Amino acid dipepetide frequency for Onchocerca flexuosa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.026AlaAla: 5.026 ± 0.063
1.193AlaCys: 1.193 ± 0.022
3.068AlaAsp: 3.068 ± 0.032
4.105AlaGlu: 4.105 ± 0.046
2.584AlaPhe: 2.584 ± 0.03
2.914AlaGly: 2.914 ± 0.039
1.329AlaHis: 1.329 ± 0.02
4.137AlaIle: 4.137 ± 0.037
3.645AlaLys: 3.645 ± 0.033
5.824AlaLeu: 5.824 ± 0.048
1.558AlaMet: 1.558 ± 0.022
2.903AlaAsn: 2.903 ± 0.034
2.307AlaPro: 2.307 ± 0.031
2.338AlaGln: 2.338 ± 0.033
3.053AlaArg: 3.053 ± 0.034
4.816AlaSer: 4.816 ± 0.047
3.543AlaThr: 3.543 ± 0.036
4.472AlaVal: 4.472 ± 0.041
0.565AlaTrp: 0.565 ± 0.013
1.761AlaTyr: 1.761 ± 0.025
0.0AlaXaa: 0.0 ± 0.0
Cys
1.259CysAla: 1.259 ± 0.023
0.639CysCys: 0.639 ± 0.019
1.279CysAsp: 1.279 ± 0.03
1.273CysGlu: 1.273 ± 0.029
0.98CysPhe: 0.98 ± 0.018
1.309CysGly: 1.309 ± 0.026
0.58CysHis: 0.58 ± 0.016
1.47CysIle: 1.47 ± 0.026
1.231CysLys: 1.231 ± 0.028
1.956CysLeu: 1.956 ± 0.03
0.49CysMet: 0.49 ± 0.013
1.071CysAsn: 1.071 ± 0.02
1.012CysPro: 1.012 ± 0.03
0.806CysGln: 0.806 ± 0.02
1.284CysArg: 1.284 ± 0.024
1.968CysSer: 1.968 ± 0.031
1.106CysThr: 1.106 ± 0.022
1.183CysVal: 1.183 ± 0.023
0.253CysTrp: 0.253 ± 0.009
0.712CysTyr: 0.712 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.153AspAla: 3.153 ± 0.033
1.077AspCys: 1.077 ± 0.023
3.951AspAsp: 3.951 ± 0.052
4.659AspGlu: 4.659 ± 0.045
2.432AspPhe: 2.432 ± 0.027
3.282AspGly: 3.282 ± 0.049
1.128AspHis: 1.128 ± 0.015
3.65AspIle: 3.65 ± 0.035
2.915AspLys: 2.915 ± 0.033
4.823AspLeu: 4.823 ± 0.045
1.246AspMet: 1.246 ± 0.02
2.567AspAsn: 2.567 ± 0.03
2.043AspPro: 2.043 ± 0.031
1.796AspGln: 1.796 ± 0.027
2.799AspArg: 2.799 ± 0.031
4.104AspSer: 4.104 ± 0.042
2.461AspThr: 2.461 ± 0.026
3.36AspVal: 3.36 ± 0.037
0.629AspTrp: 0.629 ± 0.014
1.82AspTyr: 1.82 ± 0.025
0.0AspXaa: 0.0 ± 0.0
Glu
3.857GluAla: 3.857 ± 0.042
1.281GluCys: 1.281 ± 0.029
3.31GluAsp: 3.31 ± 0.038
5.421GluGlu: 5.421 ± 0.066
2.321GluPhe: 2.321 ± 0.028
2.654GluGly: 2.654 ± 0.035
1.498GluHis: 1.498 ± 0.023
4.613GluIle: 4.613 ± 0.048
5.519GluLys: 5.519 ± 0.06
5.94GluLeu: 5.94 ± 0.058
2.06GluMet: 2.06 ± 0.027
4.088GluAsn: 4.088 ± 0.046
2.035GluPro: 2.035 ± 0.032
3.131GluGln: 3.131 ± 0.039
4.088GluArg: 4.088 ± 0.048
4.521GluSer: 4.521 ± 0.05
3.514GluThr: 3.514 ± 0.042
3.458GluVal: 3.458 ± 0.035
0.755GluTrp: 0.755 ± 0.018
2.005GluTyr: 2.005 ± 0.024
0.0GluXaa: 0.0 ± 0.0
Phe
2.753PheAla: 2.753 ± 0.03
1.129PheCys: 1.129 ± 0.02
2.569PheAsp: 2.569 ± 0.028
2.558PheGlu: 2.558 ± 0.03
2.194PhePhe: 2.194 ± 0.03
2.653PheGly: 2.653 ± 0.033
1.108PheHis: 1.108 ± 0.017
2.977PheIle: 2.977 ± 0.035
2.034PheLys: 2.034 ± 0.027
4.176PheLeu: 4.176 ± 0.05
1.024PheMet: 1.024 ± 0.019
1.875PheAsn: 1.875 ± 0.026
1.843PhePro: 1.843 ± 0.026
1.509PheGln: 1.509 ± 0.021
2.296PheArg: 2.296 ± 0.028
3.539PheSer: 3.539 ± 0.035
2.297PheThr: 2.297 ± 0.028
2.788PheVal: 2.788 ± 0.03
0.531PheTrp: 0.531 ± 0.014
1.539PheTyr: 1.539 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
2.825GlyAla: 2.825 ± 0.038
1.075GlyCys: 1.075 ± 0.024
2.641GlyAsp: 2.641 ± 0.03
3.006GlyGlu: 3.006 ± 0.047
2.211GlyPhe: 2.211 ± 0.031
2.995GlyGly: 2.995 ± 0.055
1.224GlyHis: 1.224 ± 0.021
3.529GlyIle: 3.529 ± 0.038
3.196GlyLys: 3.196 ± 0.041
3.983GlyLeu: 3.983 ± 0.057
1.215GlyMet: 1.215 ± 0.02
2.643GlyAsn: 2.643 ± 0.032
1.901GlyPro: 1.901 ± 0.048
1.894GlyGln: 1.894 ± 0.028
2.98GlyArg: 2.98 ± 0.039
4.07GlySer: 4.07 ± 0.042
3.034GlyThr: 3.034 ± 0.032
2.705GlyVal: 2.705 ± 0.029
0.613GlyTrp: 0.613 ± 0.016
1.732GlyTyr: 1.732 ± 0.034
0.0GlyXaa: 0.0 ± 0.0
His
1.352HisAla: 1.352 ± 0.021
0.666HisCys: 0.666 ± 0.015
1.132HisAsp: 1.132 ± 0.02
1.398HisGlu: 1.398 ± 0.024
1.303HisPhe: 1.303 ± 0.021
1.211HisGly: 1.211 ± 0.018
0.754HisHis: 0.754 ± 0.021
1.628HisIle: 1.628 ± 0.022
1.131HisLys: 1.131 ± 0.021
2.449HisLeu: 2.449 ± 0.028
0.601HisMet: 0.601 ± 0.013
1.085HisAsn: 1.085 ± 0.02
1.191HisPro: 1.191 ± 0.021
1.039HisGln: 1.039 ± 0.018
1.467HisArg: 1.467 ± 0.023
2.059HisSer: 2.059 ± 0.026
1.118HisThr: 1.118 ± 0.02
1.326HisVal: 1.326 ± 0.023
0.319HisTrp: 0.319 ± 0.011
0.925HisTyr: 0.925 ± 0.016
0.0HisXaa: 0.0 ± 0.0
Ile
4.483IleAla: 4.483 ± 0.033
1.674IleCys: 1.674 ± 0.028
3.969IleAsp: 3.969 ± 0.037
4.13IleGlu: 4.13 ± 0.042
3.119IlePhe: 3.119 ± 0.037
3.413IleGly: 3.413 ± 0.035
1.579IleHis: 1.579 ± 0.025
4.613IleIle: 4.613 ± 0.051
3.533IleLys: 3.533 ± 0.034
6.028IleLeu: 6.028 ± 0.049
1.545IleMet: 1.545 ± 0.022
3.315IleAsn: 3.315 ± 0.04
3.171IlePro: 3.171 ± 0.032
2.404IleGln: 2.404 ± 0.031
3.768IleArg: 3.768 ± 0.035
6.01IleSer: 6.01 ± 0.045
3.774IleThr: 3.774 ± 0.037
4.033IleVal: 4.033 ± 0.035
0.738IleTrp: 0.738 ± 0.017
2.173IleTyr: 2.173 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
3.349LysAla: 3.349 ± 0.035
1.398LysCys: 1.398 ± 0.03
2.992LysAsp: 2.992 ± 0.037
4.594LysGlu: 4.594 ± 0.054
2.437LysPhe: 2.437 ± 0.028
2.501LysGly: 2.501 ± 0.04
1.514LysHis: 1.514 ± 0.021
4.338LysIle: 4.338 ± 0.043
5.329LysLys: 5.329 ± 0.07
5.881LysLeu: 5.881 ± 0.051
1.82LysMet: 1.82 ± 0.02
3.525LysAsn: 3.525 ± 0.038
2.325LysPro: 2.325 ± 0.039
2.825LysGln: 2.825 ± 0.033
4.034LysArg: 4.034 ± 0.043
4.389LysSer: 4.389 ± 0.046
3.328LysThr: 3.328 ± 0.039
3.151LysVal: 3.151 ± 0.035
0.763LysTrp: 0.763 ± 0.016
2.106LysTyr: 2.106 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
5.661LeuAla: 5.661 ± 0.043
2.116LeuCys: 2.116 ± 0.033
4.576LeuAsp: 4.576 ± 0.034
5.728LeuGlu: 5.728 ± 0.05
4.199LeuPhe: 4.199 ± 0.046
3.726LeuGly: 3.726 ± 0.035
2.513LeuHis: 2.513 ± 0.03
6.061LeuIle: 6.061 ± 0.053
6.073LeuLys: 6.073 ± 0.044
9.787LeuLeu: 9.787 ± 0.082
2.34LeuMet: 2.34 ± 0.031
4.656LeuAsn: 4.656 ± 0.039
4.627LeuPro: 4.627 ± 0.052
4.269LeuGln: 4.269 ± 0.044
5.55LeuArg: 5.55 ± 0.047
7.849LeuSer: 7.849 ± 0.063
4.847LeuThr: 4.847 ± 0.041
4.73LeuVal: 4.73 ± 0.047
0.992LeuTrp: 0.992 ± 0.021
2.83LeuTyr: 2.83 ± 0.034
0.0LeuXaa: 0.0 ± 0.0
Met
1.582MetAla: 1.582 ± 0.024
0.48MetCys: 0.48 ± 0.012
1.452MetAsp: 1.452 ± 0.023
1.917MetGlu: 1.917 ± 0.027
0.919MetPhe: 0.919 ± 0.018
1.044MetGly: 1.044 ± 0.018
0.648MetHis: 0.648 ± 0.015
1.706MetIle: 1.706 ± 0.023
1.941MetLys: 1.941 ± 0.027
2.425MetLeu: 2.425 ± 0.029
0.723MetMet: 0.723 ± 0.017
1.449MetAsn: 1.449 ± 0.022
1.071MetPro: 1.071 ± 0.019
1.211MetGln: 1.211 ± 0.017
1.434MetArg: 1.434 ± 0.02
1.789MetSer: 1.789 ± 0.023
1.323MetThr: 1.323 ± 0.021
1.317MetVal: 1.317 ± 0.021
0.233MetTrp: 0.233 ± 0.009
0.645MetTyr: 0.645 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
3.225AsnAla: 3.225 ± 0.03
1.141AsnCys: 1.141 ± 0.021
3.293AsnAsp: 3.293 ± 0.037
3.905AsnGlu: 3.905 ± 0.041
2.273AsnPhe: 2.273 ± 0.03
3.166AsnGly: 3.166 ± 0.036
1.15AsnHis: 1.15 ± 0.02
3.626AsnIle: 3.626 ± 0.033
2.773AsnLys: 2.773 ± 0.032
4.508AsnLeu: 4.508 ± 0.04
1.246AsnMet: 1.246 ± 0.022
2.868AsnAsn: 2.868 ± 0.043
2.001AsnPro: 2.001 ± 0.027
1.876AsnGln: 1.876 ± 0.026
2.737AsnArg: 2.737 ± 0.031
4.213AsnSer: 4.213 ± 0.039
2.514AsnThr: 2.514 ± 0.029
3.166AsnVal: 3.166 ± 0.032
0.563AsnTrp: 0.563 ± 0.012
1.754AsnTyr: 1.754 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
2.354ProAla: 2.354 ± 0.029
0.765ProCys: 0.765 ± 0.02
2.144ProAsp: 2.144 ± 0.032
2.733ProGlu: 2.733 ± 0.034
1.879ProPhe: 1.879 ± 0.025
2.225ProGly: 2.225 ± 0.104
0.947ProHis: 0.947 ± 0.018
2.634ProIle: 2.634 ± 0.032
2.411ProLys: 2.411 ± 0.031
3.886ProLeu: 3.886 ± 0.04
0.901ProMet: 0.901 ± 0.016
2.125ProAsn: 2.125 ± 0.026
2.904ProPro: 2.904 ± 0.066
1.684ProGln: 1.684 ± 0.031
1.994ProArg: 1.994 ± 0.027
4.083ProSer: 4.083 ± 0.05
2.577ProThr: 2.577 ± 0.036
2.718ProVal: 2.718 ± 0.04
0.403ProTrp: 0.403 ± 0.012
1.407ProTyr: 1.407 ± 0.022
0.0ProXaa: 0.0 ± 0.0
Gln
2.155GlnAla: 2.155 ± 0.026
0.933GlnCys: 0.933 ± 0.024
1.478GlnAsp: 1.478 ± 0.018
2.353GlnGlu: 2.353 ± 0.034
1.746GlnPhe: 1.746 ± 0.028
1.393GlnGly: 1.393 ± 0.023
1.127GlnHis: 1.127 ± 0.021
2.883GlnIle: 2.883 ± 0.032
2.959GlnLys: 2.959 ± 0.034
4.368GlnLeu: 4.368 ± 0.045
1.289GlnMet: 1.289 ± 0.025
2.292GlnAsn: 2.292 ± 0.028
1.694GlnPro: 1.694 ± 0.029
3.078GlnGln: 3.078 ± 0.065
2.491GlnArg: 2.491 ± 0.033
3.048GlnSer: 3.048 ± 0.034
2.115GlnThr: 2.115 ± 0.025
2.001GlnVal: 2.001 ± 0.023
0.506GlnTrp: 0.506 ± 0.014
1.354GlnTyr: 1.354 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
2.939ArgAla: 2.939 ± 0.029
1.326ArgCys: 1.326 ± 0.026
2.679ArgAsp: 2.679 ± 0.033
3.469ArgGlu: 3.469 ± 0.042
2.416ArgPhe: 2.416 ± 0.026
2.472ArgGly: 2.472 ± 0.036
1.487ArgHis: 1.487 ± 0.023
3.978ArgIle: 3.978 ± 0.034
4.281ArgLys: 4.281 ± 0.041
5.311ArgLeu: 5.311 ± 0.049
1.452ArgMet: 1.452 ± 0.021
3.32ArgAsn: 3.32 ± 0.031
2.196ArgPro: 2.196 ± 0.034
2.474ArgGln: 2.474 ± 0.03
4.2ArgArg: 4.2 ± 0.05
4.516ArgSer: 4.516 ± 0.053
2.971ArgThr: 2.971 ± 0.032
2.672ArgVal: 2.672 ± 0.031
0.656ArgTrp: 0.656 ± 0.015
1.924ArgTyr: 1.924 ± 0.026
0.0ArgXaa: 0.0 ± 0.0
Ser
5.078SerAla: 5.078 ± 0.051
1.632SerCys: 1.632 ± 0.027
4.601SerAsp: 4.601 ± 0.043
4.933SerGlu: 4.933 ± 0.05
3.619SerPhe: 3.619 ± 0.037
4.483SerGly: 4.483 ± 0.04
1.799SerHis: 1.799 ± 0.028
5.083SerIle: 5.083 ± 0.041
4.589SerLys: 4.589 ± 0.043
7.471SerLeu: 7.471 ± 0.059
1.9SerMet: 1.9 ± 0.026
4.304SerAsn: 4.304 ± 0.042
3.532SerPro: 3.532 ± 0.043
3.012SerGln: 3.012 ± 0.037
4.336SerArg: 4.336 ± 0.048
9.118SerSer: 9.118 ± 0.1
5.148SerThr: 5.148 ± 0.051
5.038SerVal: 5.038 ± 0.05
0.796SerTrp: 0.796 ± 0.017
2.261SerTyr: 2.261 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
3.815ThrAla: 3.815 ± 0.037
1.1ThrCys: 1.1 ± 0.025
2.992ThrAsp: 2.992 ± 0.041
3.398ThrGlu: 3.398 ± 0.039
2.313ThrPhe: 2.313 ± 0.031
2.883ThrGly: 2.883 ± 0.032
1.125ThrHis: 1.125 ± 0.016
3.668ThrIle: 3.668 ± 0.037
3.088ThrLys: 3.088 ± 0.034
4.792ThrLeu: 4.792 ± 0.036
1.315ThrMet: 1.315 ± 0.019
2.842ThrAsn: 2.842 ± 0.031
2.44ThrPro: 2.44 ± 0.031
1.766ThrGln: 1.766 ± 0.023
2.481ThrArg: 2.481 ± 0.028
5.023ThrSer: 5.023 ± 0.051
3.736ThrThr: 3.736 ± 0.046
4.032ThrVal: 4.032 ± 0.031
0.502ThrTrp: 0.502 ± 0.013
1.583ThrTyr: 1.583 ± 0.025
0.0ThrXaa: 0.0 ± 0.0
Val
3.85ValAla: 3.85 ± 0.036
1.193ValCys: 1.193 ± 0.027
3.359ValAsp: 3.359 ± 0.033
3.96ValGlu: 3.96 ± 0.044
2.376ValPhe: 2.376 ± 0.027
2.822ValGly: 2.822 ± 0.032
1.448ValHis: 1.448 ± 0.022
4.055ValIle: 4.055 ± 0.036
3.428ValLys: 3.428 ± 0.04
5.408ValLeu: 5.408 ± 0.048
1.437ValMet: 1.437 ± 0.023
2.826ValAsn: 2.826 ± 0.031
2.7ValPro: 2.7 ± 0.033
2.403ValGln: 2.403 ± 0.027
3.096ValArg: 3.096 ± 0.034
4.391ValSer: 4.391 ± 0.037
3.364ValThr: 3.364 ± 0.036
3.755ValVal: 3.755 ± 0.049
0.606ValTrp: 0.606 ± 0.013
1.737ValTyr: 1.737 ± 0.021
0.0ValXaa: 0.0 ± 0.0
Trp
0.528TrpAla: 0.528 ± 0.012
0.216TrpCys: 0.216 ± 0.008
0.561TrpAsp: 0.561 ± 0.015
0.599TrpGlu: 0.599 ± 0.016
0.482TrpPhe: 0.482 ± 0.013
0.411TrpGly: 0.411 ± 0.012
0.292TrpHis: 0.292 ± 0.01
0.838TrpIle: 0.838 ± 0.017
0.87TrpLys: 0.87 ± 0.017
1.12TrpLeu: 1.12 ± 0.023
0.337TrpMet: 0.337 ± 0.012
0.725TrpAsn: 0.725 ± 0.016
0.425TrpPro: 0.425 ± 0.012
0.467TrpGln: 0.467 ± 0.013
0.684TrpArg: 0.684 ± 0.015
0.83TrpSer: 0.83 ± 0.02
0.619TrpThr: 0.619 ± 0.014
0.448TrpVal: 0.448 ± 0.012
0.153TrpTrp: 0.153 ± 0.007
0.365TrpTyr: 0.365 ± 0.011
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.895TyrAla: 1.895 ± 0.025
0.824TyrCys: 0.824 ± 0.015
1.849TyrAsp: 1.849 ± 0.026
1.93TyrGlu: 1.93 ± 0.024
1.59TyrPhe: 1.59 ± 0.027
1.912TyrGly: 1.912 ± 0.03
0.904TyrHis: 0.904 ± 0.018
1.987TyrIle: 1.987 ± 0.029
1.655TyrLys: 1.655 ± 0.024
2.995TyrLeu: 2.995 ± 0.031
0.808TyrMet: 0.808 ± 0.016
1.522TyrAsn: 1.522 ± 0.025
1.356TyrPro: 1.356 ± 0.027
1.284TyrGln: 1.284 ± 0.023
1.966TyrArg: 1.966 ± 0.026
2.395TyrSer: 2.395 ± 0.032
1.505TyrThr: 1.505 ± 0.023
1.859TyrVal: 1.859 ± 0.027
0.393TyrTrp: 0.393 ± 0.013
1.283TyrTyr: 1.283 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8122 proteins (3352156 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski