Amino acid dipepetide frequency for Culicoidibacter larvae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.387AlaAla: 7.387 ± 0.117
0.538AlaCys: 0.538 ± 0.03
4.895AlaAsp: 4.895 ± 0.087
5.295AlaGlu: 5.295 ± 0.093
3.353AlaPhe: 3.353 ± 0.078
5.827AlaGly: 5.827 ± 0.214
1.328AlaHis: 1.328 ± 0.043
6.847AlaIle: 6.847 ± 0.124
4.703AlaLys: 4.703 ± 0.083
7.356AlaLeu: 7.356 ± 0.126
2.125AlaMet: 2.125 ± 0.056
3.737AlaAsn: 3.737 ± 0.102
2.325AlaPro: 2.325 ± 0.079
3.028AlaGln: 3.028 ± 0.065
2.703AlaArg: 2.703 ± 0.071
4.528AlaSer: 4.528 ± 0.095
5.148AlaThr: 5.148 ± 0.13
5.899AlaVal: 5.899 ± 0.101
0.754AlaTrp: 0.754 ± 0.044
2.683AlaTyr: 2.683 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
0.507CysAla: 0.507 ± 0.026
0.092CysCys: 0.092 ± 0.011
0.415CysAsp: 0.415 ± 0.023
0.458CysGlu: 0.458 ± 0.028
0.361CysPhe: 0.361 ± 0.024
0.735CysGly: 0.735 ± 0.037
0.181CysHis: 0.181 ± 0.016
0.6CysIle: 0.6 ± 0.03
0.366CysLys: 0.366 ± 0.024
0.575CysLeu: 0.575 ± 0.03
0.184CysMet: 0.184 ± 0.015
0.301CysAsn: 0.301 ± 0.02
0.301CysPro: 0.301 ± 0.022
0.255CysGln: 0.255 ± 0.021
0.274CysArg: 0.274 ± 0.021
0.534CysSer: 0.534 ± 0.028
0.348CysThr: 0.348 ± 0.025
0.435CysVal: 0.435 ± 0.022
0.069CysTrp: 0.069 ± 0.01
0.296CysTyr: 0.296 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
4.829AspAla: 4.829 ± 0.099
0.408AspCys: 0.408 ± 0.025
3.347AspAsp: 3.347 ± 0.081
4.495AspGlu: 4.495 ± 0.077
3.047AspPhe: 3.047 ± 0.07
4.439AspGly: 4.439 ± 0.15
0.837AspHis: 0.837 ± 0.031
4.713AspIle: 4.713 ± 0.079
3.194AspLys: 3.194 ± 0.076
5.031AspLeu: 5.031 ± 0.085
1.489AspMet: 1.489 ± 0.047
2.903AspAsn: 2.903 ± 0.072
1.719AspPro: 1.719 ± 0.052
1.665AspGln: 1.665 ± 0.055
1.849AspArg: 1.849 ± 0.057
3.1AspSer: 3.1 ± 0.078
3.234AspThr: 3.234 ± 0.084
4.357AspVal: 4.357 ± 0.108
0.636AspTrp: 0.636 ± 0.033
2.737AspTyr: 2.737 ± 0.077
0.0AspXaa: 0.0 ± 0.0
Glu
5.562GluAla: 5.562 ± 0.104
0.404GluCys: 0.404 ± 0.025
2.996GluAsp: 2.996 ± 0.067
4.224GluGlu: 4.224 ± 0.1
2.692GluPhe: 2.692 ± 0.07
2.866GluGly: 2.866 ± 0.068
1.464GluHis: 1.464 ± 0.04
4.859GluIle: 4.859 ± 0.103
3.913GluLys: 3.913 ± 0.086
7.045GluLeu: 7.045 ± 0.124
1.969GluMet: 1.969 ± 0.05
3.327GluAsn: 3.327 ± 0.068
2.002GluPro: 2.002 ± 0.071
3.652GluGln: 3.652 ± 0.083
3.231GluArg: 3.231 ± 0.081
3.154GluSer: 3.154 ± 0.072
3.663GluThr: 3.663 ± 0.102
4.733GluVal: 4.733 ± 0.102
0.534GluTrp: 0.534 ± 0.028
2.839GluTyr: 2.839 ± 0.068
0.0GluXaa: 0.0 ± 0.0
Phe
3.816PheAla: 3.816 ± 0.082
0.427PheCys: 0.427 ± 0.029
3.154PheAsp: 3.154 ± 0.07
2.849PheGlu: 2.849 ± 0.059
2.152PhePhe: 2.152 ± 0.071
3.29PheGly: 3.29 ± 0.081
0.639PheHis: 0.639 ± 0.031
3.742PheIle: 3.742 ± 0.082
2.222PheLys: 2.222 ± 0.065
3.97PheLeu: 3.97 ± 0.103
1.091PheMet: 1.091 ± 0.045
2.226PheAsn: 2.226 ± 0.057
1.44PhePro: 1.44 ± 0.049
1.21PheGln: 1.21 ± 0.041
1.31PheArg: 1.31 ± 0.045
3.215PheSer: 3.215 ± 0.077
2.741PheThr: 2.741 ± 0.074
3.278PheVal: 3.278 ± 0.079
0.466PheTrp: 0.466 ± 0.025
1.78PheTyr: 1.78 ± 0.065
0.0PheXaa: 0.0 ± 0.0
Gly
5.046GlyAla: 5.046 ± 0.106
0.566GlyCys: 0.566 ± 0.032
3.509GlyAsp: 3.509 ± 0.154
3.866GlyGlu: 3.866 ± 0.103
3.177GlyPhe: 3.177 ± 0.072
4.828GlyGly: 4.828 ± 0.104
1.199GlyHis: 1.199 ± 0.045
5.58GlyIle: 5.58 ± 0.105
3.978GlyLys: 3.978 ± 0.083
5.805GlyLeu: 5.805 ± 0.103
1.876GlyMet: 1.876 ± 0.048
3.324GlyAsn: 3.324 ± 0.102
1.206GlyPro: 1.206 ± 0.044
2.215GlyGln: 2.215 ± 0.068
2.392GlyArg: 2.392 ± 0.07
4.132GlySer: 4.132 ± 0.101
4.471GlyThr: 4.471 ± 0.126
5.203GlyVal: 5.203 ± 0.102
0.765GlyTrp: 0.765 ± 0.039
3.019GlyTyr: 3.019 ± 0.064
0.0GlyXaa: 0.0 ± 0.0
His
1.287HisAla: 1.287 ± 0.04
0.154HisCys: 0.154 ± 0.014
1.035HisAsp: 1.035 ± 0.044
1.105HisGlu: 1.105 ± 0.047
0.859HisPhe: 0.859 ± 0.04
1.206HisGly: 1.206 ± 0.04
0.403HisHis: 0.403 ± 0.025
1.461HisIle: 1.461 ± 0.052
0.877HisLys: 0.877 ± 0.039
1.679HisLeu: 1.679 ± 0.045
0.419HisMet: 0.419 ± 0.023
0.867HisAsn: 0.867 ± 0.038
0.801HisPro: 0.801 ± 0.038
0.766HisGln: 0.766 ± 0.036
0.688HisArg: 0.688 ± 0.031
0.894HisSer: 0.894 ± 0.037
0.931HisThr: 0.931 ± 0.035
1.212HisVal: 1.212 ± 0.046
0.174HisTrp: 0.174 ± 0.015
0.728HisTyr: 0.728 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
7.016IleAla: 7.016 ± 0.117
0.67IleCys: 0.67 ± 0.034
5.364IleAsp: 5.364 ± 0.097
5.497IleGlu: 5.497 ± 0.116
3.369IlePhe: 3.369 ± 0.081
5.557IleGly: 5.557 ± 0.11
1.43IleHis: 1.43 ± 0.049
6.806IleIle: 6.806 ± 0.129
4.051IleLys: 4.051 ± 0.08
6.735IleLeu: 6.735 ± 0.112
1.764IleMet: 1.764 ± 0.066
4.083IleAsn: 4.083 ± 0.094
3.054IlePro: 3.054 ± 0.076
2.673IleGln: 2.673 ± 0.055
3.031IleArg: 3.031 ± 0.071
5.122IleSer: 5.122 ± 0.105
5.237IleThr: 5.237 ± 0.115
5.945IleVal: 5.945 ± 0.099
0.69IleTrp: 0.69 ± 0.038
2.904IleTyr: 2.904 ± 0.08
0.0IleXaa: 0.0 ± 0.0
Lys
4.313LysAla: 4.313 ± 0.099
0.312LysCys: 0.312 ± 0.023
3.304LysAsp: 3.304 ± 0.068
3.97LysGlu: 3.97 ± 0.082
1.878LysPhe: 1.878 ± 0.054
2.865LysGly: 2.865 ± 0.074
1.112LysHis: 1.112 ± 0.044
4.364LysIle: 4.364 ± 0.077
4.367LysLys: 4.367 ± 0.111
4.895LysLeu: 4.895 ± 0.096
1.994LysMet: 1.994 ± 0.054
3.088LysAsn: 3.088 ± 0.076
1.902LysPro: 1.902 ± 0.051
2.808LysGln: 2.808 ± 0.077
2.645LysArg: 2.645 ± 0.073
3.059LysSer: 3.059 ± 0.065
3.625LysThr: 3.625 ± 0.086
4.028LysVal: 4.028 ± 0.092
0.485LysTrp: 0.485 ± 0.027
2.547LysTyr: 2.547 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
8.152LeuAla: 8.152 ± 0.139
0.675LeuCys: 0.675 ± 0.031
5.269LeuAsp: 5.269 ± 0.1
5.751LeuGlu: 5.751 ± 0.101
4.237LeuPhe: 4.237 ± 0.102
5.805LeuGly: 5.805 ± 0.105
1.645LeuHis: 1.645 ± 0.047
6.67LeuIle: 6.67 ± 0.127
5.08LeuLys: 5.08 ± 0.091
8.995LeuLeu: 8.995 ± 0.155
2.218LeuMet: 2.218 ± 0.06
4.429LeuAsn: 4.429 ± 0.082
3.656LeuPro: 3.656 ± 0.085
3.723LeuGln: 3.723 ± 0.083
3.521LeuArg: 3.521 ± 0.081
6.132LeuSer: 6.132 ± 0.098
5.542LeuThr: 5.542 ± 0.09
6.4LeuVal: 6.4 ± 0.105
0.748LeuTrp: 0.748 ± 0.036
3.149LeuTyr: 3.149 ± 0.082
0.0LeuXaa: 0.0 ± 0.0
Met
2.064MetAla: 2.064 ± 0.056
0.161MetCys: 0.161 ± 0.014
1.308MetAsp: 1.308 ± 0.041
1.52MetGlu: 1.52 ± 0.049
0.96MetPhe: 0.96 ± 0.042
1.459MetGly: 1.459 ± 0.045
0.497MetHis: 0.497 ± 0.025
2.025MetIle: 2.025 ± 0.049
1.937MetLys: 1.937 ± 0.055
2.525MetLeu: 2.525 ± 0.064
0.806MetMet: 0.806 ± 0.039
1.549MetAsn: 1.549 ± 0.048
1.198MetPro: 1.198 ± 0.052
1.278MetGln: 1.278 ± 0.046
1.094MetArg: 1.094 ± 0.045
1.702MetSer: 1.702 ± 0.051
1.509MetThr: 1.509 ± 0.048
1.637MetVal: 1.637 ± 0.056
0.159MetTrp: 0.159 ± 0.015
0.825MetTyr: 0.825 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
3.444AsnAla: 3.444 ± 0.085
0.359AsnCys: 0.359 ± 0.025
3.026AsnAsp: 3.026 ± 0.07
3.35AsnGlu: 3.35 ± 0.078
2.102AsnPhe: 2.102 ± 0.054
3.937AsnGly: 3.937 ± 0.123
0.902AsnHis: 0.902 ± 0.035
4.314AsnIle: 4.314 ± 0.082
3.211AsnLys: 3.211 ± 0.085
3.944AsnLeu: 3.944 ± 0.106
1.302AsnMet: 1.302 ± 0.047
3.274AsnAsn: 3.274 ± 0.101
2.118AsnPro: 2.118 ± 0.056
2.257AsnGln: 2.257 ± 0.066
1.775AsnArg: 1.775 ± 0.057
2.618AsnSer: 2.618 ± 0.07
3.022AsnThr: 3.022 ± 0.097
3.332AsnVal: 3.332 ± 0.09
0.463AsnTrp: 0.463 ± 0.024
2.207AsnTyr: 2.207 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
2.52ProAla: 2.52 ± 0.066
0.205ProCys: 0.205 ± 0.018
1.988ProAsp: 1.988 ± 0.053
2.68ProGlu: 2.68 ± 0.07
1.591ProPhe: 1.591 ± 0.056
2.071ProGly: 2.071 ± 0.055
0.546ProHis: 0.546 ± 0.028
2.669ProIle: 2.669 ± 0.07
1.859ProLys: 1.859 ± 0.054
3.047ProLeu: 3.047 ± 0.072
0.805ProMet: 0.805 ± 0.036
1.701ProAsn: 1.701 ± 0.057
0.774ProPro: 0.774 ± 0.039
1.216ProGln: 1.216 ± 0.04
0.925ProArg: 0.925 ± 0.038
1.814ProSer: 1.814 ± 0.058
2.14ProThr: 2.14 ± 0.07
2.853ProVal: 2.853 ± 0.08
0.324ProTrp: 0.324 ± 0.022
1.278ProTyr: 1.278 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.244GlnAla: 3.244 ± 0.071
0.205GlnCys: 0.205 ± 0.017
1.73GlnAsp: 1.73 ± 0.048
2.339GlnGlu: 2.339 ± 0.065
1.942GlnPhe: 1.942 ± 0.049
1.948GlnGly: 1.948 ± 0.065
0.692GlnHis: 0.692 ± 0.033
2.938GlnIle: 2.938 ± 0.069
2.483GlnLys: 2.483 ± 0.064
4.457GlnLeu: 4.457 ± 0.11
1.141GlnMet: 1.141 ± 0.042
1.865GlnAsn: 1.865 ± 0.055
1.22GlnPro: 1.22 ± 0.043
1.899GlnGln: 1.899 ± 0.063
1.39GlnArg: 1.39 ± 0.045
2.104GlnSer: 2.104 ± 0.054
2.303GlnThr: 2.303 ± 0.063
2.926GlnVal: 2.926 ± 0.077
0.38GlnTrp: 0.38 ± 0.023
1.761GlnTyr: 1.761 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
2.426ArgAla: 2.426 ± 0.064
0.282ArgCys: 0.282 ± 0.019
1.988ArgAsp: 1.988 ± 0.064
2.67ArgGlu: 2.67 ± 0.075
1.733ArgPhe: 1.733 ± 0.049
2.161ArgGly: 2.161 ± 0.062
0.643ArgHis: 0.643 ± 0.032
3.23ArgIle: 3.23 ± 0.068
2.479ArgLys: 2.479 ± 0.068
3.679ArgLeu: 3.679 ± 0.083
1.137ArgMet: 1.137 ± 0.043
1.861ArgAsn: 1.861 ± 0.052
1.064ArgPro: 1.064 ± 0.044
1.434ArgGln: 1.434 ± 0.046
1.853ArgArg: 1.853 ± 0.06
2.019ArgSer: 2.019 ± 0.057
1.883ArgThr: 1.883 ± 0.051
2.722ArgVal: 2.722 ± 0.071
0.308ArgTrp: 0.308 ± 0.022
1.657ArgTyr: 1.657 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
4.407SerAla: 4.407 ± 0.095
0.377SerCys: 0.377 ± 0.021
3.384SerAsp: 3.384 ± 0.082
3.81SerGlu: 3.81 ± 0.08
2.823SerPhe: 2.823 ± 0.066
5.272SerGly: 5.272 ± 0.105
0.928SerHis: 0.928 ± 0.038
4.664SerIle: 4.664 ± 0.076
3.401SerLys: 3.401 ± 0.072
5.092SerLeu: 5.092 ± 0.099
1.498SerMet: 1.498 ± 0.046
3.016SerAsn: 3.016 ± 0.075
1.683SerPro: 1.683 ± 0.052
2.007SerGln: 2.007 ± 0.05
2.144SerArg: 2.144 ± 0.053
3.759SerSer: 3.759 ± 0.081
3.351SerThr: 3.351 ± 0.081
4.437SerVal: 4.437 ± 0.092
0.554SerTrp: 0.554 ± 0.032
2.637SerTyr: 2.637 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
4.864ThrAla: 4.864 ± 0.128
0.366ThrCys: 0.366 ± 0.023
3.534ThrAsp: 3.534 ± 0.108
3.624ThrGlu: 3.624 ± 0.114
2.912ThrPhe: 2.912 ± 0.077
4.195ThrGly: 4.195 ± 0.098
0.968ThrHis: 0.968 ± 0.037
5.661ThrIle: 5.661 ± 0.13
3.261ThrLys: 3.261 ± 0.076
5.6ThrLeu: 5.6 ± 0.115
1.449ThrMet: 1.449 ± 0.048
3.073ThrAsn: 3.073 ± 0.098
2.358ThrPro: 2.358 ± 0.077
1.855ThrGln: 1.855 ± 0.057
1.763ThrArg: 1.763 ± 0.052
3.573ThrSer: 3.573 ± 0.09
4.105ThrThr: 4.105 ± 0.141
4.891ThrVal: 4.891 ± 0.17
0.527ThrTrp: 0.527 ± 0.025
2.554ThrTyr: 2.554 ± 0.085
0.0ThrXaa: 0.0 ± 0.0
Val
6.273ValAla: 6.273 ± 0.119
0.631ValCys: 0.631 ± 0.033
4.598ValAsp: 4.598 ± 0.094
4.632ValGlu: 4.632 ± 0.087
3.288ValPhe: 3.288 ± 0.07
4.491ValGly: 4.491 ± 0.097
1.201ValHis: 1.201 ± 0.043
6.188ValIle: 6.188 ± 0.118
3.605ValLys: 3.605 ± 0.081
6.836ValLeu: 6.836 ± 0.117
1.776ValMet: 1.776 ± 0.053
3.498ValAsn: 3.498 ± 0.097
2.53ValPro: 2.53 ± 0.064
2.361ValGln: 2.361 ± 0.063
2.568ValArg: 2.568 ± 0.069
4.768ValSer: 4.768 ± 0.09
4.814ValThr: 4.814 ± 0.163
6.055ValVal: 6.055 ± 0.125
0.675ValTrp: 0.675 ± 0.031
2.718ValTyr: 2.718 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.527TrpAla: 0.527 ± 0.027
0.08TrpCys: 0.08 ± 0.011
0.516TrpAsp: 0.516 ± 0.026
0.45TrpGlu: 0.45 ± 0.025
0.516TrpPhe: 0.516 ± 0.028
0.548TrpGly: 0.548 ± 0.032
0.2TrpHis: 0.2 ± 0.018
0.686TrpIle: 0.686 ± 0.032
0.408TrpLys: 0.408 ± 0.027
1.002TrpLeu: 1.002 ± 0.043
0.223TrpMet: 0.223 ± 0.016
0.628TrpAsn: 0.628 ± 0.031
0.216TrpPro: 0.216 ± 0.019
0.647TrpGln: 0.647 ± 0.031
0.404TrpArg: 0.404 ± 0.026
0.554TrpSer: 0.554 ± 0.03
0.504TrpThr: 0.504 ± 0.028
0.542TrpVal: 0.542 ± 0.029
0.123TrpTrp: 0.123 ± 0.014
0.442TrpTyr: 0.442 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.772TyrAla: 2.772 ± 0.08
0.374TyrCys: 0.374 ± 0.027
2.672TyrAsp: 2.672 ± 0.081
2.546TyrGlu: 2.546 ± 0.057
2.026TyrPhe: 2.026 ± 0.057
2.657TyrGly: 2.657 ± 0.057
0.729TyrHis: 0.729 ± 0.031
2.982TyrIle: 2.982 ± 0.091
2.167TyrLys: 2.167 ± 0.061
3.528TyrLeu: 3.528 ± 0.07
0.944TyrMet: 0.944 ± 0.034
2.206TyrAsn: 2.206 ± 0.072
1.437TyrPro: 1.437 ± 0.048
2.018TyrGln: 2.018 ± 0.05
1.672TyrArg: 1.672 ± 0.052
2.464TyrSer: 2.464 ± 0.072
2.564TyrThr: 2.564 ± 0.101
2.622TyrVal: 2.622 ± 0.063
0.381TyrTrp: 0.381 ± 0.03
1.79TyrTyr: 1.79 ± 0.058
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2363 proteins (740341 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski