Amino acid dipepetide frequency for Bisgaard taxon 44 str. 111

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.926AlaAla: 7.926 ± 0.167
0.82AlaCys: 0.82 ± 0.039
4.353AlaAsp: 4.353 ± 0.091
4.537AlaGlu: 4.537 ± 0.129
3.169AlaPhe: 3.169 ± 0.096
4.683AlaGly: 4.683 ± 0.115
1.611AlaHis: 1.611 ± 0.058
5.057AlaIle: 5.057 ± 0.118
6.332AlaLys: 6.332 ± 0.129
8.856AlaLeu: 8.856 ± 0.138
1.484AlaMet: 1.484 ± 0.055
5.652AlaAsn: 5.652 ± 0.111
2.772AlaPro: 2.772 ± 0.071
6.23AlaGln: 6.23 ± 0.161
3.028AlaArg: 3.028 ± 0.087
5.881AlaSer: 5.881 ± 0.127
5.735AlaThr: 5.735 ± 0.159
5.17AlaVal: 5.17 ± 0.104
0.733AlaTrp: 0.733 ± 0.034
3.317AlaTyr: 3.317 ± 0.075
0.0AlaXaa: 0.0 ± 0.0
Cys
0.641CysAla: 0.641 ± 0.034
0.115CysCys: 0.115 ± 0.015
0.457CysAsp: 0.457 ± 0.024
0.407CysGlu: 0.407 ± 0.024
0.424CysPhe: 0.424 ± 0.027
0.628CysGly: 0.628 ± 0.037
0.188CysHis: 0.188 ± 0.018
0.54CysIle: 0.54 ± 0.032
0.52CysLys: 0.52 ± 0.028
0.978CysLeu: 0.978 ± 0.042
0.17CysMet: 0.17 ± 0.017
0.419CysAsn: 0.419 ± 0.028
0.335CysPro: 0.335 ± 0.022
0.413CysGln: 0.413 ± 0.032
0.295CysArg: 0.295 ± 0.022
0.556CysSer: 0.556 ± 0.031
0.468CysThr: 0.468 ± 0.026
0.518CysVal: 0.518 ± 0.032
0.061CysTrp: 0.061 ± 0.01
0.346CysTyr: 0.346 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
3.457AspAla: 3.457 ± 0.076
0.416AspCys: 0.416 ± 0.029
2.489AspAsp: 2.489 ± 0.084
2.865AspGlu: 2.865 ± 0.094
2.987AspPhe: 2.987 ± 0.078
2.461AspGly: 2.461 ± 0.103
0.878AspHis: 0.878 ± 0.041
3.395AspIle: 3.395 ± 0.085
3.684AspLys: 3.684 ± 0.087
6.637AspLeu: 6.637 ± 0.133
0.906AspMet: 0.906 ± 0.037
3.086AspAsn: 3.086 ± 0.079
2.272AspPro: 2.272 ± 0.061
2.09AspGln: 2.09 ± 0.065
1.811AspArg: 1.811 ± 0.06
2.929AspSer: 2.929 ± 0.083
2.682AspThr: 2.682 ± 0.085
3.131AspVal: 3.131 ± 0.09
0.488AspTrp: 0.488 ± 0.032
2.791AspTyr: 2.791 ± 0.068
0.0AspXaa: 0.0 ± 0.0
Glu
4.088GluAla: 4.088 ± 0.111
0.361GluCys: 0.361 ± 0.026
2.665GluAsp: 2.665 ± 0.077
3.45GluGlu: 3.45 ± 0.116
2.684GluPhe: 2.684 ± 0.071
2.257GluGly: 2.257 ± 0.077
1.338GluHis: 1.338 ± 0.05
3.612GluIle: 3.612 ± 0.075
3.752GluLys: 3.752 ± 0.099
6.811GluLeu: 6.811 ± 0.178
0.942GluMet: 0.942 ± 0.04
3.35GluAsn: 3.35 ± 0.085
1.561GluPro: 1.561 ± 0.055
5.259GluGln: 5.259 ± 0.167
2.343GluArg: 2.343 ± 0.09
2.631GluSer: 2.631 ± 0.077
2.877GluThr: 2.877 ± 0.086
4.16GluVal: 4.16 ± 0.101
0.352GluTrp: 0.352 ± 0.025
2.26GluTyr: 2.26 ± 0.065
0.0GluXaa: 0.0 ± 0.0
Phe
4.24PheAla: 4.24 ± 0.114
0.4PheCys: 0.4 ± 0.029
2.232PheAsp: 2.232 ± 0.065
1.825PheGlu: 1.825 ± 0.059
1.922PhePhe: 1.922 ± 0.069
2.55PheGly: 2.55 ± 0.062
0.597PheHis: 0.597 ± 0.037
3.127PheIle: 3.127 ± 0.088
2.872PheLys: 2.872 ± 0.075
3.855PheLeu: 3.855 ± 0.107
0.912PheMet: 0.912 ± 0.04
3.114PheAsn: 3.114 ± 0.066
1.286PhePro: 1.286 ± 0.051
1.08PheGln: 1.08 ± 0.043
1.314PheArg: 1.314 ± 0.05
3.296PheSer: 3.296 ± 0.076
3.439PheThr: 3.439 ± 0.075
2.89PheVal: 2.89 ± 0.076
0.455PheTrp: 0.455 ± 0.03
1.792PheTyr: 1.792 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
4.049GlyAla: 4.049 ± 0.111
0.573GlyCys: 0.573 ± 0.032
2.81GlyAsp: 2.81 ± 0.093
2.654GlyGlu: 2.654 ± 0.078
2.682GlyPhe: 2.682 ± 0.08
3.254GlyGly: 3.254 ± 0.107
1.066GlyHis: 1.066 ± 0.038
3.942GlyIle: 3.942 ± 0.088
4.279GlyLys: 4.279 ± 0.101
5.354GlyLeu: 5.354 ± 0.111
1.247GlyMet: 1.247 ± 0.048
3.196GlyAsn: 3.196 ± 0.174
0.949GlyPro: 0.949 ± 0.045
2.543GlyGln: 2.543 ± 0.074
2.049GlyArg: 2.049 ± 0.064
3.607GlySer: 3.607 ± 0.147
3.513GlyThr: 3.513 ± 0.154
4.104GlyVal: 4.104 ± 0.098
0.506GlyTrp: 0.506 ± 0.033
2.508GlyTyr: 2.508 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
1.415HisAla: 1.415 ± 0.053
0.209HisCys: 0.209 ± 0.019
0.878HisAsp: 0.878 ± 0.046
1.051HisGlu: 1.051 ± 0.04
0.846HisPhe: 0.846 ± 0.032
1.073HisGly: 1.073 ± 0.04
0.437HisHis: 0.437 ± 0.037
1.205HisIle: 1.205 ± 0.044
1.164HisLys: 1.164 ± 0.046
2.152HisLeu: 2.152 ± 0.069
0.333HisMet: 0.333 ± 0.023
1.104HisAsn: 1.104 ± 0.041
0.835HisPro: 0.835 ± 0.037
0.975HisGln: 0.975 ± 0.042
0.729HisArg: 0.729 ± 0.033
1.115HisSer: 1.115 ± 0.045
1.002HisThr: 1.002 ± 0.041
1.131HisVal: 1.131 ± 0.041
0.209HisTrp: 0.209 ± 0.021
0.812HisTyr: 0.812 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
5.87IleAla: 5.87 ± 0.11
0.716IleCys: 0.716 ± 0.038
3.785IleAsp: 3.785 ± 0.093
3.342IleGlu: 3.342 ± 0.088
2.821IlePhe: 2.821 ± 0.09
3.713IleGly: 3.713 ± 0.096
1.033IleHis: 1.033 ± 0.043
4.137IleIle: 4.137 ± 0.118
3.813IleLys: 3.813 ± 0.088
5.297IleLeu: 5.297 ± 0.141
1.106IleMet: 1.106 ± 0.046
4.225IleAsn: 4.225 ± 0.106
2.419IlePro: 2.419 ± 0.071
1.99IleGln: 1.99 ± 0.058
2.345IleArg: 2.345 ± 0.074
4.622IleSer: 4.622 ± 0.106
4.215IleThr: 4.215 ± 0.157
4.276IleVal: 4.276 ± 0.086
0.418IleTrp: 0.418 ± 0.026
2.419IleTyr: 2.419 ± 0.067
0.0IleXaa: 0.0 ± 0.0
Lys
5.691LysAla: 5.691 ± 0.128
0.352LysCys: 0.352 ± 0.024
3.458LysAsp: 3.458 ± 0.08
4.126LysGlu: 4.126 ± 0.108
2.577LysPhe: 2.577 ± 0.068
2.97LysGly: 2.97 ± 0.08
1.212LysHis: 1.212 ± 0.047
3.475LysIle: 3.475 ± 0.082
3.099LysLys: 3.099 ± 0.091
6.219LysLeu: 6.219 ± 0.116
1.352LysMet: 1.352 ± 0.048
3.139LysAsn: 3.139 ± 0.076
2.159LysPro: 2.159 ± 0.067
3.562LysGln: 3.562 ± 0.089
2.561LysArg: 2.561 ± 0.074
3.475LysSer: 3.475 ± 0.088
3.42LysThr: 3.42 ± 0.085
4.878LysVal: 4.878 ± 0.094
0.449LysTrp: 0.449 ± 0.029
2.654LysTyr: 2.654 ± 0.069
0.0LysXaa: 0.0 ± 0.0
Leu
10.155LeuAla: 10.155 ± 0.197
0.922LeuCys: 0.922 ± 0.04
5.971LeuAsp: 5.971 ± 0.114
6.718LeuGlu: 6.718 ± 0.143
3.931LeuPhe: 3.931 ± 0.102
6.12LeuGly: 6.12 ± 0.113
1.779LeuHis: 1.779 ± 0.05
6.252LeuIle: 6.252 ± 0.147
5.412LeuLys: 5.412 ± 0.106
9.137LeuLeu: 9.137 ± 0.17
1.819LeuMet: 1.819 ± 0.061
6.112LeuAsn: 6.112 ± 0.146
4.14LeuPro: 4.14 ± 0.089
4.79LeuGln: 4.79 ± 0.152
3.992LeuArg: 3.992 ± 0.101
7.427LeuSer: 7.427 ± 0.124
6.803LeuThr: 6.803 ± 0.149
7.058LeuVal: 7.058 ± 0.132
0.831LeuTrp: 0.831 ± 0.044
3.373LeuTyr: 3.373 ± 0.085
0.0LeuXaa: 0.0 ± 0.0
Met
1.451MetAla: 1.451 ± 0.054
0.163MetCys: 0.163 ± 0.016
0.773MetAsp: 0.773 ± 0.037
0.792MetGlu: 0.792 ± 0.044
0.799MetPhe: 0.799 ± 0.039
0.956MetGly: 0.956 ± 0.043
0.443MetHis: 0.443 ± 0.028
1.049MetIle: 1.049 ± 0.047
0.839MetLys: 0.839 ± 0.039
1.955MetLeu: 1.955 ± 0.056
0.396MetMet: 0.396 ± 0.028
0.785MetAsn: 0.785 ± 0.041
0.757MetPro: 0.757 ± 0.04
1.194MetGln: 1.194 ± 0.048
0.901MetArg: 0.901 ± 0.04
1.371MetSer: 1.371 ± 0.053
1.109MetThr: 1.109 ± 0.043
1.107MetVal: 1.107 ± 0.04
0.129MetTrp: 0.129 ± 0.015
0.638MetTyr: 0.638 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
4.974AsnAla: 4.974 ± 0.147
0.422AsnCys: 0.422 ± 0.027
2.502AsnAsp: 2.502 ± 0.065
2.791AsnGlu: 2.791 ± 0.067
2.811AsnPhe: 2.811 ± 0.073
3.35AsnGly: 3.35 ± 0.15
1.027AsnHis: 1.027 ± 0.044
3.813AsnIle: 3.813 ± 0.156
3.637AsnLys: 3.637 ± 0.09
6.893AsnLeu: 6.893 ± 0.166
0.991AsnMet: 0.991 ± 0.045
3.965AsnAsn: 3.965 ± 0.133
2.932AsnPro: 2.932 ± 0.078
3.015AsnGln: 3.015 ± 0.09
2.111AsnArg: 2.111 ± 0.061
4.407AsnSer: 4.407 ± 0.151
3.876AsnThr: 3.876 ± 0.151
3.808AsnVal: 3.808 ± 0.238
0.57AsnTrp: 0.57 ± 0.032
2.775AsnTyr: 2.775 ± 0.068
0.0AsnXaa: 0.0 ± 0.0
Pro
3.128ProAla: 3.128 ± 0.097
0.226ProCys: 0.226 ± 0.017
1.723ProAsp: 1.723 ± 0.054
3.278ProGlu: 3.278 ± 0.081
1.45ProPhe: 1.45 ± 0.054
1.717ProGly: 1.717 ± 0.057
0.862ProHis: 0.862 ± 0.04
2.009ProIle: 2.009 ± 0.056
1.701ProLys: 1.701 ± 0.055
3.403ProLeu: 3.403 ± 0.075
0.587ProMet: 0.587 ± 0.04
1.971ProAsn: 1.971 ± 0.065
0.879ProPro: 0.879 ± 0.046
2.034ProGln: 2.034 ± 0.071
1.123ProArg: 1.123 ± 0.047
2.398ProSer: 2.398 ± 0.067
2.351ProThr: 2.351 ± 0.065
2.649ProVal: 2.649 ± 0.076
0.339ProTrp: 0.339 ± 0.024
1.556ProTyr: 1.556 ± 0.059
0.0ProXaa: 0.0 ± 0.0
Gln
6.681GlnAla: 6.681 ± 0.183
0.225GlnCys: 0.225 ± 0.02
2.645GlnAsp: 2.645 ± 0.08
3.975GlnGlu: 3.975 ± 0.134
1.666GlnPhe: 1.666 ± 0.056
2.948GlnGly: 2.948 ± 0.077
1.005GlnHis: 1.005 ± 0.051
3.354GlnIle: 3.354 ± 0.08
2.615GlnLys: 2.615 ± 0.087
4.799GlnLeu: 4.799 ± 0.142
0.955GlnMet: 0.955 ± 0.038
2.585GlnAsn: 2.585 ± 0.069
1.691GlnPro: 1.691 ± 0.085
4.306GlnGln: 4.306 ± 0.164
2.031GlnArg: 2.031 ± 0.067
2.728GlnSer: 2.728 ± 0.077
3.171GlnThr: 3.171 ± 0.1
4.55GlnVal: 4.55 ± 0.118
0.375GlnTrp: 0.375 ± 0.026
1.665GlnTyr: 1.665 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
2.946ArgAla: 2.946 ± 0.08
0.335ArgCys: 0.335 ± 0.024
1.947ArgAsp: 1.947 ± 0.06
2.331ArgGlu: 2.331 ± 0.082
1.784ArgPhe: 1.784 ± 0.056
1.9ArgGly: 1.9 ± 0.067
0.664ArgHis: 0.664 ± 0.03
2.601ArgIle: 2.601 ± 0.079
2.448ArgLys: 2.448 ± 0.073
4.182ArgLeu: 4.182 ± 0.098
0.733ArgMet: 0.733 ± 0.037
2.067ArgAsn: 2.067 ± 0.067
1.277ArgPro: 1.277 ± 0.058
1.998ArgGln: 1.998 ± 0.058
1.837ArgArg: 1.837 ± 0.069
2.035ArgSer: 2.035 ± 0.059
1.847ArgThr: 1.847 ± 0.066
2.464ArgVal: 2.464 ± 0.075
0.294ArgTrp: 0.294 ± 0.022
1.578ArgTyr: 1.578 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
5.377SerAla: 5.377 ± 0.124
0.597SerCys: 0.597 ± 0.033
2.968SerAsp: 2.968 ± 0.08
3.328SerGlu: 3.328 ± 0.083
3.023SerPhe: 3.023 ± 0.086
3.692SerGly: 3.692 ± 0.122
1.249SerHis: 1.249 ± 0.048
3.994SerIle: 3.994 ± 0.1
4.133SerLys: 4.133 ± 0.104
7.756SerLeu: 7.756 ± 0.137
0.989SerMet: 0.989 ± 0.037
4.045SerAsn: 4.045 ± 0.165
2.254SerPro: 2.254 ± 0.075
3.505SerGln: 3.505 ± 0.097
2.302SerArg: 2.302 ± 0.069
5.676SerSer: 5.676 ± 0.177
4.539SerThr: 4.539 ± 0.166
4.08SerVal: 4.08 ± 0.106
0.693SerTrp: 0.693 ± 0.041
2.973SerTyr: 2.973 ± 0.074
0.0SerXaa: 0.0 ± 0.0
Thr
5.398ThrAla: 5.398 ± 0.161
0.488ThrCys: 0.488 ± 0.026
3.073ThrAsp: 3.073 ± 0.086
2.808ThrGlu: 2.808 ± 0.081
2.532ThrPhe: 2.532 ± 0.07
3.954ThrGly: 3.954 ± 0.163
1.04ThrHis: 1.04 ± 0.041
3.805ThrIle: 3.805 ± 0.109
3.686ThrLys: 3.686 ± 0.104
6.516ThrLeu: 6.516 ± 0.119
0.835ThrMet: 0.835 ± 0.037
4.284ThrAsn: 4.284 ± 0.217
3.003ThrPro: 3.003 ± 0.089
3.127ThrGln: 3.127 ± 0.099
1.977ThrArg: 1.977 ± 0.059
4.867ThrSer: 4.867 ± 0.17
4.97ThrThr: 4.97 ± 0.192
4.038ThrVal: 4.038 ± 0.167
0.512ThrTrp: 0.512 ± 0.03
2.723ThrTyr: 2.723 ± 0.077
0.0ThrXaa: 0.0 ± 0.0
Val
5.924ValAla: 5.924 ± 0.112
0.656ValCys: 0.656 ± 0.036
4.091ValAsp: 4.091 ± 0.094
4.177ValGlu: 4.177 ± 0.098
2.657ValPhe: 2.657 ± 0.073
3.895ValGly: 3.895 ± 0.106
1.115ValHis: 1.115 ± 0.042
4.418ValIle: 4.418 ± 0.093
4.25ValLys: 4.25 ± 0.096
6.081ValLeu: 6.081 ± 0.13
1.088ValMet: 1.088 ± 0.042
4.744ValAsn: 4.744 ± 0.176
2.265ValPro: 2.265 ± 0.075
2.717ValGln: 2.717 ± 0.069
2.351ValArg: 2.351 ± 0.056
4.864ValSer: 4.864 ± 0.128
4.755ValThr: 4.755 ± 0.22
5.148ValVal: 5.148 ± 0.105
0.424ValTrp: 0.424 ± 0.031
2.522ValTyr: 2.522 ± 0.077
0.0ValXaa: 0.0 ± 0.0
Trp
0.526TrpAla: 0.526 ± 0.03
0.094TrpCys: 0.094 ± 0.013
0.49TrpAsp: 0.49 ± 0.03
0.416TrpGlu: 0.416 ± 0.025
0.364TrpPhe: 0.364 ± 0.026
0.471TrpGly: 0.471 ± 0.026
0.251TrpHis: 0.251 ± 0.02
0.413TrpIle: 0.413 ± 0.025
0.389TrpLys: 0.389 ± 0.025
1.165TrpLeu: 1.165 ± 0.052
0.144TrpMet: 0.144 ± 0.013
0.396TrpAsn: 0.396 ± 0.026
0.199TrpPro: 0.199 ± 0.016
0.85TrpGln: 0.85 ± 0.054
0.388TrpArg: 0.388 ± 0.025
0.476TrpSer: 0.476 ± 0.03
0.388TrpThr: 0.388 ± 0.03
0.506TrpVal: 0.506 ± 0.032
0.115TrpTrp: 0.115 ± 0.014
0.327TrpTyr: 0.327 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.411TyrAla: 3.411 ± 0.084
0.388TyrCys: 0.388 ± 0.025
2.147TyrAsp: 2.147 ± 0.064
1.885TyrGlu: 1.885 ± 0.057
2.071TyrPhe: 2.071 ± 0.068
2.293TyrGly: 2.293 ± 0.075
0.876TyrHis: 0.876 ± 0.038
2.362TyrIle: 2.362 ± 0.076
2.206TyrLys: 2.206 ± 0.065
4.694TyrLeu: 4.694 ± 0.118
0.614TyrMet: 0.614 ± 0.034
2.429TyrAsn: 2.429 ± 0.069
1.399TyrPro: 1.399 ± 0.046
2.291TyrGln: 2.291 ± 0.075
1.779TyrArg: 1.779 ± 0.064
2.813TyrSer: 2.813 ± 0.082
2.475TyrThr: 2.475 ± 0.071
2.477TyrVal: 2.477 ± 0.068
0.416TyrTrp: 0.416 ± 0.028
1.831TyrTyr: 1.831 ± 0.066
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1591 proteins (636759 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski