Amino acid dipepetide frequency for Prauserella muralis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.894AlaAla: 20.894 ± 0.147	1.112AlaCys: 1.112 ± 0.027	8.422AlaAsp: 8.422 ± 0.061	9.731AlaGlu: 9.731 ± 0.077	3.636AlaPhe: 3.636 ± 0.041	13.649AlaGly: 13.649 ± 0.097	2.711AlaHis: 2.711 ± 0.036	4.167AlaIle: 4.167 ± 0.05	2.525AlaLys: 2.525 ± 0.041	14.53AlaLeu: 14.53 ± 0.108	2.608AlaMet: 2.608 ± 0.035	1.996AlaAsn: 1.996 ± 0.034	6.256AlaPro: 6.256 ± 0.069	3.612AlaGln: 3.612 ± 0.047	10.703AlaArg: 10.703 ± 0.088	5.876AlaSer: 5.876 ± 0.053	7.316AlaThr: 7.316 ± 0.056	12.213AlaVal: 12.213 ± 0.089	1.861AlaTrp: 1.861 ± 0.031	2.397AlaTyr: 2.397 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.079CysAla: 1.079 ± 0.024	0.115CysCys: 0.115 ± 0.007	0.452CysAsp: 0.452 ± 0.015	0.42CysGlu: 0.42 ± 0.013	0.211CysPhe: 0.211 ± 0.011	0.955CysGly: 0.955 ± 0.024	0.218CysHis: 0.218 ± 0.01	0.167CysIle: 0.167 ± 0.008	0.1CysLys: 0.1 ± 0.007	0.734CysLeu: 0.734 ± 0.017	0.098CysMet: 0.098 ± 0.006	0.115CysAsn: 0.115 ± 0.007	0.481CysPro: 0.481 ± 0.018	0.188CysGln: 0.188 ± 0.009	0.606CysArg: 0.606 ± 0.018	0.425CysSer: 0.425 ± 0.015	0.482CysThr: 0.482 ± 0.013	0.682CysVal: 0.682 ± 0.016	0.131CysTrp: 0.131 ± 0.008	0.18CysTyr: 0.18 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.608AspAla: 7.608 ± 0.056	0.391AspCys: 0.391 ± 0.014	3.672AspAsp: 3.672 ± 0.048	4.224AspGlu: 4.224 ± 0.042	1.443AspPhe: 1.443 ± 0.025	6.062AspGly: 6.062 ± 0.061	1.276AspHis: 1.276 ± 0.025	1.906AspIle: 1.906 ± 0.028	0.964AspLys: 0.964 ± 0.023	6.15AspLeu: 6.15 ± 0.052	0.76AspMet: 0.76 ± 0.018	0.979AspAsn: 0.979 ± 0.023	4.354AspPro: 4.354 ± 0.049	1.434AspGln: 1.434 ± 0.029	4.666AspArg: 4.666 ± 0.05	2.325AspSer: 2.325 ± 0.041	3.208AspThr: 3.208 ± 0.039	5.476AspVal: 5.476 ± 0.047	0.932AspTrp: 0.932 ± 0.024	1.262AspTyr: 1.262 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	7.029GluAla: 7.029 ± 0.064	0.358GluCys: 0.358 ± 0.014	2.664GluAsp: 2.664 ± 0.035	2.957GluGlu: 2.957 ± 0.041	1.698GluPhe: 1.698 ± 0.029	4.091GluGly: 4.091 ± 0.053	1.948GluHis: 1.948 ± 0.032	2.255GluIle: 2.255 ± 0.036	1.091GluLys: 1.091 ± 0.025	7.734GluLeu: 7.734 ± 0.076	0.857GluMet: 0.857 ± 0.019	1.019GluAsn: 1.019 ± 0.021	3.936GluPro: 3.936 ± 0.06	2.798GluGln: 2.798 ± 0.04	6.065GluArg: 6.065 ± 0.055	2.511GluSer: 2.511 ± 0.036	2.787GluThr: 2.787 ± 0.04	4.851GluVal: 4.851 ± 0.045	0.815GluTrp: 0.815 ± 0.019	1.063GluTyr: 1.063 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.052PheAla: 4.052 ± 0.045	0.282PheCys: 0.282 ± 0.013	2.003PheAsp: 2.003 ± 0.032	1.4PheGlu: 1.4 ± 0.026	0.894PhePhe: 0.894 ± 0.023	3.398PheGly: 3.398 ± 0.044	0.576PheHis: 0.576 ± 0.017	0.684PheIle: 0.684 ± 0.018	0.364PheLys: 0.364 ± 0.011	2.661PheLeu: 2.661 ± 0.036	0.331PheMet: 0.331 ± 0.014	0.541PheAsn: 0.541 ± 0.017	1.348PhePro: 1.348 ± 0.027	0.598PheGln: 0.598 ± 0.018	1.824PheArg: 1.824 ± 0.032	1.45PheSer: 1.45 ± 0.026	1.962PheThr: 1.962 ± 0.032	2.566PheVal: 2.566 ± 0.034	0.403PheTrp: 0.403 ± 0.014	0.585PheTyr: 0.585 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	10.776GlyAla: 10.776 ± 0.084	0.807GlyCys: 0.807 ± 0.022	5.168GlyAsp: 5.168 ± 0.052	5.824GlyGlu: 5.824 ± 0.058	3.03GlyPhe: 3.03 ± 0.039	8.76GlyGly: 8.76 ± 0.084	2.209GlyHis: 2.209 ± 0.037	3.681GlyIle: 3.681 ± 0.039	2.152GlyLys: 2.152 ± 0.036	9.703GlyLeu: 9.703 ± 0.074	2.051GlyMet: 2.051 ± 0.029	1.74GlyAsn: 1.74 ± 0.032	4.63GlyPro: 4.63 ± 0.046	2.852GlyGln: 2.852 ± 0.043	7.471GlyArg: 7.471 ± 0.07	5.108GlySer: 5.108 ± 0.051	5.84GlyThr: 5.84 ± 0.058	8.13GlyVal: 8.13 ± 0.074	1.763GlyTrp: 1.763 ± 0.031	2.402GlyTyr: 2.402 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	2.86HisAla: 2.86 ± 0.039	0.224HisCys: 0.224 ± 0.01	1.461HisAsp: 1.461 ± 0.029	1.278HisGlu: 1.278 ± 0.028	0.598HisPhe: 0.598 ± 0.017	2.464HisGly: 2.464 ± 0.036	0.68HisHis: 0.68 ± 0.02	0.601HisIle: 0.601 ± 0.016	0.288HisLys: 0.288 ± 0.011	2.333HisLeu: 2.333 ± 0.035	0.29HisMet: 0.29 ± 0.012	0.403HisAsn: 0.403 ± 0.015	1.691HisPro: 1.691 ± 0.026	0.625HisGln: 0.625 ± 0.019	2.02HisArg: 2.02 ± 0.031	0.921HisSer: 0.921 ± 0.021	1.283HisThr: 1.283 ± 0.026	1.903HisVal: 1.903 ± 0.033	0.359HisTrp: 0.359 ± 0.012	0.529HisTyr: 0.529 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	5.185IleAla: 5.185 ± 0.055	0.268IleCys: 0.268 ± 0.009	2.41IleAsp: 2.41 ± 0.038	2.13IleGlu: 2.13 ± 0.037	0.69IlePhe: 0.69 ± 0.019	3.729IleGly: 3.729 ± 0.044	0.598IleHis: 0.598 ± 0.017	0.929IleIle: 0.929 ± 0.024	0.606IleLys: 0.606 ± 0.017	2.447IleLeu: 2.447 ± 0.037	0.463IleMet: 0.463 ± 0.017	0.75IleAsn: 0.75 ± 0.021	1.745IlePro: 1.745 ± 0.028	0.711IleGln: 0.711 ± 0.022	2.282IleArg: 2.282 ± 0.032	1.619IleSer: 1.619 ± 0.027	2.332IleThr: 2.332 ± 0.033	3.157IleVal: 3.157 ± 0.036	0.351IleTrp: 0.351 ± 0.012	0.611IleTyr: 0.611 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.432LysAla: 2.432 ± 0.044	0.091LysCys: 0.091 ± 0.007	0.933LysAsp: 0.933 ± 0.024	0.889LysGlu: 0.889 ± 0.021	0.407LysPhe: 0.407 ± 0.014	1.354LysGly: 1.354 ± 0.03	0.411LysHis: 0.411 ± 0.015	0.758LysIle: 0.758 ± 0.021	0.496LysLys: 0.496 ± 0.017	1.833LysLeu: 1.833 ± 0.035	0.305LysMet: 0.305 ± 0.012	0.349LysAsn: 0.349 ± 0.013	1.251LysPro: 1.251 ± 0.027	0.636LysGln: 0.636 ± 0.016	1.398LysArg: 1.398 ± 0.025	0.822LysSer: 0.822 ± 0.02	1.03LysThr: 1.03 ± 0.021	1.625LysVal: 1.625 ± 0.028	0.206LysTrp: 0.206 ± 0.011	0.359LysTyr: 0.359 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	17.036LeuAla: 17.036 ± 0.113	0.851LeuCys: 0.851 ± 0.021	6.891LeuAsp: 6.891 ± 0.07	4.843LeuGlu: 4.843 ± 0.052	2.691LeuPhe: 2.691 ± 0.045	10.064LeuGly: 10.064 ± 0.077	2.287LeuHis: 2.287 ± 0.037	3.107LeuIle: 3.107 ± 0.044	1.453LeuLys: 1.453 ± 0.031	11.744LeuLeu: 11.744 ± 0.105	1.425LeuMet: 1.425 ± 0.028	1.691LeuAsn: 1.691 ± 0.031	6.463LeuPro: 6.463 ± 0.062	2.051LeuGln: 2.051 ± 0.032	9.522LeuArg: 9.522 ± 0.077	5.358LeuSer: 5.358 ± 0.047	6.526LeuThr: 6.526 ± 0.061	9.727LeuVal: 9.727 ± 0.083	1.29LeuTrp: 1.29 ± 0.027	1.732LeuTyr: 1.732 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.18MetAla: 2.18 ± 0.031	0.126MetCys: 0.126 ± 0.008	0.775MetAsp: 0.775 ± 0.016	0.649MetGlu: 0.649 ± 0.018	0.492MetPhe: 0.492 ± 0.015	1.207MetGly: 1.207 ± 0.029	0.309MetHis: 0.309 ± 0.013	0.712MetIle: 0.712 ± 0.021	0.341MetLys: 0.341 ± 0.013	1.857MetLeu: 1.857 ± 0.03	0.284MetMet: 0.284 ± 0.013	0.387MetAsn: 0.387 ± 0.014	1.158MetPro: 1.158 ± 0.022	0.409MetGln: 0.409 ± 0.014	1.456MetArg: 1.456 ± 0.03	1.26MetSer: 1.26 ± 0.024	1.529MetThr: 1.529 ± 0.023	1.275MetVal: 1.275 ± 0.022	0.206MetTrp: 0.206 ± 0.009	0.255MetTyr: 0.255 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.205AsnAla: 2.205 ± 0.037	0.138AsnCys: 0.138 ± 0.008	0.924AsnAsp: 0.924 ± 0.02	0.847AsnGlu: 0.847 ± 0.02	0.469AsnPhe: 0.469 ± 0.017	1.68AsnGly: 1.68 ± 0.033	0.394AsnHis: 0.394 ± 0.014	0.621AsnIle: 0.621 ± 0.016	0.322AsnLys: 0.322 ± 0.013	1.806AsnLeu: 1.806 ± 0.031	0.278AsnMet: 0.278 ± 0.01	0.414AsnAsn: 0.414 ± 0.015	1.453AsnPro: 1.453 ± 0.031	0.51AsnGln: 0.51 ± 0.017	1.286AsnArg: 1.286 ± 0.025	0.82AsnSer: 0.82 ± 0.019	1.074AsnThr: 1.074 ± 0.023	1.451AsnVal: 1.451 ± 0.028	0.274AsnTrp: 0.274 ± 0.011	0.413AsnTyr: 0.413 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.221ProAla: 8.221 ± 0.072	0.329ProCys: 0.329 ± 0.014	4.263ProAsp: 4.263 ± 0.043	4.33ProGlu: 4.33 ± 0.058	1.571ProPhe: 1.571 ± 0.027	6.58ProGly: 6.58 ± 0.062	1.332ProHis: 1.332 ± 0.027	1.574ProIle: 1.574 ± 0.026	1.034ProLys: 1.034 ± 0.025	5.138ProLeu: 5.138 ± 0.059	1.03ProMet: 1.03 ± 0.022	0.925ProAsn: 0.925 ± 0.022	3.706ProPro: 3.706 ± 0.062	1.614ProGln: 1.614 ± 0.035	4.168ProArg: 4.168 ± 0.046	3.008ProSer: 3.008 ± 0.042	2.936ProThr: 2.936 ± 0.042	5.374ProVal: 5.374 ± 0.054	0.885ProTrp: 0.885 ± 0.024	1.137ProTyr: 1.137 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.931GlnAla: 3.931 ± 0.049	0.181GlnCys: 0.181 ± 0.009	1.207GlnAsp: 1.207 ± 0.022	1.31GlnGlu: 1.31 ± 0.025	0.734GlnPhe: 0.734 ± 0.018	2.116GlnGly: 2.116 ± 0.031	0.715GlnHis: 0.715 ± 0.018	1.027GlnIle: 1.027 ± 0.024	0.438GlnLys: 0.438 ± 0.013	3.282GlnLeu: 3.282 ± 0.045	0.424GlnMet: 0.424 ± 0.015	0.457GlnAsn: 0.457 ± 0.015	1.871GlnPro: 1.871 ± 0.037	1.299GlnGln: 1.299 ± 0.032	2.925GlnArg: 2.925 ± 0.042	1.144GlnSer: 1.144 ± 0.024	1.241GlnThr: 1.241 ± 0.024	2.475GlnVal: 2.475 ± 0.038	0.442GlnTrp: 0.442 ± 0.012	0.534GlnTyr: 0.534 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.166ArgAla: 10.166 ± 0.072	0.65ArgCys: 0.65 ± 0.019	4.619ArgAsp: 4.619 ± 0.052	4.962ArgGlu: 4.962 ± 0.05	2.534ArgPhe: 2.534 ± 0.036	6.04ArgGly: 6.04 ± 0.057	2.197ArgHis: 2.197 ± 0.035	3.288ArgIle: 3.288 ± 0.041	1.654ArgLys: 1.654 ± 0.031	9.306ArgLeu: 9.306 ± 0.095	1.867ArgMet: 1.867 ± 0.03	1.439ArgAsn: 1.439 ± 0.029	4.84ArgPro: 4.84 ± 0.059	2.712ArgGln: 2.712 ± 0.038	8.37ArgArg: 8.37 ± 0.086	3.988ArgSer: 3.988 ± 0.04	4.884ArgThr: 4.884 ± 0.048	6.321ArgVal: 6.321 ± 0.063	1.54ArgTrp: 1.54 ± 0.027	1.962ArgTyr: 1.962 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	6.473SerAla: 6.473 ± 0.053	0.378SerCys: 0.378 ± 0.013	2.534SerAsp: 2.534 ± 0.034	2.477SerGlu: 2.477 ± 0.038	1.452SerPhe: 1.452 ± 0.025	5.604SerGly: 5.604 ± 0.051	0.867SerHis: 0.867 ± 0.021	1.594SerIle: 1.594 ± 0.027	0.832SerLys: 0.832 ± 0.019	4.646SerLeu: 4.646 ± 0.049	1.127SerMet: 1.127 ± 0.022	0.804SerAsn: 0.804 ± 0.021	2.959SerPro: 2.959 ± 0.037	1.212SerGln: 1.212 ± 0.02	3.731SerArg: 3.731 ± 0.041	2.568SerSer: 2.568 ± 0.039	3.009SerThr: 3.009 ± 0.039	4.254SerVal: 4.254 ± 0.047	0.835SerTrp: 0.835 ± 0.021	1.075SerTyr: 1.075 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	7.883ThrAla: 7.883 ± 0.06	0.425ThrCys: 0.425 ± 0.013	3.295ThrAsp: 3.295 ± 0.04	3.505ThrGlu: 3.505 ± 0.044	1.633ThrPhe: 1.633 ± 0.032	6.398ThrGly: 6.398 ± 0.056	1.15ThrHis: 1.15 ± 0.025	2.042ThrIle: 2.042 ± 0.031	1.02ThrLys: 1.02 ± 0.022	5.765ThrLeu: 5.765 ± 0.056	1.036ThrMet: 1.036 ± 0.021	0.954ThrAsn: 0.954 ± 0.021	3.677ThrPro: 3.677 ± 0.041	1.317ThrGln: 1.317 ± 0.026	4.084ThrArg: 4.084 ± 0.047	2.954ThrSer: 2.954 ± 0.042	3.783ThrThr: 3.783 ± 0.047	6.081ThrVal: 6.081 ± 0.056	0.889ThrTrp: 0.889 ± 0.019	1.156ThrTyr: 1.156 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	12.134ValAla: 12.134 ± 0.101	0.769ValCys: 0.769 ± 0.019	5.318ValAsp: 5.318 ± 0.048	5.003ValGlu: 5.003 ± 0.052	2.577ValPhe: 2.577 ± 0.032	6.95ValGly: 6.95 ± 0.055	2.074ValHis: 2.074 ± 0.034	2.905ValIle: 2.905 ± 0.038	1.363ValLys: 1.363 ± 0.029	10.769ValLeu: 10.769 ± 0.092	1.157ValMet: 1.157 ± 0.024	1.701ValAsn: 1.701 ± 0.032	5.361ValPro: 5.361 ± 0.055	1.955ValGln: 1.955 ± 0.033	7.421ValArg: 7.421 ± 0.067	4.508ValSer: 4.508 ± 0.047	5.764ValThr: 5.764 ± 0.055	8.961ValVal: 8.961 ± 0.074	1.091ValTrp: 1.091 ± 0.023	1.517ValTyr: 1.517 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.618TrpAla: 1.618 ± 0.029	0.158TrpCys: 0.158 ± 0.008	0.757TrpAsp: 0.757 ± 0.021	0.661TrpGlu: 0.661 ± 0.017	0.536TrpPhe: 0.536 ± 0.017	0.982TrpGly: 0.982 ± 0.021	0.396TrpHis: 0.396 ± 0.013	0.547TrpIle: 0.547 ± 0.016	0.262TrpLys: 0.262 ± 0.011	2.001TrpLeu: 2.001 ± 0.032	0.286TrpMet: 0.286 ± 0.011	0.349TrpAsn: 0.349 ± 0.011	0.845TrpPro: 0.845 ± 0.021	0.643TrpGln: 0.643 ± 0.019	1.46TrpArg: 1.46 ± 0.023	0.828TrpSer: 0.828 ± 0.02	0.93TrpThr: 0.93 ± 0.024	1.039TrpVal: 1.039 ± 0.023	0.373TrpTrp: 0.373 ± 0.016	0.293TrpTyr: 0.293 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.457TyrAla: 2.457 ± 0.034	0.188TyrCys: 0.188 ± 0.009	1.322TyrAsp: 1.322 ± 0.03	1.086TyrGlu: 1.086 ± 0.022	0.626TyrPhe: 0.626 ± 0.019	2.016TyrGly: 2.016 ± 0.029	0.464TyrHis: 0.464 ± 0.014	0.447TyrIle: 0.447 ± 0.015	0.281TyrLys: 0.281 ± 0.013	2.312TyrLeu: 2.312 ± 0.032	0.188TyrMet: 0.188 ± 0.01	0.367TyrAsn: 0.367 ± 0.014	1.128TyrPro: 1.128 ± 0.026	0.574TyrGln: 0.574 ± 0.018	1.884TyrArg: 1.884 ± 0.033	0.938TyrSer: 0.938 ± 0.024	1.133TyrThr: 1.133 ± 0.025	1.737TyrVal: 1.737 ± 0.03	0.314TyrTrp: 0.314 ± 0.012	0.46TyrTyr: 0.46 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7018 proteins (2183359 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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