Amino acid dipepetide frequency for Arthrobacter rhombi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.161AlaAla: 18.161 ± 0.238	0.717AlaCys: 0.717 ± 0.028	7.014AlaAsp: 7.014 ± 0.086	8.14AlaGlu: 8.14 ± 0.104	3.638AlaPhe: 3.638 ± 0.058	12.673AlaGly: 12.673 ± 0.132	2.369AlaHis: 2.369 ± 0.053	5.175AlaIle: 5.175 ± 0.086	3.108AlaLys: 3.108 ± 0.071	12.569AlaLeu: 12.569 ± 0.151	2.751AlaMet: 2.751 ± 0.051	2.487AlaAsn: 2.487 ± 0.054	5.662AlaPro: 5.662 ± 0.09	3.965AlaGln: 3.965 ± 0.066	7.888AlaArg: 7.888 ± 0.11	7.263AlaSer: 7.263 ± 0.098	7.382AlaThr: 7.382 ± 0.098	10.459AlaVal: 10.459 ± 0.143	1.675AlaTrp: 1.675 ± 0.044	2.254AlaTyr: 2.254 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.723CysAla: 0.723 ± 0.028	0.059CysCys: 0.059 ± 0.009	0.307CysAsp: 0.307 ± 0.018	0.301CysGlu: 0.301 ± 0.018	0.197CysPhe: 0.197 ± 0.015	0.679CysGly: 0.679 ± 0.028	0.166CysHis: 0.166 ± 0.015	0.211CysIle: 0.211 ± 0.013	0.102CysLys: 0.102 ± 0.01	0.602CysLeu: 0.602 ± 0.025	0.111CysMet: 0.111 ± 0.01	0.129CysAsn: 0.129 ± 0.011	0.364CysPro: 0.364 ± 0.021	0.171CysGln: 0.171 ± 0.016	0.412CysArg: 0.412 ± 0.021	0.45CysSer: 0.45 ± 0.02	0.414CysThr: 0.414 ± 0.018	0.445CysVal: 0.445 ± 0.021	0.091CysTrp: 0.091 ± 0.011	0.119CysTyr: 0.119 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.046AspAla: 7.046 ± 0.099	0.325AspCys: 0.325 ± 0.02	3.341AspAsp: 3.341 ± 0.064	3.857AspGlu: 3.857 ± 0.07	1.952AspPhe: 1.952 ± 0.053	5.517AspGly: 5.517 ± 0.084	1.296AspHis: 1.296 ± 0.041	2.451AspIle: 2.451 ± 0.056	1.086AspLys: 1.086 ± 0.038	5.941AspLeu: 5.941 ± 0.092	0.966AspMet: 0.966 ± 0.028	0.969AspAsn: 0.969 ± 0.035	4.025AspPro: 4.025 ± 0.065	1.942AspGln: 1.942 ± 0.048	3.588AspArg: 3.588 ± 0.068	2.988AspSer: 2.988 ± 0.057	3.068AspThr: 3.068 ± 0.058	4.774AspVal: 4.774 ± 0.075	0.875AspTrp: 0.875 ± 0.033	1.373AspTyr: 1.373 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	7.862GluAla: 7.862 ± 0.101	0.287GluCys: 0.287 ± 0.017	3.452GluAsp: 3.452 ± 0.068	3.69GluGlu: 3.69 ± 0.072	1.757GluPhe: 1.757 ± 0.044	4.439GluGly: 4.439 ± 0.082	1.688GluHis: 1.688 ± 0.039	2.665GluIle: 2.665 ± 0.055	1.806GluLys: 1.806 ± 0.05	6.869GluLeu: 6.869 ± 0.102	1.022GluMet: 1.022 ± 0.035	1.522GluAsn: 1.522 ± 0.042	3.059GluPro: 3.059 ± 0.065	2.502GluGln: 2.502 ± 0.05	4.481GluArg: 4.481 ± 0.081	3.09GluSer: 3.09 ± 0.057	3.342GluThr: 3.342 ± 0.056	4.31GluVal: 4.31 ± 0.078	0.682GluTrp: 0.682 ± 0.023	1.191GluTyr: 1.191 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.878PheAla: 3.878 ± 0.07	0.25PheCys: 0.25 ± 0.014	2.133PheAsp: 2.133 ± 0.046	1.751PheGlu: 1.751 ± 0.045	1.137PhePhe: 1.137 ± 0.041	3.435PheGly: 3.435 ± 0.077	0.669PheHis: 0.669 ± 0.029	1.477PheIle: 1.477 ± 0.044	0.707PheLys: 0.707 ± 0.03	3.0PheLeu: 3.0 ± 0.059	0.609PheMet: 0.609 ± 0.026	0.815PheAsn: 0.815 ± 0.032	1.382PhePro: 1.382 ± 0.031	0.749PheGln: 0.749 ± 0.029	1.707PheArg: 1.707 ± 0.045	2.189PheSer: 2.189 ± 0.051	2.183PheThr: 2.183 ± 0.044	2.512PheVal: 2.512 ± 0.047	0.465PheTrp: 0.465 ± 0.025	0.694PheTyr: 0.694 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.039GlyAla: 10.039 ± 0.1	0.658GlyCys: 0.658 ± 0.027	4.349GlyAsp: 4.349 ± 0.065	4.758GlyGlu: 4.758 ± 0.078	3.471GlyPhe: 3.471 ± 0.068	7.582GlyGly: 7.582 ± 0.126	2.205GlyHis: 2.205 ± 0.043	4.993GlyIle: 4.993 ± 0.075	2.81GlyLys: 2.81 ± 0.062	9.563GlyLeu: 9.563 ± 0.113	2.252GlyMet: 2.252 ± 0.052	2.176GlyAsn: 2.176 ± 0.054	4.21GlyPro: 4.21 ± 0.074	3.292GlyGln: 3.292 ± 0.062	6.034GlyArg: 6.034 ± 0.093	5.869GlySer: 5.869 ± 0.094	6.174GlyThr: 6.174 ± 0.081	7.181GlyVal: 7.181 ± 0.089	1.645GlyTrp: 1.645 ± 0.044	2.297GlyTyr: 2.297 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.32HisAla: 2.32 ± 0.046	0.163HisCys: 0.163 ± 0.014	1.388HisAsp: 1.388 ± 0.043	1.347HisGlu: 1.347 ± 0.038	0.638HisPhe: 0.638 ± 0.025	2.227HisGly: 2.227 ± 0.053	0.68HisHis: 0.68 ± 0.03	0.8HisIle: 0.8 ± 0.032	0.318HisLys: 0.318 ± 0.019	2.192HisLeu: 2.192 ± 0.053	0.334HisMet: 0.334 ± 0.019	0.404HisAsn: 0.404 ± 0.022	1.632HisPro: 1.632 ± 0.046	0.826HisGln: 0.826 ± 0.029	1.766HisArg: 1.766 ± 0.046	1.15HisSer: 1.15 ± 0.034	1.108HisThr: 1.108 ± 0.032	1.62HisVal: 1.62 ± 0.041	0.35HisTrp: 0.35 ± 0.019	0.499HisTyr: 0.499 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.844IleAla: 5.844 ± 0.081	0.351IleCys: 0.351 ± 0.018	3.125IleAsp: 3.125 ± 0.053	2.624IleGlu: 2.624 ± 0.053	1.383IlePhe: 1.383 ± 0.041	4.741IleGly: 4.741 ± 0.088	0.928IleHis: 0.928 ± 0.031	2.196IleIle: 2.196 ± 0.052	1.064IleLys: 1.064 ± 0.038	4.175IleLeu: 4.175 ± 0.077	0.881IleMet: 0.881 ± 0.032	1.259IleAsn: 1.259 ± 0.042	2.418IlePro: 2.418 ± 0.049	1.087IleGln: 1.087 ± 0.038	2.678IleArg: 2.678 ± 0.051	2.822IleSer: 2.822 ± 0.059	2.864IleThr: 2.864 ± 0.054	3.909IleVal: 3.909 ± 0.073	0.57IleTrp: 0.57 ± 0.028	0.847IleTyr: 0.847 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.125LysAla: 3.125 ± 0.081	0.101LysCys: 0.101 ± 0.01	1.611LysAsp: 1.611 ± 0.052	1.312LysGlu: 1.312 ± 0.047	0.682LysPhe: 0.682 ± 0.026	1.752LysGly: 1.752 ± 0.052	0.566LysHis: 0.566 ± 0.028	1.365LysIle: 1.365 ± 0.038	1.283LysLys: 1.283 ± 0.057	2.401LysLeu: 2.401 ± 0.052	0.646LysMet: 0.646 ± 0.027	0.77LysAsn: 0.77 ± 0.03	1.516LysPro: 1.516 ± 0.05	0.789LysGln: 0.789 ± 0.034	1.578LysArg: 1.578 ± 0.043	1.533LysSer: 1.533 ± 0.043	1.738LysThr: 1.738 ± 0.05	2.128LysVal: 2.128 ± 0.053	0.269LysTrp: 0.269 ± 0.015	0.638LysTyr: 0.638 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.825LeuAla: 13.825 ± 0.159	0.622LeuCys: 0.622 ± 0.027	6.221LeuAsp: 6.221 ± 0.089	6.002LeuGlu: 6.002 ± 0.089	3.008LeuPhe: 3.008 ± 0.062	9.666LeuGly: 9.666 ± 0.125	2.017LeuHis: 2.017 ± 0.05	4.608LeuIle: 4.608 ± 0.092	2.518LeuLys: 2.518 ± 0.063	10.791LeuLeu: 10.791 ± 0.171	2.094LeuMet: 2.094 ± 0.046	2.388LeuAsn: 2.388 ± 0.05	5.811LeuPro: 5.811 ± 0.087	2.859LeuGln: 2.859 ± 0.05	7.053LeuArg: 7.053 ± 0.106	6.189LeuSer: 6.189 ± 0.088	5.864LeuThr: 5.864 ± 0.085	8.555LeuVal: 8.555 ± 0.115	1.261LeuTrp: 1.261 ± 0.04	1.647LeuTyr: 1.647 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.742MetAla: 2.742 ± 0.055	0.135MetCys: 0.135 ± 0.012	1.176MetAsp: 1.176 ± 0.039	1.064MetGlu: 1.064 ± 0.037	0.612MetPhe: 0.612 ± 0.025	1.69MetGly: 1.69 ± 0.045	0.387MetHis: 0.387 ± 0.021	1.113MetIle: 1.113 ± 0.037	0.64MetLys: 0.64 ± 0.024	2.059MetLeu: 2.059 ± 0.042	0.471MetMet: 0.471 ± 0.022	0.723MetAsn: 0.723 ± 0.026	1.126MetPro: 1.126 ± 0.035	0.545MetGln: 0.545 ± 0.021	1.325MetArg: 1.325 ± 0.033	1.612MetSer: 1.612 ± 0.038	1.505MetThr: 1.505 ± 0.038	1.654MetVal: 1.654 ± 0.039	0.191MetTrp: 0.191 ± 0.013	0.348MetTyr: 0.348 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.673AsnAla: 2.673 ± 0.051	0.149AsnCys: 0.149 ± 0.012	1.395AsnAsp: 1.395 ± 0.044	1.272AsnGlu: 1.272 ± 0.04	0.718AsnPhe: 0.718 ± 0.024	2.065AsnGly: 2.065 ± 0.052	0.584AsnHis: 0.584 ± 0.023	1.074AsnIle: 1.074 ± 0.037	0.603AsnLys: 0.603 ± 0.028	2.187AsnLeu: 2.187 ± 0.05	0.497AsnMet: 0.497 ± 0.021	0.607AsnAsn: 0.607 ± 0.027	1.735AsnPro: 1.735 ± 0.042	0.798AsnGln: 0.798 ± 0.031	1.525AsnArg: 1.525 ± 0.048	1.239AsnSer: 1.239 ± 0.038	1.439AsnThr: 1.439 ± 0.039	1.734AsnVal: 1.734 ± 0.044	0.364AsnTrp: 0.364 ± 0.021	0.557AsnTyr: 0.557 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.02ProAla: 7.02 ± 0.086	0.215ProCys: 0.215 ± 0.015	3.331ProAsp: 3.331 ± 0.064	4.327ProGlu: 4.327 ± 0.076	1.556ProPhe: 1.556 ± 0.038	5.411ProGly: 5.411 ± 0.08	1.078ProHis: 1.078 ± 0.034	1.769ProIle: 1.769 ± 0.042	1.248ProLys: 1.248 ± 0.04	4.975ProLeu: 4.975 ± 0.088	1.071ProMet: 1.071 ± 0.036	1.063ProAsn: 1.063 ± 0.034	2.024ProPro: 2.024 ± 0.055	1.838ProGln: 1.838 ± 0.044	3.129ProArg: 3.129 ± 0.058	3.211ProSer: 3.211 ± 0.063	3.109ProThr: 3.109 ± 0.062	4.605ProVal: 4.605 ± 0.07	0.777ProTrp: 0.777 ± 0.031	0.986ProTyr: 0.986 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.194GlnAla: 4.194 ± 0.077	0.14GlnCys: 0.14 ± 0.012	1.785GlnAsp: 1.785 ± 0.044	1.933GlnGlu: 1.933 ± 0.049	0.853GlnPhe: 0.853 ± 0.029	2.505GlnGly: 2.505 ± 0.055	0.717GlnHis: 0.717 ± 0.029	1.516GlnIle: 1.516 ± 0.044	0.895GlnLys: 0.895 ± 0.031	3.608GlnLeu: 3.608 ± 0.059	0.701GlnMet: 0.701 ± 0.029	0.722GlnAsn: 0.722 ± 0.025	1.642GlnPro: 1.642 ± 0.045	1.473GlnGln: 1.473 ± 0.041	2.579GlnArg: 2.579 ± 0.052	1.601GlnSer: 1.601 ± 0.04	1.585GlnThr: 1.585 ± 0.037	2.592GlnVal: 2.592 ± 0.047	0.51GlnTrp: 0.51 ± 0.02	0.622GlnTyr: 0.622 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.239ArgAla: 7.239 ± 0.099	0.334ArgCys: 0.334 ± 0.017	3.37ArgAsp: 3.37 ± 0.06	4.116ArgGlu: 4.116 ± 0.061	2.211ArgPhe: 2.211 ± 0.04	5.003ArgGly: 5.003 ± 0.078	1.714ArgHis: 1.714 ± 0.046	3.435ArgIle: 3.435 ± 0.058	1.802ArgLys: 1.802 ± 0.042	6.983ArgLeu: 6.983 ± 0.101	1.577ArgMet: 1.577 ± 0.04	1.599ArgAsn: 1.599 ± 0.039	3.334ArgPro: 3.334 ± 0.06	2.483ArgGln: 2.483 ± 0.053	5.85ArgArg: 5.85 ± 0.104	3.932ArgSer: 3.932 ± 0.071	3.932ArgThr: 3.932 ± 0.069	4.862ArgVal: 4.862 ± 0.078	1.081ArgTrp: 1.081 ± 0.035	1.45ArgTyr: 1.45 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	7.091SerAla: 7.091 ± 0.097	0.401SerCys: 0.401 ± 0.022	2.959SerAsp: 2.959 ± 0.062	3.197SerGlu: 3.197 ± 0.055	1.965SerPhe: 1.965 ± 0.045	6.187SerGly: 6.187 ± 0.08	1.171SerHis: 1.171 ± 0.034	2.646SerIle: 2.646 ± 0.054	1.608SerLys: 1.608 ± 0.046	5.989SerLeu: 5.989 ± 0.088	1.551SerMet: 1.551 ± 0.04	1.437SerAsn: 1.437 ± 0.037	3.133SerPro: 3.133 ± 0.061	1.729SerGln: 1.729 ± 0.045	3.773SerArg: 3.773 ± 0.06	3.956SerSer: 3.956 ± 0.077	4.115SerThr: 4.115 ± 0.07	4.597SerVal: 4.597 ± 0.068	0.992SerTrp: 0.992 ± 0.035	1.296SerTyr: 1.296 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	7.754ThrAla: 7.754 ± 0.09	0.314ThrCys: 0.314 ± 0.019	3.451ThrAsp: 3.451 ± 0.064	3.519ThrGlu: 3.519 ± 0.071	1.792ThrPhe: 1.792 ± 0.042	6.285ThrGly: 6.285 ± 0.078	1.204ThrHis: 1.204 ± 0.036	2.66ThrIle: 2.66 ± 0.061	1.316ThrLys: 1.316 ± 0.039	5.843ThrLeu: 5.843 ± 0.079	1.186ThrMet: 1.186 ± 0.032	1.309ThrAsn: 1.309 ± 0.042	3.577ThrPro: 3.577 ± 0.06	1.629ThrGln: 1.629 ± 0.04	3.465ThrArg: 3.465 ± 0.057	3.758ThrSer: 3.758 ± 0.062	3.97ThrThr: 3.97 ± 0.078	5.472ThrVal: 5.472 ± 0.078	0.759ThrTrp: 0.759 ± 0.03	1.232ThrTyr: 1.232 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.963ValAla: 9.963 ± 0.115	0.56ValCys: 0.56 ± 0.026	4.954ValAsp: 4.954 ± 0.08	4.798ValGlu: 4.798 ± 0.078	2.818ValPhe: 2.818 ± 0.064	6.716ValGly: 6.716 ± 0.101	1.701ValHis: 1.701 ± 0.047	4.164ValIle: 4.164 ± 0.071	2.022ValLys: 2.022 ± 0.06	9.243ValLeu: 9.243 ± 0.118	1.715ValMet: 1.715 ± 0.044	1.905ValAsn: 1.905 ± 0.05	4.371ValPro: 4.371 ± 0.06	2.292ValGln: 2.292 ± 0.048	4.903ValArg: 4.903 ± 0.067	4.917ValSer: 4.917 ± 0.071	4.724ValThr: 4.724 ± 0.079	7.658ValVal: 7.658 ± 0.105	0.885ValTrp: 0.885 ± 0.031	1.384ValTyr: 1.384 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.517TrpAla: 1.517 ± 0.045	0.105TrpCys: 0.105 ± 0.009	0.736TrpAsp: 0.736 ± 0.024	0.66TrpGlu: 0.66 ± 0.026	0.567TrpPhe: 0.567 ± 0.027	1.022TrpGly: 1.022 ± 0.034	0.291TrpHis: 0.291 ± 0.018	0.747TrpIle: 0.747 ± 0.028	0.446TrpLys: 0.446 ± 0.02	1.688TrpLeu: 1.688 ± 0.051	0.376TrpMet: 0.376 ± 0.019	0.455TrpAsn: 0.455 ± 0.023	0.671TrpPro: 0.671 ± 0.032	0.528TrpGln: 0.528 ± 0.023	0.996TrpArg: 0.996 ± 0.03	0.795TrpSer: 0.795 ± 0.027	0.814TrpThr: 0.814 ± 0.03	1.078TrpVal: 1.078 ± 0.038	0.331TrpTrp: 0.331 ± 0.022	0.301TrpTyr: 0.301 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.331TyrAla: 2.331 ± 0.045	0.169TyrCys: 0.169 ± 0.014	1.287TyrAsp: 1.287 ± 0.039	1.047TyrGlu: 1.047 ± 0.036	0.787TyrPhe: 0.787 ± 0.03	1.962TyrGly: 1.962 ± 0.044	0.33TyrHis: 0.33 ± 0.02	0.701TyrIle: 0.701 ± 0.025	0.421TyrLys: 0.421 ± 0.025	2.322TyrLeu: 2.322 ± 0.044	0.307TyrMet: 0.307 ± 0.019	0.474TyrAsn: 0.474 ± 0.022	1.053TyrPro: 1.053 ± 0.034	0.674TyrGln: 0.674 ± 0.025	1.577TyrArg: 1.577 ± 0.043	1.229TyrSer: 1.229 ± 0.037	1.166TyrThr: 1.166 ± 0.035	1.548TyrVal: 1.548 ± 0.037	0.35TyrTrp: 0.35 ± 0.019	0.473TyrTyr: 0.473 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3075 proteins (982341 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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