Amino acid dipepetide frequency for Serinibacter salmoneus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.856AlaAla: 21.856 ± 0.255
0.889AlaCys: 0.889 ± 0.031
8.078AlaAsp: 8.078 ± 0.112
8.779AlaGlu: 8.779 ± 0.122
3.502AlaPhe: 3.502 ± 0.069
13.376AlaGly: 13.376 ± 0.127
2.78AlaHis: 2.78 ± 0.061
5.171AlaIle: 5.171 ± 0.078
1.94AlaLys: 1.94 ± 0.054
15.566AlaLeu: 15.566 ± 0.175
3.092AlaMet: 3.092 ± 0.058
1.974AlaAsn: 1.974 ± 0.053
7.476AlaPro: 7.476 ± 0.12
4.917AlaGln: 4.917 ± 0.07
10.669AlaArg: 10.669 ± 0.149
7.312AlaSer: 7.312 ± 0.089
8.526AlaThr: 8.526 ± 0.126
12.363AlaVal: 12.363 ± 0.133
2.377AlaTrp: 2.377 ± 0.047
2.276AlaTyr: 2.276 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.738CysAla: 0.738 ± 0.033
0.061CysCys: 0.061 ± 0.009
0.329CysAsp: 0.329 ± 0.017
0.341CysGlu: 0.341 ± 0.019
0.144CysPhe: 0.144 ± 0.013
0.674CysGly: 0.674 ± 0.028
0.134CysHis: 0.134 ± 0.011
0.15CysIle: 0.15 ± 0.014
0.047CysLys: 0.047 ± 0.006
0.515CysLeu: 0.515 ± 0.025
0.075CysMet: 0.075 ± 0.01
0.088CysAsn: 0.088 ± 0.009
0.351CysPro: 0.351 ± 0.023
0.15CysGln: 0.15 ± 0.012
0.364CysArg: 0.364 ± 0.02
0.354CysSer: 0.354 ± 0.018
0.379CysThr: 0.379 ± 0.02
0.455CysVal: 0.455 ± 0.026
0.056CysTrp: 0.056 ± 0.009
0.111CysTyr: 0.111 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
8.265AspAla: 8.265 ± 0.118
0.244AspCys: 0.244 ± 0.015
3.154AspAsp: 3.154 ± 0.078
3.403AspGlu: 3.403 ± 0.07
1.308AspPhe: 1.308 ± 0.043
6.028AspGly: 6.028 ± 0.106
1.292AspHis: 1.292 ± 0.034
1.763AspIle: 1.763 ± 0.046
0.611AspLys: 0.611 ± 0.033
7.556AspLeu: 7.556 ± 0.09
0.812AspMet: 0.812 ± 0.03
0.677AspAsn: 0.677 ± 0.03
4.636AspPro: 4.636 ± 0.085
1.481AspGln: 1.481 ± 0.042
3.798AspArg: 3.798 ± 0.06
2.817AspSer: 2.817 ± 0.051
2.732AspThr: 2.732 ± 0.052
5.306AspVal: 5.306 ± 0.078
0.824AspTrp: 0.824 ± 0.027
1.156AspTyr: 1.156 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
8.429GluAla: 8.429 ± 0.113
0.313GluCys: 0.313 ± 0.016
3.407GluAsp: 3.407 ± 0.067
3.881GluGlu: 3.881 ± 0.077
1.464GluPhe: 1.464 ± 0.048
5.006GluGly: 5.006 ± 0.086
1.632GluHis: 1.632 ± 0.043
2.766GluIle: 2.766 ± 0.051
1.002GluLys: 1.002 ± 0.036
5.859GluLeu: 5.859 ± 0.086
1.103GluMet: 1.103 ± 0.032
1.113GluAsn: 1.113 ± 0.037
3.421GluPro: 3.421 ± 0.079
2.253GluGln: 2.253 ± 0.057
5.554GluArg: 5.554 ± 0.099
3.196GluSer: 3.196 ± 0.055
3.067GluThr: 3.067 ± 0.062
6.184GluVal: 6.184 ± 0.088
0.795GluTrp: 0.795 ± 0.032
1.02GluTyr: 1.02 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.647PheAla: 3.647 ± 0.069
0.159PheCys: 0.159 ± 0.013
1.728PheAsp: 1.728 ± 0.05
1.409PheGlu: 1.409 ± 0.044
0.785PhePhe: 0.785 ± 0.031
2.706PheGly: 2.706 ± 0.049
0.507PheHis: 0.507 ± 0.022
0.794PheIle: 0.794 ± 0.032
0.308PheLys: 0.308 ± 0.019
2.461PheLeu: 2.461 ± 0.054
0.37PheMet: 0.37 ± 0.019
0.473PheAsn: 0.473 ± 0.024
1.186PhePro: 1.186 ± 0.037
0.597PheGln: 0.597 ± 0.029
1.441PheArg: 1.441 ± 0.035
1.514PheSer: 1.514 ± 0.038
1.939PheThr: 1.939 ± 0.045
2.233PheVal: 2.233 ± 0.051
0.38PheTrp: 0.38 ± 0.02
0.548PheTyr: 0.548 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
12.308GlyAla: 12.308 ± 0.147
0.559GlyCys: 0.559 ± 0.023
5.117GlyAsp: 5.117 ± 0.082
6.46GlyGlu: 6.46 ± 0.089
2.589GlyPhe: 2.589 ± 0.059
8.228GlyGly: 8.228 ± 0.151
1.874GlyHis: 1.874 ± 0.044
3.928GlyIle: 3.928 ± 0.07
1.771GlyLys: 1.771 ± 0.046
8.853GlyLeu: 8.853 ± 0.128
2.08GlyMet: 2.08 ± 0.05
1.562GlyAsn: 1.562 ± 0.04
4.122GlyPro: 4.122 ± 0.076
2.505GlyGln: 2.505 ± 0.053
6.4GlyArg: 6.4 ± 0.083
5.768GlySer: 5.768 ± 0.091
5.898GlyThr: 5.898 ± 0.101
8.444GlyVal: 8.444 ± 0.103
1.787GlyTrp: 1.787 ± 0.047
2.247GlyTyr: 2.247 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.791HisAla: 2.791 ± 0.058
0.125HisCys: 0.125 ± 0.012
1.261HisAsp: 1.261 ± 0.04
1.265HisGlu: 1.265 ± 0.038
0.397HisPhe: 0.397 ± 0.023
1.983HisGly: 1.983 ± 0.043
0.634HisHis: 0.634 ± 0.029
0.621HisIle: 0.621 ± 0.025
0.237HisLys: 0.237 ± 0.015
2.49HisLeu: 2.49 ± 0.058
0.31HisMet: 0.31 ± 0.017
0.332HisAsn: 0.332 ± 0.02
1.686HisPro: 1.686 ± 0.044
0.591HisGln: 0.591 ± 0.024
1.757HisArg: 1.757 ± 0.042
0.853HisSer: 0.853 ± 0.03
1.212HisThr: 1.212 ± 0.032
1.73HisVal: 1.73 ± 0.045
0.286HisTrp: 0.286 ± 0.018
0.406HisTyr: 0.406 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
6.244IleAla: 6.244 ± 0.083
0.203IleCys: 0.203 ± 0.012
2.652IleAsp: 2.652 ± 0.06
2.389IleGlu: 2.389 ± 0.057
0.815IlePhe: 0.815 ± 0.035
3.971IleGly: 3.971 ± 0.07
0.613IleHis: 0.613 ± 0.026
1.217IleIle: 1.217 ± 0.045
0.558IleLys: 0.558 ± 0.025
3.13IleLeu: 3.13 ± 0.065
0.514IleMet: 0.514 ± 0.022
0.665IleAsn: 0.665 ± 0.031
2.03IlePro: 2.03 ± 0.045
0.834IleGln: 0.834 ± 0.027
2.304IleArg: 2.304 ± 0.05
1.919IleSer: 1.919 ± 0.05
2.7IleThr: 2.7 ± 0.064
3.513IleVal: 3.513 ± 0.065
0.404IleTrp: 0.404 ± 0.019
0.598IleTyr: 0.598 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
1.768LysAla: 1.768 ± 0.052
0.055LysCys: 0.055 ± 0.008
0.804LysAsp: 0.804 ± 0.035
0.831LysGlu: 0.831 ± 0.033
0.312LysPhe: 0.312 ± 0.017
1.163LysGly: 1.163 ± 0.038
0.331LysHis: 0.331 ± 0.017
0.531LysIle: 0.531 ± 0.027
0.46LysLys: 0.46 ± 0.027
1.073LysLeu: 1.073 ± 0.04
0.278LysMet: 0.278 ± 0.019
0.341LysAsn: 0.341 ± 0.022
0.873LysPro: 0.873 ± 0.034
0.491LysGln: 0.491 ± 0.023
1.149LysArg: 1.149 ± 0.037
0.809LysSer: 0.809 ± 0.029
0.818LysThr: 0.818 ± 0.031
1.311LysVal: 1.311 ± 0.043
0.146LysTrp: 0.146 ± 0.012
0.302LysTyr: 0.302 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
16.964LeuAla: 16.964 ± 0.189
0.472LeuCys: 0.472 ± 0.022
6.3LeuAsp: 6.3 ± 0.081
5.912LeuGlu: 5.912 ± 0.094
2.199LeuPhe: 2.199 ± 0.059
9.659LeuGly: 9.659 ± 0.12
1.904LeuHis: 1.904 ± 0.042
3.582LeuIle: 3.582 ± 0.072
1.156LeuLys: 1.156 ± 0.038
10.505LeuLeu: 10.505 ± 0.159
1.689LeuMet: 1.689 ± 0.047
1.452LeuAsn: 1.452 ± 0.043
5.978LeuPro: 5.978 ± 0.088
2.449LeuGln: 2.449 ± 0.049
8.1LeuArg: 8.1 ± 0.109
4.957LeuSer: 4.957 ± 0.078
7.145LeuThr: 7.145 ± 0.086
9.585LeuVal: 9.585 ± 0.128
1.232LeuTrp: 1.232 ± 0.035
1.463LeuTyr: 1.463 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
2.52MetAla: 2.52 ± 0.052
0.104MetCys: 0.104 ± 0.01
0.918MetAsp: 0.918 ± 0.03
0.719MetGlu: 0.719 ± 0.026
0.468MetPhe: 0.468 ± 0.025
1.304MetGly: 1.304 ± 0.037
0.313MetHis: 0.313 ± 0.019
0.761MetIle: 0.761 ± 0.027
0.307MetLys: 0.307 ± 0.021
1.896MetLeu: 1.896 ± 0.052
0.304MetMet: 0.304 ± 0.017
0.381MetAsn: 0.381 ± 0.019
1.111MetPro: 1.111 ± 0.032
0.478MetGln: 0.478 ± 0.022
1.57MetArg: 1.57 ± 0.048
1.484MetSer: 1.484 ± 0.036
1.706MetThr: 1.706 ± 0.043
1.488MetVal: 1.488 ± 0.037
0.239MetTrp: 0.239 ± 0.016
0.286MetTyr: 0.286 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
2.224AsnAla: 2.224 ± 0.054
0.095AsnCys: 0.095 ± 0.01
0.912AsnAsp: 0.912 ± 0.033
0.878AsnGlu: 0.878 ± 0.033
0.408AsnPhe: 0.408 ± 0.023
1.483AsnGly: 1.483 ± 0.043
0.352AsnHis: 0.352 ± 0.018
0.6AsnIle: 0.6 ± 0.032
0.224AsnLys: 0.224 ± 0.017
1.63AsnLeu: 1.63 ± 0.036
0.27AsnMet: 0.27 ± 0.02
0.376AsnAsn: 0.376 ± 0.023
1.283AsnPro: 1.283 ± 0.036
0.47AsnGln: 0.47 ± 0.022
1.05AsnArg: 1.05 ± 0.03
0.726AsnSer: 0.726 ± 0.031
0.941AsnThr: 0.941 ± 0.032
1.359AsnVal: 1.359 ± 0.038
0.251AsnTrp: 0.251 ± 0.017
0.415AsnTyr: 0.415 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
8.007ProAla: 8.007 ± 0.114
0.247ProCys: 0.247 ± 0.018
3.906ProAsp: 3.906 ± 0.079
4.418ProGlu: 4.418 ± 0.079
1.439ProPhe: 1.439 ± 0.04
6.23ProGly: 6.23 ± 0.1
1.278ProHis: 1.278 ± 0.037
1.847ProIle: 1.847 ± 0.048
0.641ProLys: 0.641 ± 0.027
4.92ProLeu: 4.92 ± 0.072
0.969ProMet: 0.969 ± 0.034
0.803ProAsn: 0.803 ± 0.029
2.871ProPro: 2.871 ± 0.071
1.879ProGln: 1.879 ± 0.047
3.933ProArg: 3.933 ± 0.065
3.404ProSer: 3.404 ± 0.066
3.997ProThr: 3.997 ± 0.09
4.932ProVal: 4.932 ± 0.086
0.988ProTrp: 0.988 ± 0.035
1.005ProTyr: 1.005 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
4.215GlnAla: 4.215 ± 0.071
0.144GlnCys: 0.144 ± 0.013
1.573GlnAsp: 1.573 ± 0.036
1.952GlnGlu: 1.952 ± 0.048
0.716GlnPhe: 0.716 ± 0.025
2.341GlnGly: 2.341 ± 0.052
0.648GlnHis: 0.648 ± 0.025
1.244GlnIle: 1.244 ± 0.035
0.401GlnLys: 0.401 ± 0.021
2.565GlnLeu: 2.565 ± 0.05
0.515GlnMet: 0.515 ± 0.024
0.415GlnAsn: 0.415 ± 0.021
1.576GlnPro: 1.576 ± 0.051
1.137GlnGln: 1.137 ± 0.044
2.665GlnArg: 2.665 ± 0.057
1.28GlnSer: 1.28 ± 0.035
1.29GlnThr: 1.29 ± 0.037
3.209GlnVal: 3.209 ± 0.057
0.501GlnTrp: 0.501 ± 0.023
0.561GlnTyr: 0.561 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
10.178ArgAla: 10.178 ± 0.148
0.425ArgCys: 0.425 ± 0.023
4.044ArgAsp: 4.044 ± 0.069
5.554ArgGlu: 5.554 ± 0.098
1.866ArgPhe: 1.866 ± 0.047
6.018ArgGly: 6.018 ± 0.097
1.737ArgHis: 1.737 ± 0.046
3.163ArgIle: 3.163 ± 0.053
1.026ArgLys: 1.026 ± 0.036
7.503ArgLeu: 7.503 ± 0.112
1.663ArgMet: 1.663 ± 0.041
1.127ArgAsn: 1.127 ± 0.034
3.947ArgPro: 3.947 ± 0.071
1.948ArgGln: 1.948 ± 0.041
7.467ArgArg: 7.467 ± 0.136
4.249ArgSer: 4.249 ± 0.077
4.68ArgThr: 4.68 ± 0.071
6.433ArgVal: 6.433 ± 0.105
1.321ArgTrp: 1.321 ± 0.043
1.603ArgTyr: 1.603 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
7.626SerAla: 7.626 ± 0.085
0.296SerCys: 0.296 ± 0.02
2.991SerAsp: 2.991 ± 0.06
3.002SerGlu: 3.002 ± 0.062
1.565SerPhe: 1.565 ± 0.039
5.964SerGly: 5.964 ± 0.083
1.132SerHis: 1.132 ± 0.038
2.001SerIle: 2.001 ± 0.045
0.697SerLys: 0.697 ± 0.031
5.364SerLeu: 5.364 ± 0.083
1.067SerMet: 1.067 ± 0.035
0.868SerAsn: 0.868 ± 0.03
3.328SerPro: 3.328 ± 0.082
1.606SerGln: 1.606 ± 0.038
3.861SerArg: 3.861 ± 0.07
3.296SerSer: 3.296 ± 0.081
3.492SerThr: 3.492 ± 0.067
4.421SerVal: 4.421 ± 0.067
0.867SerTrp: 0.867 ± 0.029
1.1SerTyr: 1.1 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
8.244ThrAla: 8.244 ± 0.11
0.333ThrCys: 0.333 ± 0.019
3.519ThrAsp: 3.519 ± 0.057
3.341ThrGlu: 3.341 ± 0.065
1.809ThrPhe: 1.809 ± 0.046
6.088ThrGly: 6.088 ± 0.099
1.286ThrHis: 1.286 ± 0.037
2.465ThrIle: 2.465 ± 0.051
0.817ThrLys: 0.817 ± 0.035
6.38ThrLeu: 6.38 ± 0.078
1.103ThrMet: 1.103 ± 0.035
1.017ThrAsn: 1.017 ± 0.034
4.73ThrPro: 4.73 ± 0.107
1.852ThrGln: 1.852 ± 0.048
4.207ThrArg: 4.207 ± 0.073
3.773ThrSer: 3.773 ± 0.075
4.567ThrThr: 4.567 ± 0.086
5.398ThrVal: 5.398 ± 0.081
1.088ThrTrp: 1.088 ± 0.034
1.395ThrTyr: 1.395 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
12.885ValAla: 12.885 ± 0.14
0.53ValCys: 0.53 ± 0.026
5.083ValAsp: 5.083 ± 0.072
5.084ValGlu: 5.084 ± 0.08
2.315ValPhe: 2.315 ± 0.053
7.309ValGly: 7.309 ± 0.087
1.833ValHis: 1.833 ± 0.048
3.624ValIle: 3.624 ± 0.076
1.167ValLys: 1.167 ± 0.041
10.297ValLeu: 10.297 ± 0.131
1.661ValMet: 1.661 ± 0.043
1.58ValAsn: 1.58 ± 0.045
5.318ValPro: 5.318 ± 0.087
2.241ValGln: 2.241 ± 0.049
6.599ValArg: 6.599 ± 0.104
4.846ValSer: 4.846 ± 0.083
6.307ValThr: 6.307 ± 0.09
9.557ValVal: 9.557 ± 0.121
1.224ValTrp: 1.224 ± 0.04
1.364ValTyr: 1.364 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.652TrpAla: 1.652 ± 0.044
0.132TrpCys: 0.132 ± 0.011
0.942TrpAsp: 0.942 ± 0.032
0.794TrpGlu: 0.794 ± 0.027
0.533TrpPhe: 0.533 ± 0.021
1.185TrpGly: 1.185 ± 0.035
0.344TrpHis: 0.344 ± 0.021
0.557TrpIle: 0.557 ± 0.026
0.204TrpLys: 0.204 ± 0.015
1.829TrpLeu: 1.829 ± 0.05
0.287TrpMet: 0.287 ± 0.017
0.363TrpAsn: 0.363 ± 0.023
0.751TrpPro: 0.751 ± 0.027
0.551TrpGln: 0.551 ± 0.024
1.506TrpArg: 1.506 ± 0.049
0.955TrpSer: 0.955 ± 0.032
0.858TrpThr: 0.858 ± 0.03
1.335TrpVal: 1.335 ± 0.033
0.424TrpTrp: 0.424 ± 0.023
0.285TrpTyr: 0.285 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.357TyrAla: 2.357 ± 0.053
0.133TyrCys: 0.133 ± 0.011
1.145TyrAsp: 1.145 ± 0.038
1.054TyrGlu: 1.054 ± 0.037
0.552TyrPhe: 0.552 ± 0.023
1.781TyrGly: 1.781 ± 0.047
0.34TyrHis: 0.34 ± 0.02
0.489TyrIle: 0.489 ± 0.022
0.272TyrLys: 0.272 ± 0.018
2.31TyrLeu: 2.31 ± 0.05
0.196TyrMet: 0.196 ± 0.015
0.339TyrAsn: 0.339 ± 0.019
1.042TyrPro: 1.042 ± 0.035
0.52TyrGln: 0.52 ± 0.025
1.556TyrArg: 1.556 ± 0.043
1.032TyrSer: 1.032 ± 0.036
1.157TyrThr: 1.157 ± 0.037
1.569TyrVal: 1.569 ± 0.044
0.297TyrTrp: 0.297 ± 0.016
0.431TyrTyr: 0.431 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2863 proteins (984522 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski