Amino acid dipepetide frequency for Meiothermus silvanus (strain ATCC 700542 / DSM 9946 / VI-R2) (Thermus silvanus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.759AlaAla: 11.759 ± 0.131
0.674AlaCys: 0.674 ± 0.03
3.95AlaAsp: 3.95 ± 0.063
7.562AlaGlu: 7.562 ± 0.108
3.972AlaPhe: 3.972 ± 0.073
8.94AlaGly: 8.94 ± 0.095
2.114AlaHis: 2.114 ± 0.047
4.488AlaIle: 4.488 ± 0.065
4.175AlaLys: 4.175 ± 0.078
15.739AlaLeu: 15.739 ± 0.166
2.242AlaMet: 2.242 ± 0.048
2.314AlaAsn: 2.314 ± 0.05
4.85AlaPro: 4.85 ± 0.08
5.397AlaGln: 5.397 ± 0.077
8.043AlaArg: 8.043 ± 0.101
4.963AlaSer: 4.963 ± 0.08
4.531AlaThr: 4.531 ± 0.064
7.775AlaVal: 7.775 ± 0.093
1.938AlaTrp: 1.938 ± 0.052
3.338AlaTyr: 3.338 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
0.548CysAla: 0.548 ± 0.024
0.116CysCys: 0.116 ± 0.011
0.263CysAsp: 0.263 ± 0.018
0.283CysGlu: 0.283 ± 0.016
0.182CysPhe: 0.182 ± 0.015
0.576CysGly: 0.576 ± 0.029
0.178CysHis: 0.178 ± 0.013
0.198CysIle: 0.198 ± 0.014
0.178CysLys: 0.178 ± 0.015
0.516CysLeu: 0.516 ± 0.023
0.084CysMet: 0.084 ± 0.01
0.157CysAsn: 0.157 ± 0.011
0.412CysPro: 0.412 ± 0.022
0.207CysGln: 0.207 ± 0.016
0.333CysArg: 0.333 ± 0.018
0.316CysSer: 0.316 ± 0.019
0.349CysThr: 0.349 ± 0.02
0.334CysVal: 0.334 ± 0.017
0.09CysTrp: 0.09 ± 0.01
0.166CysTyr: 0.166 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
3.843AspAla: 3.843 ± 0.069
0.223AspCys: 0.223 ± 0.016
1.525AspAsp: 1.525 ± 0.04
2.518AspGlu: 2.518 ± 0.057
1.677AspPhe: 1.677 ± 0.041
3.249AspGly: 3.249 ± 0.058
0.775AspHis: 0.775 ± 0.026
1.558AspIle: 1.558 ± 0.042
1.237AspLys: 1.237 ± 0.042
5.957AspLeu: 5.957 ± 0.077
0.606AspMet: 0.606 ± 0.024
0.808AspAsn: 0.808 ± 0.032
3.778AspPro: 3.778 ± 0.066
1.392AspGln: 1.392 ± 0.04
2.653AspArg: 2.653 ± 0.05
1.555AspSer: 1.555 ± 0.038
2.028AspThr: 2.028 ± 0.052
2.621AspVal: 2.621 ± 0.058
0.849AspTrp: 0.849 ± 0.028
1.443AspTyr: 1.443 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
9.848GluAla: 9.848 ± 0.13
0.24GluCys: 0.24 ± 0.016
2.521GluAsp: 2.521 ± 0.052
5.053GluGlu: 5.053 ± 0.094
2.179GluPhe: 2.179 ± 0.053
6.319GluGly: 6.319 ± 0.104
1.35GluHis: 1.35 ± 0.036
3.166GluIle: 3.166 ± 0.066
2.471GluLys: 2.471 ± 0.061
7.433GluLeu: 7.433 ± 0.097
1.189GluMet: 1.189 ± 0.039
1.636GluAsn: 1.636 ± 0.039
3.368GluPro: 3.368 ± 0.067
2.468GluGln: 2.468 ± 0.055
6.354GluArg: 6.354 ± 0.088
2.676GluSer: 2.676 ± 0.054
2.747GluThr: 2.747 ± 0.054
6.294GluVal: 6.294 ± 0.087
0.969GluTrp: 0.969 ± 0.032
1.558GluTyr: 1.558 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.827PheAla: 3.827 ± 0.075
0.235PheCys: 0.235 ± 0.017
1.703PheAsp: 1.703 ± 0.042
1.929PheGlu: 1.929 ± 0.046
1.505PhePhe: 1.505 ± 0.045
3.069PheGly: 3.069 ± 0.067
0.704PheHis: 0.704 ± 0.03
1.44PheIle: 1.44 ± 0.038
1.199PheLys: 1.199 ± 0.039
4.141PheLeu: 4.141 ± 0.076
0.584PheMet: 0.584 ± 0.023
0.94PheAsn: 0.94 ± 0.031
2.053PhePro: 2.053 ± 0.047
1.279PheGln: 1.279 ± 0.035
2.435PheArg: 2.435 ± 0.047
2.167PheSer: 2.167 ± 0.052
1.957PheThr: 1.957 ± 0.047
2.62PheVal: 2.62 ± 0.048
0.677PheTrp: 0.677 ± 0.027
1.237PheTyr: 1.237 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
7.707GlyAla: 7.707 ± 0.098
0.543GlyCys: 0.543 ± 0.029
3.265GlyAsp: 3.265 ± 0.065
5.557GlyGlu: 5.557 ± 0.089
3.85GlyPhe: 3.85 ± 0.073
7.384GlyGly: 7.384 ± 0.105
1.686GlyHis: 1.686 ± 0.045
4.226GlyIle: 4.226 ± 0.069
3.778GlyLys: 3.778 ± 0.063
11.422GlyLeu: 11.422 ± 0.148
2.018GlyMet: 2.018 ± 0.047
2.15GlyAsn: 2.15 ± 0.042
3.634GlyPro: 3.634 ± 0.06
3.52GlyGln: 3.52 ± 0.07
5.902GlyArg: 5.902 ± 0.085
4.76GlySer: 4.76 ± 0.069
3.835GlyThr: 3.835 ± 0.076
7.243GlyVal: 7.243 ± 0.088
1.525GlyTrp: 1.525 ± 0.044
2.995GlyTyr: 2.995 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
1.696HisAla: 1.696 ± 0.043
0.138HisCys: 0.138 ± 0.013
0.822HisAsp: 0.822 ± 0.026
0.89HisGlu: 0.89 ± 0.032
0.78HisPhe: 0.78 ± 0.027
1.447HisGly: 1.447 ± 0.037
0.559HisHis: 0.559 ± 0.031
0.742HisIle: 0.742 ± 0.025
0.593HisLys: 0.593 ± 0.025
2.728HisLeu: 2.728 ± 0.058
0.347HisMet: 0.347 ± 0.017
0.488HisAsn: 0.488 ± 0.022
1.781HisPro: 1.781 ± 0.044
0.775HisGln: 0.775 ± 0.029
1.616HisArg: 1.616 ± 0.039
0.986HisSer: 0.986 ± 0.031
1.055HisThr: 1.055 ± 0.034
1.108HisVal: 1.108 ± 0.035
0.404HisTrp: 0.404 ± 0.019
0.643HisTyr: 0.643 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
4.859IleAla: 4.859 ± 0.081
0.239IleCys: 0.239 ± 0.013
1.646IleAsp: 1.646 ± 0.038
2.65IleGlu: 2.65 ± 0.057
1.365IlePhe: 1.365 ± 0.038
3.641IleGly: 3.641 ± 0.069
0.879IleHis: 0.879 ± 0.028
1.326IleIle: 1.326 ± 0.045
1.195IleLys: 1.195 ± 0.04
4.715IleLeu: 4.715 ± 0.08
0.504IleMet: 0.504 ± 0.024
1.019IleAsn: 1.019 ± 0.033
2.94IlePro: 2.94 ± 0.056
1.587IleGln: 1.587 ± 0.04
3.013IleArg: 3.013 ± 0.047
2.064IleSer: 2.064 ± 0.05
2.114IleThr: 2.114 ± 0.055
2.933IleVal: 2.933 ± 0.059
0.631IleTrp: 0.631 ± 0.028
1.203IleTyr: 1.203 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
4.337LysAla: 4.337 ± 0.08
0.104LysCys: 0.104 ± 0.01
1.597LysAsp: 1.597 ± 0.048
2.553LysGlu: 2.553 ± 0.058
0.829LysPhe: 0.829 ± 0.031
3.097LysGly: 3.097 ± 0.062
0.735LysHis: 0.735 ± 0.032
1.452LysIle: 1.452 ± 0.039
1.479LysLys: 1.479 ± 0.048
3.785LysLeu: 3.785 ± 0.066
0.631LysMet: 0.631 ± 0.023
1.005LysAsn: 1.005 ± 0.04
2.435LysPro: 2.435 ± 0.052
0.994LysGln: 0.994 ± 0.03
2.551LysArg: 2.551 ± 0.05
1.707LysSer: 1.707 ± 0.043
1.946LysThr: 1.946 ± 0.047
2.793LysVal: 2.793 ± 0.056
0.355LysTrp: 0.355 ± 0.019
0.816LysTyr: 0.816 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
15.177LeuAla: 15.177 ± 0.174
0.635LeuCys: 0.635 ± 0.026
4.973LeuAsp: 4.973 ± 0.074
12.389LeuGlu: 12.389 ± 0.138
3.774LeuPhe: 3.774 ± 0.078
11.168LeuGly: 11.168 ± 0.125
2.209LeuHis: 2.209 ± 0.05
4.528LeuIle: 4.528 ± 0.068
4.367LeuLys: 4.367 ± 0.071
14.209LeuLeu: 14.209 ± 0.18
2.033LeuMet: 2.033 ± 0.045
2.587LeuAsn: 2.587 ± 0.048
7.262LeuPro: 7.262 ± 0.099
4.038LeuGln: 4.038 ± 0.057
9.105LeuArg: 9.105 ± 0.13
7.521LeuSer: 7.521 ± 0.114
5.729LeuThr: 5.729 ± 0.086
8.627LeuVal: 8.627 ± 0.098
1.778LeuTrp: 1.778 ± 0.052
3.076LeuTyr: 3.076 ± 0.057
0.0LeuXaa: 0.0 ± 0.0
Met
2.091MetAla: 2.091 ± 0.048
0.092MetCys: 0.092 ± 0.008
0.809MetAsp: 0.809 ± 0.029
1.024MetGlu: 1.024 ± 0.03
0.44MetPhe: 0.44 ± 0.021
1.77MetGly: 1.77 ± 0.049
0.35MetHis: 0.35 ± 0.018
0.734MetIle: 0.734 ± 0.027
0.801MetLys: 0.801 ± 0.027
2.026MetLeu: 2.026 ± 0.051
0.342MetMet: 0.342 ± 0.02
0.578MetAsn: 0.578 ± 0.025
1.002MetPro: 1.002 ± 0.029
0.811MetGln: 0.811 ± 0.034
1.498MetArg: 1.498 ± 0.039
1.046MetSer: 1.046 ± 0.034
0.828MetThr: 0.828 ± 0.029
1.418MetVal: 1.418 ± 0.038
0.156MetTrp: 0.156 ± 0.013
0.364MetTyr: 0.364 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
2.377AsnAla: 2.377 ± 0.048
0.138AsnCys: 0.138 ± 0.012
0.875AsnAsp: 0.875 ± 0.031
0.962AsnGlu: 0.962 ± 0.033
0.894AsnPhe: 0.894 ± 0.031
1.757AsnGly: 1.757 ± 0.051
0.446AsnHis: 0.446 ± 0.019
0.886AsnIle: 0.886 ± 0.034
0.619AsnLys: 0.619 ± 0.028
3.494AsnLeu: 3.494 ± 0.059
0.332AsnMet: 0.332 ± 0.02
0.557AsnAsn: 0.557 ± 0.026
2.672AsnPro: 2.672 ± 0.056
0.898AsnGln: 0.898 ± 0.032
1.779AsnArg: 1.779 ± 0.041
0.955AsnSer: 0.955 ± 0.037
1.233AsnThr: 1.233 ± 0.037
1.542AsnVal: 1.542 ± 0.042
0.384AsnTrp: 0.384 ± 0.02
0.705AsnTyr: 0.705 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
5.602ProAla: 5.602 ± 0.084
0.256ProCys: 0.256 ± 0.016
3.005ProAsp: 3.005 ± 0.053
5.171ProGlu: 5.171 ± 0.078
2.118ProPhe: 2.118 ± 0.049
5.467ProGly: 5.467 ± 0.084
1.288ProHis: 1.288 ± 0.035
2.265ProIle: 2.265 ± 0.051
2.326ProLys: 2.326 ± 0.053
6.439ProLeu: 6.439 ± 0.091
1.013ProMet: 1.013 ± 0.031
1.502ProAsn: 1.502 ± 0.038
3.608ProPro: 3.608 ± 0.071
2.791ProGln: 2.791 ± 0.059
3.673ProArg: 3.673 ± 0.07
3.08ProSer: 3.08 ± 0.057
3.097ProThr: 3.097 ± 0.06
3.988ProVal: 3.988 ± 0.069
0.941ProTrp: 0.941 ± 0.033
1.851ProTyr: 1.851 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
5.847GlnAla: 5.847 ± 0.097
0.108GlnCys: 0.108 ± 0.011
1.678GlnAsp: 1.678 ± 0.042
2.734GlnGlu: 2.734 ± 0.06
0.991GlnPhe: 0.991 ± 0.034
3.846GlnGly: 3.846 ± 0.073
0.729GlnHis: 0.729 ± 0.029
1.647GlnIle: 1.647 ± 0.039
1.383GlnLys: 1.383 ± 0.044
3.35GlnLeu: 3.35 ± 0.061
0.774GlnMet: 0.774 ± 0.028
1.053GlnAsn: 1.053 ± 0.036
2.108GlnPro: 2.108 ± 0.048
1.63GlnGln: 1.63 ± 0.049
2.892GlnArg: 2.892 ± 0.058
1.828GlnSer: 1.828 ± 0.05
1.97GlnThr: 1.97 ± 0.044
3.361GlnVal: 3.361 ± 0.066
0.413GlnTrp: 0.413 ± 0.021
0.832GlnTyr: 0.832 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
7.347ArgAla: 7.347 ± 0.093
0.422ArgCys: 0.422 ± 0.026
2.632ArgAsp: 2.632 ± 0.059
5.589ArgGlu: 5.589 ± 0.086
3.145ArgPhe: 3.145 ± 0.056
5.492ArgGly: 5.492 ± 0.083
1.321ArgHis: 1.321 ± 0.039
3.626ArgIle: 3.626 ± 0.057
2.69ArgLys: 2.69 ± 0.057
9.78ArgLeu: 9.78 ± 0.127
1.837ArgMet: 1.837 ± 0.042
1.48ArgAsn: 1.48 ± 0.039
3.855ArgPro: 3.855 ± 0.07
2.867ArgGln: 2.867 ± 0.056
5.561ArgArg: 5.561 ± 0.092
3.424ArgSer: 3.424 ± 0.058
3.243ArgThr: 3.243 ± 0.059
5.9ArgVal: 5.9 ± 0.084
1.454ArgTrp: 1.454 ± 0.044
2.676ArgTyr: 2.676 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
4.637SerAla: 4.637 ± 0.072
0.303SerCys: 0.303 ± 0.017
2.042SerAsp: 2.042 ± 0.045
3.136SerGlu: 3.136 ± 0.06
2.015SerPhe: 2.015 ± 0.042
5.185SerGly: 5.185 ± 0.093
0.817SerHis: 0.817 ± 0.028
1.851SerIle: 1.851 ± 0.048
1.546SerLys: 1.546 ± 0.041
6.493SerLeu: 6.493 ± 0.087
0.837SerMet: 0.837 ± 0.03
1.181SerAsn: 1.181 ± 0.036
3.315SerPro: 3.315 ± 0.055
1.828SerGln: 1.828 ± 0.052
3.855SerArg: 3.855 ± 0.067
2.649SerSer: 2.649 ± 0.069
2.262SerThr: 2.262 ± 0.051
3.474SerVal: 3.474 ± 0.067
0.905SerTrp: 0.905 ± 0.032
1.435SerTyr: 1.435 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
4.602ThrAla: 4.602 ± 0.076
0.268ThrCys: 0.268 ± 0.017
1.965ThrAsp: 1.965 ± 0.046
2.158ThrGlu: 2.158 ± 0.047
1.799ThrPhe: 1.799 ± 0.043
4.009ThrGly: 4.009 ± 0.069
1.028ThrHis: 1.028 ± 0.028
1.603ThrIle: 1.603 ± 0.047
1.18ThrLys: 1.18 ± 0.034
7.211ThrLeu: 7.211 ± 0.083
0.575ThrMet: 0.575 ± 0.025
0.975ThrAsn: 0.975 ± 0.034
3.944ThrPro: 3.944 ± 0.071
1.893ThrGln: 1.893 ± 0.041
3.069ThrArg: 3.069 ± 0.058
2.149ThrSer: 2.149 ± 0.048
2.229ThrThr: 2.229 ± 0.053
3.808ThrVal: 3.808 ± 0.06
0.757ThrTrp: 0.757 ± 0.029
1.606ThrTyr: 1.606 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
7.855ValAla: 7.855 ± 0.1
0.452ValCys: 0.452 ± 0.02
3.099ValAsp: 3.099 ± 0.061
5.089ValGlu: 5.089 ± 0.084
2.697ValPhe: 2.697 ± 0.058
6.587ValGly: 6.587 ± 0.084
1.466ValHis: 1.466 ± 0.038
3.171ValIle: 3.171 ± 0.062
2.543ValLys: 2.543 ± 0.052
9.594ValLeu: 9.594 ± 0.108
1.51ValMet: 1.51 ± 0.037
1.875ValAsn: 1.875 ± 0.048
3.795ValPro: 3.795 ± 0.067
2.757ValGln: 2.757 ± 0.052
5.965ValArg: 5.965 ± 0.071
3.821ValSer: 3.821 ± 0.066
3.202ValThr: 3.202 ± 0.062
6.41ValVal: 6.41 ± 0.095
1.265ValTrp: 1.265 ± 0.036
2.222ValTyr: 2.222 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
1.621TrpAla: 1.621 ± 0.041
0.101TrpCys: 0.101 ± 0.01
0.6TrpAsp: 0.6 ± 0.026
1.087TrpGlu: 1.087 ± 0.037
0.491TrpPhe: 0.491 ± 0.023
1.478TrpGly: 1.478 ± 0.039
0.307TrpHis: 0.307 ± 0.017
0.653TrpIle: 0.653 ± 0.023
0.637TrpLys: 0.637 ± 0.026
2.08TrpLeu: 2.08 ± 0.049
0.353TrpMet: 0.353 ± 0.018
0.467TrpAsn: 0.467 ± 0.025
0.784TrpPro: 0.784 ± 0.028
0.776TrpGln: 0.776 ± 0.026
1.277TrpArg: 1.277 ± 0.038
0.763TrpSer: 0.763 ± 0.026
0.719TrpThr: 0.719 ± 0.026
1.43TrpVal: 1.43 ± 0.041
0.281TrpTrp: 0.281 ± 0.018
0.367TrpTyr: 0.367 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.184TyrAla: 3.184 ± 0.052
0.2TyrCys: 0.2 ± 0.014
1.327TyrAsp: 1.327 ± 0.038
1.504TyrGlu: 1.504 ± 0.04
0.998TyrPhe: 0.998 ± 0.035
2.52TyrGly: 2.52 ± 0.049
0.656TyrHis: 0.656 ± 0.025
0.962TyrIle: 0.962 ± 0.034
0.806TyrLys: 0.806 ± 0.032
4.075TyrLeu: 4.075 ± 0.066
0.367TyrMet: 0.367 ± 0.02
0.733TyrAsn: 0.733 ± 0.029
1.886TyrPro: 1.886 ± 0.044
1.266TyrGln: 1.266 ± 0.033
2.765TyrArg: 2.765 ± 0.048
1.336TyrSer: 1.336 ± 0.039
1.754TyrThr: 1.754 ± 0.047
1.698TyrVal: 1.698 ± 0.042
0.495TyrTrp: 0.495 ± 0.022
0.952TyrTyr: 0.952 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3383 proteins (1043606 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski