Amino acid dipepetide frequency for Thiohalophilus thiocyanatoxydans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.761AlaAla: 9.761 ± 0.147	1.007AlaCys: 1.007 ± 0.034	5.484AlaAsp: 5.484 ± 0.098	6.49AlaGlu: 6.49 ± 0.103	3.037AlaPhe: 3.037 ± 0.067	8.065AlaGly: 8.065 ± 0.118	2.065AlaHis: 2.065 ± 0.056	5.569AlaIle: 5.569 ± 0.096	2.796AlaLys: 2.796 ± 0.077	10.904AlaLeu: 10.904 ± 0.142	2.733AlaMet: 2.733 ± 0.062	2.655AlaAsn: 2.655 ± 0.047	3.47AlaPro: 3.47 ± 0.068	3.646AlaGln: 3.646 ± 0.08	7.045AlaArg: 7.045 ± 0.121	4.807AlaSer: 4.807 ± 0.074	4.18AlaThr: 4.18 ± 0.071	6.686AlaVal: 6.686 ± 0.092	1.344AlaTrp: 1.344 ± 0.047	2.451AlaTyr: 2.451 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.786CysAla: 0.786 ± 0.033	0.132CysCys: 0.132 ± 0.014	0.593CysAsp: 0.593 ± 0.027	0.526CysGlu: 0.526 ± 0.024	0.305CysPhe: 0.305 ± 0.017	0.933CysGly: 0.933 ± 0.036	0.365CysHis: 0.365 ± 0.021	0.405CysIle: 0.405 ± 0.024	0.293CysLys: 0.293 ± 0.019	0.897CysLeu: 0.897 ± 0.035	0.168CysMet: 0.168 ± 0.015	0.323CysAsn: 0.323 ± 0.021	0.595CysPro: 0.595 ± 0.029	0.408CysGln: 0.408 ± 0.024	0.694CysArg: 0.694 ± 0.031	0.518CysSer: 0.518 ± 0.026	0.441CysThr: 0.441 ± 0.026	0.566CysVal: 0.566 ± 0.028	0.073CysTrp: 0.073 ± 0.009	0.294CysTyr: 0.294 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	5.145AspAla: 5.145 ± 0.088	0.541AspCys: 0.541 ± 0.027	3.494AspAsp: 3.494 ± 0.069	4.545AspGlu: 4.545 ± 0.085	2.205AspPhe: 2.205 ± 0.05	4.069AspGly: 4.069 ± 0.092	1.381AspHis: 1.381 ± 0.038	3.43AspIle: 3.43 ± 0.06	2.694AspLys: 2.694 ± 0.066	5.563AspLeu: 5.563 ± 0.076	1.551AspMet: 1.551 ± 0.044	2.261AspAsn: 2.261 ± 0.059	3.213AspPro: 3.213 ± 0.061	2.255AspGln: 2.255 ± 0.05	3.677AspArg: 3.677 ± 0.077	3.115AspSer: 3.115 ± 0.07	2.966AspThr: 2.966 ± 0.069	3.708AspVal: 3.708 ± 0.063	0.929AspTrp: 0.929 ± 0.036	2.248AspTyr: 2.248 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	6.65GluAla: 6.65 ± 0.12	0.449GluCys: 0.449 ± 0.021	3.043GluAsp: 3.043 ± 0.064	4.501GluGlu: 4.501 ± 0.109	2.172GluPhe: 2.172 ± 0.054	4.161GluGly: 4.161 ± 0.08	1.732GluHis: 1.732 ± 0.045	3.753GluIle: 3.753 ± 0.07	2.991GluLys: 2.991 ± 0.07	7.249GluLeu: 7.249 ± 0.102	1.832GluMet: 1.832 ± 0.052	2.168GluAsn: 2.168 ± 0.058	3.024GluPro: 3.024 ± 0.075	4.799GluGln: 4.799 ± 0.102	4.52GluArg: 4.52 ± 0.089	3.496GluSer: 3.496 ± 0.075	3.497GluThr: 3.497 ± 0.066	4.415GluVal: 4.415 ± 0.074	0.8GluTrp: 0.8 ± 0.034	1.906GluTyr: 1.906 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.283PheAla: 3.283 ± 0.075	0.39PheCys: 0.39 ± 0.023	2.53PheAsp: 2.53 ± 0.055	2.466PheGlu: 2.466 ± 0.053	1.349PhePhe: 1.349 ± 0.052	2.965PheGly: 2.965 ± 0.067	0.846PheHis: 0.846 ± 0.032	2.156PheIle: 2.156 ± 0.062	1.118PheLys: 1.118 ± 0.035	3.213PheLeu: 3.213 ± 0.068	0.909PheMet: 0.909 ± 0.039	1.383PheAsn: 1.383 ± 0.037	1.431PhePro: 1.431 ± 0.045	1.093PheGln: 1.093 ± 0.035	1.952PheArg: 1.952 ± 0.05	2.336PheSer: 2.336 ± 0.053	1.886PheThr: 1.886 ± 0.045	2.553PheVal: 2.553 ± 0.061	0.489PheTrp: 0.489 ± 0.024	1.198PheTyr: 1.198 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	5.953GlyAla: 5.953 ± 0.101	0.867GlyCys: 0.867 ± 0.033	4.203GlyAsp: 4.203 ± 0.081	5.455GlyGlu: 5.455 ± 0.09	3.031GlyPhe: 3.031 ± 0.065	5.695GlyGly: 5.695 ± 0.115	1.965GlyHis: 1.965 ± 0.055	4.627GlyIle: 4.627 ± 0.084	3.38GlyLys: 3.38 ± 0.067	8.029GlyLeu: 8.029 ± 0.104	2.435GlyMet: 2.435 ± 0.061	2.353GlyAsn: 2.353 ± 0.062	2.508GlyPro: 2.508 ± 0.068	3.168GlyGln: 3.168 ± 0.065	4.741GlyArg: 4.741 ± 0.084	4.076GlySer: 4.076 ± 0.079	3.491GlyThr: 3.491 ± 0.069	5.349GlyVal: 5.349 ± 0.091	1.201GlyTrp: 1.201 ± 0.042	2.745GlyTyr: 2.745 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.254HisAla: 2.254 ± 0.052	0.316HisCys: 0.316 ± 0.021	1.52HisAsp: 1.52 ± 0.049	1.479HisGlu: 1.479 ± 0.044	0.995HisPhe: 0.995 ± 0.036	2.048HisGly: 2.048 ± 0.05	0.826HisHis: 0.826 ± 0.03	1.38HisIle: 1.38 ± 0.04	0.83HisLys: 0.83 ± 0.032	2.532HisLeu: 2.532 ± 0.056	0.549HisMet: 0.549 ± 0.027	0.913HisAsn: 0.913 ± 0.035	1.587HisPro: 1.587 ± 0.046	1.067HisGln: 1.067 ± 0.037	1.605HisArg: 1.605 ± 0.041	1.296HisSer: 1.296 ± 0.042	1.196HisThr: 1.196 ± 0.042	1.518HisVal: 1.518 ± 0.045	0.452HisTrp: 0.452 ± 0.024	0.967HisTyr: 0.967 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.693IleAla: 5.693 ± 0.086	0.489IleCys: 0.489 ± 0.022	3.97IleAsp: 3.97 ± 0.078	4.305IleGlu: 4.305 ± 0.08	1.738IlePhe: 1.738 ± 0.052	4.517IleGly: 4.517 ± 0.088	1.359IleHis: 1.359 ± 0.036	3.05IleIle: 3.05 ± 0.074	2.22IleLys: 2.22 ± 0.058	5.188IleLeu: 5.188 ± 0.084	1.204IleMet: 1.204 ± 0.041	2.24IleAsn: 2.24 ± 0.057	2.696IlePro: 2.696 ± 0.059	1.88IleGln: 1.88 ± 0.045	3.56IleArg: 3.56 ± 0.067	3.14IleSer: 3.14 ± 0.068	3.156IleThr: 3.156 ± 0.066	3.684IleVal: 3.684 ± 0.077	0.651IleTrp: 0.651 ± 0.028	1.604IleTyr: 1.604 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	3.281LysAla: 3.281 ± 0.066	0.24LysCys: 0.24 ± 0.021	1.809LysAsp: 1.809 ± 0.056	2.254LysGlu: 2.254 ± 0.055	0.939LysPhe: 0.939 ± 0.039	2.418LysGly: 2.418 ± 0.058	0.888LysHis: 0.888 ± 0.039	1.965LysIle: 1.965 ± 0.054	2.059LysLys: 2.059 ± 0.124	3.944LysLeu: 3.944 ± 0.072	0.974LysMet: 0.974 ± 0.036	1.219LysAsn: 1.219 ± 0.04	2.008LysPro: 2.008 ± 0.054	2.207LysGln: 2.207 ± 0.056	2.466LysArg: 2.466 ± 0.054	2.03LysSer: 2.03 ± 0.051	2.047LysThr: 2.047 ± 0.042	2.519LysVal: 2.519 ± 0.06	0.398LysTrp: 0.398 ± 0.021	0.914LysTyr: 0.914 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	11.435LeuAla: 11.435 ± 0.145	0.923LeuCys: 0.923 ± 0.034	6.737LeuAsp: 6.737 ± 0.104	6.986LeuGlu: 6.986 ± 0.11	4.23LeuPhe: 4.23 ± 0.089	7.914LeuGly: 7.914 ± 0.1	2.652LeuHis: 2.652 ± 0.063	6.058LeuIle: 6.058 ± 0.093	3.995LeuLys: 3.995 ± 0.067	12.638LeuLeu: 12.638 ± 0.19	2.439LeuMet: 2.439 ± 0.057	3.461LeuAsn: 3.461 ± 0.056	5.586LeuPro: 5.586 ± 0.084	4.97LeuGln: 4.97 ± 0.093	6.873LeuArg: 6.873 ± 0.097	6.476LeuSer: 6.476 ± 0.081	5.225LeuThr: 5.225 ± 0.08	7.03LeuVal: 7.03 ± 0.1	1.332LeuTrp: 1.332 ± 0.044	2.845LeuTyr: 2.845 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.605MetAla: 2.605 ± 0.057	0.162MetCys: 0.162 ± 0.014	1.371MetAsp: 1.371 ± 0.045	1.491MetGlu: 1.491 ± 0.045	0.747MetPhe: 0.747 ± 0.034	1.676MetGly: 1.676 ± 0.054	0.583MetHis: 0.583 ± 0.028	1.254MetIle: 1.254 ± 0.039	1.088MetLys: 1.088 ± 0.036	2.729MetLeu: 2.729 ± 0.068	0.628MetMet: 0.628 ± 0.032	0.942MetAsn: 0.942 ± 0.032	1.353MetPro: 1.353 ± 0.038	1.285MetGln: 1.285 ± 0.04	1.557MetArg: 1.557 ± 0.04	1.828MetSer: 1.828 ± 0.048	1.44MetThr: 1.44 ± 0.036	1.648MetVal: 1.648 ± 0.044	0.215MetTrp: 0.215 ± 0.019	0.495MetTyr: 0.495 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.794AsnAla: 2.794 ± 0.058	0.292AsnCys: 0.292 ± 0.02	1.84AsnAsp: 1.84 ± 0.05	1.917AsnGlu: 1.917 ± 0.052	1.111AsnPhe: 1.111 ± 0.033	2.201AsnGly: 2.201 ± 0.057	0.774AsnHis: 0.774 ± 0.027	1.947AsnIle: 1.947 ± 0.046	1.366AsnLys: 1.366 ± 0.046	3.431AsnLeu: 3.431 ± 0.071	0.829AsnMet: 0.829 ± 0.036	1.283AsnAsn: 1.283 ± 0.045	2.042AsnPro: 2.042 ± 0.055	1.319AsnGln: 1.319 ± 0.04	2.272AsnArg: 2.272 ± 0.054	1.626AsnSer: 1.626 ± 0.049	1.711AsnThr: 1.711 ± 0.054	2.113AsnVal: 2.113 ± 0.053	0.48AsnTrp: 0.48 ± 0.028	0.996AsnTyr: 0.996 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	4.769ProAla: 4.769 ± 0.092	0.365ProCys: 0.365 ± 0.025	3.749ProAsp: 3.749 ± 0.068	3.97ProGlu: 3.97 ± 0.084	1.709ProPhe: 1.709 ± 0.05	4.266ProGly: 4.266 ± 0.081	1.09ProHis: 1.09 ± 0.038	2.132ProIle: 2.132 ± 0.054	1.216ProLys: 1.216 ± 0.042	4.882ProLeu: 4.882 ± 0.091	1.104ProMet: 1.104 ± 0.038	1.18ProAsn: 1.18 ± 0.037	2.133ProPro: 2.133 ± 0.063	1.992ProGln: 1.992 ± 0.046	2.74ProArg: 2.74 ± 0.061	1.98ProSer: 1.98 ± 0.048	1.995ProThr: 1.995 ± 0.049	4.073ProVal: 4.073 ± 0.077	0.629ProTrp: 0.629 ± 0.03	1.361ProTyr: 1.361 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	4.927GlnAla: 4.927 ± 0.116	0.414GlnCys: 0.414 ± 0.025	2.019GlnAsp: 2.019 ± 0.045	2.538GlnGlu: 2.538 ± 0.059	1.404GlnPhe: 1.404 ± 0.04	3.138GlnGly: 3.138 ± 0.063	1.413GlnHis: 1.413 ± 0.047	2.351GlnIle: 2.351 ± 0.048	1.515GlnLys: 1.515 ± 0.043	5.312GlnLeu: 5.312 ± 0.109	1.032GlnMet: 1.032 ± 0.029	1.188GlnAsn: 1.188 ± 0.034	2.199GlnPro: 2.199 ± 0.063	3.419GlnGln: 3.419 ± 0.092	3.508GlnArg: 3.508 ± 0.076	2.299GlnSer: 2.299 ± 0.054	2.066GlnThr: 2.066 ± 0.049	3.011GlnVal: 3.011 ± 0.059	0.723GlnTrp: 0.723 ± 0.029	1.094GlnTyr: 1.094 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	5.551ArgAla: 5.551 ± 0.098	0.551ArgCys: 0.551 ± 0.028	3.972ArgAsp: 3.972 ± 0.078	5.014ArgGlu: 5.014 ± 0.091	2.853ArgPhe: 2.853 ± 0.063	4.005ArgGly: 4.005 ± 0.071	2.149ArgHis: 2.149 ± 0.054	4.13ArgIle: 4.13 ± 0.086	2.358ArgLys: 2.358 ± 0.058	7.858ArgLeu: 7.858 ± 0.115	1.617ArgMet: 1.617 ± 0.043	2.181ArgAsn: 2.181 ± 0.051	2.884ArgPro: 2.884 ± 0.062	3.693ArgGln: 3.693 ± 0.08	4.971ArgArg: 4.971 ± 0.099	2.992ArgSer: 2.992 ± 0.065	2.739ArgThr: 2.739 ± 0.062	4.365ArgVal: 4.365 ± 0.081	0.979ArgTrp: 0.979 ± 0.038	2.363ArgTyr: 2.363 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	4.64SerAla: 4.64 ± 0.066	0.49SerCys: 0.49 ± 0.024	3.365SerAsp: 3.365 ± 0.076	3.492SerGlu: 3.492 ± 0.069	1.893SerPhe: 1.893 ± 0.051	5.102SerGly: 5.102 ± 0.08	1.381SerHis: 1.381 ± 0.047	2.777SerIle: 2.777 ± 0.065	1.719SerLys: 1.719 ± 0.048	5.994SerLeu: 5.994 ± 0.085	1.375SerMet: 1.375 ± 0.042	1.682SerAsn: 1.682 ± 0.042	2.5SerPro: 2.5 ± 0.056	2.065SerGln: 2.065 ± 0.048	3.861SerArg: 3.861 ± 0.067	2.828SerSer: 2.828 ± 0.066	2.568SerThr: 2.568 ± 0.059	3.702SerVal: 3.702 ± 0.072	0.671SerTrp: 0.671 ± 0.029	1.408SerTyr: 1.408 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.64ThrAla: 4.64 ± 0.086	0.459ThrCys: 0.459 ± 0.029	2.866ThrAsp: 2.866 ± 0.075	2.776ThrGlu: 2.776 ± 0.057	1.628ThrPhe: 1.628 ± 0.052	4.559ThrGly: 4.559 ± 0.073	1.17ThrHis: 1.17 ± 0.044	2.649ThrIle: 2.649 ± 0.058	1.126ThrLys: 1.126 ± 0.041	6.475ThrLeu: 6.475 ± 0.106	0.942ThrMet: 0.942 ± 0.029	1.278ThrAsn: 1.278 ± 0.041	2.894ThrPro: 2.894 ± 0.061	1.54ThrGln: 1.54 ± 0.042	3.545ThrArg: 3.545 ± 0.067	2.383ThrSer: 2.383 ± 0.054	2.495ThrThr: 2.495 ± 0.06	3.657ThrVal: 3.657 ± 0.078	0.545ThrTrp: 0.545 ± 0.027	1.325ThrTyr: 1.325 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	6.455ValAla: 6.455 ± 0.099	0.714ValCys: 0.714 ± 0.027	4.16ValAsp: 4.16 ± 0.084	4.601ValGlu: 4.601 ± 0.075	2.482ValPhe: 2.482 ± 0.052	4.657ValGly: 4.657 ± 0.072	1.473ValHis: 1.473 ± 0.042	4.586ValIle: 4.586 ± 0.091	2.472ValLys: 2.472 ± 0.058	7.414ValLeu: 7.414 ± 0.102	1.861ValMet: 1.861 ± 0.048	2.279ValAsn: 2.279 ± 0.056	3.024ValPro: 3.024 ± 0.066	2.304ValGln: 2.304 ± 0.055	4.273ValArg: 4.273 ± 0.075	3.991ValSer: 3.991 ± 0.065	3.879ValThr: 3.879 ± 0.063	5.301ValVal: 5.301 ± 0.095	0.754ValTrp: 0.754 ± 0.034	1.91ValTyr: 1.91 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.937TrpAla: 0.937 ± 0.032	0.159TrpCys: 0.159 ± 0.015	0.619TrpAsp: 0.619 ± 0.027	0.7TrpGlu: 0.7 ± 0.026	0.567TrpPhe: 0.567 ± 0.025	0.787TrpGly: 0.787 ± 0.032	0.388TrpHis: 0.388 ± 0.024	0.684TrpIle: 0.684 ± 0.025	0.413TrpLys: 0.413 ± 0.021	2.059TrpLeu: 2.059 ± 0.06	0.31TrpMet: 0.31 ± 0.02	0.376TrpAsn: 0.376 ± 0.023	0.652TrpPro: 0.652 ± 0.035	1.009TrpGln: 1.009 ± 0.04	1.045TrpArg: 1.045 ± 0.038	0.679TrpSer: 0.679 ± 0.03	0.466TrpThr: 0.466 ± 0.029	0.877TrpVal: 0.877 ± 0.035	0.235TrpTrp: 0.235 ± 0.017	0.387TrpTyr: 0.387 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.636TyrAla: 2.636 ± 0.052	0.357TyrCys: 0.357 ± 0.02	1.646TyrAsp: 1.646 ± 0.047	1.65TyrGlu: 1.65 ± 0.051	1.151TyrPhe: 1.151 ± 0.037	2.1TyrGly: 2.1 ± 0.053	0.83TyrHis: 0.83 ± 0.032	1.44TyrIle: 1.44 ± 0.042	0.929TyrLys: 0.929 ± 0.032	3.491TyrLeu: 3.491 ± 0.067	0.605TyrMet: 0.605 ± 0.031	0.979TyrAsn: 0.979 ± 0.035	1.536TyrPro: 1.536 ± 0.047	1.455TyrGln: 1.455 ± 0.048	2.322TyrArg: 2.322 ± 0.055	1.618TyrSer: 1.618 ± 0.043	1.506TyrThr: 1.506 ± 0.051	1.813TyrVal: 1.813 ± 0.056	0.446TyrTrp: 0.446 ± 0.023	0.989TyrTyr: 0.989 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2775 proteins (832478 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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