Amino acid dipepetide frequency for Arthrobacter phage Qui

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.329AlaAla: 7.329 ± 0.598
0.371AlaCys: 0.371 ± 0.111
4.591AlaAsp: 4.591 ± 0.417
5.019AlaGlu: 5.019 ± 0.442
2.738AlaPhe: 2.738 ± 0.261
5.561AlaGly: 5.561 ± 0.833
1.568AlaHis: 1.568 ± 0.239
5.618AlaIle: 5.618 ± 0.423
6.673AlaLys: 6.673 ± 0.454
6.502AlaLeu: 6.502 ± 0.754
2.11AlaMet: 2.11 ± 0.265
3.793AlaAsn: 3.793 ± 0.407
2.709AlaPro: 2.709 ± 0.322
2.852AlaGln: 2.852 ± 0.322
4.135AlaArg: 4.135 ± 0.38
4.363AlaSer: 4.363 ± 0.58
4.249AlaThr: 4.249 ± 0.475
5.875AlaVal: 5.875 ± 0.438
0.913AlaTrp: 0.913 ± 0.154
2.367AlaTyr: 2.367 ± 0.251
0.0AlaXaa: 0.0 ± 0.0
Cys
0.371CysAla: 0.371 ± 0.119
0.2CysCys: 0.2 ± 0.076
0.684CysAsp: 0.684 ± 0.167
0.542CysGlu: 0.542 ± 0.125
0.2CysPhe: 0.2 ± 0.078
1.055CysGly: 1.055 ± 0.227
0.257CysHis: 0.257 ± 0.102
0.314CysIle: 0.314 ± 0.105
0.684CysLys: 0.684 ± 0.138
0.485CysLeu: 0.485 ± 0.125
0.2CysMet: 0.2 ± 0.078
0.257CysAsn: 0.257 ± 0.091
0.599CysPro: 0.599 ± 0.145
0.228CysGln: 0.228 ± 0.074
0.371CysArg: 0.371 ± 0.11
0.371CysSer: 0.371 ± 0.075
0.314CysThr: 0.314 ± 0.107
0.656CysVal: 0.656 ± 0.14
0.2CysTrp: 0.2 ± 0.076
0.285CysTyr: 0.285 ± 0.098
0.0CysXaa: 0.0 ± 0.0
Asp
4.62AspAla: 4.62 ± 0.36
0.713AspCys: 0.713 ± 0.164
3.85AspAsp: 3.85 ± 0.452
5.19AspGlu: 5.19 ± 0.513
2.795AspPhe: 2.795 ± 0.31
5.162AspGly: 5.162 ± 0.417
1.312AspHis: 1.312 ± 0.21
4.249AspIle: 4.249 ± 0.347
3.308AspLys: 3.308 ± 0.33
5.276AspLeu: 5.276 ± 0.477
2.453AspMet: 2.453 ± 0.248
2.595AspAsn: 2.595 ± 0.349
2.567AspPro: 2.567 ± 0.337
1.825AspGln: 1.825 ± 0.218
3.023AspArg: 3.023 ± 0.302
2.795AspSer: 2.795 ± 0.274
2.624AspThr: 2.624 ± 0.295
4.135AspVal: 4.135 ± 0.368
1.397AspTrp: 1.397 ± 0.174
2.367AspTyr: 2.367 ± 0.281
0.0AspXaa: 0.0 ± 0.0
Glu
6.103GluAla: 6.103 ± 0.507
0.399GluCys: 0.399 ± 0.126
4.934GluAsp: 4.934 ± 0.463
6.958GluGlu: 6.958 ± 0.703
2.424GluPhe: 2.424 ± 0.318
4.335GluGly: 4.335 ± 0.365
1.369GluHis: 1.369 ± 0.203
3.736GluIle: 3.736 ± 0.348
5.219GluLys: 5.219 ± 0.457
6.217GluLeu: 6.217 ± 0.431
2.367GluMet: 2.367 ± 0.269
3.536GluAsn: 3.536 ± 0.342
2.624GluPro: 2.624 ± 0.32
2.937GluGln: 2.937 ± 0.309
3.764GluArg: 3.764 ± 0.386
3.222GluSer: 3.222 ± 0.347
4.021GluThr: 4.021 ± 0.341
5.076GluVal: 5.076 ± 0.472
1.626GluTrp: 1.626 ± 0.211
2.51GluTyr: 2.51 ± 0.309
0.0GluXaa: 0.0 ± 0.0
Phe
2.281PheAla: 2.281 ± 0.24
0.513PheCys: 0.513 ± 0.133
2.88PheAsp: 2.88 ± 0.312
2.88PheGlu: 2.88 ± 0.288
1.454PhePhe: 1.454 ± 0.203
2.852PheGly: 2.852 ± 0.334
0.542PheHis: 0.542 ± 0.134
1.911PheIle: 1.911 ± 0.247
2.567PheLys: 2.567 ± 0.283
2.595PheLeu: 2.595 ± 0.365
1.055PheMet: 1.055 ± 0.158
1.854PheAsn: 1.854 ± 0.246
1.683PhePro: 1.683 ± 0.234
0.77PheGln: 0.77 ± 0.156
1.882PheArg: 1.882 ± 0.249
1.825PheSer: 1.825 ± 0.244
2.253PheThr: 2.253 ± 0.288
2.253PheVal: 2.253 ± 0.24
0.684PheTrp: 0.684 ± 0.154
1.283PheTyr: 1.283 ± 0.187
0.0PheXaa: 0.0 ± 0.0
Gly
5.504GlyAla: 5.504 ± 0.564
0.456GlyCys: 0.456 ± 0.137
4.078GlyAsp: 4.078 ± 0.395
4.534GlyGlu: 4.534 ± 0.395
2.766GlyPhe: 2.766 ± 0.283
5.846GlyGly: 5.846 ± 0.978
1.483GlyHis: 1.483 ± 0.23
4.648GlyIle: 4.648 ± 0.531
3.764GlyLys: 3.764 ± 0.332
5.589GlyLeu: 5.589 ± 0.665
2.253GlyMet: 2.253 ± 0.361
2.196GlyAsn: 2.196 ± 0.265
2.139GlyPro: 2.139 ± 0.293
1.768GlyGln: 1.768 ± 0.226
2.567GlyArg: 2.567 ± 0.283
4.192GlySer: 4.192 ± 0.477
5.219GlyThr: 5.219 ± 0.434
5.846GlyVal: 5.846 ± 0.444
1.74GlyTrp: 1.74 ± 0.21
3.308GlyTyr: 3.308 ± 0.404
0.0GlyXaa: 0.0 ± 0.0
His
1.34HisAla: 1.34 ± 0.212
0.257HisCys: 0.257 ± 0.087
0.856HisAsp: 0.856 ± 0.161
1.198HisGlu: 1.198 ± 0.2
0.57HisPhe: 0.57 ± 0.139
1.34HisGly: 1.34 ± 0.177
0.599HisHis: 0.599 ± 0.145
1.854HisIle: 1.854 ± 0.269
1.283HisLys: 1.283 ± 0.229
1.426HisLeu: 1.426 ± 0.2
0.599HisMet: 0.599 ± 0.148
0.684HisAsn: 0.684 ± 0.167
1.169HisPro: 1.169 ± 0.203
0.456HisGln: 0.456 ± 0.112
0.884HisArg: 0.884 ± 0.173
1.312HisSer: 1.312 ± 0.221
1.34HisThr: 1.34 ± 0.219
1.141HisVal: 1.141 ± 0.169
0.399HisTrp: 0.399 ± 0.11
1.255HisTyr: 1.255 ± 0.189
0.0HisXaa: 0.0 ± 0.0
Ile
4.506IleAla: 4.506 ± 0.439
0.57IleCys: 0.57 ± 0.139
3.679IleAsp: 3.679 ± 0.301
4.392IleGlu: 4.392 ± 0.48
2.367IlePhe: 2.367 ± 0.234
3.907IleGly: 3.907 ± 0.459
1.283IleHis: 1.283 ± 0.24
3.365IleIle: 3.365 ± 0.291
4.05IleLys: 4.05 ± 0.279
5.475IleLeu: 5.475 ± 0.471
1.597IleMet: 1.597 ± 0.205
2.281IleAsn: 2.281 ± 0.196
2.966IlePro: 2.966 ± 0.225
2.167IleGln: 2.167 ± 0.222
3.337IleArg: 3.337 ± 0.302
4.021IleSer: 4.021 ± 0.425
4.135IleThr: 4.135 ± 0.443
4.05IleVal: 4.05 ± 0.347
1.283IleTrp: 1.283 ± 0.213
2.196IleTyr: 2.196 ± 0.242
0.0IleXaa: 0.0 ± 0.0
Lys
5.875LysAla: 5.875 ± 0.55
0.342LysCys: 0.342 ± 0.098
4.563LysAsp: 4.563 ± 0.395
4.62LysGlu: 4.62 ± 0.406
2.338LysPhe: 2.338 ± 0.274
3.508LysGly: 3.508 ± 0.316
1.74LysHis: 1.74 ± 0.231
4.249LysIle: 4.249 ± 0.412
5.19LysLys: 5.19 ± 0.526
5.589LysLeu: 5.589 ± 0.438
2.424LysMet: 2.424 ± 0.26
2.709LysAsn: 2.709 ± 0.302
3.707LysPro: 3.707 ± 0.384
2.395LysGln: 2.395 ± 0.317
3.251LysArg: 3.251 ± 0.355
4.506LysSer: 4.506 ± 0.385
3.793LysThr: 3.793 ± 0.344
4.164LysVal: 4.164 ± 0.379
1.312LysTrp: 1.312 ± 0.213
2.082LysTyr: 2.082 ± 0.261
0.0LysXaa: 0.0 ± 0.0
Leu
6.217LeuAla: 6.217 ± 0.694
0.542LeuCys: 0.542 ± 0.139
5.618LeuAsp: 5.618 ± 0.356
5.162LeuGlu: 5.162 ± 0.385
2.31LeuPhe: 2.31 ± 0.319
5.532LeuGly: 5.532 ± 0.448
1.198LeuHis: 1.198 ± 0.2
4.934LeuIle: 4.934 ± 0.332
5.39LeuLys: 5.39 ± 0.476
5.361LeuLeu: 5.361 ± 0.51
1.996LeuMet: 1.996 ± 0.252
3.85LeuAsn: 3.85 ± 0.404
3.394LeuPro: 3.394 ± 0.355
2.224LeuGln: 2.224 ± 0.291
3.85LeuArg: 3.85 ± 0.346
5.361LeuSer: 5.361 ± 0.472
5.846LeuThr: 5.846 ± 0.38
5.247LeuVal: 5.247 ± 0.488
1.198LeuTrp: 1.198 ± 0.187
2.624LeuTyr: 2.624 ± 0.318
0.0LeuXaa: 0.0 ± 0.0
Met
2.481MetAla: 2.481 ± 0.283
0.114MetCys: 0.114 ± 0.057
1.454MetAsp: 1.454 ± 0.191
1.483MetGlu: 1.483 ± 0.195
1.141MetPhe: 1.141 ± 0.185
1.511MetGly: 1.511 ± 0.235
0.513MetHis: 0.513 ± 0.106
1.597MetIle: 1.597 ± 0.22
2.481MetLys: 2.481 ± 0.265
2.281MetLeu: 2.281 ± 0.287
0.656MetMet: 0.656 ± 0.139
1.626MetAsn: 1.626 ± 0.212
0.941MetPro: 0.941 ± 0.141
0.656MetGln: 0.656 ± 0.139
1.568MetArg: 1.568 ± 0.223
2.823MetSer: 2.823 ± 0.29
2.538MetThr: 2.538 ± 0.211
1.397MetVal: 1.397 ± 0.178
0.257MetTrp: 0.257 ± 0.096
0.97MetTyr: 0.97 ± 0.169
0.0MetXaa: 0.0 ± 0.0
Asn
3.479AsnAla: 3.479 ± 0.253
0.542AsnCys: 0.542 ± 0.123
2.88AsnAsp: 2.88 ± 0.288
3.479AsnGlu: 3.479 ± 0.333
1.454AsnPhe: 1.454 ± 0.174
3.707AsnGly: 3.707 ± 0.412
1.027AsnHis: 1.027 ± 0.165
2.453AsnIle: 2.453 ± 0.246
3.023AsnLys: 3.023 ± 0.341
3.365AsnLeu: 3.365 ± 0.381
0.941AsnMet: 0.941 ± 0.217
1.882AsnAsn: 1.882 ± 0.258
2.937AsnPro: 2.937 ± 0.253
1.511AsnGln: 1.511 ± 0.214
2.167AsnArg: 2.167 ± 0.227
2.795AsnSer: 2.795 ± 0.332
2.852AsnThr: 2.852 ± 0.334
2.966AsnVal: 2.966 ± 0.332
1.027AsnTrp: 1.027 ± 0.189
1.312AsnTyr: 1.312 ± 0.196
0.0AsnXaa: 0.0 ± 0.0
Pro
3.165ProAla: 3.165 ± 0.346
0.456ProCys: 0.456 ± 0.112
2.51ProAsp: 2.51 ± 0.254
4.42ProGlu: 4.42 ± 0.476
1.397ProPhe: 1.397 ± 0.177
2.738ProGly: 2.738 ± 0.279
0.884ProHis: 0.884 ± 0.177
2.395ProIle: 2.395 ± 0.255
2.823ProLys: 2.823 ± 0.318
2.51ProLeu: 2.51 ± 0.232
1.084ProMet: 1.084 ± 0.162
1.911ProAsn: 1.911 ± 0.286
1.226ProPro: 1.226 ± 0.169
0.998ProGln: 0.998 ± 0.178
1.882ProArg: 1.882 ± 0.21
2.738ProSer: 2.738 ± 0.294
3.251ProThr: 3.251 ± 0.302
3.051ProVal: 3.051 ± 0.309
0.456ProTrp: 0.456 ± 0.116
1.654ProTyr: 1.654 ± 0.223
0.0ProXaa: 0.0 ± 0.0
Gln
2.681GlnAla: 2.681 ± 0.318
0.2GlnCys: 0.2 ± 0.07
1.597GlnAsp: 1.597 ± 0.188
1.882GlnGlu: 1.882 ± 0.24
1.084GlnPhe: 1.084 ± 0.196
2.196GlnGly: 2.196 ± 0.25
0.599GlnHis: 0.599 ± 0.141
1.968GlnIle: 1.968 ± 0.209
2.453GlnLys: 2.453 ± 0.288
2.766GlnLeu: 2.766 ± 0.325
0.713GlnMet: 0.713 ± 0.156
1.911GlnAsn: 1.911 ± 0.267
0.97GlnPro: 0.97 ± 0.145
1.141GlnGln: 1.141 ± 0.193
1.939GlnArg: 1.939 ± 0.286
1.454GlnSer: 1.454 ± 0.219
1.711GlnThr: 1.711 ± 0.295
2.338GlnVal: 2.338 ± 0.244
0.371GlnTrp: 0.371 ± 0.092
1.226GlnTyr: 1.226 ± 0.189
0.0GlnXaa: 0.0 ± 0.0
Arg
3.394ArgAla: 3.394 ± 0.363
0.542ArgCys: 0.542 ± 0.139
2.909ArgAsp: 2.909 ± 0.287
3.707ArgGlu: 3.707 ± 0.36
1.654ArgPhe: 1.654 ± 0.23
2.738ArgGly: 2.738 ± 0.259
1.027ArgHis: 1.027 ± 0.218
2.652ArgIle: 2.652 ± 0.23
3.907ArgLys: 3.907 ± 0.385
4.078ArgLeu: 4.078 ± 0.36
1.568ArgMet: 1.568 ± 0.237
3.137ArgAsn: 3.137 ± 0.297
2.053ArgPro: 2.053 ± 0.222
2.082ArgGln: 2.082 ± 0.296
3.736ArgArg: 3.736 ± 0.396
2.338ArgSer: 2.338 ± 0.248
3.422ArgThr: 3.422 ± 0.327
3.08ArgVal: 3.08 ± 0.327
0.627ArgTrp: 0.627 ± 0.138
1.882ArgTyr: 1.882 ± 0.256
0.0ArgXaa: 0.0 ± 0.0
Ser
4.877SerAla: 4.877 ± 0.441
0.399SerCys: 0.399 ± 0.105
4.021SerAsp: 4.021 ± 0.349
4.477SerGlu: 4.477 ± 0.435
2.338SerPhe: 2.338 ± 0.272
4.734SerGly: 4.734 ± 0.515
0.998SerHis: 0.998 ± 0.16
3.536SerIle: 3.536 ± 0.384
3.565SerLys: 3.565 ± 0.356
4.05SerLeu: 4.05 ± 0.35
1.854SerMet: 1.854 ± 0.209
3.222SerAsn: 3.222 ± 0.286
2.167SerPro: 2.167 ± 0.224
1.397SerGln: 1.397 ± 0.248
2.624SerArg: 2.624 ± 0.281
3.622SerSer: 3.622 ± 0.393
3.821SerThr: 3.821 ± 0.42
3.992SerVal: 3.992 ± 0.326
1.141SerTrp: 1.141 ± 0.18
2.053SerTyr: 2.053 ± 0.254
0.0SerXaa: 0.0 ± 0.0
Thr
5.789ThrAla: 5.789 ± 0.764
0.57ThrCys: 0.57 ± 0.159
3.764ThrAsp: 3.764 ± 0.289
4.249ThrGlu: 4.249 ± 0.372
2.053ThrPhe: 2.053 ± 0.228
5.019ThrGly: 5.019 ± 0.544
1.369ThrHis: 1.369 ± 0.254
4.05ThrIle: 4.05 ± 0.377
4.107ThrLys: 4.107 ± 0.334
5.504ThrLeu: 5.504 ± 0.472
1.283ThrMet: 1.283 ± 0.183
2.738ThrAsn: 2.738 ± 0.271
3.394ThrPro: 3.394 ± 0.335
2.053ThrGln: 2.053 ± 0.305
2.338ThrArg: 2.338 ± 0.313
3.308ThrSer: 3.308 ± 0.381
4.335ThrThr: 4.335 ± 0.453
4.221ThrVal: 4.221 ± 0.391
1.283ThrTrp: 1.283 ± 0.231
1.968ThrTyr: 1.968 ± 0.26
0.0ThrXaa: 0.0 ± 0.0
Val
5.989ValAla: 5.989 ± 0.514
0.542ValCys: 0.542 ± 0.125
4.477ValAsp: 4.477 ± 0.34
5.304ValGlu: 5.304 ± 0.423
2.453ValPhe: 2.453 ± 0.268
4.306ValGly: 4.306 ± 0.41
1.141ValHis: 1.141 ± 0.167
4.705ValIle: 4.705 ± 0.385
4.677ValLys: 4.677 ± 0.348
4.648ValLeu: 4.648 ± 0.342
2.281ValMet: 2.281 ± 0.23
2.937ValAsn: 2.937 ± 0.316
2.338ValPro: 2.338 ± 0.283
1.711ValGln: 1.711 ± 0.232
3.793ValArg: 3.793 ± 0.291
4.506ValSer: 4.506 ± 0.365
4.534ValThr: 4.534 ± 0.425
5.276ValVal: 5.276 ± 0.471
1.169ValTrp: 1.169 ± 0.191
2.11ValTyr: 2.11 ± 0.267
0.0ValXaa: 0.0 ± 0.0
Trp
1.055TrpAla: 1.055 ± 0.161
0.228TrpCys: 0.228 ± 0.093
1.112TrpAsp: 1.112 ± 0.19
1.283TrpGlu: 1.283 ± 0.21
0.713TrpPhe: 0.713 ± 0.169
1.027TrpGly: 1.027 ± 0.169
0.371TrpHis: 0.371 ± 0.102
0.798TrpIle: 0.798 ± 0.143
0.941TrpLys: 0.941 ± 0.181
1.483TrpLeu: 1.483 ± 0.183
0.456TrpMet: 0.456 ± 0.112
0.941TrpAsn: 0.941 ± 0.184
0.57TrpPro: 0.57 ± 0.138
0.741TrpGln: 0.741 ± 0.162
1.597TrpArg: 1.597 ± 0.298
0.856TrpSer: 0.856 ± 0.141
1.027TrpThr: 1.027 ± 0.166
1.711TrpVal: 1.711 ± 0.272
0.713TrpTrp: 0.713 ± 0.143
0.856TrpTyr: 0.856 ± 0.149
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.281TyrAla: 2.281 ± 0.293
0.314TyrCys: 0.314 ± 0.113
1.797TyrAsp: 1.797 ± 0.277
2.595TyrGlu: 2.595 ± 0.272
1.768TyrPhe: 1.768 ± 0.234
2.823TyrGly: 2.823 ± 0.308
0.684TyrHis: 0.684 ± 0.134
2.624TyrIle: 2.624 ± 0.288
2.253TyrLys: 2.253 ± 0.278
2.652TyrLeu: 2.652 ± 0.272
0.57TyrMet: 0.57 ± 0.131
1.74TyrAsn: 1.74 ± 0.193
1.397TyrPro: 1.397 ± 0.2
1.283TyrGln: 1.283 ± 0.192
1.825TyrArg: 1.825 ± 0.243
2.481TyrSer: 2.481 ± 0.263
2.11TyrThr: 2.11 ± 0.269
2.424TyrVal: 2.424 ± 0.267
0.684TyrTrp: 0.684 ± 0.146
1.511TyrTyr: 1.511 ± 0.25
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 247 proteins (35067 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski