Amino acid dipepetide frequency for Sphingosinicella humi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.981AlaAla: 18.981 ± 0.221	1.013AlaCys: 1.013 ± 0.037	7.331AlaAsp: 7.331 ± 0.102	9.041AlaGlu: 9.041 ± 0.105	4.418AlaPhe: 4.418 ± 0.076	10.971AlaGly: 10.971 ± 0.128	2.239AlaHis: 2.239 ± 0.059	6.446AlaIle: 6.446 ± 0.094	3.906AlaLys: 3.906 ± 0.085	14.081AlaLeu: 14.081 ± 0.169	3.508AlaMet: 3.508 ± 0.063	2.774AlaAsn: 2.774 ± 0.051	5.98AlaPro: 5.98 ± 0.091	3.883AlaGln: 3.883 ± 0.07	9.929AlaArg: 9.929 ± 0.139	6.506AlaSer: 6.506 ± 0.081	6.155AlaThr: 6.155 ± 0.086	8.768AlaVal: 8.768 ± 0.107	1.62AlaTrp: 1.62 ± 0.047	2.625AlaTyr: 2.625 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.981CysAla: 0.981 ± 0.035	0.085CysCys: 0.085 ± 0.011	0.503CysAsp: 0.503 ± 0.026	0.434CysGlu: 0.434 ± 0.025	0.299CysPhe: 0.299 ± 0.018	0.874CysGly: 0.874 ± 0.032	0.237CysHis: 0.237 ± 0.022	0.338CysIle: 0.338 ± 0.018	0.134CysLys: 0.134 ± 0.011	0.695CysLeu: 0.695 ± 0.028	0.127CysMet: 0.127 ± 0.013	0.175CysAsn: 0.175 ± 0.015	0.444CysPro: 0.444 ± 0.026	0.182CysGln: 0.182 ± 0.015	0.606CysArg: 0.606 ± 0.03	0.435CysSer: 0.435 ± 0.023	0.357CysThr: 0.357 ± 0.018	0.486CysVal: 0.486 ± 0.024	0.109CysTrp: 0.109 ± 0.012	0.181CysTyr: 0.181 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.988AspAla: 6.988 ± 0.078	0.484AspCys: 0.484 ± 0.023	3.138AspAsp: 3.138 ± 0.069	4.072AspGlu: 4.072 ± 0.071	2.148AspPhe: 2.148 ± 0.057	5.246AspGly: 5.246 ± 0.097	1.222AspHis: 1.222 ± 0.037	2.867AspIle: 2.867 ± 0.062	1.713AspLys: 1.713 ± 0.048	5.665AspLeu: 5.665 ± 0.089	1.382AspMet: 1.382 ± 0.042	1.34AspAsn: 1.34 ± 0.046	3.764AspPro: 3.764 ± 0.07	1.8AspGln: 1.8 ± 0.048	5.068AspArg: 5.068 ± 0.091	2.331AspSer: 2.331 ± 0.053	2.323AspThr: 2.323 ± 0.057	4.205AspVal: 4.205 ± 0.072	1.017AspTrp: 1.017 ± 0.038	1.702AspTyr: 1.702 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	9.637GluAla: 9.637 ± 0.122	0.348GluCys: 0.348 ± 0.022	3.11GluAsp: 3.11 ± 0.067	4.242GluGlu: 4.242 ± 0.09	1.593GluPhe: 1.593 ± 0.041	5.501GluGly: 5.501 ± 0.087	1.156GluHis: 1.156 ± 0.038	3.099GluIle: 3.099 ± 0.063	2.139GluLys: 2.139 ± 0.052	5.645GluLeu: 5.645 ± 0.088	1.667GluMet: 1.667 ± 0.047	1.437GluAsn: 1.437 ± 0.046	3.267GluPro: 3.267 ± 0.068	2.289GluGln: 2.289 ± 0.048	6.076GluArg: 6.076 ± 0.074	2.606GluSer: 2.606 ± 0.054	3.632GluThr: 3.632 ± 0.069	4.322GluVal: 4.322 ± 0.083	0.899GluTrp: 0.899 ± 0.027	1.009GluTyr: 1.009 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	4.469PheAla: 4.469 ± 0.075	0.312PheCys: 0.312 ± 0.018	2.577PheAsp: 2.577 ± 0.054	2.246PheGlu: 2.246 ± 0.049	1.302PhePhe: 1.302 ± 0.04	3.462PheGly: 3.462 ± 0.063	0.717PheHis: 0.717 ± 0.029	1.587PheIle: 1.587 ± 0.041	0.864PheLys: 0.864 ± 0.035	3.144PheLeu: 3.144 ± 0.068	0.758PheMet: 0.758 ± 0.026	0.964PheAsn: 0.964 ± 0.035	1.48PhePro: 1.48 ± 0.044	0.892PheGln: 0.892 ± 0.027	2.277PheArg: 2.277 ± 0.046	1.919PheSer: 1.919 ± 0.041	1.897PheThr: 1.897 ± 0.05	2.595PheVal: 2.595 ± 0.057	0.552PheTrp: 0.552 ± 0.028	0.903PheTyr: 0.903 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	9.786GlyAla: 9.786 ± 0.125	0.855GlyCys: 0.855 ± 0.032	4.999GlyAsp: 4.999 ± 0.084	5.701GlyGlu: 5.701 ± 0.09	3.561GlyPhe: 3.561 ± 0.06	8.286GlyGly: 8.286 ± 0.175	1.893GlyHis: 1.893 ± 0.057	4.307GlyIle: 4.307 ± 0.078	2.943GlyLys: 2.943 ± 0.062	8.821GlyLeu: 8.821 ± 0.113	2.149GlyMet: 2.149 ± 0.052	2.079GlyAsn: 2.079 ± 0.067	3.796GlyPro: 3.796 ± 0.063	2.866GlyGln: 2.866 ± 0.063	7.024GlyArg: 7.024 ± 0.092	4.82GlySer: 4.82 ± 0.081	4.638GlyThr: 4.638 ± 0.097	6.128GlyVal: 6.128 ± 0.087	1.636GlyTrp: 1.636 ± 0.048	2.183GlyTyr: 2.183 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.203HisAla: 2.203 ± 0.055	0.223HisCys: 0.223 ± 0.016	1.101HisAsp: 1.101 ± 0.035	1.152HisGlu: 1.152 ± 0.036	0.817HisPhe: 0.817 ± 0.031	1.985HisGly: 1.985 ± 0.057	0.53HisHis: 0.53 ± 0.026	0.917HisIle: 0.917 ± 0.029	0.512HisLys: 0.512 ± 0.023	1.925HisLeu: 1.925 ± 0.049	0.435HisMet: 0.435 ± 0.02	0.425HisAsn: 0.425 ± 0.023	1.251HisPro: 1.251 ± 0.038	0.574HisGln: 0.574 ± 0.024	1.489HisArg: 1.489 ± 0.047	0.953HisSer: 0.953 ± 0.037	0.619HisThr: 0.619 ± 0.025	1.444HisVal: 1.444 ± 0.041	0.335HisTrp: 0.335 ± 0.02	0.593HisTyr: 0.593 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	7.234IleAla: 7.234 ± 0.091	0.428IleCys: 0.428 ± 0.022	3.797IleAsp: 3.797 ± 0.061	3.833IleGlu: 3.833 ± 0.069	1.585IlePhe: 1.585 ± 0.048	5.092IleGly: 5.092 ± 0.099	0.883IleHis: 0.883 ± 0.031	2.133IleIle: 2.133 ± 0.054	1.184IleLys: 1.184 ± 0.044	4.376IleLeu: 4.376 ± 0.074	0.859IleMet: 0.859 ± 0.03	1.187IleAsn: 1.187 ± 0.043	2.244IlePro: 2.244 ± 0.046	1.179IleGln: 1.179 ± 0.038	3.145IleArg: 3.145 ± 0.059	2.496IleSer: 2.496 ± 0.047	2.272IleThr: 2.272 ± 0.057	4.288IleVal: 4.288 ± 0.067	0.558IleTrp: 0.558 ± 0.024	0.991IleTyr: 0.991 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.303LysAla: 4.303 ± 0.078	0.143LysCys: 0.143 ± 0.013	1.429LysAsp: 1.429 ± 0.044	1.592LysGlu: 1.592 ± 0.039	0.756LysPhe: 0.756 ± 0.034	2.645LysGly: 2.645 ± 0.062	0.492LysHis: 0.492 ± 0.025	1.434LysIle: 1.434 ± 0.043	1.112LysLys: 1.112 ± 0.051	3.194LysLeu: 3.194 ± 0.064	0.694LysMet: 0.694 ± 0.031	0.678LysAsn: 0.678 ± 0.032	1.907LysPro: 1.907 ± 0.051	0.834LysGln: 0.834 ± 0.033	2.442LysArg: 2.442 ± 0.057	1.609LysSer: 1.609 ± 0.044	1.547LysThr: 1.547 ± 0.045	2.143LysVal: 2.143 ± 0.053	0.346LysTrp: 0.346 ± 0.019	0.531LysTyr: 0.531 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	14.09LeuAla: 14.09 ± 0.137	0.755LeuCys: 0.755 ± 0.026	6.236LeuAsp: 6.236 ± 0.093	5.683LeuGlu: 5.683 ± 0.073	3.783LeuPhe: 3.783 ± 0.066	8.567LeuGly: 8.567 ± 0.119	1.857LeuHis: 1.857 ± 0.045	5.255LeuIle: 5.255 ± 0.091	3.36LeuLys: 3.36 ± 0.065	10.252LeuLeu: 10.252 ± 0.147	2.136LeuMet: 2.136 ± 0.05	2.271LeuAsn: 2.271 ± 0.045	5.444LeuPro: 5.444 ± 0.083	2.455LeuGln: 2.455 ± 0.057	6.874LeuArg: 6.874 ± 0.092	6.028LeuSer: 6.028 ± 0.093	5.381LeuThr: 5.381 ± 0.082	7.489LeuVal: 7.489 ± 0.1	1.299LeuTrp: 1.299 ± 0.047	2.013LeuTyr: 2.013 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	3.103MetAla: 3.103 ± 0.071	0.162MetCys: 0.162 ± 0.013	1.079MetAsp: 1.079 ± 0.042	1.194MetGlu: 1.194 ± 0.039	0.653MetPhe: 0.653 ± 0.024	1.886MetGly: 1.886 ± 0.047	0.397MetHis: 0.397 ± 0.019	1.345MetIle: 1.345 ± 0.043	0.954MetLys: 0.954 ± 0.033	2.556MetLeu: 2.556 ± 0.054	0.614MetMet: 0.614 ± 0.027	0.677MetAsn: 0.677 ± 0.028	1.334MetPro: 1.334 ± 0.037	0.675MetGln: 0.675 ± 0.027	1.785MetArg: 1.785 ± 0.047	1.348MetSer: 1.348 ± 0.036	1.579MetThr: 1.579 ± 0.041	1.578MetVal: 1.578 ± 0.043	0.236MetTrp: 0.236 ± 0.015	0.236MetTyr: 0.236 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.855AsnAla: 2.855 ± 0.062	0.209AsnCys: 0.209 ± 0.015	1.293AsnAsp: 1.293 ± 0.042	1.277AsnGlu: 1.277 ± 0.04	0.792AsnPhe: 0.792 ± 0.028	2.159AsnGly: 2.159 ± 0.062	0.449AsnHis: 0.449 ± 0.022	1.315AsnIle: 1.315 ± 0.039	0.573AsnLys: 0.573 ± 0.026	2.405AsnLeu: 2.405 ± 0.062	0.552AsnMet: 0.552 ± 0.023	0.636AsnAsn: 0.636 ± 0.039	1.704AsnPro: 1.704 ± 0.043	0.731AsnGln: 0.731 ± 0.042	1.772AsnArg: 1.772 ± 0.04	1.162AsnSer: 1.162 ± 0.039	0.94AsnThr: 0.94 ± 0.037	1.826AsnVal: 1.826 ± 0.058	0.339AsnTrp: 0.339 ± 0.02	0.567AsnTyr: 0.567 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.813ProAla: 6.813 ± 0.103	0.324ProCys: 0.324 ± 0.022	3.708ProAsp: 3.708 ± 0.064	4.132ProGlu: 4.132 ± 0.076	1.844ProPhe: 1.844 ± 0.043	4.676ProGly: 4.676 ± 0.077	1.07ProHis: 1.07 ± 0.035	2.482ProIle: 2.482 ± 0.05	1.59ProLys: 1.59 ± 0.044	5.048ProLeu: 5.048 ± 0.079	1.203ProMet: 1.203 ± 0.036	1.213ProAsn: 1.213 ± 0.037	3.124ProPro: 3.124 ± 0.094	1.482ProGln: 1.482 ± 0.04	3.239ProArg: 3.239 ± 0.068	2.891ProSer: 2.891 ± 0.058	2.513ProThr: 2.513 ± 0.047	4.184ProVal: 4.184 ± 0.069	0.711ProTrp: 0.711 ± 0.028	1.138ProTyr: 1.138 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.016GlnAla: 4.016 ± 0.071	0.183GlnCys: 0.183 ± 0.014	1.375GlnAsp: 1.375 ± 0.042	1.486GlnGlu: 1.486 ± 0.047	0.986GlnPhe: 0.986 ± 0.029	2.478GlnGly: 2.478 ± 0.053	0.545GlnHis: 0.545 ± 0.025	1.518GlnIle: 1.518 ± 0.039	0.865GlnLys: 0.865 ± 0.03	2.994GlnLeu: 2.994 ± 0.058	0.781GlnMet: 0.781 ± 0.029	0.671GlnAsn: 0.671 ± 0.036	1.84GlnPro: 1.84 ± 0.044	1.055GlnGln: 1.055 ± 0.041	2.49GlnArg: 2.49 ± 0.06	1.666GlnSer: 1.666 ± 0.055	1.532GlnThr: 1.532 ± 0.056	2.132GlnVal: 2.132 ± 0.056	0.383GlnTrp: 0.383 ± 0.022	0.54GlnTyr: 0.54 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.969ArgAla: 8.969 ± 0.119	0.551ArgCys: 0.551 ± 0.026	4.292ArgAsp: 4.292 ± 0.079	4.775ArgGlu: 4.775 ± 0.076	3.133ArgPhe: 3.133 ± 0.064	5.139ArgGly: 5.139 ± 0.085	1.694ArgHis: 1.694 ± 0.047	4.256ArgIle: 4.256 ± 0.061	2.092ArgLys: 2.092 ± 0.057	9.104ArgLeu: 9.104 ± 0.126	1.917ArgMet: 1.917 ± 0.048	1.799ArgAsn: 1.799 ± 0.049	4.086ArgPro: 4.086 ± 0.077	2.562ArgGln: 2.562 ± 0.062	6.629ArgArg: 6.629 ± 0.131	3.94ArgSer: 3.94 ± 0.063	3.561ArgThr: 3.561 ± 0.066	4.987ArgVal: 4.987 ± 0.081	1.208ArgTrp: 1.208 ± 0.038	1.878ArgTyr: 1.878 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	6.227SerAla: 6.227 ± 0.08	0.429SerCys: 0.429 ± 0.025	3.049SerAsp: 3.049 ± 0.065	3.006SerGlu: 3.006 ± 0.061	2.096SerPhe: 2.096 ± 0.049	5.458SerGly: 5.458 ± 0.093	1.009SerHis: 1.009 ± 0.026	2.598SerIle: 2.598 ± 0.058	1.405SerLys: 1.405 ± 0.044	5.443SerLeu: 5.443 ± 0.08	1.13SerMet: 1.13 ± 0.033	1.262SerAsn: 1.262 ± 0.044	2.744SerPro: 2.744 ± 0.058	1.53SerGln: 1.53 ± 0.044	3.805SerArg: 3.805 ± 0.063	2.788SerSer: 2.788 ± 0.085	2.5SerThr: 2.5 ± 0.068	3.62SerVal: 3.62 ± 0.069	0.719SerTrp: 0.719 ± 0.028	1.3SerTyr: 1.3 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	6.12ThrAla: 6.12 ± 0.103	0.356ThrCys: 0.356 ± 0.021	2.691ThrAsp: 2.691 ± 0.056	2.566ThrGlu: 2.566 ± 0.048	1.716ThrPhe: 1.716 ± 0.044	5.156ThrGly: 5.156 ± 0.106	0.872ThrHis: 0.872 ± 0.032	2.795ThrIle: 2.795 ± 0.057	1.245ThrLys: 1.245 ± 0.047	5.556ThrLeu: 5.556 ± 0.078	1.091ThrMet: 1.091 ± 0.035	1.194ThrAsn: 1.194 ± 0.045	3.176ThrPro: 3.176 ± 0.064	1.375ThrGln: 1.375 ± 0.058	3.326ThrArg: 3.326 ± 0.061	2.567ThrSer: 2.567 ± 0.074	2.372ThrThr: 2.372 ± 0.048	4.089ThrVal: 4.089 ± 0.067	0.556ThrTrp: 0.556 ± 0.027	1.071ThrTyr: 1.071 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	9.617ValAla: 9.617 ± 0.103	0.507ValCys: 0.507 ± 0.027	4.528ValAsp: 4.528 ± 0.068	5.268ValGlu: 5.268 ± 0.077	2.087ValPhe: 2.087 ± 0.046	5.838ValGly: 5.838 ± 0.102	1.392ValHis: 1.392 ± 0.044	3.528ValIle: 3.528 ± 0.065	2.169ValLys: 2.169 ± 0.059	6.38ValLeu: 6.38 ± 0.098	1.611ValMet: 1.611 ± 0.047	1.866ValAsn: 1.866 ± 0.046	4.002ValPro: 4.002 ± 0.072	2.035ValGln: 2.035 ± 0.052	5.243ValArg: 5.243 ± 0.073	3.975ValSer: 3.975 ± 0.065	4.396ValThr: 4.396 ± 0.074	5.352ValVal: 5.352 ± 0.086	0.84ValTrp: 0.84 ± 0.026	1.449ValTyr: 1.449 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.326TrpAla: 1.326 ± 0.04	0.117TrpCys: 0.117 ± 0.013	0.705TrpAsp: 0.705 ± 0.025	0.657TrpGlu: 0.657 ± 0.023	0.52TrpPhe: 0.52 ± 0.025	0.889TrpGly: 0.889 ± 0.033	0.332TrpHis: 0.332 ± 0.02	0.676TrpIle: 0.676 ± 0.028	0.504TrpLys: 0.504 ± 0.026	1.831TrpLeu: 1.831 ± 0.054	0.376TrpMet: 0.376 ± 0.018	0.397TrpAsn: 0.397 ± 0.02	0.722TrpPro: 0.722 ± 0.029	0.5TrpGln: 0.5 ± 0.023	1.366TrpArg: 1.366 ± 0.041	0.871TrpSer: 0.871 ± 0.029	0.809TrpThr: 0.809 ± 0.034	0.83TrpVal: 0.83 ± 0.031	0.261TrpTrp: 0.261 ± 0.018	0.274TrpTyr: 0.274 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.456TyrAla: 2.456 ± 0.056	0.199TyrCys: 0.199 ± 0.014	1.532TyrAsp: 1.532 ± 0.05	1.316TyrGlu: 1.316 ± 0.041	0.828TyrPhe: 0.828 ± 0.032	2.165TyrGly: 2.165 ± 0.053	0.496TyrHis: 0.496 ± 0.027	0.87TyrIle: 0.87 ± 0.034	0.564TyrLys: 0.564 ± 0.025	2.111TyrLeu: 2.111 ± 0.053	0.399TyrMet: 0.399 ± 0.021	0.512TyrAsn: 0.512 ± 0.024	1.072TyrPro: 1.072 ± 0.036	0.637TyrGln: 0.637 ± 0.028	1.988TyrArg: 1.988 ± 0.051	1.205TyrSer: 1.205 ± 0.039	0.872TyrThr: 0.872 ± 0.038	1.62TyrVal: 1.62 ± 0.049	0.339TyrTrp: 0.339 ± 0.019	0.627TyrTyr: 0.627 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2892 proteins (902573 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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