlnPhe: 1.827 ± 0.068
2.613GlnGly: 2.613 ± 0.068
1.118GlnHis: 1.118 ± 0.05
2.982GlnIle: 2.982 ± 0.085
2.223GlnLys: 2.223 ± 0.06
4.659GlnLeu: 4.659 ± 0.13
1.266GlnMet: 1.266 ± 0.056
1.79GlnAsn: 1.79 ± 0.06
1.769GlnPro: 1.769 ± 0.071
2.405GlnGln: 2.405 ± 0.098
2.174GlnArg: 2.174 ± 0.077
2.184GlnSer: 2.184 ± 0.072
3.147GlnThr: 3.147 ± 0.096
3.415GlnVal: 3.415 ± 0.089
0.495GlnTrp: 0.495 ± 0.035
1.485GlnTyr: 1.485 ± 0.052
0.0GlnXaa: 0.0 ± 0.0
Arg
3.51ArgAla: 3.51 ± 0.096
0.058ArgCys: 0.058 ± 0.011
2.438ArgAsp: 2.438 ± 0.079
2.796ArgGlu: 2.796 ± 0.082
1.889ArgPhe: 1.889 ± 0.065
2.603ArgGly: 2.603 ± 0.084
1.044ArgHis: 1.044 ± 0.045
2.73ArgIle: 2.73 ± 0.073
2.015ArgLys: 2.015 ± 0.066
4.415ArgLeu: 4.415 ± 0.109
1.184ArgMet: 1.184 ± 0.054
1.615ArgAsn: 1.615 ± 0.057
1.429ArgPro: 1.429 ± 0.05
2.332ArgGln: 2.332 ± 0.074
2.211ArgArg: 2.211 ± 0.068
2.017ArgSer: 2.017 ± 0.063
2.297ArgThr: 2.297 ± 0.067
3.273ArgVal: 3.273 ± 0.088
0.466ArgTrp: 0.466 ± 0.03
1.724ArgTyr: 1.724 ± 0.064
0.0ArgXaa: 0.0 ± 0.0
Ser
4.756SerAla: 4.756 ± 0.134
0.07SerCys: 0.07 ± 0.013
3.114SerAsp: 3.114 ± 0.09
2.994SerGlu: 2.994 ± 0.083
2.479SerPhe: 2.479 ± 0.077
4.184SerGly: 4.184 ± 0.095
1.085SerHis: 1.085 ± 0.043
3.665SerIle: 3.665 ± 0.091
2.85SerLys: 2.85 ± 0.077
5.092SerLeu: 5.092 ± 0.11
1.328SerMet: 1.328 ± 0.051
2.091SerAsn: 2.091 ± 0.084
1.625SerPro: 1.625 ± 0.058
2.161SerGln: 2.161 ± 0.073
2.165SerArg: 2.165 ± 0.071
3.281SerSer: 3.281 ± 0.178
3.469SerThr: 3.469 ± 0.101
4.205SerVal: 4.205 ± 0.1
0.687SerTrp: 0.687 ± 0.041
1.879SerTyr: 1.879 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
6.255ThrAla: 6.255 ± 0.134
0.068ThrCys: 0.068 ± 0.015
3.844ThrAsp: 3.844 ± 0.085
3.331ThrGlu: 3.331 ± 0.094
2.737ThrPhe: 2.737 ± 0.077
4.844ThrGly: 4.844 ± 0.116
1.367ThrHis: 1.367 ± 0.06
4.677ThrIle: 4.677 ± 0.099
3.448ThrLys: 3.448 ± 0.09
6.48ThrLeu: 6.48 ± 0.13
1.536ThrMet: 1.536 ± 0.06
2.937ThrAsn: 2.937 ± 0.074
2.881ThrPro: 2.881 ± 0.082
2.33ThrGln: 2.33 ± 0.079
2.425ThrArg: 2.425 ± 0.074
3.632ThrSer: 3.632 ± 0.116
4.96ThrThr: 4.96 ± 0.137
5.356ThrVal: 5.356 ± 0.127
0.732ThrTrp: 0.732 ± 0.04
2.202ThrTyr: 2.202 ± 0.079
0.0ThrXaa: 0.0 ± 0.0
Val
8.292ValAla: 8.292 ± 0.15
0.087ValCys: 0.087 ± 0.014
4.599ValAsp: 4.599 ± 0.107
4.116ValGlu: 4.116 ± 0.111
2.97ValPhe: 2.97 ± 0.085
5.393ValGly: 5.393 ± 0.112
1.439ValHis: 1.439 ± 0.069
5.554ValIle: 5.554 ± 0.109
4.092ValLys: 4.092 ± 0.105
7.41ValLeu: 7.41 ± 0.137
2.031ValMet: 2.031 ± 0.065
3.211ValAsn: 3.211 ± 0.08
3.126ValPro: 3.126 ± 0.079
2.939ValGln: 2.939 ± 0.077
3.04ValArg: 3.04 ± 0.098
4.364ValSer: 4.364 ± 0.1
5.692ValThr: 5.692 ± 0.115
6.356ValVal: 6.356 ± 0.133
0.813ValTrp: 0.813 ± 0.043
2.273ValTyr: 2.273 ± 0.069
0.0ValXaa: 0.0 ± 0.0
Trp
0.885TrpAla: 0.885 ± 0.044
0.021TrpCys: 0.021 ± 0.007
0.557TrpAsp: 0.557 ± 0.036
0.454TrpGlu: 0.454 ± 0.031
0.565TrpPhe: 0.565 ± 0.034
0.751TrpGly: 0.751 ± 0.044
0.39TrpHis: 0.39 ± 0.026
0.711TrpIle: 0.711 ± 0.043
0.349TrpLys: 0.349 ± 0.025
1.555TrpLeu: 1.555 ± 0.065
0.336TrpMet: 0.336 ± 0.028
0.439TrpAsn: 0.439 ± 0.03
0.363TrpPro: 0.363 ± 0.028
0.827TrpGln: 0.827 ± 0.05
0.602TrpArg: 0.602 ± 0.035
0.775TrpSer: 0.775 ± 0.044
0.635TrpThr: 0.635 ± 0.042
0.777TrpVal: 0.777 ± 0.046
0.212TrpTrp: 0.212 ± 0.025
0.363TrpTyr: 0.363 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.034TyrAla: 3.034 ± 0.08
0.058TyrCys: 0.058 ± 0.012
2.095TyrAsp: 2.095 ± 0.061
1.807TyrGlu: 1.807 ± 0.06
1.745TyrPhe: 1.745 ± 0.061
2.44TyrGly: 2.44 ± 0.081
0.852TyrHis: 0.852 ± 0.042
2.015TyrIle: 2.015 ± 0.054
1.406TyrLys: 1.406 ± 0.057
3.471TyrLeu: 3.471 ± 0.092
0.841TyrMet: 0.841 ± 0.039
1.314TyrAsn: 1.314 ± 0.056
1.343TyrPro: 1.343 ± 0.059
1.807TyrGln: 1.807 ± 0.075
1.635TyrArg: 1.635 ± 0.065
1.683TyrSer: 1.683 ± 0.055
2.002TyrThr: 2.002 ± 0.076
2.39TyrVal: 2.39 ± 0.061
0.425TyrTrp: 0.425 ± 0.032
1.382TyrTyr: 1.382 ± 0.065
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1537 proteins (484907 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski