Amino acid dipepetide frequency for Dictyobacter vulcani

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.71AlaAla: 8.71 ± 0.093
1.043AlaCys: 1.043 ± 0.027
4.272AlaAsp: 4.272 ± 0.057
5.21AlaGlu: 5.21 ± 0.068
3.299AlaPhe: 3.299 ± 0.044
6.399AlaGly: 6.399 ± 0.067
2.411AlaHis: 2.411 ± 0.035
5.873AlaIle: 5.873 ± 0.078
2.605AlaLys: 2.605 ± 0.041
10.935AlaLeu: 10.935 ± 0.1
2.248AlaMet: 2.248 ± 0.037
3.04AlaAsn: 3.04 ± 0.05
3.95AlaPro: 3.95 ± 0.049
4.772AlaGln: 4.772 ± 0.058
5.839AlaArg: 5.839 ± 0.063
5.682AlaSer: 5.682 ± 0.058
5.638AlaThr: 5.638 ± 0.065
5.839AlaVal: 5.839 ± 0.059
1.257AlaTrp: 1.257 ± 0.028
2.943AlaTyr: 2.943 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.814CysAla: 0.814 ± 0.02
0.152CysCys: 0.152 ± 0.009
0.481CysAsp: 0.481 ± 0.016
0.454CysGlu: 0.454 ± 0.016
0.372CysPhe: 0.372 ± 0.016
0.875CysGly: 0.875 ± 0.025
0.281CysHis: 0.281 ± 0.013
0.593CysIle: 0.593 ± 0.018
0.291CysLys: 0.291 ± 0.013
1.033CysLeu: 1.033 ± 0.022
0.249CysMet: 0.249 ± 0.012
0.302CysAsn: 0.302 ± 0.014
0.511CysPro: 0.511 ± 0.019
0.497CysGln: 0.497 ± 0.017
0.531CysArg: 0.531 ± 0.019
0.675CysSer: 0.675 ± 0.018
0.593CysThr: 0.593 ± 0.018
0.629CysVal: 0.629 ± 0.019
0.182CysTrp: 0.182 ± 0.01
0.358CysTyr: 0.358 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.477AspAla: 4.477 ± 0.05
0.404AspCys: 0.404 ± 0.016
2.329AspAsp: 2.329 ± 0.038
3.315AspGlu: 3.315 ± 0.047
1.811AspPhe: 1.811 ± 0.036
3.513AspGly: 3.513 ± 0.055
1.218AspHis: 1.218 ± 0.029
3.18AspIle: 3.18 ± 0.038
1.72AspLys: 1.72 ± 0.032
5.101AspLeu: 5.101 ± 0.067
1.172AspMet: 1.172 ± 0.023
1.636AspAsn: 1.636 ± 0.035
2.877AspPro: 2.877 ± 0.037
2.353AspGln: 2.353 ± 0.039
2.507AspArg: 2.507 ± 0.04
2.302AspSer: 2.302 ± 0.037
2.842AspThr: 2.842 ± 0.042
3.501AspVal: 3.501 ± 0.043
0.802AspTrp: 0.802 ± 0.024
1.654AspTyr: 1.654 ± 0.029
0.0AspXaa: 0.0 ± 0.0
Glu
5.498GluAla: 5.498 ± 0.071
0.432GluCys: 0.432 ± 0.014
2.795GluAsp: 2.795 ± 0.045
4.15GluGlu: 4.15 ± 0.065
1.48GluPhe: 1.48 ± 0.029
3.118GluGly: 3.118 ± 0.048
1.861GluHis: 1.861 ± 0.031
3.504GluIle: 3.504 ± 0.047
2.699GluLys: 2.699 ± 0.037
6.041GluLeu: 6.041 ± 0.067
1.411GluMet: 1.411 ± 0.027
1.923GluAsn: 1.923 ± 0.037
2.371GluPro: 2.371 ± 0.039
4.567GluGln: 4.567 ± 0.062
4.413GluArg: 4.413 ± 0.065
2.61GluSer: 2.61 ± 0.039
3.179GluThr: 3.179 ± 0.052
3.732GluVal: 3.732 ± 0.046
0.681GluTrp: 0.681 ± 0.018
1.64GluTyr: 1.64 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
3.238PheAla: 3.238 ± 0.043
0.447PheCys: 0.447 ± 0.016
1.95PheAsp: 1.95 ± 0.032
1.96PheGlu: 1.96 ± 0.038
1.739PhePhe: 1.739 ± 0.037
2.683PheGly: 2.683 ± 0.044
0.912PheHis: 0.912 ± 0.021
2.131PheIle: 2.131 ± 0.036
1.097PheLys: 1.097 ± 0.028
3.823PheLeu: 3.823 ± 0.051
0.847PheMet: 0.847 ± 0.025
1.189PheAsn: 1.189 ± 0.023
1.563PhePro: 1.563 ± 0.028
1.57PheGln: 1.57 ± 0.028
1.605PheArg: 1.605 ± 0.029
2.541PheSer: 2.541 ± 0.038
2.241PheThr: 2.241 ± 0.036
2.534PheVal: 2.534 ± 0.033
0.592PheTrp: 0.592 ± 0.019
1.204PheTyr: 1.204 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
5.363GlyAla: 5.363 ± 0.063
0.731GlyCys: 0.731 ± 0.023
3.015GlyAsp: 3.015 ± 0.042
3.582GlyGlu: 3.582 ± 0.051
2.506GlyPhe: 2.506 ± 0.039
4.976GlyGly: 4.976 ± 0.085
1.743GlyHis: 1.743 ± 0.029
4.609GlyIle: 4.609 ± 0.057
3.27GlyLys: 3.27 ± 0.041
6.986GlyLeu: 6.986 ± 0.071
1.89GlyMet: 1.89 ± 0.034
2.608GlyAsn: 2.608 ± 0.047
2.643GlyPro: 2.643 ± 0.044
3.425GlyGln: 3.425 ± 0.051
3.789GlyArg: 3.789 ± 0.047
4.598GlySer: 4.598 ± 0.053
4.23GlyThr: 4.23 ± 0.056
4.616GlyVal: 4.616 ± 0.058
1.136GlyTrp: 1.136 ± 0.027
2.543GlyTyr: 2.543 ± 0.037
0.0GlyXaa: 0.0 ± 0.0
His
2.239HisAla: 2.239 ± 0.04
0.312HisCys: 0.312 ± 0.013
1.208HisAsp: 1.208 ± 0.029
1.475HisGlu: 1.475 ± 0.024
1.024HisPhe: 1.024 ± 0.026
1.836HisGly: 1.836 ± 0.033
0.82HisHis: 0.82 ± 0.021
1.728HisIle: 1.728 ± 0.027
0.858HisLys: 0.858 ± 0.022
2.931HisLeu: 2.931 ± 0.044
0.673HisMet: 0.673 ± 0.02
0.883HisAsn: 0.883 ± 0.022
1.605HisPro: 1.605 ± 0.031
1.23HisGln: 1.23 ± 0.026
1.283HisArg: 1.283 ± 0.025
1.488HisSer: 1.488 ± 0.027
1.61HisThr: 1.61 ± 0.028
1.759HisVal: 1.759 ± 0.03
0.452HisTrp: 0.452 ± 0.016
0.934HisTyr: 0.934 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
5.984IleAla: 5.984 ± 0.063
0.721IleCys: 0.721 ± 0.019
3.174IleAsp: 3.174 ± 0.045
3.824IleGlu: 3.824 ± 0.055
2.311IlePhe: 2.311 ± 0.037
4.397IleGly: 4.397 ± 0.058
1.5IleHis: 1.5 ± 0.028
3.658IleIle: 3.658 ± 0.053
2.059IleLys: 2.059 ± 0.035
6.104IleLeu: 6.104 ± 0.064
1.207IleMet: 1.207 ± 0.027
2.135IleAsn: 2.135 ± 0.033
3.085IlePro: 3.085 ± 0.043
2.857IleGln: 2.857 ± 0.041
2.894IleArg: 2.894 ± 0.043
3.929IleSer: 3.929 ± 0.042
3.575IleThr: 3.575 ± 0.046
4.351IleVal: 4.351 ± 0.054
0.839IleTrp: 0.839 ± 0.021
1.849IleTyr: 1.849 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
3.168LysAla: 3.168 ± 0.043
0.211LysCys: 0.211 ± 0.011
1.911LysAsp: 1.911 ± 0.031
2.27LysGlu: 2.27 ± 0.034
0.872LysPhe: 0.872 ± 0.023
2.247LysGly: 2.247 ± 0.037
0.967LysHis: 0.967 ± 0.025
2.068LysIle: 2.068 ± 0.037
1.883LysLys: 1.883 ± 0.038
3.432LysLeu: 3.432 ± 0.049
0.967LysMet: 0.967 ± 0.022
1.415LysAsn: 1.415 ± 0.028
1.902LysPro: 1.902 ± 0.032
2.157LysGln: 2.157 ± 0.032
2.489LysArg: 2.489 ± 0.041
1.998LysSer: 1.998 ± 0.035
2.197LysThr: 2.197 ± 0.036
2.369LysVal: 2.369 ± 0.041
0.405LysTrp: 0.405 ± 0.014
1.012LysTyr: 1.012 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
11.051LeuAla: 11.051 ± 0.097
1.193LeuCys: 1.193 ± 0.028
5.369LeuAsp: 5.369 ± 0.052
5.922LeuGlu: 5.922 ± 0.073
4.039LeuPhe: 4.039 ± 0.054
6.905LeuGly: 6.905 ± 0.075
2.834LeuHis: 2.834 ± 0.037
6.005LeuIle: 6.005 ± 0.081
3.88LeuLys: 3.88 ± 0.043
12.987LeuLeu: 12.987 ± 0.127
2.144LeuMet: 2.144 ± 0.037
3.463LeuAsn: 3.463 ± 0.047
6.059LeuPro: 6.059 ± 0.06
5.654LeuGln: 5.654 ± 0.075
6.295LeuArg: 6.295 ± 0.062
7.129LeuSer: 7.129 ± 0.063
6.232LeuThr: 6.232 ± 0.069
7.152LeuVal: 7.152 ± 0.075
1.398LeuTrp: 1.398 ± 0.032
3.098LeuTyr: 3.098 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
2.267MetAla: 2.267 ± 0.036
0.177MetCys: 0.177 ± 0.01
1.187MetAsp: 1.187 ± 0.025
1.161MetGlu: 1.161 ± 0.024
0.689MetPhe: 0.689 ± 0.019
1.525MetGly: 1.525 ± 0.034
0.625MetHis: 0.625 ± 0.019
1.31MetIle: 1.31 ± 0.028
0.902MetLys: 0.902 ± 0.022
2.716MetLeu: 2.716 ± 0.04
0.558MetMet: 0.558 ± 0.02
0.808MetAsn: 0.808 ± 0.021
1.323MetPro: 1.323 ± 0.028
1.361MetGln: 1.361 ± 0.024
1.529MetArg: 1.529 ± 0.029
1.555MetSer: 1.555 ± 0.025
1.433MetThr: 1.433 ± 0.031
1.623MetVal: 1.623 ± 0.028
0.203MetTrp: 0.203 ± 0.01
0.571MetTyr: 0.571 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.076AsnAla: 3.076 ± 0.04
0.31AsnCys: 0.31 ± 0.014
1.673AsnAsp: 1.673 ± 0.033
1.762AsnGlu: 1.762 ± 0.034
1.215AsnPhe: 1.215 ± 0.025
2.597AsnGly: 2.597 ± 0.048
0.787AsnHis: 0.787 ± 0.023
2.184AsnIle: 2.184 ± 0.037
1.238AsnLys: 1.238 ± 0.028
3.308AsnLeu: 3.308 ± 0.042
0.838AsnMet: 0.838 ± 0.02
1.479AsnAsn: 1.479 ± 0.043
2.088AsnPro: 2.088 ± 0.032
1.733AsnGln: 1.733 ± 0.036
1.73AsnArg: 1.73 ± 0.032
1.955AsnSer: 1.955 ± 0.038
2.284AsnThr: 2.284 ± 0.042
2.233AsnVal: 2.233 ± 0.031
0.589AsnTrp: 0.589 ± 0.019
1.178AsnTyr: 1.178 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
5.161ProAla: 5.161 ± 0.057
0.353ProCys: 0.353 ± 0.015
3.074ProAsp: 3.074 ± 0.041
3.583ProGlu: 3.583 ± 0.049
1.917ProPhe: 1.917 ± 0.034
3.744ProGly: 3.744 ± 0.054
1.197ProHis: 1.197 ± 0.027
2.677ProIle: 2.677 ± 0.037
1.459ProLys: 1.459 ± 0.029
5.326ProLeu: 5.326 ± 0.067
1.065ProMet: 1.065 ± 0.022
1.516ProAsn: 1.516 ± 0.035
2.342ProPro: 2.342 ± 0.047
2.511ProGln: 2.511 ± 0.038
2.484ProArg: 2.484 ± 0.039
2.903ProSer: 2.903 ± 0.038
3.37ProThr: 3.37 ± 0.062
3.721ProVal: 3.721 ± 0.041
0.673ProTrp: 0.673 ± 0.02
1.474ProTyr: 1.474 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
5.568GlnAla: 5.568 ± 0.066
0.373GlnCys: 0.373 ± 0.013
2.331GlnAsp: 2.331 ± 0.038
3.418GlnGlu: 3.418 ± 0.053
1.459GlnPhe: 1.459 ± 0.027
3.232GlnGly: 3.232 ± 0.046
1.702GlnHis: 1.702 ± 0.034
2.85GlnIle: 2.85 ± 0.04
2.192GlnLys: 2.192 ± 0.036
5.53GlnLeu: 5.53 ± 0.068
1.229GlnMet: 1.229 ± 0.023
1.585GlnAsn: 1.585 ± 0.03
2.892GlnPro: 2.892 ± 0.044
4.292GlnGln: 4.292 ± 0.075
3.815GlnArg: 3.815 ± 0.049
3.017GlnSer: 3.017 ± 0.047
3.041GlnThr: 3.041 ± 0.05
3.466GlnVal: 3.466 ± 0.049
0.705GlnTrp: 0.705 ± 0.019
1.396GlnTyr: 1.396 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
4.759ArgAla: 4.759 ± 0.057
0.572ArgCys: 0.572 ± 0.021
2.696ArgAsp: 2.696 ± 0.038
3.737ArgGlu: 3.737 ± 0.054
2.264ArgPhe: 2.264 ± 0.029
3.39ArgGly: 3.39 ± 0.047
1.516ArgHis: 1.516 ± 0.032
3.619ArgIle: 3.619 ± 0.049
2.367ArgLys: 2.367 ± 0.037
6.442ArgLeu: 6.442 ± 0.067
1.502ArgMet: 1.502 ± 0.026
1.872ArgAsn: 1.872 ± 0.031
2.695ArgPro: 2.695 ± 0.038
3.396ArgGln: 3.396 ± 0.045
4.012ArgArg: 4.012 ± 0.059
3.493ArgSer: 3.493 ± 0.041
3.25ArgThr: 3.25 ± 0.044
3.738ArgVal: 3.738 ± 0.045
1.015ArgTrp: 1.015 ± 0.026
2.118ArgTyr: 2.118 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
5.2SerAla: 5.2 ± 0.06
0.594SerCys: 0.594 ± 0.018
2.89SerAsp: 2.89 ± 0.041
3.131SerGlu: 3.131 ± 0.048
2.41SerPhe: 2.41 ± 0.031
4.776SerGly: 4.776 ± 0.06
1.492SerHis: 1.492 ± 0.028
3.854SerIle: 3.854 ± 0.05
1.936SerLys: 1.936 ± 0.035
6.615SerLeu: 6.615 ± 0.054
1.629SerMet: 1.629 ± 0.03
2.231SerAsn: 2.231 ± 0.038
3.045SerPro: 3.045 ± 0.042
3.018SerGln: 3.018 ± 0.046
3.261SerArg: 3.261 ± 0.045
4.411SerSer: 4.411 ± 0.061
3.981SerThr: 3.981 ± 0.051
3.813SerVal: 3.813 ± 0.044
1.052SerTrp: 1.052 ± 0.026
2.048SerTyr: 2.048 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
5.19ThrAla: 5.19 ± 0.066
0.581ThrCys: 0.581 ± 0.019
2.733ThrAsp: 2.733 ± 0.04
2.83ThrGlu: 2.83 ± 0.041
2.418ThrPhe: 2.418 ± 0.033
4.492ThrGly: 4.492 ± 0.061
1.578ThrHis: 1.578 ± 0.026
4.06ThrIle: 4.06 ± 0.044
1.681ThrLys: 1.681 ± 0.028
6.738ThrLeu: 6.738 ± 0.065
1.303ThrMet: 1.303 ± 0.026
2.144ThrAsn: 2.144 ± 0.034
3.909ThrPro: 3.909 ± 0.06
2.801ThrGln: 2.801 ± 0.047
3.2ThrArg: 3.2 ± 0.042
3.956ThrSer: 3.956 ± 0.05
4.123ThrThr: 4.123 ± 0.071
4.065ThrVal: 4.065 ± 0.048
0.816ThrTrp: 0.816 ± 0.023
2.008ThrTyr: 2.008 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
6.47ValAla: 6.47 ± 0.065
0.701ValCys: 0.701 ± 0.019
3.352ValAsp: 3.352 ± 0.043
3.889ValGlu: 3.889 ± 0.049
2.373ValPhe: 2.373 ± 0.038
4.518ValGly: 4.518 ± 0.052
1.557ValHis: 1.557 ± 0.029
3.998ValIle: 3.998 ± 0.049
2.301ValLys: 2.301 ± 0.038
7.457ValLeu: 7.457 ± 0.074
1.534ValMet: 1.534 ± 0.034
2.229ValAsn: 2.229 ± 0.036
3.461ValPro: 3.461 ± 0.051
3.116ValGln: 3.116 ± 0.046
3.806ValArg: 3.806 ± 0.046
4.241ValSer: 4.241 ± 0.05
4.066ValThr: 4.066 ± 0.052
5.102ValVal: 5.102 ± 0.058
0.824ValTrp: 0.824 ± 0.021
1.903ValTyr: 1.903 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
0.949TrpAla: 0.949 ± 0.022
0.174TrpCys: 0.174 ± 0.01
0.623TrpAsp: 0.623 ± 0.02
0.738TrpGlu: 0.738 ± 0.019
0.544TrpPhe: 0.544 ± 0.019
0.823TrpGly: 0.823 ± 0.022
0.43TrpHis: 0.43 ± 0.015
0.829TrpIle: 0.829 ± 0.025
0.586TrpLys: 0.586 ± 0.018
1.876TrpLeu: 1.876 ± 0.042
0.392TrpMet: 0.392 ± 0.015
0.628TrpAsn: 0.628 ± 0.018
0.61TrpPro: 0.61 ± 0.018
0.974TrpGln: 0.974 ± 0.02
0.964TrpArg: 0.964 ± 0.02
1.082TrpSer: 1.082 ± 0.032
0.768TrpThr: 0.768 ± 0.019
0.705TrpVal: 0.705 ± 0.022
0.272TrpTrp: 0.272 ± 0.012
0.447TrpTyr: 0.447 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.784TyrAla: 2.784 ± 0.041
0.398TyrCys: 0.398 ± 0.017
1.65TyrAsp: 1.65 ± 0.042
1.694TyrGlu: 1.694 ± 0.036
1.125TyrPhe: 1.125 ± 0.023
2.215TyrGly: 2.215 ± 0.039
0.915TyrHis: 0.915 ± 0.021
1.718TyrIle: 1.718 ± 0.036
0.913TyrLys: 0.913 ± 0.024
3.428TyrLeu: 3.428 ± 0.046
0.664TyrMet: 0.664 ± 0.019
1.17TyrAsn: 1.17 ± 0.026
1.618TyrPro: 1.618 ± 0.033
1.808TyrGln: 1.808 ± 0.034
2.006TyrArg: 2.006 ± 0.034
1.824TyrSer: 1.824 ± 0.031
1.977TyrThr: 1.977 ± 0.036
1.951TyrVal: 1.951 ± 0.037
0.521TyrTrp: 0.521 ± 0.018
1.083TyrTyr: 1.083 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6350 proteins (1951268 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski