Amino acid dipepetide frequency for Psychrilyobacter sp. S5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.956AlaAla: 3.956 ± 0.093	0.579AlaCys: 0.579 ± 0.03	2.849AlaAsp: 2.849 ± 0.061	3.846AlaGlu: 3.846 ± 0.062	2.418AlaPhe: 2.418 ± 0.063	4.8AlaGly: 4.8 ± 0.092	0.947AlaHis: 0.947 ± 0.037	4.806AlaIle: 4.806 ± 0.081	4.421AlaLys: 4.421 ± 0.075	5.255AlaLeu: 5.255 ± 0.083	1.664AlaMet: 1.664 ± 0.049	2.186AlaAsn: 2.186 ± 0.054	1.483AlaPro: 1.483 ± 0.048	1.205AlaGln: 1.205 ± 0.036	2.08AlaArg: 2.08 ± 0.048	2.887AlaSer: 2.887 ± 0.058	2.837AlaThr: 2.837 ± 0.059	4.454AlaVal: 4.454 ± 0.084	0.338AlaTrp: 0.338 ± 0.017	1.944AlaTyr: 1.944 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.449CysAla: 0.449 ± 0.023	0.108CysCys: 0.108 ± 0.012	0.495CysAsp: 0.495 ± 0.025	0.595CysGlu: 0.595 ± 0.028	0.361CysPhe: 0.361 ± 0.021	0.983CysGly: 0.983 ± 0.035	0.212CysHis: 0.212 ± 0.015	0.736CysIle: 0.736 ± 0.035	0.611CysLys: 0.611 ± 0.028	0.653CysLeu: 0.653 ± 0.026	0.218CysMet: 0.218 ± 0.015	0.418CysAsn: 0.418 ± 0.022	0.425CysPro: 0.425 ± 0.025	0.18CysGln: 0.18 ± 0.017	0.358CysArg: 0.358 ± 0.02	0.603CysSer: 0.603 ± 0.027	0.476CysThr: 0.476 ± 0.024	0.49CysVal: 0.49 ± 0.026	0.059CysTrp: 0.059 ± 0.008	0.301CysTyr: 0.301 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	2.597AspAla: 2.597 ± 0.062	0.406AspCys: 0.406 ± 0.023	2.427AspAsp: 2.427 ± 0.072	4.627AspGlu: 4.627 ± 0.078	2.81AspPhe: 2.81 ± 0.058	4.038AspGly: 4.038 ± 0.114	0.856AspHis: 0.856 ± 0.03	5.701AspIle: 5.701 ± 0.076	4.771AspLys: 4.771 ± 0.076	5.768AspLeu: 5.768 ± 0.085	1.486AspMet: 1.486 ± 0.04	2.571AspAsn: 2.571 ± 0.058	1.64AspPro: 1.64 ± 0.048	1.031AspGln: 1.031 ± 0.038	2.292AspArg: 2.292 ± 0.055	3.048AspSer: 3.048 ± 0.061	2.619AspThr: 2.619 ± 0.056	3.211AspVal: 3.211 ± 0.067	0.376AspTrp: 0.376 ± 0.024	2.57AspTyr: 2.57 ± 0.065	0.0AspXaa: 0.0 ± 0.0
Glu	4.101GluAla: 4.101 ± 0.08	0.511GluCys: 0.511 ± 0.024	4.476GluAsp: 4.476 ± 0.073	7.216GluGlu: 7.216 ± 0.099	3.603GluPhe: 3.603 ± 0.067	4.646GluGly: 4.646 ± 0.081	0.972GluHis: 0.972 ± 0.036	8.173GluIle: 8.173 ± 0.105	9.253GluLys: 9.253 ± 0.127	7.245GluLeu: 7.245 ± 0.103	2.171GluMet: 2.171 ± 0.052	5.265GluAsn: 5.265 ± 0.092	1.315GluPro: 1.315 ± 0.038	1.34GluGln: 1.34 ± 0.035	2.769GluArg: 2.769 ± 0.05	3.384GluSer: 3.384 ± 0.061	3.596GluThr: 3.596 ± 0.061	5.28GluVal: 5.28 ± 0.083	0.508GluTrp: 0.508 ± 0.024	3.054GluTyr: 3.054 ± 0.069	0.0GluXaa: 0.0 ± 0.0
Phe	2.267PheAla: 2.267 ± 0.055	0.372PheCys: 0.372 ± 0.021	2.533PheAsp: 2.533 ± 0.049	3.119PheGlu: 3.119 ± 0.06	2.483PhePhe: 2.483 ± 0.08	3.397PheGly: 3.397 ± 0.068	0.757PheHis: 0.757 ± 0.033	4.602PheIle: 4.602 ± 0.087	3.969PheLys: 3.969 ± 0.074	4.594PheLeu: 4.594 ± 0.097	1.348PheMet: 1.348 ± 0.042	2.581PheAsn: 2.581 ± 0.054	1.31PhePro: 1.31 ± 0.036	0.96PheGln: 0.96 ± 0.032	1.353PheArg: 1.353 ± 0.035	3.363PheSer: 3.363 ± 0.064	2.437PheThr: 2.437 ± 0.059	2.386PheVal: 2.386 ± 0.05	0.349PheTrp: 0.349 ± 0.022	1.933PheTyr: 1.933 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	4.533GlyAla: 4.533 ± 0.086	0.773GlyCys: 0.773 ± 0.034	3.79GlyAsp: 3.79 ± 0.075	5.316GlyGlu: 5.316 ± 0.09	3.25GlyPhe: 3.25 ± 0.06	5.485GlyGly: 5.485 ± 0.106	1.127GlyHis: 1.127 ± 0.035	7.723GlyIle: 7.723 ± 0.105	6.033GlyLys: 6.033 ± 0.087	6.201GlyLeu: 6.201 ± 0.098	2.306GlyMet: 2.306 ± 0.065	3.296GlyAsn: 3.296 ± 0.071	1.237GlyPro: 1.237 ± 0.042	1.454GlyGln: 1.454 ± 0.044	2.717GlyArg: 2.717 ± 0.057	4.05GlySer: 4.05 ± 0.083	3.832GlyThr: 3.832 ± 0.079	5.621GlyVal: 5.621 ± 0.092	0.565GlyTrp: 0.565 ± 0.026	3.095GlyTyr: 3.095 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	0.738HisAla: 0.738 ± 0.033	0.166HisCys: 0.166 ± 0.013	0.731HisAsp: 0.731 ± 0.031	1.062HisGlu: 1.062 ± 0.04	0.719HisPhe: 0.719 ± 0.025	1.156HisGly: 1.156 ± 0.036	0.326HisHis: 0.326 ± 0.02	1.427HisIle: 1.427 ± 0.043	1.156HisLys: 1.156 ± 0.037	1.449HisLeu: 1.449 ± 0.046	0.458HisMet: 0.458 ± 0.022	0.739HisAsn: 0.739 ± 0.028	0.719HisPro: 0.719 ± 0.029	0.346HisGln: 0.346 ± 0.022	0.701HisArg: 0.701 ± 0.028	0.948HisSer: 0.948 ± 0.036	0.773HisThr: 0.773 ± 0.026	0.728HisVal: 0.728 ± 0.026	0.144HisTrp: 0.144 ± 0.014	0.599HisTyr: 0.599 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.447IleAla: 5.447 ± 0.084	0.888IleCys: 0.888 ± 0.035	5.687IleAsp: 5.687 ± 0.098	7.439IleGlu: 7.439 ± 0.104	4.673IlePhe: 4.673 ± 0.09	6.413IleGly: 6.413 ± 0.099	1.319IleHis: 1.319 ± 0.039	8.656IleIle: 8.656 ± 0.125	8.472IleLys: 8.472 ± 0.099	9.91IleLeu: 9.91 ± 0.136	2.378IleMet: 2.378 ± 0.055	4.794IleAsn: 4.794 ± 0.07	3.257IlePro: 3.257 ± 0.057	1.991IleGln: 1.991 ± 0.046	3.041IleArg: 3.041 ± 0.061	6.66IleSer: 6.66 ± 0.087	4.905IleThr: 4.905 ± 0.077	5.574IleVal: 5.574 ± 0.097	0.497IleTrp: 0.497 ± 0.022	3.458IleTyr: 3.458 ± 0.07	0.0IleXaa: 0.0 ± 0.0
Lys	4.236LysAla: 4.236 ± 0.076	0.592LysCys: 0.592 ± 0.03	5.46LysAsp: 5.46 ± 0.081	8.399LysGlu: 8.399 ± 0.101	3.693LysPhe: 3.693 ± 0.07	5.302LysGly: 5.302 ± 0.085	1.131LysHis: 1.131 ± 0.036	9.667LysIle: 9.667 ± 0.135	10.636LysLys: 10.636 ± 0.151	8.323LysLeu: 8.323 ± 0.105	2.686LysMet: 2.686 ± 0.062	6.618LysAsn: 6.618 ± 0.102	1.822LysPro: 1.822 ± 0.047	1.795LysGln: 1.795 ± 0.049	3.183LysArg: 3.183 ± 0.059	4.576LysSer: 4.576 ± 0.068	4.628LysThr: 4.628 ± 0.073	5.415LysVal: 5.415 ± 0.081	0.62LysTrp: 0.62 ± 0.027	4.079LysTyr: 4.079 ± 0.081	0.0LysXaa: 0.0 ± 0.0
Leu	5.472LeuAla: 5.472 ± 0.083	0.777LeuCys: 0.777 ± 0.029	5.708LeuAsp: 5.708 ± 0.086	8.072LeuGlu: 8.072 ± 0.111	4.087LeuPhe: 4.087 ± 0.09	7.427LeuGly: 7.427 ± 0.117	1.267LeuHis: 1.267 ± 0.038	8.162LeuIle: 8.162 ± 0.113	9.718LeuLys: 9.718 ± 0.128	8.404LeuLeu: 8.404 ± 0.117	2.501LeuMet: 2.501 ± 0.051	5.363LeuAsn: 5.363 ± 0.079	2.898LeuPro: 2.898 ± 0.066	1.818LeuGln: 1.818 ± 0.048	3.183LeuArg: 3.183 ± 0.061	6.234LeuSer: 6.234 ± 0.087	4.842LeuThr: 4.842 ± 0.09	5.424LeuVal: 5.424 ± 0.082	0.626LeuTrp: 0.626 ± 0.03	3.053LeuTyr: 3.053 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	1.943MetAla: 1.943 ± 0.049	0.202MetCys: 0.202 ± 0.015	1.673MetAsp: 1.673 ± 0.043	2.356MetGlu: 2.356 ± 0.049	1.003MetPhe: 1.003 ± 0.037	2.401MetGly: 2.401 ± 0.054	0.342MetHis: 0.342 ± 0.017	2.366MetIle: 2.366 ± 0.052	3.042MetLys: 3.042 ± 0.06	2.027MetLeu: 2.027 ± 0.047	0.837MetMet: 0.837 ± 0.034	1.523MetAsn: 1.523 ± 0.046	0.82MetPro: 0.82 ± 0.029	0.531MetGln: 0.531 ± 0.026	1.001MetArg: 1.001 ± 0.039	1.555MetSer: 1.555 ± 0.042	1.43MetThr: 1.43 ± 0.038	1.907MetVal: 1.907 ± 0.047	0.163MetTrp: 0.163 ± 0.015	0.777MetTyr: 0.777 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	2.195AsnAla: 2.195 ± 0.055	0.481AsnCys: 0.481 ± 0.025	2.431AsnAsp: 2.431 ± 0.055	3.421AsnGlu: 3.421 ± 0.067	2.862AsnPhe: 2.862 ± 0.054	3.423AsnGly: 3.423 ± 0.086	0.808AsnHis: 0.808 ± 0.035	5.839AsnIle: 5.839 ± 0.091	5.027AsnLys: 5.027 ± 0.084	5.888AsnLeu: 5.888 ± 0.093	1.578AsnMet: 1.578 ± 0.042	3.146AsnAsn: 3.146 ± 0.071	2.086AsnPro: 2.086 ± 0.052	1.218AsnGln: 1.218 ± 0.038	2.037AsnArg: 2.037 ± 0.045	3.212AsnSer: 3.212 ± 0.071	2.516AsnThr: 2.516 ± 0.063	2.596AsnVal: 2.596 ± 0.049	0.411AsnTrp: 0.411 ± 0.024	2.632AsnTyr: 2.632 ± 0.071	0.0AsnXaa: 0.0 ± 0.0
Pro	1.605ProAla: 1.605 ± 0.053	0.281ProCys: 0.281 ± 0.018	1.354ProAsp: 1.354 ± 0.043	2.404ProGlu: 2.404 ± 0.064	1.359ProPhe: 1.359 ± 0.038	1.896ProGly: 1.896 ± 0.047	0.582ProHis: 0.582 ± 0.025	2.439ProIle: 2.439 ± 0.048	2.365ProLys: 2.365 ± 0.049	2.71ProLeu: 2.71 ± 0.057	0.8ProMet: 0.8 ± 0.033	1.4ProAsn: 1.4 ± 0.044	0.601ProPro: 0.601 ± 0.03	0.775ProGln: 0.775 ± 0.027	0.895ProArg: 0.895 ± 0.035	1.632ProSer: 1.632 ± 0.037	1.485ProThr: 1.485 ± 0.037	2.127ProVal: 2.127 ± 0.055	0.212ProTrp: 0.212 ± 0.016	1.19ProTyr: 1.19 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	1.183GlnAla: 1.183 ± 0.038	0.189GlnCys: 0.189 ± 0.013	1.004GlnAsp: 1.004 ± 0.034	1.547GlnGlu: 1.547 ± 0.048	0.786GlnPhe: 0.786 ± 0.029	1.514GlnGly: 1.514 ± 0.044	0.305GlnHis: 0.305 ± 0.018	2.108GlnIle: 2.108 ± 0.055	1.887GlnLys: 1.887 ± 0.044	2.006GlnLeu: 2.006 ± 0.045	0.629GlnMet: 0.629 ± 0.022	1.296GlnAsn: 1.296 ± 0.042	0.517GlnPro: 0.517 ± 0.023	0.49GlnGln: 0.49 ± 0.025	0.866GlnArg: 0.866 ± 0.03	1.073GlnSer: 1.073 ± 0.037	1.044GlnThr: 1.044 ± 0.035	1.298GlnVal: 1.298 ± 0.038	0.198GlnTrp: 0.198 ± 0.013	0.778GlnTyr: 0.778 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	1.836ArgAla: 1.836 ± 0.046	0.395ArgCys: 0.395 ± 0.023	2.137ArgAsp: 2.137 ± 0.052	3.423ArgGlu: 3.423 ± 0.065	1.445ArgPhe: 1.445 ± 0.04	2.581ArgGly: 2.581 ± 0.058	0.509ArgHis: 0.509 ± 0.024	3.209ArgIle: 3.209 ± 0.053	3.266ArgLys: 3.266 ± 0.065	3.13ArgLeu: 3.13 ± 0.051	1.03ArgMet: 1.03 ± 0.032	1.742ArgAsn: 1.742 ± 0.041	0.85ArgPro: 0.85 ± 0.033	0.741ArgGln: 0.741 ± 0.028	1.444ArgArg: 1.444 ± 0.045	1.95ArgSer: 1.95 ± 0.051	1.579ArgThr: 1.579 ± 0.04	2.663ArgVal: 2.663 ± 0.048	0.333ArgTrp: 0.333 ± 0.022	1.577ArgTyr: 1.577 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	3.116SerAla: 3.116 ± 0.053	0.614SerCys: 0.614 ± 0.03	2.942SerAsp: 2.942 ± 0.063	4.01SerGlu: 4.01 ± 0.074	3.012SerPhe: 3.012 ± 0.064	4.574SerGly: 4.574 ± 0.098	1.085SerHis: 1.085 ± 0.038	5.387SerIle: 5.387 ± 0.081	5.052SerLys: 5.052 ± 0.074	5.941SerLeu: 5.941 ± 0.096	1.647SerMet: 1.647 ± 0.045	2.842SerAsn: 2.842 ± 0.06	1.784SerPro: 1.784 ± 0.049	1.483SerGln: 1.483 ± 0.049	2.165SerArg: 2.165 ± 0.044	3.765SerSer: 3.765 ± 0.077	2.859SerThr: 2.859 ± 0.051	3.611SerVal: 3.611 ± 0.062	0.483SerTrp: 0.483 ± 0.026	2.604SerTyr: 2.604 ± 0.067	0.0SerXaa: 0.0 ± 0.0
Thr	3.278ThrAla: 3.278 ± 0.068	0.422ThrCys: 0.422 ± 0.024	2.655ThrAsp: 2.655 ± 0.081	3.219ThrGlu: 3.219 ± 0.065	2.246ThrPhe: 2.246 ± 0.049	4.193ThrGly: 4.193 ± 0.081	0.937ThrHis: 0.937 ± 0.034	4.42ThrIle: 4.42 ± 0.069	3.829ThrLys: 3.829 ± 0.071	5.197ThrLeu: 5.197 ± 0.084	1.258ThrMet: 1.258 ± 0.034	2.349ThrAsn: 2.349 ± 0.056	2.098ThrPro: 2.098 ± 0.046	1.042ThrGln: 1.042 ± 0.034	1.638ThrArg: 1.638 ± 0.041	3.017ThrSer: 3.017 ± 0.057	2.794ThrThr: 2.794 ± 0.067	3.278ThrVal: 3.278 ± 0.065	0.339ThrTrp: 0.339 ± 0.018	1.988ThrTyr: 1.988 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	3.884ValAla: 3.884 ± 0.087	0.56ValCys: 0.56 ± 0.024	3.735ValAsp: 3.735 ± 0.067	5.321ValGlu: 5.321 ± 0.078	2.864ValPhe: 2.864 ± 0.061	4.713ValGly: 4.713 ± 0.084	0.882ValHis: 0.882 ± 0.033	5.889ValIle: 5.889 ± 0.094	5.266ValLys: 5.266 ± 0.075	5.616ValLeu: 5.616 ± 0.085	1.67ValMet: 1.67 ± 0.043	2.927ValAsn: 2.927 ± 0.059	1.839ValPro: 1.839 ± 0.049	1.215ValGln: 1.215 ± 0.038	2.179ValArg: 2.179 ± 0.051	3.926ValSer: 3.926 ± 0.051	3.137ValThr: 3.137 ± 0.063	4.633ValVal: 4.633 ± 0.084	0.454ValTrp: 0.454 ± 0.023	2.302ValTyr: 2.302 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.399TrpAla: 0.399 ± 0.024	0.063TrpCys: 0.063 ± 0.008	0.463TrpAsp: 0.463 ± 0.026	0.529TrpGlu: 0.529 ± 0.024	0.345TrpPhe: 0.345 ± 0.018	0.604TrpGly: 0.604 ± 0.028	0.097TrpHis: 0.097 ± 0.009	0.638TrpIle: 0.638 ± 0.029	0.573TrpLys: 0.573 ± 0.027	0.577TrpLeu: 0.577 ± 0.023	0.228TrpMet: 0.228 ± 0.017	0.452TrpAsn: 0.452 ± 0.022	0.135TrpPro: 0.135 ± 0.01	0.154TrpGln: 0.154 ± 0.01	0.222TrpArg: 0.222 ± 0.015	0.381TrpSer: 0.381 ± 0.02	0.336TrpThr: 0.336 ± 0.021	0.448TrpVal: 0.448 ± 0.021	0.091TrpTrp: 0.091 ± 0.011	0.293TrpTyr: 0.293 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.72TyrAla: 1.72 ± 0.052	0.352TyrCys: 0.352 ± 0.021	2.296TyrAsp: 2.296 ± 0.06	2.958TyrGlu: 2.958 ± 0.071	2.09TyrPhe: 2.09 ± 0.053	2.86TyrGly: 2.86 ± 0.062	0.627TyrHis: 0.627 ± 0.023	3.511TyrIle: 3.511 ± 0.067	3.514TyrLys: 3.514 ± 0.079	4.143TyrLeu: 4.143 ± 0.087	1.006TyrMet: 1.006 ± 0.032	2.298TyrAsn: 2.298 ± 0.061	1.276TyrPro: 1.276 ± 0.036	0.951TyrGln: 0.951 ± 0.031	1.714TyrArg: 1.714 ± 0.047	2.713TyrSer: 2.713 ± 0.057	2.072TyrThr: 2.072 ± 0.055	1.867TyrVal: 1.867 ± 0.046	0.26TyrTrp: 0.26 ± 0.017	1.812TyrTyr: 1.812 ± 0.058	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3023 proteins (935799 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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