Amino acid dipepetide frequency for Dysgonomonas gadei ATCC BAA-286

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.684AlaAla: 4.684 ± 0.072	0.719AlaCys: 0.719 ± 0.022	3.85AlaAsp: 3.85 ± 0.052	3.987AlaGlu: 3.987 ± 0.06	2.988AlaPhe: 2.988 ± 0.051	4.779AlaGly: 4.779 ± 0.067	0.991AlaHis: 0.991 ± 0.03	5.159AlaIle: 5.159 ± 0.067	4.367AlaLys: 4.367 ± 0.054	5.869AlaLeu: 5.869 ± 0.084	1.592AlaMet: 1.592 ± 0.038	3.315AlaAsn: 3.315 ± 0.053	1.931AlaPro: 1.931 ± 0.035	2.359AlaGln: 2.359 ± 0.039	2.439AlaArg: 2.439 ± 0.042	4.273AlaSer: 4.273 ± 0.065	3.489AlaThr: 3.489 ± 0.054	4.104AlaVal: 4.104 ± 0.063	0.74AlaTrp: 0.74 ± 0.024	2.953AlaTyr: 2.953 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.546CysAla: 0.546 ± 0.02	0.143CysCys: 0.143 ± 0.011	0.566CysAsp: 0.566 ± 0.02	0.508CysGlu: 0.508 ± 0.02	0.516CysPhe: 0.516 ± 0.019	0.772CysGly: 0.772 ± 0.027	0.186CysHis: 0.186 ± 0.013	0.85CysIle: 0.85 ± 0.027	0.571CysLys: 0.571 ± 0.02	0.849CysLeu: 0.849 ± 0.026	0.226CysMet: 0.226 ± 0.013	0.485CysAsn: 0.485 ± 0.019	0.384CysPro: 0.384 ± 0.016	0.221CysGln: 0.221 ± 0.013	0.404CysArg: 0.404 ± 0.019	0.687CysSer: 0.687 ± 0.025	0.503CysThr: 0.503 ± 0.017	0.528CysVal: 0.528 ± 0.017	0.134CysTrp: 0.134 ± 0.008	0.406CysTyr: 0.406 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.746AspAla: 3.746 ± 0.062	0.508AspCys: 0.508 ± 0.02	2.89AspAsp: 2.89 ± 0.05	3.703AspGlu: 3.703 ± 0.052	3.195AspPhe: 3.195 ± 0.046	4.224AspGly: 4.224 ± 0.065	0.785AspHis: 0.785 ± 0.025	5.147AspIle: 5.147 ± 0.062	4.994AspLys: 4.994 ± 0.056	4.748AspLeu: 4.748 ± 0.056	1.643AspMet: 1.643 ± 0.041	3.549AspAsn: 3.549 ± 0.054	1.995AspPro: 1.995 ± 0.039	1.326AspGln: 1.326 ± 0.031	2.342AspArg: 2.342 ± 0.035	3.266AspSer: 3.266 ± 0.046	2.711AspThr: 2.711 ± 0.047	3.502AspVal: 3.502 ± 0.047	0.881AspTrp: 0.881 ± 0.027	3.044AspTyr: 3.044 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.098GluAla: 4.098 ± 0.056	0.447GluCys: 0.447 ± 0.021	3.409GluAsp: 3.409 ± 0.047	4.277GluGlu: 4.277 ± 0.073	2.524GluPhe: 2.524 ± 0.037	3.734GluGly: 3.734 ± 0.055	1.005GluHis: 1.005 ± 0.023	4.885GluIle: 4.885 ± 0.067	5.391GluLys: 5.391 ± 0.071	5.584GluLeu: 5.584 ± 0.072	1.752GluMet: 1.752 ± 0.042	3.918GluAsn: 3.918 ± 0.052	1.738GluPro: 1.738 ± 0.036	2.291GluGln: 2.291 ± 0.047	2.686GluArg: 2.686 ± 0.05	3.461GluSer: 3.461 ± 0.047	3.224GluThr: 3.224 ± 0.053	3.809GluVal: 3.809 ± 0.053	0.79GluTrp: 0.79 ± 0.024	2.968GluTyr: 2.968 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.946PheAla: 2.946 ± 0.053	0.564PheCys: 0.564 ± 0.02	3.018PheAsp: 3.018 ± 0.046	2.696PheGlu: 2.696 ± 0.043	2.53PhePhe: 2.53 ± 0.053	3.345PheGly: 3.345 ± 0.051	0.772PheHis: 0.772 ± 0.023	3.776PheIle: 3.776 ± 0.064	2.802PheLys: 2.802 ± 0.046	4.08PheLeu: 4.08 ± 0.065	1.199PheMet: 1.199 ± 0.027	2.662PheAsn: 2.662 ± 0.046	1.658PhePro: 1.658 ± 0.032	1.226PheGln: 1.226 ± 0.028	2.011PheArg: 2.011 ± 0.036	3.934PheSer: 3.934 ± 0.051	2.892PheThr: 2.892 ± 0.043	2.857PheVal: 2.857 ± 0.049	0.633PheTrp: 0.633 ± 0.022	2.147PheTyr: 2.147 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	4.075GlyAla: 4.075 ± 0.063	0.696GlyCys: 0.696 ± 0.023	3.548GlyAsp: 3.548 ± 0.049	3.923GlyGlu: 3.923 ± 0.052	3.412GlyPhe: 3.412 ± 0.047	4.724GlyGly: 4.724 ± 0.081	1.153GlyHis: 1.153 ± 0.03	5.622GlyIle: 5.622 ± 0.07	5.173GlyLys: 5.173 ± 0.065	5.84GlyLeu: 5.84 ± 0.065	1.775GlyMet: 1.775 ± 0.035	3.893GlyAsn: 3.893 ± 0.062	1.246GlyPro: 1.246 ± 0.031	2.141GlyGln: 2.141 ± 0.041	2.553GlyArg: 2.553 ± 0.042	4.079GlySer: 4.079 ± 0.065	4.125GlyThr: 4.125 ± 0.065	4.378GlyVal: 4.378 ± 0.062	1.061GlyTrp: 1.061 ± 0.027	3.617GlyTyr: 3.617 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	0.925HisAla: 0.925 ± 0.025	0.18HisCys: 0.18 ± 0.011	0.864HisAsp: 0.864 ± 0.024	0.851HisGlu: 0.851 ± 0.025	0.924HisPhe: 0.924 ± 0.025	1.071HisGly: 1.071 ± 0.026	0.381HisHis: 0.381 ± 0.018	1.393HisIle: 1.393 ± 0.029	1.063HisLys: 1.063 ± 0.027	1.496HisLeu: 1.496 ± 0.037	0.366HisMet: 0.366 ± 0.014	0.967HisAsn: 0.967 ± 0.026	0.819HisPro: 0.819 ± 0.027	0.529HisGln: 0.529 ± 0.017	0.733HisArg: 0.733 ± 0.021	0.999HisSer: 0.999 ± 0.027	0.972HisThr: 0.972 ± 0.027	0.806HisVal: 0.806 ± 0.023	0.226HisTrp: 0.226 ± 0.013	0.853HisTyr: 0.853 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.382IleAla: 5.382 ± 0.073	0.878IleCys: 0.878 ± 0.028	4.82IleAsp: 4.82 ± 0.069	5.036IleGlu: 5.036 ± 0.066	3.501IlePhe: 3.501 ± 0.066	5.016IleGly: 5.016 ± 0.07	1.314IleHis: 1.314 ± 0.032	5.906IleIle: 5.906 ± 0.071	5.27IleLys: 5.27 ± 0.066	7.03IleLeu: 7.03 ± 0.092	1.553IleMet: 1.553 ± 0.032	4.326IleAsn: 4.326 ± 0.056	3.466IlePro: 3.466 ± 0.046	2.326IleGln: 2.326 ± 0.038	3.313IleArg: 3.313 ± 0.047	5.82IleSer: 5.82 ± 0.069	4.593IleThr: 4.593 ± 0.055	4.725IleVal: 4.725 ± 0.061	0.807IleTrp: 0.807 ± 0.028	3.335IleTyr: 3.335 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	4.777LysAla: 4.777 ± 0.066	0.443LysCys: 0.443 ± 0.017	5.001LysAsp: 5.001 ± 0.069	5.871LysGlu: 5.871 ± 0.072	2.51LysPhe: 2.51 ± 0.039	4.753LysGly: 4.753 ± 0.059	1.179LysHis: 1.179 ± 0.029	5.289LysIle: 5.289 ± 0.071	5.865LysLys: 5.865 ± 0.067	5.561LysLeu: 5.561 ± 0.058	2.107LysMet: 2.107 ± 0.037	4.408LysAsn: 4.408 ± 0.058	2.388LysPro: 2.388 ± 0.041	2.561LysGln: 2.561 ± 0.043	2.939LysArg: 2.939 ± 0.046	4.21LysSer: 4.21 ± 0.058	4.174LysThr: 4.174 ± 0.054	4.497LysVal: 4.497 ± 0.057	0.876LysTrp: 0.876 ± 0.025	3.567LysTyr: 3.567 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	5.623LeuAla: 5.623 ± 0.075	0.974LeuCys: 0.974 ± 0.027	4.843LeuAsp: 4.843 ± 0.053	4.789LeuGlu: 4.789 ± 0.067	4.583LeuPhe: 4.583 ± 0.071	5.296LeuGly: 5.296 ± 0.076	1.46LeuHis: 1.46 ± 0.032	6.547LeuIle: 6.547 ± 0.084	6.6LeuLys: 6.6 ± 0.072	8.345LeuLeu: 8.345 ± 0.109	2.102LeuMet: 2.102 ± 0.039	5.09LeuAsn: 5.09 ± 0.061	3.696LeuPro: 3.696 ± 0.047	2.9LeuGln: 2.9 ± 0.049	3.586LeuArg: 3.586 ± 0.046	7.019LeuSer: 7.019 ± 0.083	5.091LeuThr: 5.091 ± 0.053	4.76LeuVal: 4.76 ± 0.065	1.019LeuTrp: 1.019 ± 0.028	3.784LeuTyr: 3.784 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	1.694MetAla: 1.694 ± 0.039	0.211MetCys: 0.211 ± 0.012	1.39MetAsp: 1.39 ± 0.029	1.529MetGlu: 1.529 ± 0.031	1.032MetPhe: 1.032 ± 0.03	1.64MetGly: 1.64 ± 0.035	0.42MetHis: 0.42 ± 0.019	1.652MetIle: 1.652 ± 0.035	2.427MetLys: 2.427 ± 0.043	2.188MetLeu: 2.188 ± 0.042	0.658MetMet: 0.658 ± 0.022	1.497MetAsn: 1.497 ± 0.028	1.019MetPro: 1.019 ± 0.024	0.958MetGln: 0.958 ± 0.026	1.149MetArg: 1.149 ± 0.034	1.553MetSer: 1.553 ± 0.029	1.418MetThr: 1.418 ± 0.029	1.407MetVal: 1.407 ± 0.033	0.248MetTrp: 0.248 ± 0.014	0.907MetTyr: 0.907 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.418AsnAla: 3.418 ± 0.05	0.452AsnCys: 0.452 ± 0.019	3.053AsnAsp: 3.053 ± 0.044	3.273AsnGlu: 3.273 ± 0.046	2.438AsnPhe: 2.438 ± 0.04	3.971AsnGly: 3.971 ± 0.066	0.946AsnHis: 0.946 ± 0.028	5.098AsnIle: 5.098 ± 0.073	4.272AsnLys: 4.272 ± 0.052	4.841AsnLeu: 4.841 ± 0.068	1.515AsnMet: 1.515 ± 0.028	3.609AsnAsn: 3.609 ± 0.062	2.769AsnPro: 2.769 ± 0.05	1.786AsnGln: 1.786 ± 0.038	2.458AsnArg: 2.458 ± 0.045	3.52AsnSer: 3.52 ± 0.056	3.413AsnThr: 3.413 ± 0.053	3.262AsnVal: 3.262 ± 0.049	0.74AsnTrp: 0.74 ± 0.025	2.715AsnTyr: 2.715 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	2.565ProAla: 2.565 ± 0.038	0.26ProCys: 0.26 ± 0.012	2.579ProAsp: 2.579 ± 0.042	3.05ProGlu: 3.05 ± 0.045	1.844ProPhe: 1.844 ± 0.037	2.215ProGly: 2.215 ± 0.04	0.593ProHis: 0.593 ± 0.021	2.361ProIle: 2.361 ± 0.038	2.135ProLys: 2.135 ± 0.036	3.115ProLeu: 3.115 ± 0.05	0.819ProMet: 0.819 ± 0.022	1.781ProAsn: 1.781 ± 0.042	0.902ProPro: 0.902 ± 0.026	1.295ProGln: 1.295 ± 0.032	1.146ProArg: 1.146 ± 0.029	2.284ProSer: 2.284 ± 0.043	1.82ProThr: 1.82 ± 0.036	3.025ProVal: 3.025 ± 0.053	0.438ProTrp: 0.438 ± 0.016	1.69ProTyr: 1.69 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	2.182GlnAla: 2.182 ± 0.042	0.204GlnCys: 0.204 ± 0.012	1.646GlnAsp: 1.646 ± 0.036	2.051GlnGlu: 2.051 ± 0.039	1.33GlnPhe: 1.33 ± 0.033	1.911GlnGly: 1.911 ± 0.036	0.511GlnHis: 0.511 ± 0.021	2.542GlnIle: 2.542 ± 0.043	2.559GlnLys: 2.559 ± 0.041	2.918GlnLeu: 2.918 ± 0.045	0.874GlnMet: 0.874 ± 0.022	1.902GlnAsn: 1.902 ± 0.036	1.139GlnPro: 1.139 ± 0.031	1.355GlnGln: 1.355 ± 0.035	1.365GlnArg: 1.365 ± 0.032	2.08GlnSer: 2.08 ± 0.035	1.987GlnThr: 1.987 ± 0.035	1.876GlnVal: 1.876 ± 0.035	0.439GlnTrp: 0.439 ± 0.017	1.481GlnTyr: 1.481 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.287ArgAla: 2.287 ± 0.044	0.311ArgCys: 0.311 ± 0.015	2.113ArgAsp: 2.113 ± 0.038	2.615ArgGlu: 2.615 ± 0.051	2.144ArgPhe: 2.144 ± 0.044	2.277ArgGly: 2.277 ± 0.045	0.7ArgHis: 0.7 ± 0.021	3.489ArgIle: 3.489 ± 0.05	3.202ArgLys: 3.202 ± 0.051	3.738ArgLeu: 3.738 ± 0.052	1.202ArgMet: 1.202 ± 0.024	2.439ArgAsn: 2.439 ± 0.041	1.289ArgPro: 1.289 ± 0.035	1.427ArgGln: 1.427 ± 0.029	1.711ArgArg: 1.711 ± 0.038	2.237ArgSer: 2.237 ± 0.038	2.168ArgThr: 2.168 ± 0.041	2.334ArgVal: 2.334 ± 0.039	0.596ArgTrp: 0.596 ± 0.021	2.067ArgTyr: 2.067 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.23SerAla: 4.23 ± 0.061	0.733SerCys: 0.733 ± 0.024	3.861SerAsp: 3.861 ± 0.052	3.686SerGlu: 3.686 ± 0.054	3.571SerPhe: 3.571 ± 0.05	5.009SerGly: 5.009 ± 0.073	1.132SerHis: 1.132 ± 0.027	5.093SerIle: 5.093 ± 0.067	4.112SerLys: 4.112 ± 0.048	6.296SerLeu: 6.296 ± 0.07	1.476SerMet: 1.476 ± 0.033	3.385SerAsn: 3.385 ± 0.063	2.373SerPro: 2.373 ± 0.041	2.203SerGln: 2.203 ± 0.036	2.537SerArg: 2.537 ± 0.046	4.425SerSer: 4.425 ± 0.079	3.452SerThr: 3.452 ± 0.05	4.588SerVal: 4.588 ± 0.058	0.811SerTrp: 0.811 ± 0.022	3.161SerTyr: 3.161 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	3.733ThrAla: 3.733 ± 0.061	0.447ThrCys: 0.447 ± 0.017	3.667ThrAsp: 3.667 ± 0.055	3.299ThrGlu: 3.299 ± 0.05	2.785ThrPhe: 2.785 ± 0.048	4.581ThrGly: 4.581 ± 0.059	0.933ThrHis: 0.933 ± 0.024	4.463ThrIle: 4.463 ± 0.054	3.406ThrLys: 3.406 ± 0.047	5.062ThrLeu: 5.062 ± 0.056	1.149ThrMet: 1.149 ± 0.029	3.016ThrAsn: 3.016 ± 0.052	2.537ThrPro: 2.537 ± 0.044	1.728ThrGln: 1.728 ± 0.036	1.932ThrArg: 1.932 ± 0.04	3.53ThrSer: 3.53 ± 0.054	3.267ThrThr: 3.267 ± 0.055	3.827ThrVal: 3.827 ± 0.053	0.674ThrTrp: 0.674 ± 0.022	2.594ThrTyr: 2.594 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	4.093ValAla: 4.093 ± 0.062	0.718ValCys: 0.718 ± 0.02	3.553ValAsp: 3.553 ± 0.055	3.682ValGlu: 3.682 ± 0.056	3.024ValPhe: 3.024 ± 0.046	3.689ValGly: 3.689 ± 0.059	0.927ValHis: 0.927 ± 0.026	4.561ValIle: 4.561 ± 0.064	4.509ValLys: 4.509 ± 0.054	5.339ValLeu: 5.339 ± 0.071	1.468ValMet: 1.468 ± 0.035	3.474ValAsn: 3.474 ± 0.05	2.289ValPro: 2.289 ± 0.042	1.76ValGln: 1.76 ± 0.036	2.462ValArg: 2.462 ± 0.04	4.716ValSer: 4.716 ± 0.06	3.591ValThr: 3.591 ± 0.057	4.04ValVal: 4.04 ± 0.063	0.719ValTrp: 0.719 ± 0.021	2.791ValTyr: 2.791 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.773TrpAla: 0.773 ± 0.025	0.146TrpCys: 0.146 ± 0.009	0.823TrpAsp: 0.823 ± 0.026	0.707TrpGlu: 0.707 ± 0.023	0.557TrpPhe: 0.557 ± 0.022	1.005TrpGly: 1.005 ± 0.028	0.221TrpHis: 0.221 ± 0.013	0.935TrpIle: 0.935 ± 0.025	0.87TrpLys: 0.87 ± 0.024	1.128TrpLeu: 1.128 ± 0.03	0.396TrpMet: 0.396 ± 0.016	0.82TrpAsn: 0.82 ± 0.023	0.288TrpPro: 0.288 ± 0.015	0.468TrpGln: 0.468 ± 0.014	0.546TrpArg: 0.546 ± 0.021	0.75TrpSer: 0.75 ± 0.025	0.738TrpThr: 0.738 ± 0.022	0.736TrpVal: 0.736 ± 0.025	0.197TrpTrp: 0.197 ± 0.012	0.567TrpTyr: 0.567 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.806TyrAla: 2.806 ± 0.038	0.452TyrCys: 0.452 ± 0.016	2.702TyrAsp: 2.702 ± 0.048	2.459TyrGlu: 2.459 ± 0.042	2.339TyrPhe: 2.339 ± 0.042	3.024TyrGly: 3.024 ± 0.048	0.811TyrHis: 0.811 ± 0.025	3.647TyrIle: 3.647 ± 0.052	3.391TyrLys: 3.391 ± 0.049	4.081TyrLeu: 4.081 ± 0.053	1.127TyrMet: 1.127 ± 0.025	3.014TyrAsn: 3.014 ± 0.058	1.993TyrPro: 1.993 ± 0.04	1.492TyrGln: 1.492 ± 0.033	2.033TyrArg: 2.033 ± 0.037	3.292TyrSer: 3.292 ± 0.049	3.001TyrThr: 3.001 ± 0.05	2.343TyrVal: 2.343 ± 0.039	0.641TyrTrp: 0.641 ± 0.018	2.382TyrTyr: 2.382 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4153 proteins (1514011 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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