Amino acid dipepetide frequency for Streptococcus satellite phage Javan763

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.293AlaAla: 0.293 ± 0.317
0.293AlaCys: 0.293 ± 0.307
2.636AlaAsp: 2.636 ± 1.09
4.101AlaGlu: 4.101 ± 1.067
3.515AlaPhe: 3.515 ± 0.786
2.343AlaGly: 2.343 ± 0.775
1.465AlaHis: 1.465 ± 0.686
3.808AlaIle: 3.808 ± 1.319
6.444AlaLys: 6.444 ± 1.734
3.808AlaLeu: 3.808 ± 0.917
1.465AlaMet: 1.465 ± 0.684
2.929AlaAsn: 2.929 ± 1.02
0.586AlaPro: 0.586 ± 0.415
3.515AlaGln: 3.515 ± 0.703
3.808AlaArg: 3.808 ± 1.021
2.636AlaSer: 2.636 ± 0.847
4.394AlaThr: 4.394 ± 1.146
1.757AlaVal: 1.757 ± 0.696
0.293AlaTrp: 0.293 ± 0.303
3.808AlaTyr: 3.808 ± 1.332
0.0AlaXaa: 0.0 ± 0.0
Cys
0.293CysAla: 0.293 ± 0.258
0.0CysCys: 0.0 ± 0.0
0.293CysAsp: 0.293 ± 0.274
0.293CysGlu: 0.293 ± 0.273
0.293CysPhe: 0.293 ± 0.317
0.586CysGly: 0.586 ± 0.36
0.293CysHis: 0.293 ± 0.273
0.586CysIle: 0.586 ± 0.372
0.586CysLys: 0.586 ± 0.409
0.879CysLeu: 0.879 ± 0.423
0.293CysMet: 0.293 ± 0.322
0.293CysAsn: 0.293 ± 0.284
0.879CysPro: 0.879 ± 0.423
0.0CysGln: 0.0 ± 0.0
0.293CysArg: 0.293 ± 0.317
0.293CysSer: 0.293 ± 0.307
0.293CysThr: 0.293 ± 0.269
0.586CysVal: 0.586 ± 0.413
0.0CysTrp: 0.0 ± 0.0
0.293CysTyr: 0.293 ± 0.303
0.0CysXaa: 0.0 ± 0.0
Asp
1.465AspAla: 1.465 ± 0.544
0.879AspCys: 0.879 ± 0.393
4.101AspAsp: 4.101 ± 1.093
2.636AspGlu: 2.636 ± 0.759
4.101AspPhe: 4.101 ± 0.765
2.929AspGly: 2.929 ± 0.939
0.0AspHis: 0.0 ± 0.0
5.565AspIle: 5.565 ± 0.897
5.858AspLys: 5.858 ± 1.588
6.444AspLeu: 6.444 ± 1.174
1.172AspMet: 1.172 ± 0.459
5.565AspAsn: 5.565 ± 0.881
0.879AspPro: 0.879 ± 0.452
0.586AspGln: 0.586 ± 0.388
2.929AspArg: 2.929 ± 1.028
3.808AspSer: 3.808 ± 1.536
3.808AspThr: 3.808 ± 1.161
3.515AspVal: 3.515 ± 0.997
0.293AspTrp: 0.293 ± 0.284
2.343AspTyr: 2.343 ± 0.776
0.0AspXaa: 0.0 ± 0.0
Glu
3.515GluAla: 3.515 ± 0.983
1.172GluCys: 1.172 ± 0.478
4.394GluAsp: 4.394 ± 1.249
3.808GluGlu: 3.808 ± 0.833
4.394GluPhe: 4.394 ± 1.224
3.222GluGly: 3.222 ± 1.023
1.172GluHis: 1.172 ± 0.553
8.787GluIle: 8.787 ± 1.115
9.08GluLys: 9.08 ± 1.671
8.494GluLeu: 8.494 ± 1.272
2.05GluMet: 2.05 ± 0.818
5.565GluAsn: 5.565 ± 1.27
0.879GluPro: 0.879 ± 0.599
4.101GluGln: 4.101 ± 1.032
2.929GluArg: 2.929 ± 0.822
5.272GluSer: 5.272 ± 1.27
5.272GluThr: 5.272 ± 0.929
1.757GluVal: 1.757 ± 0.699
0.586GluTrp: 0.586 ± 0.372
3.515GluTyr: 3.515 ± 1.295
0.0GluXaa: 0.0 ± 0.0
Phe
1.757PheAla: 1.757 ± 0.757
0.586PheCys: 0.586 ± 0.569
2.636PheAsp: 2.636 ± 0.96
3.808PheGlu: 3.808 ± 1.172
1.757PhePhe: 1.757 ± 0.681
1.465PheGly: 1.465 ± 0.465
1.172PheHis: 1.172 ± 0.478
2.636PheIle: 2.636 ± 0.772
4.394PheLys: 4.394 ± 1.294
4.394PheLeu: 4.394 ± 1.029
0.879PheMet: 0.879 ± 0.476
2.343PheAsn: 2.343 ± 0.827
0.879PhePro: 0.879 ± 0.59
1.757PheGln: 1.757 ± 0.721
1.465PheArg: 1.465 ± 0.495
2.929PheSer: 2.929 ± 0.753
1.465PheThr: 1.465 ± 0.728
1.465PheVal: 1.465 ± 0.899
0.586PheTrp: 0.586 ± 0.398
2.05PheTyr: 2.05 ± 0.761
0.0PheXaa: 0.0 ± 0.0
Gly
2.636GlyAla: 2.636 ± 0.857
0.0GlyCys: 0.0 ± 0.0
0.586GlyAsp: 0.586 ± 0.442
4.101GlyGlu: 4.101 ± 1.147
1.172GlyPhe: 1.172 ± 0.555
2.05GlyGly: 2.05 ± 1.05
1.172GlyHis: 1.172 ± 0.592
3.222GlyIle: 3.222 ± 0.7
4.394GlyLys: 4.394 ± 0.994
4.979GlyLeu: 4.979 ± 1.138
1.172GlyMet: 1.172 ± 0.538
1.465GlyAsn: 1.465 ± 0.82
0.0GlyPro: 0.0 ± 0.0
3.222GlyGln: 3.222 ± 0.935
1.757GlyArg: 1.757 ± 0.734
3.222GlySer: 3.222 ± 1.34
2.343GlyThr: 2.343 ± 0.693
2.636GlyVal: 2.636 ± 0.757
0.293GlyTrp: 0.293 ± 0.284
4.101GlyTyr: 4.101 ± 1.241
0.0GlyXaa: 0.0 ± 0.0
His
2.343HisAla: 2.343 ± 0.898
0.0HisCys: 0.0 ± 0.0
1.172HisAsp: 1.172 ± 0.526
0.879HisGlu: 0.879 ± 0.503
0.879HisPhe: 0.879 ± 0.666
0.586HisGly: 0.586 ± 0.369
0.293HisHis: 0.293 ± 0.317
0.879HisIle: 0.879 ± 0.479
0.293HisLys: 0.293 ± 0.302
1.757HisLeu: 1.757 ± 0.675
0.0HisMet: 0.0 ± 0.0
1.172HisAsn: 1.172 ± 0.69
0.586HisPro: 0.586 ± 0.364
0.879HisGln: 0.879 ± 0.487
1.465HisArg: 1.465 ± 0.732
1.172HisSer: 1.172 ± 0.648
1.172HisThr: 1.172 ± 0.601
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
1.465HisTyr: 1.465 ± 0.712
0.0HisXaa: 0.0 ± 0.0
Ile
2.636IleAla: 2.636 ± 0.806
0.0IleCys: 0.0 ± 0.0
6.151IleAsp: 6.151 ± 1.173
7.03IleGlu: 7.03 ± 1.636
2.929IlePhe: 2.929 ± 0.943
1.465IleGly: 1.465 ± 0.451
1.172IleHis: 1.172 ± 0.711
5.565IleIle: 5.565 ± 1.298
9.666IleLys: 9.666 ± 1.877
9.08IleLeu: 9.08 ± 1.288
0.879IleMet: 0.879 ± 0.461
4.394IleAsn: 4.394 ± 0.861
2.636IlePro: 2.636 ± 0.874
2.636IleGln: 2.636 ± 0.475
2.636IleArg: 2.636 ± 0.741
5.565IleSer: 5.565 ± 1.147
4.101IleThr: 4.101 ± 1.193
2.636IleVal: 2.636 ± 0.63
0.293IleTrp: 0.293 ± 0.274
1.465IleTyr: 1.465 ± 0.636
0.0IleXaa: 0.0 ± 0.0
Lys
6.444LysAla: 6.444 ± 1.111
0.879LysCys: 0.879 ± 0.471
6.444LysAsp: 6.444 ± 1.394
10.545LysGlu: 10.545 ± 1.616
2.636LysPhe: 2.636 ± 0.797
5.272LysGly: 5.272 ± 1.345
2.05LysHis: 2.05 ± 0.939
4.979LysIle: 4.979 ± 1.143
6.737LysLys: 6.737 ± 1.317
9.959LysLeu: 9.959 ± 1.937
2.05LysMet: 2.05 ± 0.765
7.03LysAsn: 7.03 ± 1.222
2.05LysPro: 2.05 ± 0.857
4.979LysGln: 4.979 ± 0.855
5.565LysArg: 5.565 ± 1.128
8.202LysSer: 8.202 ± 0.988
6.151LysThr: 6.151 ± 1.82
3.808LysVal: 3.808 ± 0.768
0.586LysTrp: 0.586 ± 0.418
4.101LysTyr: 4.101 ± 1.09
0.0LysXaa: 0.0 ± 0.0
Leu
9.08LeuAla: 9.08 ± 1.772
0.293LeuCys: 0.293 ± 0.322
8.787LeuAsp: 8.787 ± 1.49
9.08LeuGlu: 9.08 ± 1.207
2.636LeuPhe: 2.636 ± 0.853
4.979LeuGly: 4.979 ± 1.002
0.879LeuHis: 0.879 ± 0.623
6.151LeuIle: 6.151 ± 1.212
9.373LeuLys: 9.373 ± 1.688
9.373LeuLeu: 9.373 ± 1.726
2.929LeuMet: 2.929 ± 0.832
8.202LeuAsn: 8.202 ± 1.586
3.222LeuPro: 3.222 ± 0.859
5.858LeuGln: 5.858 ± 1.081
3.808LeuArg: 3.808 ± 0.865
6.151LeuSer: 6.151 ± 1.178
7.323LeuThr: 7.323 ± 1.385
4.394LeuVal: 4.394 ± 1.013
0.0LeuTrp: 0.0 ± 0.0
3.222LeuTyr: 3.222 ± 0.822
0.0LeuXaa: 0.0 ± 0.0
Met
2.05MetAla: 2.05 ± 0.968
0.293MetCys: 0.293 ± 0.269
1.465MetAsp: 1.465 ± 0.705
1.757MetGlu: 1.757 ± 0.775
0.293MetPhe: 0.293 ± 0.274
0.879MetGly: 0.879 ± 0.467
0.0MetHis: 0.0 ± 0.0
1.757MetIle: 1.757 ± 0.663
3.222MetLys: 3.222 ± 0.639
0.879MetLeu: 0.879 ± 0.423
0.293MetMet: 0.293 ± 0.306
2.343MetAsn: 2.343 ± 0.867
0.879MetPro: 0.879 ± 0.465
0.293MetGln: 0.293 ± 0.258
2.05MetArg: 2.05 ± 0.722
0.879MetSer: 0.879 ± 0.455
2.343MetThr: 2.343 ± 0.806
0.586MetVal: 0.586 ± 0.394
0.0MetTrp: 0.0 ± 0.0
0.586MetTyr: 0.586 ± 0.419
0.0MetXaa: 0.0 ± 0.0
Asn
3.515AsnAla: 3.515 ± 0.66
0.293AsnCys: 0.293 ± 0.273
1.172AsnAsp: 1.172 ± 0.516
2.929AsnGlu: 2.929 ± 0.986
2.05AsnPhe: 2.05 ± 0.669
3.808AsnGly: 3.808 ± 0.882
2.343AsnHis: 2.343 ± 1.025
4.101AsnIle: 4.101 ± 1.683
6.151AsnLys: 6.151 ± 1.449
6.444AsnLeu: 6.444 ± 1.441
1.757AsnMet: 1.757 ± 0.843
5.858AsnAsn: 5.858 ± 2.402
1.465AsnPro: 1.465 ± 0.59
4.979AsnGln: 4.979 ± 1.08
2.636AsnArg: 2.636 ± 0.686
4.394AsnSer: 4.394 ± 0.941
5.272AsnThr: 5.272 ± 1.212
1.172AsnVal: 1.172 ± 0.557
1.465AsnTrp: 1.465 ± 0.589
3.515AsnTyr: 3.515 ± 0.817
0.0AsnXaa: 0.0 ± 0.0
Pro
1.172ProAla: 1.172 ± 0.62
0.293ProCys: 0.293 ± 0.263
2.343ProAsp: 2.343 ± 0.747
2.05ProGlu: 2.05 ± 0.841
2.05ProPhe: 2.05 ± 0.862
0.293ProGly: 0.293 ± 0.256
0.293ProHis: 0.293 ± 0.307
1.757ProIle: 1.757 ± 0.604
3.515ProLys: 3.515 ± 1.185
1.172ProLeu: 1.172 ± 0.481
0.0ProMet: 0.0 ± 0.0
1.465ProAsn: 1.465 ± 0.434
0.879ProPro: 0.879 ± 0.652
0.586ProGln: 0.586 ± 0.379
1.757ProArg: 1.757 ± 0.692
1.465ProSer: 1.465 ± 0.66
0.879ProThr: 0.879 ± 0.472
0.879ProVal: 0.879 ± 0.42
0.0ProTrp: 0.0 ± 0.0
1.172ProTyr: 1.172 ± 0.472
0.0ProXaa: 0.0 ± 0.0
Gln
4.394GlnAla: 4.394 ± 0.89
0.293GlnCys: 0.293 ± 0.317
3.222GlnAsp: 3.222 ± 1.236
3.222GlnGlu: 3.222 ± 0.533
2.05GlnPhe: 2.05 ± 0.903
1.172GlnGly: 1.172 ± 0.572
0.586GlnHis: 0.586 ± 0.402
3.808GlnIle: 3.808 ± 0.993
4.101GlnLys: 4.101 ± 0.918
3.222GlnLeu: 3.222 ± 1.084
0.879GlnMet: 0.879 ± 0.673
3.515GlnAsn: 3.515 ± 0.898
0.879GlnPro: 0.879 ± 0.461
1.757GlnGln: 1.757 ± 0.66
1.172GlnArg: 1.172 ± 0.652
1.465GlnSer: 1.465 ± 0.731
1.757GlnThr: 1.757 ± 0.723
3.222GlnVal: 3.222 ± 0.842
0.879GlnTrp: 0.879 ± 0.457
1.465GlnTyr: 1.465 ± 0.732
0.0GlnXaa: 0.0 ± 0.0
Arg
1.757ArgAla: 1.757 ± 0.682
0.293ArgCys: 0.293 ± 0.267
2.929ArgAsp: 2.929 ± 0.825
5.272ArgGlu: 5.272 ± 1.244
1.757ArgPhe: 1.757 ± 0.789
0.879ArgGly: 0.879 ± 0.42
0.586ArgHis: 0.586 ± 0.349
3.222ArgIle: 3.222 ± 0.903
4.979ArgLys: 4.979 ± 1.147
6.737ArgLeu: 6.737 ± 1.345
1.757ArgMet: 1.757 ± 0.594
2.343ArgAsn: 2.343 ± 0.806
1.172ArgPro: 1.172 ± 0.644
1.757ArgGln: 1.757 ± 0.573
1.757ArgArg: 1.757 ± 0.771
1.757ArgSer: 1.757 ± 0.794
2.05ArgThr: 2.05 ± 0.586
1.172ArgVal: 1.172 ± 0.56
0.586ArgTrp: 0.586 ± 0.377
2.636ArgTyr: 2.636 ± 0.683
0.0ArgXaa: 0.0 ± 0.0
Ser
2.929SerAla: 2.929 ± 1.841
0.293SerCys: 0.293 ± 0.256
4.101SerAsp: 4.101 ± 1.135
6.151SerGlu: 6.151 ± 1.383
2.05SerPhe: 2.05 ± 0.749
5.272SerGly: 5.272 ± 1.032
0.586SerHis: 0.586 ± 0.368
4.687SerIle: 4.687 ± 1.104
6.444SerLys: 6.444 ± 1.452
4.979SerLeu: 4.979 ± 1.156
1.172SerMet: 1.172 ± 0.707
3.515SerAsn: 3.515 ± 1.056
1.465SerPro: 1.465 ± 0.474
0.586SerGln: 0.586 ± 0.383
3.222SerArg: 3.222 ± 0.829
4.101SerSer: 4.101 ± 1.267
4.101SerThr: 4.101 ± 1.034
2.929SerVal: 2.929 ± 0.765
0.879SerTrp: 0.879 ± 0.48
2.05SerTyr: 2.05 ± 0.83
0.0SerXaa: 0.0 ± 0.0
Thr
2.929ThrAla: 2.929 ± 1.088
0.293ThrCys: 0.293 ± 0.263
1.757ThrAsp: 1.757 ± 0.696
4.101ThrGlu: 4.101 ± 1.158
2.05ThrPhe: 2.05 ± 0.822
4.101ThrGly: 4.101 ± 0.829
1.757ThrHis: 1.757 ± 0.537
4.101ThrIle: 4.101 ± 1.069
5.565ThrLys: 5.565 ± 1.203
9.08ThrLeu: 9.08 ± 1.418
1.757ThrMet: 1.757 ± 0.601
2.929ThrAsn: 2.929 ± 0.891
2.05ThrPro: 2.05 ± 0.558
1.465ThrGln: 1.465 ± 0.758
2.05ThrArg: 2.05 ± 0.713
2.929ThrSer: 2.929 ± 0.958
3.515ThrThr: 3.515 ± 1.207
6.737ThrVal: 6.737 ± 1.743
0.293ThrTrp: 0.293 ± 0.302
2.636ThrTyr: 2.636 ± 1.412
0.0ThrXaa: 0.0 ± 0.0
Val
2.05ValAla: 2.05 ± 0.842
0.293ValCys: 0.293 ± 0.274
2.05ValAsp: 2.05 ± 0.804
3.808ValGlu: 3.808 ± 1.007
1.172ValPhe: 1.172 ± 0.469
2.343ValGly: 2.343 ± 0.925
0.0ValHis: 0.0 ± 0.0
4.101ValIle: 4.101 ± 1.081
3.222ValLys: 3.222 ± 1.165
4.979ValLeu: 4.979 ± 1.066
0.586ValMet: 0.586 ± 0.382
2.05ValAsn: 2.05 ± 0.628
1.172ValPro: 1.172 ± 0.5
2.343ValGln: 2.343 ± 0.975
2.05ValArg: 2.05 ± 0.707
2.636ValSer: 2.636 ± 0.703
3.515ValThr: 3.515 ± 0.924
1.465ValVal: 1.465 ± 0.66
0.293ValTrp: 0.293 ± 0.263
2.343ValTyr: 2.343 ± 0.742
0.0ValXaa: 0.0 ± 0.0
Trp
1.172TrpAla: 1.172 ± 0.434
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.757TrpGlu: 1.757 ± 0.72
0.0TrpPhe: 0.0 ± 0.0
0.293TrpGly: 0.293 ± 0.286
0.293TrpHis: 0.293 ± 0.303
0.586TrpIle: 0.586 ± 0.427
0.879TrpLys: 0.879 ± 0.475
0.879TrpLeu: 0.879 ± 0.54
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.293TrpPro: 0.293 ± 0.255
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.586TrpSer: 0.586 ± 0.35
0.0TrpThr: 0.0 ± 0.0
0.586TrpVal: 0.586 ± 0.396
0.0TrpTrp: 0.0 ± 0.0
0.293TrpTyr: 0.293 ± 0.317
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.465TyrAla: 1.465 ± 0.726
0.879TyrCys: 0.879 ± 0.466
2.636TyrAsp: 2.636 ± 0.77
2.636TyrGlu: 2.636 ± 0.669
2.636TyrPhe: 2.636 ± 0.885
0.586TyrGly: 0.586 ± 0.39
0.879TyrHis: 0.879 ± 0.524
2.636TyrIle: 2.636 ± 0.814
5.565TyrLys: 5.565 ± 1.715
8.202TyrLeu: 8.202 ± 1.486
1.465TyrMet: 1.465 ± 0.671
2.343TyrAsn: 2.343 ± 1.182
1.172TyrPro: 1.172 ± 0.539
1.757TyrGln: 1.757 ± 0.598
2.05TyrArg: 2.05 ± 0.615
2.05TyrSer: 2.05 ± 0.748
2.343TyrThr: 2.343 ± 0.62
1.172TyrVal: 1.172 ± 0.532
0.293TyrTrp: 0.293 ± 0.284
1.757TyrTyr: 1.757 ± 0.965
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 24 proteins (3415 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski