Amino acid dipepetide frequency for Salinimonas sp. KX18D6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.165AlaAla: 8.165 ± 0.12
0.968AlaCys: 0.968 ± 0.032
5.214AlaAsp: 5.214 ± 0.072
5.347AlaGlu: 5.347 ± 0.082
3.747AlaPhe: 3.747 ± 0.059
6.611AlaGly: 6.611 ± 0.095
1.843AlaHis: 1.843 ± 0.041
5.713AlaIle: 5.713 ± 0.075
4.188AlaLys: 4.188 ± 0.069
10.44AlaLeu: 10.44 ± 0.111
2.791AlaMet: 2.791 ± 0.053
3.357AlaAsn: 3.357 ± 0.054
3.204AlaPro: 3.204 ± 0.056
4.373AlaGln: 4.373 ± 0.073
4.753AlaArg: 4.753 ± 0.072
5.903AlaSer: 5.903 ± 0.072
4.805AlaThr: 4.805 ± 0.069
6.259AlaVal: 6.259 ± 0.087
0.972AlaTrp: 0.972 ± 0.029
2.544AlaTyr: 2.544 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.886CysAla: 0.886 ± 0.031
0.147CysCys: 0.147 ± 0.013
0.613CysAsp: 0.613 ± 0.024
0.625CysGlu: 0.625 ± 0.02
0.401CysPhe: 0.401 ± 0.02
0.748CysGly: 0.748 ± 0.03
0.311CysHis: 0.311 ± 0.018
0.563CysIle: 0.563 ± 0.023
0.395CysLys: 0.395 ± 0.02
0.909CysLeu: 0.909 ± 0.03
0.215CysMet: 0.215 ± 0.014
0.343CysAsn: 0.343 ± 0.018
0.441CysPro: 0.441 ± 0.021
0.477CysGln: 0.477 ± 0.019
0.472CysArg: 0.472 ± 0.02
0.623CysSer: 0.623 ± 0.026
0.466CysThr: 0.466 ± 0.021
0.644CysVal: 0.644 ± 0.022
0.138CysTrp: 0.138 ± 0.01
0.316CysTyr: 0.316 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
5.613AspAla: 5.613 ± 0.075
0.487AspCys: 0.487 ± 0.021
3.833AspAsp: 3.833 ± 0.066
4.437AspGlu: 4.437 ± 0.072
2.508AspPhe: 2.508 ± 0.048
4.085AspGly: 4.085 ± 0.077
1.071AspHis: 1.071 ± 0.03
4.351AspIle: 4.351 ± 0.072
3.462AspLys: 3.462 ± 0.062
4.794AspLeu: 4.794 ± 0.062
1.55AspMet: 1.55 ± 0.04
2.801AspAsn: 2.801 ± 0.047
2.127AspPro: 2.127 ± 0.053
1.689AspGln: 1.689 ± 0.04
2.373AspArg: 2.373 ± 0.047
3.594AspSer: 3.594 ± 0.055
3.46AspThr: 3.46 ± 0.053
4.3AspVal: 4.3 ± 0.064
0.906AspTrp: 0.906 ± 0.031
2.184AspTyr: 2.184 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
5.67GluAla: 5.67 ± 0.07
0.4GluCys: 0.4 ± 0.018
3.384GluAsp: 3.384 ± 0.062
3.842GluGlu: 3.842 ± 0.068
2.275GluPhe: 2.275 ± 0.049
3.625GluGly: 3.625 ± 0.056
1.579GluHis: 1.579 ± 0.038
3.396GluIle: 3.396 ± 0.052
3.971GluLys: 3.971 ± 0.075
6.094GluLeu: 6.094 ± 0.086
1.63GluMet: 1.63 ± 0.04
2.836GluAsn: 2.836 ± 0.047
2.175GluPro: 2.175 ± 0.041
4.0GluGln: 4.0 ± 0.074
3.381GluArg: 3.381 ± 0.061
3.859GluSer: 3.859 ± 0.065
3.239GluThr: 3.239 ± 0.059
4.009GluVal: 4.009 ± 0.065
0.672GluTrp: 0.672 ± 0.026
1.769GluTyr: 1.769 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
3.703PheAla: 3.703 ± 0.065
0.53PheCys: 0.53 ± 0.024
2.936PheAsp: 2.936 ± 0.049
2.571PheGlu: 2.571 ± 0.044
1.803PhePhe: 1.803 ± 0.046
3.062PheGly: 3.062 ± 0.058
0.838PheHis: 0.838 ± 0.027
2.663PheIle: 2.663 ± 0.051
1.792PheLys: 1.792 ± 0.042
3.357PheLeu: 3.357 ± 0.064
0.998PheMet: 0.998 ± 0.03
1.907PheAsn: 1.907 ± 0.042
1.379PhePro: 1.379 ± 0.035
1.114PheGln: 1.114 ± 0.031
1.703PheArg: 1.703 ± 0.036
3.445PheSer: 3.445 ± 0.062
2.583PheThr: 2.583 ± 0.051
2.744PheVal: 2.744 ± 0.052
0.539PheTrp: 0.539 ± 0.023
1.412PheTyr: 1.412 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
5.565GlyAla: 5.565 ± 0.084
0.782GlyCys: 0.782 ± 0.029
3.807GlyAsp: 3.807 ± 0.068
4.19GlyGlu: 4.19 ± 0.069
3.301GlyPhe: 3.301 ± 0.065
4.527GlyGly: 4.527 ± 0.077
1.605GlyHis: 1.605 ± 0.036
4.389GlyIle: 4.389 ± 0.067
3.9GlyLys: 3.9 ± 0.065
6.654GlyLeu: 6.654 ± 0.081
2.057GlyMet: 2.057 ± 0.045
2.679GlyAsn: 2.679 ± 0.051
1.835GlyPro: 1.835 ± 0.042
2.901GlyGln: 2.901 ± 0.047
3.142GlyArg: 3.142 ± 0.048
3.95GlySer: 3.95 ± 0.064
3.556GlyThr: 3.556 ± 0.065
5.041GlyVal: 5.041 ± 0.072
1.011GlyTrp: 1.011 ± 0.031
2.487GlyTyr: 2.487 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
1.841HisAla: 1.841 ± 0.041
0.311HisCys: 0.311 ± 0.017
1.213HisAsp: 1.213 ± 0.03
1.289HisGlu: 1.289 ± 0.034
1.113HisPhe: 1.113 ± 0.032
1.557HisGly: 1.557 ± 0.046
0.782HisHis: 0.782 ± 0.027
1.411HisIle: 1.411 ± 0.036
1.039HisLys: 1.039 ± 0.032
2.245HisLeu: 2.245 ± 0.046
0.546HisMet: 0.546 ± 0.021
0.877HisAsn: 0.877 ± 0.028
1.192HisPro: 1.192 ± 0.033
1.054HisGln: 1.054 ± 0.032
1.173HisArg: 1.173 ± 0.037
1.422HisSer: 1.422 ± 0.038
1.162HisThr: 1.162 ± 0.032
1.338HisVal: 1.338 ± 0.035
0.372HisTrp: 0.372 ± 0.017
0.896HisTyr: 0.896 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.931IleAla: 5.931 ± 0.086
0.671IleCys: 0.671 ± 0.024
4.184IleAsp: 4.184 ± 0.062
4.101IleGlu: 4.101 ± 0.059
2.099IlePhe: 2.099 ± 0.05
4.25IleGly: 4.25 ± 0.069
1.212IleHis: 1.212 ± 0.033
3.41IleIle: 3.41 ± 0.054
2.789IleLys: 2.789 ± 0.049
4.777IleLeu: 4.777 ± 0.081
1.198IleMet: 1.198 ± 0.036
2.844IleAsn: 2.844 ± 0.048
2.449IlePro: 2.449 ± 0.043
2.04IleGln: 2.04 ± 0.039
2.916IleArg: 2.916 ± 0.05
4.383IleSer: 4.383 ± 0.059
3.518IleThr: 3.518 ± 0.056
4.022IleVal: 4.022 ± 0.062
0.625IleTrp: 0.625 ± 0.023
1.648IleTyr: 1.648 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
4.828LysAla: 4.828 ± 0.085
0.294LysCys: 0.294 ± 0.017
2.706LysAsp: 2.706 ± 0.052
2.898LysGlu: 2.898 ± 0.062
1.429LysPhe: 1.429 ± 0.034
3.099LysGly: 3.099 ± 0.058
1.238LysHis: 1.238 ± 0.033
2.541LysIle: 2.541 ± 0.046
2.772LysLys: 2.772 ± 0.059
4.723LysLeu: 4.723 ± 0.071
1.292LysMet: 1.292 ± 0.036
2.049LysAsn: 2.049 ± 0.045
2.356LysPro: 2.356 ± 0.053
2.639LysGln: 2.639 ± 0.049
2.847LysArg: 2.847 ± 0.052
3.173LysSer: 3.173 ± 0.055
2.839LysThr: 2.839 ± 0.056
3.444LysVal: 3.444 ± 0.061
0.541LysTrp: 0.541 ± 0.021
1.29LysTyr: 1.29 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
9.474LeuAla: 9.474 ± 0.099
1.094LeuCys: 1.094 ± 0.033
5.632LeuAsp: 5.632 ± 0.073
5.655LeuGlu: 5.655 ± 0.089
4.031LeuPhe: 4.031 ± 0.072
6.29LeuGly: 6.29 ± 0.097
2.173LeuHis: 2.173 ± 0.041
5.846LeuIle: 5.846 ± 0.084
4.967LeuLys: 4.967 ± 0.068
10.128LeuLeu: 10.128 ± 0.126
2.497LeuMet: 2.497 ± 0.047
4.378LeuAsn: 4.378 ± 0.06
4.796LeuPro: 4.796 ± 0.065
3.831LeuGln: 3.831 ± 0.056
4.673LeuArg: 4.673 ± 0.065
8.05LeuSer: 8.05 ± 0.086
6.148LeuThr: 6.148 ± 0.085
6.506LeuVal: 6.506 ± 0.08
1.065LeuTrp: 1.065 ± 0.034
2.751LeuTyr: 2.751 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
2.609MetAla: 2.609 ± 0.044
0.191MetCys: 0.191 ± 0.014
1.323MetAsp: 1.323 ± 0.036
1.296MetGlu: 1.296 ± 0.035
0.922MetPhe: 0.922 ± 0.027
1.683MetGly: 1.683 ± 0.039
0.569MetHis: 0.569 ± 0.021
1.262MetIle: 1.262 ± 0.036
1.407MetLys: 1.407 ± 0.039
2.782MetLeu: 2.782 ± 0.043
0.801MetMet: 0.801 ± 0.029
1.078MetAsn: 1.078 ± 0.028
1.291MetPro: 1.291 ± 0.035
1.336MetGln: 1.336 ± 0.034
1.331MetArg: 1.331 ± 0.037
1.858MetSer: 1.858 ± 0.04
1.628MetThr: 1.628 ± 0.037
1.679MetVal: 1.679 ± 0.038
0.246MetTrp: 0.246 ± 0.016
0.521MetTyr: 0.521 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.798AsnAla: 3.798 ± 0.059
0.344AsnCys: 0.344 ± 0.016
2.582AsnAsp: 2.582 ± 0.048
2.471AsnGlu: 2.471 ± 0.05
1.492AsnPhe: 1.492 ± 0.035
2.843AsnGly: 2.843 ± 0.057
0.9AsnHis: 0.9 ± 0.026
2.544AsnIle: 2.544 ± 0.049
2.038AsnLys: 2.038 ± 0.044
3.639AsnLeu: 3.639 ± 0.054
0.96AsnMet: 0.96 ± 0.025
1.827AsnAsn: 1.827 ± 0.043
1.935AsnPro: 1.935 ± 0.042
1.903AsnGln: 1.903 ± 0.047
2.119AsnArg: 2.119 ± 0.042
2.336AsnSer: 2.336 ± 0.05
2.391AsnThr: 2.391 ± 0.045
2.773AsnVal: 2.773 ± 0.06
0.632AsnTrp: 0.632 ± 0.026
1.319AsnTyr: 1.319 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
3.768ProAla: 3.768 ± 0.068
0.3ProCys: 0.3 ± 0.016
3.162ProAsp: 3.162 ± 0.056
3.265ProGlu: 3.265 ± 0.062
1.775ProPhe: 1.775 ± 0.035
2.871ProGly: 2.871 ± 0.054
0.843ProHis: 0.843 ± 0.028
1.922ProIle: 1.922 ± 0.04
1.548ProLys: 1.548 ± 0.04
3.982ProLeu: 3.982 ± 0.062
0.923ProMet: 0.923 ± 0.03
1.372ProAsn: 1.372 ± 0.037
1.323ProPro: 1.323 ± 0.037
1.691ProGln: 1.691 ± 0.039
1.57ProArg: 1.57 ± 0.035
2.461ProSer: 2.461 ± 0.048
1.939ProThr: 1.939 ± 0.04
3.794ProVal: 3.794 ± 0.059
0.492ProTrp: 0.492 ± 0.022
1.226ProTyr: 1.226 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
4.437GlnAla: 4.437 ± 0.079
0.415GlnCys: 0.415 ± 0.022
2.081GlnAsp: 2.081 ± 0.04
2.336GlnGlu: 2.336 ± 0.052
1.74GlnPhe: 1.74 ± 0.035
2.769GlnGly: 2.769 ± 0.046
1.19GlnHis: 1.19 ± 0.036
2.486GlnIle: 2.486 ± 0.05
2.206GlnLys: 2.206 ± 0.048
4.653GlnLeu: 4.653 ± 0.079
1.194GlnMet: 1.194 ± 0.035
1.759GlnAsn: 1.759 ± 0.039
1.85GlnPro: 1.85 ± 0.041
3.024GlnGln: 3.024 ± 0.071
2.661GlnArg: 2.661 ± 0.051
3.107GlnSer: 3.107 ± 0.061
2.571GlnThr: 2.571 ± 0.047
3.052GlnVal: 3.052 ± 0.053
0.746GlnTrp: 0.746 ± 0.03
1.411GlnTyr: 1.411 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
3.922ArgAla: 3.922 ± 0.064
0.458ArgCys: 0.458 ± 0.022
2.713ArgAsp: 2.713 ± 0.05
3.312ArgGlu: 3.312 ± 0.056
2.425ArgPhe: 2.425 ± 0.049
2.712ArgGly: 2.712 ± 0.051
1.381ArgHis: 1.381 ± 0.033
3.1ArgIle: 3.1 ± 0.05
2.424ArgLys: 2.424 ± 0.057
5.41ArgLeu: 5.41 ± 0.071
1.313ArgMet: 1.313 ± 0.032
1.972ArgAsn: 1.972 ± 0.04
1.83ArgPro: 1.83 ± 0.038
2.837ArgGln: 2.837 ± 0.062
2.782ArgArg: 2.782 ± 0.047
2.703ArgSer: 2.703 ± 0.05
2.345ArgThr: 2.345 ± 0.042
3.348ArgVal: 3.348 ± 0.059
0.745ArgTrp: 0.745 ± 0.026
2.007ArgTyr: 2.007 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
6.311SerAla: 6.311 ± 0.078
0.622SerCys: 0.622 ± 0.023
4.235SerAsp: 4.235 ± 0.067
4.285SerGlu: 4.285 ± 0.068
2.72SerPhe: 2.72 ± 0.049
5.082SerGly: 5.082 ± 0.071
1.575SerHis: 1.575 ± 0.036
3.497SerIle: 3.497 ± 0.06
2.791SerLys: 2.791 ± 0.058
7.124SerLeu: 7.124 ± 0.076
1.739SerMet: 1.739 ± 0.038
2.326SerAsn: 2.326 ± 0.047
2.609SerPro: 2.609 ± 0.048
3.34SerGln: 3.34 ± 0.062
3.31SerArg: 3.31 ± 0.061
4.249SerSer: 4.249 ± 0.067
3.233SerThr: 3.233 ± 0.052
5.035SerVal: 5.035 ± 0.061
0.805SerTrp: 0.805 ± 0.028
1.943SerTyr: 1.943 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
4.877ThrAla: 4.877 ± 0.065
0.502ThrCys: 0.502 ± 0.022
3.349ThrAsp: 3.349 ± 0.062
3.148ThrGlu: 3.148 ± 0.064
2.383ThrPhe: 2.383 ± 0.047
4.32ThrGly: 4.32 ± 0.067
1.287ThrHis: 1.287 ± 0.034
3.219ThrIle: 3.219 ± 0.054
1.96ThrLys: 1.96 ± 0.043
6.565ThrLeu: 6.565 ± 0.073
1.206ThrMet: 1.206 ± 0.038
1.869ThrAsn: 1.869 ± 0.044
2.748ThrPro: 2.748 ± 0.048
2.492ThrGln: 2.492 ± 0.045
2.772ThrArg: 2.772 ± 0.043
3.432ThrSer: 3.432 ± 0.06
3.045ThrThr: 3.045 ± 0.058
4.193ThrVal: 4.193 ± 0.067
0.628ThrTrp: 0.628 ± 0.025
1.648ThrTyr: 1.648 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
6.457ValAla: 6.457 ± 0.084
0.725ValCys: 0.725 ± 0.027
4.191ValAsp: 4.191 ± 0.062
4.325ValGlu: 4.325 ± 0.06
2.884ValPhe: 2.884 ± 0.055
4.406ValGly: 4.406 ± 0.07
1.271ValHis: 1.271 ± 0.034
4.493ValIle: 4.493 ± 0.072
3.534ValLys: 3.534 ± 0.055
6.696ValLeu: 6.696 ± 0.086
1.878ValMet: 1.878 ± 0.04
3.033ValAsn: 3.033 ± 0.053
2.796ValPro: 2.796 ± 0.05
2.307ValGln: 2.307 ± 0.046
3.124ValArg: 3.124 ± 0.049
5.504ValSer: 5.504 ± 0.069
4.56ValThr: 4.56 ± 0.074
5.213ValVal: 5.213 ± 0.079
0.802ValTrp: 0.802 ± 0.026
1.923ValTyr: 1.923 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
0.875TrpAla: 0.875 ± 0.029
0.149TrpCys: 0.149 ± 0.01
0.639TrpAsp: 0.639 ± 0.028
0.634TrpGlu: 0.634 ± 0.024
0.587TrpPhe: 0.587 ± 0.024
0.744TrpGly: 0.744 ± 0.03
0.362TrpHis: 0.362 ± 0.019
0.677TrpIle: 0.677 ± 0.028
0.463TrpLys: 0.463 ± 0.018
1.73TrpLeu: 1.73 ± 0.04
0.378TrpMet: 0.378 ± 0.019
0.411TrpAsn: 0.411 ± 0.021
0.53TrpPro: 0.53 ± 0.025
0.983TrpGln: 0.983 ± 0.029
0.761TrpArg: 0.761 ± 0.026
0.702TrpSer: 0.702 ± 0.024
0.498TrpThr: 0.498 ± 0.021
0.844TrpVal: 0.844 ± 0.025
0.218TrpTrp: 0.218 ± 0.014
0.435TrpTyr: 0.435 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.469TyrAla: 2.469 ± 0.051
0.343TyrCys: 0.343 ± 0.017
1.83TyrAsp: 1.83 ± 0.04
1.78TyrGlu: 1.78 ± 0.039
1.442TyrPhe: 1.442 ± 0.036
2.093TyrGly: 2.093 ± 0.036
0.803TyrHis: 0.803 ± 0.026
1.584TyrIle: 1.584 ± 0.04
1.352TyrLys: 1.352 ± 0.035
3.281TyrLeu: 3.281 ± 0.056
0.649TyrMet: 0.649 ± 0.024
1.129TyrAsn: 1.129 ± 0.031
1.359TyrPro: 1.359 ± 0.036
1.653TyrGln: 1.653 ± 0.035
1.874TyrArg: 1.874 ± 0.04
2.077TyrSer: 2.077 ± 0.041
1.659TyrThr: 1.659 ± 0.039
1.887TyrVal: 1.887 ± 0.041
0.466TyrTrp: 0.466 ± 0.021
1.036TyrTyr: 1.036 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3632 proteins (1210490 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski