Amino acid dipepetide frequency for Mycolicibacterium agri (Mycobacterium agri)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.382AlaAla: 19.382 ± 0.156	1.024AlaCys: 1.024 ± 0.023	8.257AlaAsp: 8.257 ± 0.071	8.007AlaGlu: 8.007 ± 0.081	3.575AlaPhe: 3.575 ± 0.047	10.8AlaGly: 10.8 ± 0.085	2.446AlaHis: 2.446 ± 0.039	5.559AlaIle: 5.559 ± 0.059	3.318AlaLys: 3.318 ± 0.055	12.668AlaLeu: 12.668 ± 0.097	2.988AlaMet: 2.988 ± 0.038	2.733AlaAsn: 2.733 ± 0.034	6.029AlaPro: 6.029 ± 0.071	3.812AlaGln: 3.812 ± 0.051	8.416AlaArg: 8.416 ± 0.073	6.034AlaSer: 6.034 ± 0.063	7.015AlaThr: 7.015 ± 0.057	11.559AlaVal: 11.559 ± 0.102	1.647AlaTrp: 1.647 ± 0.03	2.39AlaTyr: 2.39 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.106CysAla: 1.106 ± 0.028	0.098CysCys: 0.098 ± 0.006	0.551CysAsp: 0.551 ± 0.019	0.445CysGlu: 0.445 ± 0.015	0.257CysPhe: 0.257 ± 0.012	0.968CysGly: 0.968 ± 0.021	0.199CysHis: 0.199 ± 0.01	0.32CysIle: 0.32 ± 0.014	0.15CysLys: 0.15 ± 0.01	0.696CysLeu: 0.696 ± 0.021	0.138CysMet: 0.138 ± 0.007	0.177CysAsn: 0.177 ± 0.009	0.509CysPro: 0.509 ± 0.018	0.232CysGln: 0.232 ± 0.011	0.596CysArg: 0.596 ± 0.018	0.484CysSer: 0.484 ± 0.015	0.513CysThr: 0.513 ± 0.018	0.699CysVal: 0.699 ± 0.019	0.133CysTrp: 0.133 ± 0.009	0.196CysTyr: 0.196 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.667AspAla: 7.667 ± 0.072	0.487AspCys: 0.487 ± 0.016	4.516AspAsp: 4.516 ± 0.059	4.376AspGlu: 4.376 ± 0.058	1.856AspPhe: 1.856 ± 0.028	5.82AspGly: 5.82 ± 0.058	1.342AspHis: 1.342 ± 0.029	2.755AspIle: 2.755 ± 0.04	1.467AspLys: 1.467 ± 0.029	5.957AspLeu: 5.957 ± 0.057	1.09AspMet: 1.09 ± 0.02	1.339AspAsn: 1.339 ± 0.027	4.289AspPro: 4.289 ± 0.051	1.702AspGln: 1.702 ± 0.028	4.539AspArg: 4.539 ± 0.056	2.679AspSer: 2.679 ± 0.038	3.191AspThr: 3.191 ± 0.042	5.498AspVal: 5.498 ± 0.051	0.995AspTrp: 0.995 ± 0.023	1.478AspTyr: 1.478 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	6.513GluAla: 6.513 ± 0.072	0.416GluCys: 0.416 ± 0.014	2.591GluAsp: 2.591 ± 0.04	2.839GluGlu: 2.839 ± 0.045	1.885GluPhe: 1.885 ± 0.03	3.51GluGly: 3.51 ± 0.054	1.555GluHis: 1.555 ± 0.025	2.761GluIle: 2.761 ± 0.038	1.555GluLys: 1.555 ± 0.029	6.545GluLeu: 6.545 ± 0.07	1.15GluMet: 1.15 ± 0.025	1.271GluAsn: 1.271 ± 0.027	3.204GluPro: 3.204 ± 0.049	2.31GluGln: 2.31 ± 0.035	4.639GluArg: 4.639 ± 0.052	2.76GluSer: 2.76 ± 0.039	2.8GluThr: 2.8 ± 0.041	4.517GluVal: 4.517 ± 0.053	0.796GluTrp: 0.796 ± 0.023	1.195GluTyr: 1.195 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.981PheAla: 3.981 ± 0.045	0.347PheCys: 0.347 ± 0.012	2.542PheAsp: 2.542 ± 0.039	1.673PheGlu: 1.673 ± 0.032	1.045PhePhe: 1.045 ± 0.028	3.542PheGly: 3.542 ± 0.046	0.636PheHis: 0.636 ± 0.017	1.254PheIle: 1.254 ± 0.026	0.586PheLys: 0.586 ± 0.016	2.571PheLeu: 2.571 ± 0.045	0.525PheMet: 0.525 ± 0.018	0.777PheAsn: 0.777 ± 0.019	1.427PhePro: 1.427 ± 0.027	0.674PheGln: 0.674 ± 0.017	1.726PheArg: 1.726 ± 0.034	1.686PheSer: 1.686 ± 0.03	2.107PheThr: 2.107 ± 0.034	2.706PheVal: 2.706 ± 0.041	0.473PheTrp: 0.473 ± 0.017	0.745PheTyr: 0.745 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	9.579GlyAla: 9.579 ± 0.075	0.814GlyCys: 0.814 ± 0.021	4.926GlyAsp: 4.926 ± 0.052	4.451GlyGlu: 4.451 ± 0.049	3.079GlyPhe: 3.079 ± 0.044	7.322GlyGly: 7.322 ± 0.076	1.97GlyHis: 1.97 ± 0.034	4.235GlyIle: 4.235 ± 0.054	2.348GlyLys: 2.348 ± 0.038	8.413GlyLeu: 8.413 ± 0.073	2.113GlyMet: 2.113 ± 0.034	1.913GlyAsn: 1.913 ± 0.036	4.379GlyPro: 4.379 ± 0.053	2.718GlyGln: 2.718 ± 0.042	6.145GlyArg: 6.145 ± 0.06	4.832GlySer: 4.832 ± 0.056	5.001GlyThr: 5.001 ± 0.05	7.669GlyVal: 7.669 ± 0.069	1.648GlyTrp: 1.648 ± 0.03	2.405GlyTyr: 2.405 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.398HisAla: 2.398 ± 0.034	0.212HisCys: 0.212 ± 0.011	1.323HisAsp: 1.323 ± 0.026	1.091HisGlu: 1.091 ± 0.026	0.679HisPhe: 0.679 ± 0.017	2.068HisGly: 2.068 ± 0.029	0.672HisHis: 0.672 ± 0.02	0.935HisIle: 0.935 ± 0.022	0.413HisLys: 0.413 ± 0.014	2.102HisLeu: 2.102 ± 0.037	0.376HisMet: 0.376 ± 0.013	0.505HisAsn: 0.505 ± 0.016	1.661HisPro: 1.661 ± 0.03	0.646HisGln: 0.646 ± 0.018	1.889HisArg: 1.889 ± 0.033	1.064HisSer: 1.064 ± 0.024	1.207HisThr: 1.207 ± 0.024	1.738HisVal: 1.738 ± 0.028	0.352HisTrp: 0.352 ± 0.013	0.546HisTyr: 0.546 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	6.77IleAla: 6.77 ± 0.067	0.448IleCys: 0.448 ± 0.015	3.503IleAsp: 3.503 ± 0.048	2.869IleGlu: 2.869 ± 0.038	1.129IlePhe: 1.129 ± 0.028	4.677IleGly: 4.677 ± 0.059	0.857IleHis: 0.857 ± 0.019	1.666IleIle: 1.666 ± 0.031	1.001IleLys: 1.001 ± 0.024	3.177IleLeu: 3.177 ± 0.051	0.625IleMet: 0.625 ± 0.02	1.222IleAsn: 1.222 ± 0.023	2.44IlePro: 2.44 ± 0.031	0.955IleGln: 0.955 ± 0.023	2.76IleArg: 2.76 ± 0.038	2.349IleSer: 2.349 ± 0.033	2.86IleThr: 2.86 ± 0.033	3.995IleVal: 3.995 ± 0.05	0.522IleTrp: 0.522 ± 0.019	0.899IleTyr: 0.899 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	3.008LysAla: 3.008 ± 0.047	0.148LysCys: 0.148 ± 0.009	1.213LysAsp: 1.213 ± 0.024	1.183LysGlu: 1.183 ± 0.027	0.691LysPhe: 0.691 ± 0.019	1.667LysGly: 1.667 ± 0.031	0.525LysHis: 0.525 ± 0.017	1.1LysIle: 1.1 ± 0.028	0.747LysLys: 0.747 ± 0.026	2.377LysLeu: 2.377 ± 0.037	0.538LysMet: 0.538 ± 0.018	0.586LysAsn: 0.586 ± 0.019	1.702LysPro: 1.702 ± 0.034	0.799LysGln: 0.799 ± 0.022	1.803LysArg: 1.803 ± 0.032	1.308LysSer: 1.308 ± 0.027	1.495LysThr: 1.495 ± 0.027	2.058LysVal: 2.058 ± 0.04	0.369LysTrp: 0.369 ± 0.013	0.543LysTyr: 0.543 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	13.721LeuAla: 13.721 ± 0.089	0.822LeuCys: 0.822 ± 0.022	6.33LeuAsp: 6.33 ± 0.064	4.592LeuGlu: 4.592 ± 0.048	2.727LeuPhe: 2.727 ± 0.041	8.513LeuGly: 8.513 ± 0.077	2.031LeuHis: 2.031 ± 0.034	4.386LeuIle: 4.386 ± 0.049	2.034LeuLys: 2.034 ± 0.037	9.716LeuLeu: 9.716 ± 0.091	1.837LeuMet: 1.837 ± 0.031	2.201LeuAsn: 2.201 ± 0.031	5.665LeuPro: 5.665 ± 0.058	2.569LeuGln: 2.569 ± 0.035	7.478LeuArg: 7.478 ± 0.07	5.6LeuSer: 5.6 ± 0.057	6.228LeuThr: 6.228 ± 0.06	8.299LeuVal: 8.299 ± 0.082	1.188LeuTrp: 1.188 ± 0.027	1.751LeuTyr: 1.751 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.707MetAla: 2.707 ± 0.042	0.197MetCys: 0.197 ± 0.01	0.932MetAsp: 0.932 ± 0.021	0.744MetGlu: 0.744 ± 0.019	0.659MetPhe: 0.659 ± 0.017	1.494MetGly: 1.494 ± 0.027	0.436MetHis: 0.436 ± 0.015	0.942MetIle: 0.942 ± 0.024	0.522MetLys: 0.522 ± 0.015	2.144MetLeu: 2.144 ± 0.035	0.446MetMet: 0.446 ± 0.016	0.535MetAsn: 0.535 ± 0.013	1.281MetPro: 1.281 ± 0.024	0.603MetGln: 0.603 ± 0.019	1.664MetArg: 1.664 ± 0.03	1.529MetSer: 1.529 ± 0.029	1.898MetThr: 1.898 ± 0.032	1.697MetVal: 1.697 ± 0.03	0.28MetTrp: 0.28 ± 0.012	0.369MetTyr: 0.369 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.786AsnAla: 2.786 ± 0.041	0.207AsnCys: 0.207 ± 0.011	1.332AsnAsp: 1.332 ± 0.028	1.123AsnGlu: 1.123 ± 0.023	0.722AsnPhe: 0.722 ± 0.022	2.21AsnGly: 2.21 ± 0.037	0.498AsnHis: 0.498 ± 0.016	1.005AsnIle: 1.005 ± 0.025	0.533AsnLys: 0.533 ± 0.016	2.115AsnLeu: 2.115 ± 0.037	0.46AsnMet: 0.46 ± 0.016	0.646AsnAsn: 0.646 ± 0.021	1.811AsnPro: 1.811 ± 0.032	0.669AsnGln: 0.669 ± 0.019	1.682AsnArg: 1.682 ± 0.031	1.18AsnSer: 1.18 ± 0.024	1.369AsnThr: 1.369 ± 0.029	1.866AsnVal: 1.866 ± 0.028	0.395AsnTrp: 0.395 ± 0.014	0.599AsnTyr: 0.599 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	6.732ProAla: 6.732 ± 0.07	0.317ProCys: 0.317 ± 0.014	4.475ProAsp: 4.475 ± 0.059	3.805ProGlu: 3.805 ± 0.047	1.712ProPhe: 1.712 ± 0.029	5.338ProGly: 5.338 ± 0.057	1.244ProHis: 1.244 ± 0.031	2.267ProIle: 2.267 ± 0.037	1.437ProLys: 1.437 ± 0.033	5.005ProLeu: 5.005 ± 0.057	1.248ProMet: 1.248 ± 0.024	1.426ProAsn: 1.426 ± 0.029	3.922ProPro: 3.922 ± 0.077	1.865ProGln: 1.865 ± 0.03	3.451ProArg: 3.451 ± 0.041	3.066ProSer: 3.066 ± 0.039	3.526ProThr: 3.526 ± 0.046	4.93ProVal: 4.93 ± 0.054	0.859ProTrp: 0.859 ± 0.021	1.237ProTyr: 1.237 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.547GlnAla: 3.547 ± 0.046	0.249GlnCys: 0.249 ± 0.012	1.235GlnAsp: 1.235 ± 0.023	1.203GlnGlu: 1.203 ± 0.026	0.987GlnPhe: 0.987 ± 0.023	1.907GlnGly: 1.907 ± 0.033	0.736GlnHis: 0.736 ± 0.02	1.532GlnIle: 1.532 ± 0.026	0.721GlnLys: 0.721 ± 0.019	3.488GlnLeu: 3.488 ± 0.042	0.713GlnMet: 0.713 ± 0.019	0.672GlnAsn: 0.672 ± 0.018	1.891GlnPro: 1.891 ± 0.033	1.355GlnGln: 1.355 ± 0.032	2.86GlnArg: 2.86 ± 0.041	1.461GlnSer: 1.461 ± 0.027	1.574GlnThr: 1.574 ± 0.027	2.333GlnVal: 2.333 ± 0.038	0.586GlnTrp: 0.586 ± 0.016	0.651GlnTyr: 0.651 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.976ArgAla: 7.976 ± 0.075	0.612ArgCys: 0.612 ± 0.018	4.33ArgAsp: 4.33 ± 0.045	3.971ArgGlu: 3.971 ± 0.049	2.507ArgPhe: 2.507 ± 0.034	5.081ArgGly: 5.081 ± 0.044	1.792ArgHis: 1.792 ± 0.033	3.582ArgIle: 3.582 ± 0.045	1.791ArgLys: 1.791 ± 0.032	7.627ArgLeu: 7.627 ± 0.066	1.814ArgMet: 1.814 ± 0.035	1.738ArgAsn: 1.738 ± 0.031	3.933ArgPro: 3.933 ± 0.048	2.331ArgGln: 2.331 ± 0.03	6.659ArgArg: 6.659 ± 0.085	3.984ArgSer: 3.984 ± 0.048	4.07ArgThr: 4.07 ± 0.044	5.582ArgVal: 5.582 ± 0.064	1.315ArgTrp: 1.315 ± 0.024	1.939ArgTyr: 1.939 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.714SerAla: 6.714 ± 0.06	0.424SerCys: 0.424 ± 0.014	3.187SerAsp: 3.187 ± 0.037	2.67SerGlu: 2.67 ± 0.037	1.679SerPhe: 1.679 ± 0.03	5.331SerGly: 5.331 ± 0.051	1.055SerHis: 1.055 ± 0.023	2.217SerIle: 2.217 ± 0.033	1.233SerLys: 1.233 ± 0.027	4.743SerLeu: 4.743 ± 0.051	1.332SerMet: 1.332 ± 0.027	1.13SerAsn: 1.13 ± 0.024	3.084SerPro: 3.084 ± 0.04	1.466SerGln: 1.466 ± 0.029	3.777SerArg: 3.777 ± 0.043	3.005SerSer: 3.005 ± 0.042	3.336SerThr: 3.336 ± 0.037	4.517SerVal: 4.517 ± 0.044	0.866SerTrp: 0.866 ± 0.023	1.196SerTyr: 1.196 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	7.659ThrAla: 7.659 ± 0.062	0.439ThrCys: 0.439 ± 0.016	3.721ThrAsp: 3.721 ± 0.04	3.216ThrGlu: 3.216 ± 0.036	1.831ThrPhe: 1.831 ± 0.033	5.572ThrGly: 5.572 ± 0.052	1.186ThrHis: 1.186 ± 0.025	2.555ThrIle: 2.555 ± 0.033	1.393ThrLys: 1.393 ± 0.027	5.512ThrLeu: 5.512 ± 0.053	1.28ThrMet: 1.28 ± 0.026	1.319ThrAsn: 1.319 ± 0.03	3.824ThrPro: 3.824 ± 0.047	1.496ThrGln: 1.496 ± 0.024	3.601ThrArg: 3.601 ± 0.044	3.198ThrSer: 3.198 ± 0.043	3.848ThrThr: 3.848 ± 0.058	5.792ThrVal: 5.792 ± 0.058	0.821ThrTrp: 0.821 ± 0.024	1.331ThrTyr: 1.331 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	11.346ValAla: 11.346 ± 0.097	0.783ValCys: 0.783 ± 0.021	5.822ValAsp: 5.822 ± 0.06	4.71ValGlu: 4.71 ± 0.053	2.681ValPhe: 2.681 ± 0.04	7.034ValGly: 7.034 ± 0.075	1.838ValHis: 1.838 ± 0.031	4.163ValIle: 4.163 ± 0.046	1.831ValLys: 1.831 ± 0.031	8.813ValLeu: 8.813 ± 0.076	1.703ValMet: 1.703 ± 0.031	2.117ValAsn: 2.117 ± 0.033	4.645ValPro: 4.645 ± 0.058	2.149ValGln: 2.149 ± 0.032	5.786ValArg: 5.786 ± 0.057	4.695ValSer: 4.695 ± 0.045	5.423ValThr: 5.423 ± 0.05	8.521ValVal: 8.521 ± 0.09	1.083ValTrp: 1.083 ± 0.025	1.663ValTyr: 1.663 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.577TrpAla: 1.577 ± 0.03	0.171TrpCys: 0.171 ± 0.009	0.814TrpAsp: 0.814 ± 0.023	0.676TrpGlu: 0.676 ± 0.017	0.51TrpPhe: 0.51 ± 0.015	1.001TrpGly: 1.001 ± 0.024	0.385TrpHis: 0.385 ± 0.014	0.698TrpIle: 0.698 ± 0.019	0.349TrpLys: 0.349 ± 0.013	1.732TrpLeu: 1.732 ± 0.029	0.367TrpMet: 0.367 ± 0.015	0.412TrpAsn: 0.412 ± 0.015	0.835TrpPro: 0.835 ± 0.024	0.628TrpGln: 0.628 ± 0.019	1.291TrpArg: 1.291 ± 0.025	0.903TrpSer: 0.903 ± 0.025	0.888TrpThr: 0.888 ± 0.021	1.132TrpVal: 1.132 ± 0.024	0.33TrpTrp: 0.33 ± 0.012	0.334TrpTyr: 0.334 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.493TyrAla: 2.493 ± 0.031	0.251TyrCys: 0.251 ± 0.011	1.444TyrAsp: 1.444 ± 0.031	1.168TyrGlu: 1.168 ± 0.026	0.812TyrPhe: 0.812 ± 0.022	2.106TyrGly: 2.106 ± 0.036	0.473TyrHis: 0.473 ± 0.017	0.794TyrIle: 0.794 ± 0.023	0.434TyrLys: 0.434 ± 0.016	2.286TyrLeu: 2.286 ± 0.034	0.337TyrMet: 0.337 ± 0.013	0.489TyrAsn: 0.489 ± 0.015	1.328TyrPro: 1.328 ± 0.029	0.717TyrGln: 0.717 ± 0.02	1.869TyrArg: 1.869 ± 0.034	1.144TyrSer: 1.144 ± 0.026	1.249TyrThr: 1.249 ± 0.021	1.696TyrVal: 1.696 ± 0.03	0.376TyrTrp: 0.376 ± 0.014	0.551TyrTyr: 0.551 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6452 proteins (2059546 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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