Amino acid dipepetide frequency for Streptomyces diacarni

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.745AlaAla: 22.745 ± 0.158	1.184AlaCys: 1.184 ± 0.023	8.356AlaAsp: 8.356 ± 0.067	9.022AlaGlu: 9.022 ± 0.087	3.476AlaPhe: 3.476 ± 0.046	14.18AlaGly: 14.18 ± 0.101	3.365AlaHis: 3.365 ± 0.047	2.757AlaIle: 2.757 ± 0.038	2.641AlaLys: 2.641 ± 0.047	15.42AlaLeu: 15.42 ± 0.122	2.476AlaMet: 2.476 ± 0.037	1.685AlaAsn: 1.685 ± 0.028	7.872AlaPro: 7.872 ± 0.101	4.106AlaGln: 4.106 ± 0.05	11.436AlaArg: 11.436 ± 0.101	6.143AlaSer: 6.143 ± 0.065	6.887AlaThr: 6.887 ± 0.062	11.965AlaVal: 11.965 ± 0.094	1.836AlaTrp: 1.836 ± 0.03	2.56AlaTyr: 2.56 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.256CysAla: 1.256 ± 0.023	0.095CysCys: 0.095 ± 0.008	0.504CysAsp: 0.504 ± 0.019	0.443CysGlu: 0.443 ± 0.014	0.233CysPhe: 0.233 ± 0.011	1.029CysGly: 1.029 ± 0.024	0.193CysHis: 0.193 ± 0.011	0.141CysIle: 0.141 ± 0.008	0.109CysLys: 0.109 ± 0.007	0.778CysLeu: 0.778 ± 0.022	0.125CysMet: 0.125 ± 0.008	0.126CysAsn: 0.126 ± 0.008	0.5CysPro: 0.5 ± 0.018	0.177CysGln: 0.177 ± 0.008	0.629CysArg: 0.629 ± 0.02	0.414CysSer: 0.414 ± 0.013	0.492CysThr: 0.492 ± 0.016	0.724CysVal: 0.724 ± 0.019	0.132CysTrp: 0.132 ± 0.009	0.154CysTyr: 0.154 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.937AspAla: 7.937 ± 0.066	0.39AspCys: 0.39 ± 0.015	3.336AspAsp: 3.336 ± 0.046	4.113AspGlu: 4.113 ± 0.051	1.572AspPhe: 1.572 ± 0.03	6.347AspGly: 6.347 ± 0.059	1.383AspHis: 1.383 ± 0.028	1.658AspIle: 1.658 ± 0.031	1.195AspLys: 1.195 ± 0.025	5.707AspLeu: 5.707 ± 0.05	0.844AspMet: 0.844 ± 0.021	0.876AspAsn: 0.876 ± 0.023	4.392AspPro: 4.392 ± 0.048	1.471AspGln: 1.471 ± 0.03	4.539AspArg: 4.539 ± 0.048	2.53AspSer: 2.53 ± 0.041	3.1AspThr: 3.1 ± 0.041	4.522AspVal: 4.522 ± 0.055	0.949AspTrp: 0.949 ± 0.024	1.034AspTyr: 1.034 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	8.191GluAla: 8.191 ± 0.081	0.382GluCys: 0.382 ± 0.016	3.02GluAsp: 3.02 ± 0.041	4.158GluGlu: 4.158 ± 0.049	1.292GluPhe: 1.292 ± 0.026	5.208GluGly: 5.208 ± 0.06	1.567GluHis: 1.567 ± 0.026	1.945GluIle: 1.945 ± 0.036	1.515GluLys: 1.515 ± 0.04	6.558GluLeu: 6.558 ± 0.065	0.933GluMet: 0.933 ± 0.02	0.996GluAsn: 0.996 ± 0.024	3.636GluPro: 3.636 ± 0.05	2.377GluGln: 2.377 ± 0.041	6.059GluArg: 6.059 ± 0.062	2.675GluSer: 2.675 ± 0.039	3.153GluThr: 3.153 ± 0.037	4.419GluVal: 4.419 ± 0.051	0.765GluTrp: 0.765 ± 0.02	1.032GluTyr: 1.032 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.747PheAla: 3.747 ± 0.048	0.271PheCys: 0.271 ± 0.012	1.811PheAsp: 1.811 ± 0.031	1.35PheGlu: 1.35 ± 0.028	0.899PhePhe: 0.899 ± 0.025	2.994PheGly: 2.994 ± 0.043	0.642PheHis: 0.642 ± 0.018	0.629PheIle: 0.629 ± 0.018	0.433PheLys: 0.433 ± 0.016	2.633PheLeu: 2.633 ± 0.043	0.384PheMet: 0.384 ± 0.014	0.498PheAsn: 0.498 ± 0.015	1.335PhePro: 1.335 ± 0.026	0.625PheGln: 0.625 ± 0.018	1.759PheArg: 1.759 ± 0.028	1.448PheSer: 1.448 ± 0.027	1.89PheThr: 1.89 ± 0.03	2.151PheVal: 2.151 ± 0.036	0.39PheTrp: 0.39 ± 0.014	0.52PheTyr: 0.52 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	12.317GlyAla: 12.317 ± 0.097	0.898GlyCys: 0.898 ± 0.024	5.2GlyAsp: 5.2 ± 0.048	5.863GlyGlu: 5.863 ± 0.059	2.774GlyPhe: 2.774 ± 0.038	9.955GlyGly: 9.955 ± 0.089	2.477GlyHis: 2.477 ± 0.038	3.122GlyIle: 3.122 ± 0.042	2.472GlyLys: 2.472 ± 0.042	9.601GlyLeu: 9.601 ± 0.084	2.114GlyMet: 2.114 ± 0.034	1.701GlyAsn: 1.701 ± 0.034	5.769GlyPro: 5.769 ± 0.06	2.842GlyGln: 2.842 ± 0.045	8.029GlyArg: 8.029 ± 0.073	5.675GlySer: 5.675 ± 0.06	6.507GlyThr: 6.507 ± 0.063	7.616GlyVal: 7.616 ± 0.064	1.664GlyTrp: 1.664 ± 0.032	2.261GlyTyr: 2.261 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	3.028HisAla: 3.028 ± 0.047	0.222HisCys: 0.222 ± 0.011	1.337HisAsp: 1.337 ± 0.028	1.366HisGlu: 1.366 ± 0.025	0.67HisPhe: 0.67 ± 0.016	2.662HisGly: 2.662 ± 0.04	0.761HisHis: 0.761 ± 0.019	0.601HisIle: 0.601 ± 0.016	0.38HisLys: 0.38 ± 0.012	2.564HisLeu: 2.564 ± 0.035	0.355HisMet: 0.355 ± 0.013	0.366HisAsn: 0.366 ± 0.014	1.922HisPro: 1.922 ± 0.03	0.7HisGln: 0.7 ± 0.018	2.165HisArg: 2.165 ± 0.035	1.099HisSer: 1.099 ± 0.026	1.571HisThr: 1.571 ± 0.033	1.759HisVal: 1.759 ± 0.031	0.384HisTrp: 0.384 ± 0.013	0.481HisTyr: 0.481 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.998IleAla: 3.998 ± 0.048	0.262IleCys: 0.262 ± 0.011	1.874IleAsp: 1.874 ± 0.03	1.831IleGlu: 1.831 ± 0.029	0.609IlePhe: 0.609 ± 0.019	3.104IleGly: 3.104 ± 0.046	0.528IleHis: 0.528 ± 0.016	0.683IleIle: 0.683 ± 0.023	0.598IleLys: 0.598 ± 0.019	1.994IleLeu: 1.994 ± 0.035	0.376IleMet: 0.376 ± 0.014	0.576IleAsn: 0.576 ± 0.017	1.509IlePro: 1.509 ± 0.024	0.597IleGln: 0.597 ± 0.017	1.972IleArg: 1.972 ± 0.034	1.506IleSer: 1.506 ± 0.03	1.713IleThr: 1.713 ± 0.025	2.303IleVal: 2.303 ± 0.035	0.29IleTrp: 0.29 ± 0.011	0.43IleTyr: 0.43 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.655LysAla: 2.655 ± 0.049	0.108LysCys: 0.108 ± 0.008	1.283LysAsp: 1.283 ± 0.031	1.218LysGlu: 1.218 ± 0.032	0.401LysPhe: 0.401 ± 0.015	1.832LysGly: 1.832 ± 0.037	0.414LysHis: 0.414 ± 0.013	0.701LysIle: 0.701 ± 0.024	0.969LysLys: 0.969 ± 0.033	1.951LysLeu: 1.951 ± 0.037	0.39LysMet: 0.39 ± 0.014	0.47LysAsn: 0.47 ± 0.017	1.291LysPro: 1.291 ± 0.03	0.666LysGln: 0.666 ± 0.021	1.458LysArg: 1.458 ± 0.026	1.077LysSer: 1.077 ± 0.027	1.217LysThr: 1.217 ± 0.029	1.65LysVal: 1.65 ± 0.037	0.233LysTrp: 0.233 ± 0.01	0.379LysTyr: 0.379 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.508LeuAla: 15.508 ± 0.119	0.928LeuCys: 0.928 ± 0.024	6.402LeuAsp: 6.402 ± 0.054	4.941LeuGlu: 4.941 ± 0.053	2.673LeuPhe: 2.673 ± 0.043	9.365LeuGly: 9.365 ± 0.08	2.413LeuHis: 2.413 ± 0.038	2.848LeuIle: 2.848 ± 0.042	1.731LeuLys: 1.731 ± 0.03	11.493LeuLeu: 11.493 ± 0.109	1.611LeuMet: 1.611 ± 0.029	1.518LeuAsn: 1.518 ± 0.028	6.595LeuPro: 6.595 ± 0.064	2.039LeuGln: 2.039 ± 0.031	9.087LeuArg: 9.087 ± 0.076	5.386LeuSer: 5.386 ± 0.056	6.875LeuThr: 6.875 ± 0.066	8.818LeuVal: 8.818 ± 0.076	1.284LeuTrp: 1.284 ± 0.029	1.805LeuTyr: 1.805 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.316MetAla: 2.316 ± 0.035	0.142MetCys: 0.142 ± 0.007	0.869MetAsp: 0.869 ± 0.019	0.776MetGlu: 0.776 ± 0.02	0.461MetPhe: 0.461 ± 0.016	1.352MetGly: 1.352 ± 0.028	0.357MetHis: 0.357 ± 0.013	0.575MetIle: 0.575 ± 0.018	0.396MetLys: 0.396 ± 0.015	1.706MetLeu: 1.706 ± 0.031	0.298MetMet: 0.298 ± 0.014	0.378MetAsn: 0.378 ± 0.015	1.148MetPro: 1.148 ± 0.021	0.403MetGln: 0.403 ± 0.015	1.5MetArg: 1.5 ± 0.028	1.29MetSer: 1.29 ± 0.024	1.452MetThr: 1.452 ± 0.025	1.296MetVal: 1.296 ± 0.027	0.217MetTrp: 0.217 ± 0.01	0.3MetTyr: 0.3 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.053AsnAla: 2.053 ± 0.033	0.157AsnCys: 0.157 ± 0.008	0.841AsnAsp: 0.841 ± 0.02	0.795AsnGlu: 0.795 ± 0.019	0.429AsnPhe: 0.429 ± 0.013	1.668AsnGly: 1.668 ± 0.033	0.346AsnHis: 0.346 ± 0.012	0.552AsnIle: 0.552 ± 0.017	0.374AsnLys: 0.374 ± 0.016	1.5AsnLeu: 1.5 ± 0.026	0.285AsnMet: 0.285 ± 0.011	0.341AsnAsn: 0.341 ± 0.015	1.245AsnPro: 1.245 ± 0.027	0.458AsnGln: 0.458 ± 0.015	1.155AsnArg: 1.155 ± 0.025	0.796AsnSer: 0.796 ± 0.02	0.964AsnThr: 0.964 ± 0.024	1.258AsnVal: 1.258 ± 0.025	0.255AsnTrp: 0.255 ± 0.012	0.364AsnTyr: 0.364 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	8.877ProAla: 8.877 ± 0.097	0.365ProCys: 0.365 ± 0.015	4.385ProAsp: 4.385 ± 0.045	4.529ProGlu: 4.529 ± 0.05	1.507ProPhe: 1.507 ± 0.027	7.214ProGly: 7.214 ± 0.077	1.775ProHis: 1.775 ± 0.033	0.994ProIle: 0.994 ± 0.023	1.142ProLys: 1.142 ± 0.026	5.628ProLeu: 5.628 ± 0.051	0.952ProMet: 0.952 ± 0.025	0.746ProAsn: 0.746 ± 0.018	3.863ProPro: 3.863 ± 0.066	1.999ProGln: 1.999 ± 0.047	4.522ProArg: 4.522 ± 0.045	3.443ProSer: 3.443 ± 0.049	3.117ProThr: 3.117 ± 0.043	5.302ProVal: 5.302 ± 0.049	0.881ProTrp: 0.881 ± 0.02	1.333ProTyr: 1.333 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.807GlnAla: 3.807 ± 0.051	0.178GlnCys: 0.178 ± 0.01	1.436GlnAsp: 1.436 ± 0.027	1.618GlnGlu: 1.618 ± 0.033	0.623GlnPhe: 0.623 ± 0.018	2.436GlnGly: 2.436 ± 0.043	0.718GlnHis: 0.718 ± 0.019	0.943GlnIle: 0.943 ± 0.021	0.565GlnLys: 0.565 ± 0.019	3.046GlnLeu: 3.046 ± 0.039	0.463GlnMet: 0.463 ± 0.014	0.441GlnAsn: 0.441 ± 0.015	1.866GlnPro: 1.866 ± 0.048	1.311GlnGln: 1.311 ± 0.038	2.572GlnArg: 2.572 ± 0.037	1.199GlnSer: 1.199 ± 0.026	1.299GlnThr: 1.299 ± 0.028	2.364GlnVal: 2.364 ± 0.037	0.417GlnTrp: 0.417 ± 0.013	0.516GlnTyr: 0.516 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.82ArgAla: 10.82 ± 0.088	0.66ArgCys: 0.66 ± 0.018	4.289ArgAsp: 4.289 ± 0.053	5.277ArgGlu: 5.277 ± 0.061	2.289ArgPhe: 2.289 ± 0.035	6.551ArgGly: 6.551 ± 0.055	2.273ArgHis: 2.273 ± 0.032	2.806ArgIle: 2.806 ± 0.044	1.662ArgLys: 1.662 ± 0.033	8.831ArgLeu: 8.831 ± 0.085	1.817ArgMet: 1.817 ± 0.029	1.282ArgAsn: 1.282 ± 0.027	5.106ArgPro: 5.106 ± 0.059	2.467ArgGln: 2.467 ± 0.041	8.077ArgArg: 8.077 ± 0.08	4.22ArgSer: 4.22 ± 0.045	5.632ArgThr: 5.632 ± 0.063	6.135ArgVal: 6.135 ± 0.06	1.371ArgTrp: 1.371 ± 0.027	1.79ArgTyr: 1.79 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	7.192SerAla: 7.192 ± 0.064	0.409SerCys: 0.409 ± 0.013	2.717SerAsp: 2.717 ± 0.042	2.591SerGlu: 2.591 ± 0.038	1.529SerPhe: 1.529 ± 0.029	6.324SerGly: 6.324 ± 0.055	1.088SerHis: 1.088 ± 0.023	1.13SerIle: 1.13 ± 0.024	0.966SerLys: 0.966 ± 0.027	4.792SerLeu: 4.792 ± 0.044	1.022SerMet: 1.022 ± 0.021	0.756SerAsn: 0.756 ± 0.017	3.398SerPro: 3.398 ± 0.041	1.283SerGln: 1.283 ± 0.031	3.89SerArg: 3.89 ± 0.048	2.993SerSer: 2.993 ± 0.048	2.913SerThr: 2.913 ± 0.038	4.076SerVal: 4.076 ± 0.048	0.833SerTrp: 0.833 ± 0.021	1.137SerTyr: 1.137 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	8.761ThrAla: 8.761 ± 0.07	0.42ThrCys: 0.42 ± 0.016	3.548ThrAsp: 3.548 ± 0.055	3.268ThrGlu: 3.268 ± 0.043	1.563ThrPhe: 1.563 ± 0.03	6.751ThrGly: 6.751 ± 0.059	1.27ThrHis: 1.27 ± 0.025	1.347ThrIle: 1.347 ± 0.028	1.027ThrLys: 1.027 ± 0.023	5.766ThrLeu: 5.766 ± 0.052	0.896ThrMet: 0.896 ± 0.022	0.867ThrAsn: 0.867 ± 0.021	4.059ThrPro: 4.059 ± 0.054	1.328ThrGln: 1.328 ± 0.024	4.155ThrArg: 4.155 ± 0.052	3.149ThrSer: 3.149 ± 0.04	3.551ThrThr: 3.551 ± 0.042	5.918ThrVal: 5.918 ± 0.056	0.819ThrTrp: 0.819 ± 0.021	1.218ThrTyr: 1.218 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	10.645ValAla: 10.645 ± 0.085	0.86ValCys: 0.86 ± 0.021	4.533ValAsp: 4.533 ± 0.046	4.739ValGlu: 4.739 ± 0.055	2.332ValPhe: 2.332 ± 0.037	6.61ValGly: 6.61 ± 0.067	2.047ValHis: 2.047 ± 0.029	2.474ValIle: 2.474 ± 0.034	1.505ValLys: 1.505 ± 0.031	9.547ValLeu: 9.547 ± 0.087	1.344ValMet: 1.344 ± 0.027	1.536ValAsn: 1.536 ± 0.028	5.284ValPro: 5.284 ± 0.053	1.848ValGln: 1.848 ± 0.031	7.283ValArg: 7.283 ± 0.066	4.28ValSer: 4.28 ± 0.052	5.425ValThr: 5.425 ± 0.059	7.518ValVal: 7.518 ± 0.074	1.093ValTrp: 1.093 ± 0.025	1.418ValTyr: 1.418 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.568TrpAla: 1.568 ± 0.029	0.159TrpCys: 0.159 ± 0.009	0.823TrpAsp: 0.823 ± 0.021	0.773TrpGlu: 0.773 ± 0.019	0.475TrpPhe: 0.475 ± 0.016	1.064TrpGly: 1.064 ± 0.025	0.382TrpHis: 0.382 ± 0.015	0.469TrpIle: 0.469 ± 0.014	0.337TrpLys: 0.337 ± 0.015	1.779TrpLeu: 1.779 ± 0.036	0.302TrpMet: 0.302 ± 0.012	0.341TrpAsn: 0.341 ± 0.011	0.734TrpPro: 0.734 ± 0.019	0.585TrpGln: 0.585 ± 0.018	1.36TrpArg: 1.36 ± 0.028	0.859TrpSer: 0.859 ± 0.023	0.876TrpThr: 0.876 ± 0.022	0.936TrpVal: 0.936 ± 0.024	0.313TrpTrp: 0.313 ± 0.013	0.323TrpTyr: 0.323 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.691TyrAla: 2.691 ± 0.039	0.163TyrCys: 0.163 ± 0.008	1.331TyrAsp: 1.331 ± 0.028	1.212TyrGlu: 1.212 ± 0.025	0.605TyrPhe: 0.605 ± 0.018	2.211TyrGly: 2.211 ± 0.036	0.396TyrHis: 0.396 ± 0.012	0.377TyrIle: 0.377 ± 0.014	0.342TyrLys: 0.342 ± 0.017	2.026TyrLeu: 2.026 ± 0.03	0.243TyrMet: 0.243 ± 0.012	0.338TyrAsn: 0.338 ± 0.015	1.051TyrPro: 1.051 ± 0.027	0.535TyrGln: 0.535 ± 0.017	1.709TyrArg: 1.709 ± 0.029	0.86TyrSer: 0.86 ± 0.019	1.048TyrThr: 1.048 ± 0.024	1.587TyrVal: 1.587 ± 0.03	0.331TyrTrp: 0.331 ± 0.014	0.397TyrTyr: 0.397 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6222 proteins (2120821 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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