Amino acid dipepetide frequency for Leifsonia sp. Root112D2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.918AlaAla: 18.918 ± 0.217
0.618AlaCys: 0.618 ± 0.026
7.416AlaAsp: 7.416 ± 0.089
7.697AlaGlu: 7.697 ± 0.096
3.91AlaPhe: 3.91 ± 0.066
11.467AlaGly: 11.467 ± 0.131
2.42AlaHis: 2.42 ± 0.048
6.296AlaIle: 6.296 ± 0.105
3.088AlaLys: 3.088 ± 0.059
13.56AlaLeu: 13.56 ± 0.146
2.729AlaMet: 2.729 ± 0.048
2.834AlaAsn: 2.834 ± 0.057
5.804AlaPro: 5.804 ± 0.099
4.016AlaGln: 4.016 ± 0.073
8.549AlaArg: 8.549 ± 0.102
8.39AlaSer: 8.39 ± 0.087
7.622AlaThr: 7.622 ± 0.134
11.022AlaVal: 11.022 ± 0.126
1.775AlaTrp: 1.775 ± 0.045
2.368AlaTyr: 2.368 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.601CysAla: 0.601 ± 0.023
0.042CysCys: 0.042 ± 0.006
0.322CysAsp: 0.322 ± 0.018
0.246CysGlu: 0.246 ± 0.015
0.16CysPhe: 0.16 ± 0.013
0.495CysGly: 0.495 ± 0.022
0.116CysHis: 0.116 ± 0.01
0.233CysIle: 0.233 ± 0.015
0.061CysLys: 0.061 ± 0.007
0.447CysLeu: 0.447 ± 0.02
0.08CysMet: 0.08 ± 0.007
0.12CysAsn: 0.12 ± 0.01
0.276CysPro: 0.276 ± 0.017
0.122CysGln: 0.122 ± 0.011
0.253CysArg: 0.253 ± 0.015
0.343CysSer: 0.343 ± 0.016
0.32CysThr: 0.32 ± 0.019
0.423CysVal: 0.423 ± 0.02
0.084CysTrp: 0.084 ± 0.009
0.095CysTyr: 0.095 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
8.711AspAla: 8.711 ± 0.108
0.236AspCys: 0.236 ± 0.015
3.577AspAsp: 3.577 ± 0.067
3.886AspGlu: 3.886 ± 0.069
1.817AspPhe: 1.817 ± 0.044
5.437AspGly: 5.437 ± 0.091
1.093AspHis: 1.093 ± 0.034
2.489AspIle: 2.489 ± 0.053
1.207AspLys: 1.207 ± 0.038
5.297AspLeu: 5.297 ± 0.069
0.765AspMet: 0.765 ± 0.026
1.138AspAsn: 1.138 ± 0.036
3.401AspPro: 3.401 ± 0.055
1.389AspGln: 1.389 ± 0.038
3.769AspArg: 3.769 ± 0.067
2.906AspSer: 2.906 ± 0.053
2.906AspThr: 2.906 ± 0.054
4.901AspVal: 4.901 ± 0.076
0.933AspTrp: 0.933 ± 0.034
1.37AspTyr: 1.37 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
6.469GluAla: 6.469 ± 0.094
0.214GluCys: 0.214 ± 0.014
2.091GluAsp: 2.091 ± 0.049
2.664GluGlu: 2.664 ± 0.075
1.774GluPhe: 1.774 ± 0.041
3.467GluGly: 3.467 ± 0.063
1.487GluHis: 1.487 ± 0.043
2.79GluIle: 2.79 ± 0.062
1.625GluLys: 1.625 ± 0.045
6.909GluLeu: 6.909 ± 0.103
0.958GluMet: 0.958 ± 0.029
1.497GluAsn: 1.497 ± 0.042
2.644GluPro: 2.644 ± 0.064
2.259GluGln: 2.259 ± 0.055
4.824GluArg: 4.824 ± 0.085
3.101GluSer: 3.101 ± 0.064
3.072GluThr: 3.072 ± 0.06
4.071GluVal: 4.071 ± 0.074
0.761GluTrp: 0.761 ± 0.026
1.129GluTyr: 1.129 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
4.289PheAla: 4.289 ± 0.079
0.179PheCys: 0.179 ± 0.013
2.348PheAsp: 2.348 ± 0.06
1.758PheGlu: 1.758 ± 0.042
1.149PhePhe: 1.149 ± 0.04
3.54PheGly: 3.54 ± 0.075
0.617PheHis: 0.617 ± 0.026
1.407PheIle: 1.407 ± 0.048
0.561PheLys: 0.561 ± 0.027
2.881PheLeu: 2.881 ± 0.065
0.518PheMet: 0.518 ± 0.023
0.809PheAsn: 0.809 ± 0.031
1.359PhePro: 1.359 ± 0.04
0.792PheGln: 0.792 ± 0.032
1.745PheArg: 1.745 ± 0.041
2.041PheSer: 2.041 ± 0.04
2.268PheThr: 2.268 ± 0.046
2.894PheVal: 2.894 ± 0.061
0.449PheTrp: 0.449 ± 0.021
0.715PheTyr: 0.715 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
10.138GlyAla: 10.138 ± 0.114
0.575GlyCys: 0.575 ± 0.022
4.504GlyAsp: 4.504 ± 0.069
4.727GlyGlu: 4.727 ± 0.076
3.361GlyPhe: 3.361 ± 0.056
7.486GlyGly: 7.486 ± 0.106
1.902GlyHis: 1.902 ± 0.047
5.055GlyIle: 5.055 ± 0.075
2.587GlyLys: 2.587 ± 0.056
8.872GlyLeu: 8.872 ± 0.114
1.976GlyMet: 1.976 ± 0.048
1.843GlyAsn: 1.843 ± 0.047
3.472GlyPro: 3.472 ± 0.058
2.539GlyGln: 2.539 ± 0.052
5.626GlyArg: 5.626 ± 0.089
5.665GlySer: 5.665 ± 0.078
5.59GlyThr: 5.59 ± 0.089
7.649GlyVal: 7.649 ± 0.097
1.58GlyTrp: 1.58 ± 0.048
2.32GlyTyr: 2.32 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.376HisAla: 2.376 ± 0.057
0.111HisCys: 0.111 ± 0.01
1.396HisAsp: 1.396 ± 0.035
1.195HisGlu: 1.195 ± 0.034
0.58HisPhe: 0.58 ± 0.023
1.892HisGly: 1.892 ± 0.048
0.511HisHis: 0.511 ± 0.024
0.85HisIle: 0.85 ± 0.029
0.35HisLys: 0.35 ± 0.02
2.017HisLeu: 2.017 ± 0.051
0.344HisMet: 0.344 ± 0.02
0.434HisAsn: 0.434 ± 0.019
1.485HisPro: 1.485 ± 0.038
0.528HisGln: 0.528 ± 0.026
1.461HisArg: 1.461 ± 0.04
1.133HisSer: 1.133 ± 0.037
1.161HisThr: 1.161 ± 0.032
1.659HisVal: 1.659 ± 0.042
0.29HisTrp: 0.29 ± 0.017
0.47HisTyr: 0.47 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
7.096IleAla: 7.096 ± 0.094
0.245IleCys: 0.245 ± 0.015
3.635IleAsp: 3.635 ± 0.071
3.036IleGlu: 3.036 ± 0.064
1.487IlePhe: 1.487 ± 0.04
4.941IleGly: 4.941 ± 0.09
0.782IleHis: 0.782 ± 0.026
2.058IleIle: 2.058 ± 0.062
1.066IleLys: 1.066 ± 0.034
4.027IleLeu: 4.027 ± 0.073
0.789IleMet: 0.789 ± 0.029
1.107IleAsn: 1.107 ± 0.035
2.462IlePro: 2.462 ± 0.048
1.138IleGln: 1.138 ± 0.038
2.914IleArg: 2.914 ± 0.062
2.747IleSer: 2.747 ± 0.047
3.061IleThr: 3.061 ± 0.061
5.102IleVal: 5.102 ± 0.077
0.532IleTrp: 0.532 ± 0.023
0.903IleTyr: 0.903 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
3.024LysAla: 3.024 ± 0.062
0.068LysCys: 0.068 ± 0.008
1.326LysAsp: 1.326 ± 0.048
1.043LysGlu: 1.043 ± 0.04
0.598LysPhe: 0.598 ± 0.028
1.871LysGly: 1.871 ± 0.044
0.487LysHis: 0.487 ± 0.023
1.215LysIle: 1.215 ± 0.038
0.989LysLys: 0.989 ± 0.045
2.306LysLeu: 2.306 ± 0.052
0.51LysMet: 0.51 ± 0.02
0.78LysAsn: 0.78 ± 0.031
1.523LysPro: 1.523 ± 0.042
0.901LysGln: 0.901 ± 0.032
1.807LysArg: 1.807 ± 0.045
1.485LysSer: 1.485 ± 0.043
1.732LysThr: 1.732 ± 0.049
1.907LysVal: 1.907 ± 0.057
0.276LysTrp: 0.276 ± 0.018
0.597LysTyr: 0.597 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
14.433LeuAla: 14.433 ± 0.16
0.537LeuCys: 0.537 ± 0.024
6.268LeuAsp: 6.268 ± 0.085
5.138LeuGlu: 5.138 ± 0.085
3.039LeuPhe: 3.039 ± 0.071
9.241LeuGly: 9.241 ± 0.105
1.941LeuHis: 1.941 ± 0.047
4.89LeuIle: 4.89 ± 0.074
2.363LeuLys: 2.363 ± 0.055
10.281LeuLeu: 10.281 ± 0.146
1.621LeuMet: 1.621 ± 0.044
2.373LeuAsn: 2.373 ± 0.053
5.39LeuPro: 5.39 ± 0.083
2.713LeuGln: 2.713 ± 0.051
6.97LeuArg: 6.97 ± 0.096
6.425LeuSer: 6.425 ± 0.085
6.429LeuThr: 6.429 ± 0.081
9.106LeuVal: 9.106 ± 0.107
1.29LeuTrp: 1.29 ± 0.04
1.785LeuTyr: 1.785 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
2.32MetAla: 2.32 ± 0.046
0.096MetCys: 0.096 ± 0.011
0.856MetAsp: 0.856 ± 0.027
0.669MetGlu: 0.669 ± 0.027
0.513MetPhe: 0.513 ± 0.023
1.348MetGly: 1.348 ± 0.037
0.362MetHis: 0.362 ± 0.022
0.893MetIle: 0.893 ± 0.032
0.526MetLys: 0.526 ± 0.021
2.066MetLeu: 2.066 ± 0.044
0.34MetMet: 0.34 ± 0.022
0.56MetAsn: 0.56 ± 0.023
1.164MetPro: 1.164 ± 0.028
0.614MetGln: 0.614 ± 0.026
1.419MetArg: 1.419 ± 0.039
1.426MetSer: 1.426 ± 0.034
1.615MetThr: 1.615 ± 0.039
1.469MetVal: 1.469 ± 0.039
0.185MetTrp: 0.185 ± 0.014
0.297MetTyr: 0.297 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.015AsnAla: 3.015 ± 0.055
0.141AsnCys: 0.141 ± 0.012
1.397AsnAsp: 1.397 ± 0.043
1.222AsnGlu: 1.222 ± 0.039
0.747AsnPhe: 0.747 ± 0.029
2.35AsnGly: 2.35 ± 0.057
0.455AsnHis: 0.455 ± 0.024
1.056AsnIle: 1.056 ± 0.036
0.586AsnLys: 0.586 ± 0.023
2.182AsnLeu: 2.182 ± 0.051
0.433AsnMet: 0.433 ± 0.025
0.671AsnAsn: 0.671 ± 0.033
1.815AsnPro: 1.815 ± 0.04
0.676AsnGln: 0.676 ± 0.029
1.504AsnArg: 1.504 ± 0.041
1.335AsnSer: 1.335 ± 0.038
1.464AsnThr: 1.464 ± 0.048
2.032AsnVal: 2.032 ± 0.049
0.377AsnTrp: 0.377 ± 0.02
0.648AsnTyr: 0.648 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
6.373ProAla: 6.373 ± 0.096
0.168ProCys: 0.168 ± 0.014
3.337ProAsp: 3.337 ± 0.065
3.247ProGlu: 3.247 ± 0.062
1.674ProPhe: 1.674 ± 0.04
4.601ProGly: 4.601 ± 0.072
1.117ProHis: 1.117 ± 0.035
2.246ProIle: 2.246 ± 0.047
1.218ProLys: 1.218 ± 0.035
4.999ProLeu: 4.999 ± 0.078
0.902ProMet: 0.902 ± 0.033
1.282ProAsn: 1.282 ± 0.045
2.119ProPro: 2.119 ± 0.057
1.622ProGln: 1.622 ± 0.041
2.998ProArg: 2.998 ± 0.057
3.304ProSer: 3.304 ± 0.061
3.257ProThr: 3.257 ± 0.057
4.503ProVal: 4.503 ± 0.069
0.805ProTrp: 0.805 ± 0.025
1.122ProTyr: 1.122 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
3.67GlnAla: 3.67 ± 0.067
0.117GlnCys: 0.117 ± 0.011
1.181GlnAsp: 1.181 ± 0.033
1.194GlnGlu: 1.194 ± 0.04
0.982GlnPhe: 0.982 ± 0.029
2.144GlnGly: 2.144 ± 0.048
0.687GlnHis: 0.687 ± 0.025
1.603GlnIle: 1.603 ± 0.043
0.839GlnLys: 0.839 ± 0.031
3.761GlnLeu: 3.761 ± 0.073
0.506GlnMet: 0.506 ± 0.026
0.856GlnAsn: 0.856 ± 0.035
1.568GlnPro: 1.568 ± 0.044
1.314GlnGln: 1.314 ± 0.041
2.356GlnArg: 2.356 ± 0.054
1.902GlnSer: 1.902 ± 0.045
1.667GlnThr: 1.667 ± 0.035
2.318GlnVal: 2.318 ± 0.055
0.47GlnTrp: 0.47 ± 0.019
0.675GlnTyr: 0.675 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
8.166ArgAla: 8.166 ± 0.107
0.281ArgCys: 0.281 ± 0.018
3.626ArgAsp: 3.626 ± 0.064
4.071ArgGlu: 4.071 ± 0.079
2.29ArgPhe: 2.29 ± 0.048
5.029ArgGly: 5.029 ± 0.08
1.588ArgHis: 1.588 ± 0.042
3.508ArgIle: 3.508 ± 0.071
1.496ArgLys: 1.496 ± 0.039
7.129ArgLeu: 7.129 ± 0.103
1.719ArgMet: 1.719 ± 0.039
1.577ArgAsn: 1.577 ± 0.04
3.187ArgPro: 3.187 ± 0.071
2.068ArgGln: 2.068 ± 0.048
5.662ArgArg: 5.662 ± 0.081
4.209ArgSer: 4.209 ± 0.061
3.803ArgThr: 3.803 ± 0.064
5.719ArgVal: 5.719 ± 0.089
1.058ArgTrp: 1.058 ± 0.033
1.649ArgTyr: 1.649 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
7.678SerAla: 7.678 ± 0.101
0.289SerCys: 0.289 ± 0.017
3.426SerAsp: 3.426 ± 0.062
2.992SerGlu: 2.992 ± 0.062
2.017SerPhe: 2.017 ± 0.044
6.341SerGly: 6.341 ± 0.092
1.13SerHis: 1.13 ± 0.035
3.111SerIle: 3.111 ± 0.054
1.515SerLys: 1.515 ± 0.043
6.035SerLeu: 6.035 ± 0.077
1.308SerMet: 1.308 ± 0.036
1.474SerAsn: 1.474 ± 0.048
3.01SerPro: 3.01 ± 0.053
1.673SerGln: 1.673 ± 0.042
4.005SerArg: 4.005 ± 0.068
3.98SerSer: 3.98 ± 0.078
4.033SerThr: 4.033 ± 0.065
5.324SerVal: 5.324 ± 0.089
0.997SerTrp: 0.997 ± 0.03
1.382SerTyr: 1.382 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
7.991ThrAla: 7.991 ± 0.125
0.212ThrCys: 0.212 ± 0.016
3.515ThrAsp: 3.515 ± 0.06
2.922ThrGlu: 2.922 ± 0.06
1.975ThrPhe: 1.975 ± 0.045
5.787ThrGly: 5.787 ± 0.082
1.236ThrHis: 1.236 ± 0.035
3.116ThrIle: 3.116 ± 0.058
1.551ThrLys: 1.551 ± 0.042
6.098ThrLeu: 6.098 ± 0.072
1.082ThrMet: 1.082 ± 0.035
1.502ThrAsn: 1.502 ± 0.043
3.9ThrPro: 3.9 ± 0.067
1.712ThrGln: 1.712 ± 0.039
3.664ThrArg: 3.664 ± 0.07
3.651ThrSer: 3.651 ± 0.071
3.961ThrThr: 3.961 ± 0.077
6.204ThrVal: 6.204 ± 0.096
0.771ThrTrp: 0.771 ± 0.034
1.074ThrTyr: 1.074 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
11.258ValAla: 11.258 ± 0.103
0.496ValCys: 0.496 ± 0.023
5.041ValAsp: 5.041 ± 0.075
4.426ValGlu: 4.426 ± 0.068
2.921ValPhe: 2.921 ± 0.061
7.043ValGly: 7.043 ± 0.079
1.683ValHis: 1.683 ± 0.043
4.749ValIle: 4.749 ± 0.082
1.994ValLys: 1.994 ± 0.053
9.198ValLeu: 9.198 ± 0.112
1.539ValMet: 1.539 ± 0.045
2.222ValAsn: 2.222 ± 0.05
4.411ValPro: 4.411 ± 0.072
2.399ValGln: 2.399 ± 0.049
5.506ValArg: 5.506 ± 0.082
5.428ValSer: 5.428 ± 0.071
5.988ValThr: 5.988 ± 0.11
8.281ValVal: 8.281 ± 0.09
1.094ValTrp: 1.094 ± 0.033
1.618ValTyr: 1.618 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.531TrpAla: 1.531 ± 0.041
0.081TrpCys: 0.081 ± 0.008
0.665TrpAsp: 0.665 ± 0.03
0.55TrpGlu: 0.55 ± 0.026
0.537TrpPhe: 0.537 ± 0.028
1.014TrpGly: 1.014 ± 0.035
0.313TrpHis: 0.313 ± 0.016
0.76TrpIle: 0.76 ± 0.027
0.39TrpLys: 0.39 ± 0.021
1.802TrpLeu: 1.802 ± 0.045
0.33TrpMet: 0.33 ± 0.018
0.49TrpAsn: 0.49 ± 0.024
0.742TrpPro: 0.742 ± 0.03
0.67TrpGln: 0.67 ± 0.027
1.144TrpArg: 1.144 ± 0.038
0.935TrpSer: 0.935 ± 0.034
0.773TrpThr: 0.773 ± 0.028
1.059TrpVal: 1.059 ± 0.035
0.362TrpTrp: 0.362 ± 0.022
0.303TrpTyr: 0.303 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.442TyrAla: 2.442 ± 0.052
0.132TyrCys: 0.132 ± 0.011
1.301TyrAsp: 1.301 ± 0.039
1.124TyrGlu: 1.124 ± 0.034
0.79TyrPhe: 0.79 ± 0.03
1.972TyrGly: 1.972 ± 0.053
0.316TyrHis: 0.316 ± 0.02
0.803TyrIle: 0.803 ± 0.026
0.434TyrLys: 0.434 ± 0.024
2.364TyrLeu: 2.364 ± 0.049
0.291TyrMet: 0.291 ± 0.016
0.536TyrAsn: 0.536 ± 0.025
1.161TyrPro: 1.161 ± 0.035
0.663TyrGln: 0.663 ± 0.028
1.66TyrArg: 1.66 ± 0.043
1.317TyrSer: 1.317 ± 0.038
1.203TyrThr: 1.203 ± 0.044
1.652TyrVal: 1.652 ± 0.042
0.363TyrTrp: 0.363 ± 0.021
0.497TyrTyr: 0.497 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3046 proteins (1001125 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski