Amino acid dipepetide frequency for Streptococcus satellite phage Javan412

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.68AlaAla: 0.68 ± 0.407
1.019AlaCys: 1.019 ± 0.439
6.116AlaAsp: 6.116 ± 1.641
4.417AlaGlu: 4.417 ± 1.532
1.699AlaPhe: 1.699 ± 0.64
1.359AlaGly: 1.359 ± 0.663
0.68AlaHis: 0.68 ± 0.701
3.058AlaIle: 3.058 ± 0.705
3.738AlaLys: 3.738 ± 1.199
5.776AlaLeu: 5.776 ± 1.278
2.039AlaMet: 2.039 ± 0.728
2.718AlaAsn: 2.718 ± 1.285
0.34AlaPro: 0.34 ± 0.307
1.699AlaGln: 1.699 ± 0.719
3.058AlaArg: 3.058 ± 1.169
3.398AlaSer: 3.398 ± 1.287
2.379AlaThr: 2.379 ± 1.04
3.058AlaVal: 3.058 ± 0.809
0.0AlaTrp: 0.0 ± 0.0
1.359AlaTyr: 1.359 ± 0.482
0.0AlaXaa: 0.0 ± 0.0
Cys
0.68CysAla: 0.68 ± 0.613
0.34CysCys: 0.34 ± 0.34
0.34CysAsp: 0.34 ± 0.31
0.68CysGlu: 0.68 ± 0.478
0.34CysPhe: 0.34 ± 0.286
1.019CysGly: 1.019 ± 0.476
0.34CysHis: 0.34 ± 0.307
0.68CysIle: 0.68 ± 0.573
0.0CysLys: 0.0 ± 0.0
0.68CysLeu: 0.68 ± 0.761
0.34CysMet: 0.34 ± 0.337
0.68CysAsn: 0.68 ± 0.352
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
1.019CysVal: 1.019 ± 0.575
0.0CysTrp: 0.0 ± 0.0
0.68CysTyr: 0.68 ± 0.379
0.0CysXaa: 0.0 ± 0.0
Asp
2.039AspAla: 2.039 ± 0.956
0.34AspCys: 0.34 ± 0.307
4.417AspAsp: 4.417 ± 1.479
6.116AspGlu: 6.116 ± 1.53
4.417AspPhe: 4.417 ± 1.04
3.738AspGly: 3.738 ± 1.23
1.699AspHis: 1.699 ± 0.539
5.437AspIle: 5.437 ± 1.513
4.077AspLys: 4.077 ± 1.654
6.456AspLeu: 6.456 ± 1.399
1.699AspMet: 1.699 ± 0.692
4.757AspAsn: 4.757 ± 0.927
0.68AspPro: 0.68 ± 0.521
2.379AspGln: 2.379 ± 0.92
1.699AspArg: 1.699 ± 0.675
2.718AspSer: 2.718 ± 0.713
3.398AspThr: 3.398 ± 0.997
3.398AspVal: 3.398 ± 1.017
0.0AspTrp: 0.0 ± 0.0
3.058AspTyr: 3.058 ± 0.764
0.0AspXaa: 0.0 ± 0.0
Glu
4.757GluAla: 4.757 ± 1.241
0.34GluCys: 0.34 ± 0.286
4.077GluAsp: 4.077 ± 1.173
8.835GluGlu: 8.835 ± 3.341
3.398GluPhe: 3.398 ± 1.259
1.359GluGly: 1.359 ± 0.689
0.68GluHis: 0.68 ± 0.452
4.757GluIle: 4.757 ± 1.182
10.194GluLys: 10.194 ± 2.457
12.572GluLeu: 12.572 ± 1.689
3.058GluMet: 3.058 ± 0.85
7.136GluAsn: 7.136 ± 1.473
2.039GluPro: 2.039 ± 0.716
2.718GluGln: 2.718 ± 0.719
4.417GluArg: 4.417 ± 1.09
2.718GluSer: 2.718 ± 0.777
4.417GluThr: 4.417 ± 1.348
2.379GluVal: 2.379 ± 0.819
1.019GluTrp: 1.019 ± 0.488
3.738GluTyr: 3.738 ± 1.015
0.0GluXaa: 0.0 ± 0.0
Phe
2.379PheAla: 2.379 ± 0.759
0.34PheCys: 0.34 ± 0.34
2.718PheAsp: 2.718 ± 0.827
4.417PheGlu: 4.417 ± 1.27
2.718PhePhe: 2.718 ± 0.745
2.039PheGly: 2.039 ± 0.612
0.68PheHis: 0.68 ± 0.402
4.077PheIle: 4.077 ± 1.008
4.077PheLys: 4.077 ± 0.654
6.116PheLeu: 6.116 ± 1.964
0.68PheMet: 0.68 ± 0.398
3.058PheAsn: 3.058 ± 0.698
0.0PhePro: 0.0 ± 0.0
1.699PheGln: 1.699 ± 0.7
2.039PheArg: 2.039 ± 1.069
3.398PheSer: 3.398 ± 0.979
1.699PheThr: 1.699 ± 0.642
4.077PheVal: 4.077 ± 1.14
0.68PheTrp: 0.68 ± 0.412
1.359PheTyr: 1.359 ± 0.912
0.0PheXaa: 0.0 ± 0.0
Gly
2.379GlyAla: 2.379 ± 0.612
0.68GlyCys: 0.68 ± 0.573
1.019GlyAsp: 1.019 ± 0.523
3.738GlyGlu: 3.738 ± 1.105
2.039GlyPhe: 2.039 ± 0.977
2.379GlyGly: 2.379 ± 0.909
0.68GlyHis: 0.68 ± 0.613
4.417GlyIle: 4.417 ± 1.192
3.738GlyLys: 3.738 ± 0.995
7.475GlyLeu: 7.475 ± 1.496
1.699GlyMet: 1.699 ± 0.975
2.718GlyAsn: 2.718 ± 1.075
0.34GlyPro: 0.34 ± 0.286
1.359GlyGln: 1.359 ± 0.49
0.68GlyArg: 0.68 ± 0.352
2.718GlySer: 2.718 ± 0.6
1.699GlyThr: 1.699 ± 0.722
3.058GlyVal: 3.058 ± 0.878
0.68GlyTrp: 0.68 ± 0.407
2.039GlyTyr: 2.039 ± 0.694
0.0GlyXaa: 0.0 ± 0.0
His
1.019HisAla: 1.019 ± 0.595
0.0HisCys: 0.0 ± 0.0
0.68HisAsp: 0.68 ± 0.407
0.68HisGlu: 0.68 ± 0.457
1.019HisPhe: 1.019 ± 0.55
0.34HisGly: 0.34 ± 0.35
0.34HisHis: 0.34 ± 0.31
1.359HisIle: 1.359 ± 0.651
0.34HisLys: 0.34 ± 0.34
1.359HisLeu: 1.359 ± 0.544
0.34HisMet: 0.34 ± 0.307
0.34HisAsn: 0.34 ± 0.307
0.34HisPro: 0.34 ± 0.286
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
1.359HisSer: 1.359 ± 0.606
0.68HisThr: 0.68 ± 0.408
1.019HisVal: 1.019 ± 0.436
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
7.475IleAla: 7.475 ± 1.402
1.019IleCys: 1.019 ± 0.582
5.097IleAsp: 5.097 ± 1.569
6.456IleGlu: 6.456 ± 1.664
4.757IlePhe: 4.757 ± 1.892
4.757IleGly: 4.757 ± 1.306
0.34IleHis: 0.34 ± 0.286
6.796IleIle: 6.796 ± 1.319
5.097IleLys: 5.097 ± 1.635
7.475IleLeu: 7.475 ± 1.715
1.019IleMet: 1.019 ± 0.532
4.757IleAsn: 4.757 ± 1.186
1.019IlePro: 1.019 ± 0.496
3.398IleGln: 3.398 ± 0.948
2.039IleArg: 2.039 ± 1.206
8.155IleSer: 8.155 ± 1.256
4.417IleThr: 4.417 ± 1.404
4.757IleVal: 4.757 ± 1.67
0.0IleTrp: 0.0 ± 0.0
2.718IleTyr: 2.718 ± 0.607
0.0IleXaa: 0.0 ± 0.0
Lys
5.437LysAla: 5.437 ± 1.381
0.0LysCys: 0.0 ± 0.0
5.097LysAsp: 5.097 ± 1.584
9.514LysGlu: 9.514 ± 1.246
2.379LysPhe: 2.379 ± 1.122
4.077LysGly: 4.077 ± 1.075
0.34LysHis: 0.34 ± 0.307
8.835LysIle: 8.835 ± 1.056
11.553LysLys: 11.553 ± 2.977
8.495LysLeu: 8.495 ± 1.569
3.398LysMet: 3.398 ± 1.243
5.437LysAsn: 5.437 ± 1.252
2.718LysPro: 2.718 ± 0.78
5.776LysGln: 5.776 ± 1.371
3.058LysArg: 3.058 ± 0.883
6.456LysSer: 6.456 ± 1.459
7.475LysThr: 7.475 ± 1.051
9.514LysVal: 9.514 ± 1.873
0.0LysTrp: 0.0 ± 0.0
2.379LysTyr: 2.379 ± 0.81
0.0LysXaa: 0.0 ± 0.0
Leu
5.437LeuAla: 5.437 ± 1.538
0.68LeuCys: 0.68 ± 0.362
7.815LeuAsp: 7.815 ± 1.382
8.835LeuGlu: 8.835 ± 1.865
6.116LeuPhe: 6.116 ± 1.305
7.815LeuGly: 7.815 ± 2.35
1.019LeuHis: 1.019 ± 0.526
10.194LeuIle: 10.194 ± 1.754
10.533LeuLys: 10.533 ± 1.658
10.194LeuLeu: 10.194 ± 1.948
2.718LeuMet: 2.718 ± 0.96
7.475LeuAsn: 7.475 ± 1.467
2.039LeuPro: 2.039 ± 0.685
6.116LeuGln: 6.116 ± 1.35
2.718LeuArg: 2.718 ± 1.013
4.757LeuSer: 4.757 ± 0.847
5.097LeuThr: 5.097 ± 1.123
4.077LeuVal: 4.077 ± 1.36
0.68LeuTrp: 0.68 ± 0.352
4.077LeuTyr: 4.077 ± 0.853
0.0LeuXaa: 0.0 ± 0.0
Met
0.68MetAla: 0.68 ± 0.573
0.34MetCys: 0.34 ± 0.307
0.68MetAsp: 0.68 ± 0.479
2.379MetGlu: 2.379 ± 1.123
0.34MetPhe: 0.34 ± 0.316
0.68MetGly: 0.68 ± 0.412
0.0MetHis: 0.0 ± 0.0
3.398MetIle: 3.398 ± 1.424
4.077MetLys: 4.077 ± 1.357
2.039MetLeu: 2.039 ± 0.88
0.34MetMet: 0.34 ± 0.286
2.718MetAsn: 2.718 ± 0.708
0.0MetPro: 0.0 ± 0.0
2.039MetGln: 2.039 ± 0.721
0.34MetArg: 0.34 ± 0.34
0.34MetSer: 0.34 ± 0.35
1.359MetThr: 1.359 ± 0.567
1.359MetVal: 1.359 ± 0.517
0.34MetTrp: 0.34 ± 0.35
1.359MetTyr: 1.359 ± 0.795
0.0MetXaa: 0.0 ± 0.0
Asn
4.077AsnAla: 4.077 ± 1.224
0.0AsnCys: 0.0 ± 0.0
3.398AsnAsp: 3.398 ± 1.073
5.776AsnGlu: 5.776 ± 1.821
2.039AsnPhe: 2.039 ± 0.567
2.379AsnGly: 2.379 ± 1.271
0.68AsnHis: 0.68 ± 0.414
6.456AsnIle: 6.456 ± 1.122
8.155AsnLys: 8.155 ± 1.472
7.815AsnLeu: 7.815 ± 1.66
0.68AsnMet: 0.68 ± 0.731
4.077AsnAsn: 4.077 ± 1.459
2.718AsnPro: 2.718 ± 0.922
3.738AsnGln: 3.738 ± 0.938
1.359AsnArg: 1.359 ± 0.633
2.379AsnSer: 2.379 ± 0.822
2.718AsnThr: 2.718 ± 0.744
2.039AsnVal: 2.039 ± 0.969
1.019AsnTrp: 1.019 ± 0.551
2.718AsnTyr: 2.718 ± 0.731
0.0AsnXaa: 0.0 ± 0.0
Pro
0.68ProAla: 0.68 ± 0.487
0.0ProCys: 0.0 ± 0.0
1.699ProAsp: 1.699 ± 0.676
1.699ProGlu: 1.699 ± 0.772
1.359ProPhe: 1.359 ± 0.678
0.0ProGly: 0.0 ± 0.0
0.0ProHis: 0.0 ± 0.0
0.68ProIle: 0.68 ± 0.387
1.699ProLys: 1.699 ± 0.89
3.398ProLeu: 3.398 ± 1.314
0.0ProMet: 0.0 ± 0.0
1.359ProAsn: 1.359 ± 0.741
1.019ProPro: 1.019 ± 0.566
0.34ProGln: 0.34 ± 0.307
1.019ProArg: 1.019 ± 0.708
1.699ProSer: 1.699 ± 0.501
1.699ProThr: 1.699 ± 0.649
1.019ProVal: 1.019 ± 0.591
0.0ProTrp: 0.0 ± 0.0
1.359ProTyr: 1.359 ± 0.631
0.0ProXaa: 0.0 ± 0.0
Gln
2.379GlnAla: 2.379 ± 0.804
1.019GlnCys: 1.019 ± 0.795
3.738GlnAsp: 3.738 ± 0.644
1.699GlnGlu: 1.699 ± 0.663
2.039GlnPhe: 2.039 ± 0.76
2.718GlnGly: 2.718 ± 0.834
0.34GlnHis: 0.34 ± 0.339
3.738GlnIle: 3.738 ± 1.349
5.437GlnLys: 5.437 ± 1.405
2.379GlnLeu: 2.379 ± 0.689
2.039GlnMet: 2.039 ± 0.882
1.699GlnAsn: 1.699 ± 0.519
1.019GlnPro: 1.019 ± 0.542
1.699GlnGln: 1.699 ± 0.565
2.039GlnArg: 2.039 ± 0.745
2.039GlnSer: 2.039 ± 1.048
1.359GlnThr: 1.359 ± 0.619
2.039GlnVal: 2.039 ± 0.718
0.68GlnTrp: 0.68 ± 0.433
1.019GlnTyr: 1.019 ± 0.41
0.0GlnXaa: 0.0 ± 0.0
Arg
1.359ArgAla: 1.359 ± 0.744
0.0ArgCys: 0.0 ± 0.0
2.039ArgAsp: 2.039 ± 0.682
2.039ArgGlu: 2.039 ± 0.841
2.039ArgPhe: 2.039 ± 0.701
0.68ArgGly: 0.68 ± 0.429
0.68ArgHis: 0.68 ± 0.352
3.058ArgIle: 3.058 ± 0.909
2.718ArgLys: 2.718 ± 0.77
3.738ArgLeu: 3.738 ± 0.933
0.34ArgMet: 0.34 ± 0.343
1.699ArgAsn: 1.699 ± 0.569
1.359ArgPro: 1.359 ± 0.628
3.058ArgGln: 3.058 ± 0.884
1.359ArgArg: 1.359 ± 0.663
1.699ArgSer: 1.699 ± 0.747
2.718ArgThr: 2.718 ± 0.806
2.039ArgVal: 2.039 ± 0.882
0.68ArgTrp: 0.68 ± 0.387
1.699ArgTyr: 1.699 ± 0.512
0.0ArgXaa: 0.0 ± 0.0
Ser
2.039SerAla: 2.039 ± 0.633
1.019SerCys: 1.019 ± 0.48
4.077SerAsp: 4.077 ± 1.126
3.058SerGlu: 3.058 ± 1.023
2.039SerPhe: 2.039 ± 0.576
2.039SerGly: 2.039 ± 0.602
2.039SerHis: 2.039 ± 0.574
4.757SerIle: 4.757 ± 0.936
6.456SerLys: 6.456 ± 1.28
4.077SerLeu: 4.077 ± 1.311
1.699SerMet: 1.699 ± 0.655
2.718SerAsn: 2.718 ± 1.042
0.68SerPro: 0.68 ± 0.484
2.039SerGln: 2.039 ± 0.6
1.699SerArg: 1.699 ± 0.679
2.718SerSer: 2.718 ± 0.79
2.718SerThr: 2.718 ± 0.828
3.738SerVal: 3.738 ± 1.192
0.68SerTrp: 0.68 ± 0.704
5.776SerTyr: 5.776 ± 1.448
0.0SerXaa: 0.0 ± 0.0
Thr
1.699ThrAla: 1.699 ± 0.704
0.0ThrCys: 0.0 ± 0.0
2.379ThrAsp: 2.379 ± 0.796
6.456ThrGlu: 6.456 ± 1.092
2.379ThrPhe: 2.379 ± 0.944
3.738ThrGly: 3.738 ± 1.018
0.34ThrHis: 0.34 ± 0.307
4.077ThrIle: 4.077 ± 1.161
5.437ThrLys: 5.437 ± 1.253
6.116ThrLeu: 6.116 ± 1.433
0.34ThrMet: 0.34 ± 0.307
3.398ThrAsn: 3.398 ± 1.146
1.019ThrPro: 1.019 ± 0.533
1.699ThrGln: 1.699 ± 0.733
3.058ThrArg: 3.058 ± 0.773
1.359ThrSer: 1.359 ± 0.505
2.718ThrThr: 2.718 ± 0.785
3.398ThrVal: 3.398 ± 0.929
0.34ThrTrp: 0.34 ± 0.286
1.359ThrTyr: 1.359 ± 0.45
0.0ThrXaa: 0.0 ± 0.0
Val
3.398ValAla: 3.398 ± 0.688
0.68ValCys: 0.68 ± 0.362
4.077ValAsp: 4.077 ± 1.235
3.738ValGlu: 3.738 ± 1.077
1.699ValPhe: 1.699 ± 0.799
1.019ValGly: 1.019 ± 0.545
0.34ValHis: 0.34 ± 0.34
2.039ValIle: 2.039 ± 0.94
6.796ValLys: 6.796 ± 1.334
7.475ValLeu: 7.475 ± 1.368
1.019ValMet: 1.019 ± 0.437
5.097ValAsn: 5.097 ± 0.695
3.058ValPro: 3.058 ± 1.216
0.34ValGln: 0.34 ± 0.343
1.019ValArg: 1.019 ± 0.628
5.437ValSer: 5.437 ± 1.222
2.718ValThr: 2.718 ± 0.804
2.718ValVal: 2.718 ± 1.137
0.34ValTrp: 0.34 ± 0.286
3.398ValTyr: 3.398 ± 1.279
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.019TrpGlu: 1.019 ± 0.489
1.019TrpPhe: 1.019 ± 0.454
0.68TrpGly: 0.68 ± 0.418
0.0TrpHis: 0.0 ± 0.0
1.019TrpIle: 1.019 ± 0.602
0.34TrpLys: 0.34 ± 0.343
1.019TrpLeu: 1.019 ± 0.505
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.34TrpPro: 0.34 ± 0.307
0.0TrpGln: 0.0 ± 0.0
0.34TrpArg: 0.34 ± 0.286
0.68TrpSer: 0.68 ± 0.352
0.34TrpThr: 0.34 ± 0.34
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.68TrpTyr: 0.68 ± 0.418
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
0.0TyrCys: 0.0 ± 0.0
3.058TyrAsp: 3.058 ± 0.998
3.398TyrGlu: 3.398 ± 1.103
4.417TyrPhe: 4.417 ± 1.169
2.718TyrGly: 2.718 ± 0.97
0.0TyrHis: 0.0 ± 0.0
2.718TyrIle: 2.718 ± 0.973
7.475TyrLys: 7.475 ± 1.728
3.738TyrLeu: 3.738 ± 0.696
1.019TyrMet: 1.019 ± 0.553
2.379TyrAsn: 2.379 ± 0.897
0.0TyrPro: 0.0 ± 0.0
1.019TyrGln: 1.019 ± 0.608
3.058TyrArg: 3.058 ± 1.109
2.039TyrSer: 2.039 ± 0.86
1.699TyrThr: 1.699 ± 0.86
1.699TyrVal: 1.699 ± 0.544
0.34TyrTrp: 0.34 ± 0.343
1.699TyrTyr: 1.699 ± 0.606
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 19 proteins (2944 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski