Amino acid dipepetide frequency for Prochlorococcus phage P-SSM4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.708AlaAla: 5.708 ± 0.683
0.317AlaCys: 0.317 ± 0.073
4.07AlaAsp: 4.07 ± 0.364
3.982AlaGlu: 3.982 ± 0.315
2.502AlaPhe: 2.502 ± 0.249
5.743AlaGly: 5.743 ± 0.504
1.039AlaHis: 1.039 ± 0.128
4.721AlaIle: 4.721 ± 0.349
4.246AlaLys: 4.246 ± 0.484
4.475AlaLeu: 4.475 ± 0.331
1.48AlaMet: 1.48 ± 0.206
4.492AlaAsn: 4.492 ± 0.4
2.414AlaPro: 2.414 ± 0.25
2.766AlaGln: 2.766 ± 0.211
2.431AlaArg: 2.431 ± 0.242
5.585AlaSer: 5.585 ± 0.68
6.871AlaThr: 6.871 ± 0.969
4.158AlaVal: 4.158 ± 0.414
0.846AlaTrp: 0.846 ± 0.138
2.237AlaTyr: 2.237 ± 0.184
0.0AlaXaa: 0.0 ± 0.0
Cys
0.634CysAla: 0.634 ± 0.108
0.106CysCys: 0.106 ± 0.05
0.476CysAsp: 0.476 ± 0.125
0.458CysGlu: 0.458 ± 0.105
0.299CysPhe: 0.299 ± 0.088
0.493CysGly: 0.493 ± 0.107
0.159CysHis: 0.159 ± 0.051
0.458CysIle: 0.458 ± 0.114
0.493CysLys: 0.493 ± 0.117
0.687CysLeu: 0.687 ± 0.152
0.229CysMet: 0.229 ± 0.064
0.511CysAsn: 0.511 ± 0.107
0.229CysPro: 0.229 ± 0.076
0.37CysGln: 0.37 ± 0.072
0.282CysArg: 0.282 ± 0.092
0.581CysSer: 0.581 ± 0.098
0.493CysThr: 0.493 ± 0.097
0.352CysVal: 0.352 ± 0.106
0.106CysTrp: 0.106 ± 0.044
0.458CysTyr: 0.458 ± 0.094
0.0CysXaa: 0.0 ± 0.0
Asp
4.739AspAla: 4.739 ± 0.368
0.493AspCys: 0.493 ± 0.128
4.246AspAsp: 4.246 ± 0.37
3.929AspGlu: 3.929 ± 0.42
2.819AspPhe: 2.819 ± 0.297
5.356AspGly: 5.356 ± 0.419
0.987AspHis: 0.987 ± 0.129
4.633AspIle: 4.633 ± 0.291
3.682AspLys: 3.682 ± 0.462
5.144AspLeu: 5.144 ± 0.336
1.445AspMet: 1.445 ± 0.206
3.682AspAsn: 3.682 ± 0.284
2.924AspPro: 2.924 ± 0.213
2.396AspGln: 2.396 ± 0.221
2.748AspArg: 2.748 ± 0.261
4.034AspSer: 4.034 ± 0.262
4.387AspThr: 4.387 ± 0.3
3.982AspVal: 3.982 ± 0.278
0.81AspTrp: 0.81 ± 0.135
3.33AspTyr: 3.33 ± 0.254
0.0AspXaa: 0.0 ± 0.0
Glu
3.471GluAla: 3.471 ± 0.273
0.546GluCys: 0.546 ± 0.106
3.841GluAsp: 3.841 ± 0.391
4.246GluGlu: 4.246 ± 0.579
2.942GluPhe: 2.942 ± 0.243
3.876GluGly: 3.876 ± 0.343
1.128GluHis: 1.128 ± 0.171
4.246GluIle: 4.246 ± 0.32
3.753GluLys: 3.753 ± 0.523
4.44GluLeu: 4.44 ± 0.353
1.392GluMet: 1.392 ± 0.259
2.819GluAsn: 2.819 ± 0.296
1.709GluPro: 1.709 ± 0.193
2.061GluGln: 2.061 ± 0.24
2.66GluArg: 2.66 ± 0.337
3.523GluSer: 3.523 ± 0.342
3.911GluThr: 3.911 ± 0.31
4.087GluVal: 4.087 ± 0.216
0.775GluTrp: 0.775 ± 0.127
2.766GluTyr: 2.766 ± 0.282
0.0GluXaa: 0.0 ± 0.0
Phe
2.766PheAla: 2.766 ± 0.232
0.335PheCys: 0.335 ± 0.083
3.629PheAsp: 3.629 ± 0.267
2.555PheGlu: 2.555 ± 0.245
1.709PhePhe: 1.709 ± 0.199
2.96PheGly: 2.96 ± 0.31
0.617PheHis: 0.617 ± 0.147
2.801PheIle: 2.801 ± 0.237
2.942PheLys: 2.942 ± 0.35
3.013PheLeu: 3.013 ± 0.389
1.004PheMet: 1.004 ± 0.162
2.748PheAsn: 2.748 ± 0.254
1.497PhePro: 1.497 ± 0.169
1.603PheGln: 1.603 ± 0.153
1.568PheArg: 1.568 ± 0.165
3.171PheSer: 3.171 ± 0.236
3.242PheThr: 3.242 ± 0.343
2.784PheVal: 2.784 ± 0.305
0.299PheTrp: 0.299 ± 0.081
1.797PheTyr: 1.797 ± 0.161
0.0PheXaa: 0.0 ± 0.0
Gly
5.884GlyAla: 5.884 ± 0.641
0.564GlyCys: 0.564 ± 0.111
5.003GlyAsp: 5.003 ± 0.379
3.612GlyGlu: 3.612 ± 0.239
3.4GlyPhe: 3.4 ± 0.283
8.139GlyGly: 8.139 ± 1.009
1.163GlyHis: 1.163 ± 0.154
4.686GlyIle: 4.686 ± 0.339
4.334GlyLys: 4.334 ± 0.482
4.44GlyLeu: 4.44 ± 0.344
1.638GlyMet: 1.638 ± 0.277
5.056GlyAsn: 5.056 ± 0.9
1.533GlyPro: 1.533 ± 0.186
2.731GlyGln: 2.731 ± 0.33
2.748GlyArg: 2.748 ± 0.242
6.378GlySer: 6.378 ± 0.631
7.558GlyThr: 7.558 ± 1.036
4.862GlyVal: 4.862 ± 0.336
1.11GlyTrp: 1.11 ± 0.145
3.488GlyTyr: 3.488 ± 0.321
0.0GlyXaa: 0.0 ± 0.0
His
0.898HisAla: 0.898 ± 0.133
0.211HisCys: 0.211 ± 0.064
0.898HisAsp: 0.898 ± 0.142
0.951HisGlu: 0.951 ± 0.182
0.564HisPhe: 0.564 ± 0.11
1.216HisGly: 1.216 ± 0.169
0.37HisHis: 0.37 ± 0.109
1.128HisIle: 1.128 ± 0.166
1.022HisLys: 1.022 ± 0.193
0.969HisLeu: 0.969 ± 0.162
0.352HisMet: 0.352 ± 0.082
1.004HisAsn: 1.004 ± 0.147
0.951HisPro: 0.951 ± 0.154
0.44HisGln: 0.44 ± 0.101
0.669HisArg: 0.669 ± 0.138
1.057HisSer: 1.057 ± 0.145
1.198HisThr: 1.198 ± 0.206
0.758HisVal: 0.758 ± 0.127
0.211HisTrp: 0.211 ± 0.064
0.951HisTyr: 0.951 ± 0.157
0.0HisXaa: 0.0 ± 0.0
Ile
4.598IleAla: 4.598 ± 0.293
0.511IleCys: 0.511 ± 0.105
4.704IleAsp: 4.704 ± 0.274
4.193IleGlu: 4.193 ± 0.375
2.854IlePhe: 2.854 ± 0.227
4.581IleGly: 4.581 ± 0.37
0.898IleHis: 0.898 ± 0.147
3.717IleIle: 3.717 ± 0.334
4.175IleLys: 4.175 ± 0.265
4.316IleLeu: 4.316 ± 0.36
1.233IleMet: 1.233 ± 0.188
4.334IleAsn: 4.334 ± 0.298
3.171IlePro: 3.171 ± 0.279
2.713IleGln: 2.713 ± 0.241
2.308IleArg: 2.308 ± 0.218
4.387IleSer: 4.387 ± 0.386
5.884IleThr: 5.884 ± 0.786
4.158IleVal: 4.158 ± 0.311
0.722IleTrp: 0.722 ± 0.11
2.343IleTyr: 2.343 ± 0.264
0.0IleXaa: 0.0 ± 0.0
Lys
3.594LysAla: 3.594 ± 0.422
0.581LysCys: 0.581 ± 0.108
4.475LysAsp: 4.475 ± 0.46
4.369LysGlu: 4.369 ± 0.624
2.766LysPhe: 2.766 ± 0.293
3.858LysGly: 3.858 ± 0.527
1.075LysHis: 1.075 ± 0.181
4.563LysIle: 4.563 ± 0.397
5.461LysLys: 5.461 ± 0.887
4.704LysLeu: 4.704 ± 0.378
1.497LysMet: 1.497 ± 0.278
3.224LysAsn: 3.224 ± 0.411
2.237LysPro: 2.237 ± 0.24
2.079LysGln: 2.079 ± 0.304
2.449LysArg: 2.449 ± 0.31
3.999LysSer: 3.999 ± 0.394
3.805LysThr: 3.805 ± 0.2
3.982LysVal: 3.982 ± 0.284
1.092LysTrp: 1.092 ± 0.144
3.294LysTyr: 3.294 ± 0.412
0.0LysXaa: 0.0 ± 0.0
Leu
4.563LeuAla: 4.563 ± 0.314
0.634LeuCys: 0.634 ± 0.123
5.514LeuAsp: 5.514 ± 0.331
3.717LeuGlu: 3.717 ± 0.36
2.678LeuPhe: 2.678 ± 0.245
4.51LeuGly: 4.51 ± 0.455
1.268LeuHis: 1.268 ± 0.186
3.841LeuIle: 3.841 ± 0.37
5.356LeuLys: 5.356 ± 0.468
4.792LeuLeu: 4.792 ± 0.394
1.216LeuMet: 1.216 ± 0.21
4.369LeuAsn: 4.369 ± 0.311
2.766LeuPro: 2.766 ± 0.25
2.678LeuGln: 2.678 ± 0.26
3.136LeuArg: 3.136 ± 0.246
4.862LeuSer: 4.862 ± 0.377
6.166LeuThr: 6.166 ± 0.6
4.034LeuVal: 4.034 ± 0.249
0.476LeuTrp: 0.476 ± 0.115
3.154LeuTyr: 3.154 ± 0.289
0.0LeuXaa: 0.0 ± 0.0
Met
1.48MetAla: 1.48 ± 0.208
0.106MetCys: 0.106 ± 0.042
1.251MetAsp: 1.251 ± 0.206
1.357MetGlu: 1.357 ± 0.213
0.793MetPhe: 0.793 ± 0.134
1.004MetGly: 1.004 ± 0.242
0.352MetHis: 0.352 ± 0.108
1.233MetIle: 1.233 ± 0.18
2.079MetLys: 2.079 ± 0.383
1.286MetLeu: 1.286 ± 0.208
0.37MetMet: 0.37 ± 0.097
1.163MetAsn: 1.163 ± 0.16
0.934MetPro: 0.934 ± 0.224
0.775MetGln: 0.775 ± 0.158
1.145MetArg: 1.145 ± 0.185
1.462MetSer: 1.462 ± 0.201
1.621MetThr: 1.621 ± 0.189
1.075MetVal: 1.075 ± 0.15
0.264MetTrp: 0.264 ± 0.08
0.775MetTyr: 0.775 ± 0.132
0.0MetXaa: 0.0 ± 0.0
Asn
4.14AsnAla: 4.14 ± 0.476
0.37AsnCys: 0.37 ± 0.09
2.977AsnAsp: 2.977 ± 0.229
3.136AsnGlu: 3.136 ± 0.222
3.048AsnPhe: 3.048 ± 0.251
4.986AsnGly: 4.986 ± 0.585
0.898AsnHis: 0.898 ± 0.118
4.052AsnIle: 4.052 ± 0.33
3.383AsnLys: 3.383 ± 0.334
4.898AsnLeu: 4.898 ± 0.553
1.004AsnMet: 1.004 ± 0.166
3.982AsnAsn: 3.982 ± 0.347
2.713AsnPro: 2.713 ± 0.243
2.431AsnGln: 2.431 ± 0.215
2.202AsnArg: 2.202 ± 0.171
4.158AsnSer: 4.158 ± 0.361
4.246AsnThr: 4.246 ± 0.417
4.193AsnVal: 4.193 ± 0.427
0.652AsnTrp: 0.652 ± 0.119
2.907AsnTyr: 2.907 ± 0.3
0.0AsnXaa: 0.0 ± 0.0
Pro
2.185ProAla: 2.185 ± 0.23
0.194ProCys: 0.194 ± 0.07
2.431ProAsp: 2.431 ± 0.228
2.343ProGlu: 2.343 ± 0.238
1.586ProPhe: 1.586 ± 0.211
2.731ProGly: 2.731 ± 0.284
0.863ProHis: 0.863 ± 0.145
2.237ProIle: 2.237 ± 0.232
2.519ProLys: 2.519 ± 0.372
2.378ProLeu: 2.378 ± 0.249
0.511ProMet: 0.511 ± 0.121
2.308ProAsn: 2.308 ± 0.208
1.497ProPro: 1.497 ± 0.262
1.039ProGln: 1.039 ± 0.111
1.48ProArg: 1.48 ± 0.236
2.59ProSer: 2.59 ± 0.254
3.171ProThr: 3.171 ± 0.331
2.678ProVal: 2.678 ± 0.226
0.581ProTrp: 0.581 ± 0.119
1.85ProTyr: 1.85 ± 0.2
0.0ProXaa: 0.0 ± 0.0
Gln
2.414GlnAla: 2.414 ± 0.222
0.423GlnCys: 0.423 ± 0.107
2.449GlnAsp: 2.449 ± 0.212
2.431GlnGlu: 2.431 ± 0.276
1.638GlnPhe: 1.638 ± 0.204
2.607GlnGly: 2.607 ± 0.224
0.546GlnHis: 0.546 ± 0.117
2.308GlnIle: 2.308 ± 0.159
2.29GlnLys: 2.29 ± 0.246
2.784GlnLeu: 2.784 ± 0.238
0.916GlnMet: 0.916 ± 0.177
2.061GlnAsn: 2.061 ± 0.195
1.075GlnPro: 1.075 ± 0.13
1.251GlnGln: 1.251 ± 0.171
1.462GlnArg: 1.462 ± 0.158
2.237GlnSer: 2.237 ± 0.172
2.819GlnThr: 2.819 ± 0.295
2.396GlnVal: 2.396 ± 0.277
0.529GlnTrp: 0.529 ± 0.091
1.674GlnTyr: 1.674 ± 0.174
0.0GlnXaa: 0.0 ± 0.0
Arg
2.466ArgAla: 2.466 ± 0.217
0.211ArgCys: 0.211 ± 0.052
2.202ArgAsp: 2.202 ± 0.237
2.449ArgGlu: 2.449 ± 0.361
1.832ArgPhe: 1.832 ± 0.204
2.678ArgGly: 2.678 ± 0.341
0.74ArgHis: 0.74 ± 0.138
2.801ArgIle: 2.801 ± 0.215
2.889ArgLys: 2.889 ± 0.399
3.33ArgLeu: 3.33 ± 0.222
1.145ArgMet: 1.145 ± 0.216
1.762ArgAsn: 1.762 ± 0.216
1.233ArgPro: 1.233 ± 0.151
1.55ArgGln: 1.55 ± 0.157
1.638ArgArg: 1.638 ± 0.255
2.255ArgSer: 2.255 ± 0.209
2.466ArgThr: 2.466 ± 0.192
2.889ArgVal: 2.889 ± 0.236
0.564ArgTrp: 0.564 ± 0.107
2.114ArgTyr: 2.114 ± 0.204
0.0ArgXaa: 0.0 ± 0.0
Ser
5.796SerAla: 5.796 ± 0.522
0.529SerCys: 0.529 ± 0.127
4.211SerAsp: 4.211 ± 0.256
3.154SerGlu: 3.154 ± 0.254
3.136SerPhe: 3.136 ± 0.227
7.153SerGly: 7.153 ± 0.867
0.934SerHis: 0.934 ± 0.138
4.933SerIle: 4.933 ± 0.489
3.841SerLys: 3.841 ± 0.4
4.44SerLeu: 4.44 ± 0.252
1.392SerMet: 1.392 ± 0.196
3.805SerAsn: 3.805 ± 0.503
2.66SerPro: 2.66 ± 0.311
2.273SerGln: 2.273 ± 0.179
2.079SerArg: 2.079 ± 0.173
5.655SerSer: 5.655 ± 0.804
5.902SerThr: 5.902 ± 0.571
4.158SerVal: 4.158 ± 0.292
0.74SerTrp: 0.74 ± 0.157
2.625SerTyr: 2.625 ± 0.291
0.0SerXaa: 0.0 ± 0.0
Thr
6.554ThrAla: 6.554 ± 0.714
0.652ThrCys: 0.652 ± 0.128
4.492ThrAsp: 4.492 ± 0.388
4.034ThrGlu: 4.034 ± 0.292
3.576ThrPhe: 3.576 ± 0.486
7.857ThrGly: 7.857 ± 1.206
0.969ThrHis: 0.969 ± 0.151
6.078ThrIle: 6.078 ± 0.634
3.805ThrLys: 3.805 ± 0.304
5.867ThrLeu: 5.867 ± 0.521
1.092ThrMet: 1.092 ± 0.147
4.968ThrAsn: 4.968 ± 0.563
2.924ThrPro: 2.924 ± 0.296
2.484ThrGln: 2.484 ± 0.212
2.643ThrArg: 2.643 ± 0.235
5.426ThrSer: 5.426 ± 0.8
7.487ThrThr: 7.487 ± 1.179
5.655ThrVal: 5.655 ± 0.794
0.705ThrTrp: 0.705 ± 0.132
2.713ThrTyr: 2.713 ± 0.266
0.0ThrXaa: 0.0 ± 0.0
Val
4.457ValAla: 4.457 ± 0.334
0.423ValCys: 0.423 ± 0.126
4.651ValAsp: 4.651 ± 0.465
4.316ValGlu: 4.316 ± 0.283
2.695ValPhe: 2.695 ± 0.218
5.127ValGly: 5.127 ± 0.396
0.863ValHis: 0.863 ± 0.112
4.034ValIle: 4.034 ± 0.26
3.682ValLys: 3.682 ± 0.262
3.858ValLeu: 3.858 ± 0.281
1.145ValMet: 1.145 ± 0.158
4.316ValAsn: 4.316 ± 0.419
2.643ValPro: 2.643 ± 0.223
2.59ValGln: 2.59 ± 0.223
2.854ValArg: 2.854 ± 0.281
4.933ValSer: 4.933 ± 0.319
4.968ValThr: 4.968 ± 0.558
4.122ValVal: 4.122 ± 0.422
0.546ValTrp: 0.546 ± 0.107
2.29ValTyr: 2.29 ± 0.232
0.0ValXaa: 0.0 ± 0.0
Trp
0.793TrpAla: 0.793 ± 0.147
0.176TrpCys: 0.176 ± 0.06
0.74TrpAsp: 0.74 ± 0.125
0.599TrpGlu: 0.599 ± 0.13
0.529TrpPhe: 0.529 ± 0.116
0.863TrpGly: 0.863 ± 0.135
0.229TrpHis: 0.229 ± 0.085
0.775TrpIle: 0.775 ± 0.123
0.705TrpLys: 0.705 ± 0.128
0.758TrpLeu: 0.758 ± 0.109
0.299TrpMet: 0.299 ± 0.074
0.81TrpAsn: 0.81 ± 0.131
0.229TrpPro: 0.229 ± 0.058
0.405TrpGln: 0.405 ± 0.085
0.511TrpArg: 0.511 ± 0.122
0.74TrpSer: 0.74 ± 0.117
0.863TrpThr: 0.863 ± 0.118
1.022TrpVal: 1.022 ± 0.18
0.176TrpTrp: 0.176 ± 0.064
0.458TrpTyr: 0.458 ± 0.092
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.942TyrAla: 2.942 ± 0.271
0.493TyrCys: 0.493 ± 0.105
3.506TyrAsp: 3.506 ± 0.26
2.361TyrGlu: 2.361 ± 0.3
1.674TyrPhe: 1.674 ± 0.177
2.59TyrGly: 2.59 ± 0.193
0.722TyrHis: 0.722 ± 0.126
2.555TyrIle: 2.555 ± 0.278
2.449TyrLys: 2.449 ± 0.248
3.171TyrLeu: 3.171 ± 0.277
1.145TyrMet: 1.145 ± 0.182
2.96TyrAsn: 2.96 ± 0.321
1.832TyrPro: 1.832 ± 0.225
1.674TyrGln: 1.674 ± 0.177
2.202TyrArg: 2.202 ± 0.264
2.378TyrSer: 2.378 ± 0.209
2.924TyrThr: 2.924 ± 0.486
3.171TyrVal: 3.171 ± 0.22
0.476TyrTrp: 0.476 ± 0.093
1.85TyrTyr: 1.85 ± 0.221
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 221 proteins (56763 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski