Amino acid dipepetide frequency for Desulfofustis sp. PB-SRB1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.957AlaAla: 10.957 ± 0.128	1.147AlaCys: 1.147 ± 0.038	5.367AlaAsp: 5.367 ± 0.08	6.072AlaGlu: 6.072 ± 0.083	3.187AlaPhe: 3.187 ± 0.061	8.078AlaGly: 8.078 ± 0.11	2.153AlaHis: 2.153 ± 0.048	6.057AlaIle: 6.057 ± 0.087	3.275AlaLys: 3.275 ± 0.061	9.874AlaLeu: 9.874 ± 0.1	2.786AlaMet: 2.786 ± 0.054	2.436AlaAsn: 2.436 ± 0.048	3.691AlaPro: 3.691 ± 0.064	3.167AlaGln: 3.167 ± 0.058	5.705AlaArg: 5.705 ± 0.086	4.344AlaSer: 4.344 ± 0.064	5.042AlaThr: 5.042 ± 0.073	7.31AlaVal: 7.31 ± 0.089	0.946AlaTrp: 0.946 ± 0.035	2.351AlaTyr: 2.351 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.186CysAla: 1.186 ± 0.033	0.246CysCys: 0.246 ± 0.016	0.567CysAsp: 0.567 ± 0.025	0.673CysGlu: 0.673 ± 0.027	0.564CysPhe: 0.564 ± 0.024	1.336CysGly: 1.336 ± 0.043	0.399CysHis: 0.399 ± 0.029	0.712CysIle: 0.712 ± 0.025	0.365CysLys: 0.365 ± 0.021	1.245CysLeu: 1.245 ± 0.037	0.316CysMet: 0.316 ± 0.016	0.372CysAsn: 0.372 ± 0.016	0.728CysPro: 0.728 ± 0.031	0.319CysGln: 0.319 ± 0.016	0.956CysArg: 0.956 ± 0.031	0.741CysSer: 0.741 ± 0.029	0.692CysThr: 0.692 ± 0.027	0.693CysVal: 0.693 ± 0.025	0.147CysTrp: 0.147 ± 0.01	0.404CysTyr: 0.404 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.013AspAla: 4.013 ± 0.06	0.68AspCys: 0.68 ± 0.026	3.259AspAsp: 3.259 ± 0.057	4.257AspGlu: 4.257 ± 0.07	2.576AspPhe: 2.576 ± 0.049	4.306AspGly: 4.306 ± 0.077	1.392AspHis: 1.392 ± 0.039	3.95AspIle: 3.95 ± 0.068	2.127AspLys: 2.127 ± 0.049	5.315AspLeu: 5.315 ± 0.086	1.361AspMet: 1.361 ± 0.034	1.736AspAsn: 1.736 ± 0.04	2.77AspPro: 2.77 ± 0.05	2.038AspGln: 2.038 ± 0.053	3.043AspArg: 3.043 ± 0.054	2.752AspSer: 2.752 ± 0.056	3.115AspThr: 3.115 ± 0.054	3.327AspVal: 3.327 ± 0.052	0.718AspTrp: 0.718 ± 0.028	1.906AspTyr: 1.906 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	5.476GluAla: 5.476 ± 0.081	0.541GluCys: 0.541 ± 0.023	2.983GluAsp: 2.983 ± 0.058	3.884GluGlu: 3.884 ± 0.073	2.106GluPhe: 2.106 ± 0.046	3.467GluGly: 3.467 ± 0.067	1.578GluHis: 1.578 ± 0.043	4.433GluIle: 4.433 ± 0.074	3.603GluLys: 3.603 ± 0.069	6.794GluLeu: 6.794 ± 0.089	1.72GluMet: 1.72 ± 0.045	2.154GluAsn: 2.154 ± 0.047	2.745GluPro: 2.745 ± 0.058	3.309GluGln: 3.309 ± 0.06	4.18GluArg: 4.18 ± 0.062	3.056GluSer: 3.056 ± 0.054	3.209GluThr: 3.209 ± 0.056	4.183GluVal: 4.183 ± 0.065	0.576GluTrp: 0.576 ± 0.023	1.591GluTyr: 1.591 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.828PheAla: 3.828 ± 0.064	0.651PheCys: 0.651 ± 0.026	2.574PheAsp: 2.574 ± 0.048	2.044PheGlu: 2.044 ± 0.043	2.311PhePhe: 2.311 ± 0.059	3.5PheGly: 3.5 ± 0.062	0.887PheHis: 0.887 ± 0.027	2.874PheIle: 2.874 ± 0.068	1.444PheLys: 1.444 ± 0.037	3.973PheLeu: 3.973 ± 0.069	1.058PheMet: 1.058 ± 0.032	1.496PheAsn: 1.496 ± 0.038	1.658PhePro: 1.658 ± 0.041	1.182PheGln: 1.182 ± 0.038	2.001PheArg: 2.001 ± 0.041	3.378PheSer: 3.378 ± 0.062	2.789PheThr: 2.789 ± 0.053	2.879PheVal: 2.879 ± 0.056	0.559PheTrp: 0.559 ± 0.025	1.405PheTyr: 1.405 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	7.608GlyAla: 7.608 ± 0.095	1.181GlyCys: 1.181 ± 0.037	4.105GlyAsp: 4.105 ± 0.06	4.557GlyGlu: 4.557 ± 0.07	3.561GlyPhe: 3.561 ± 0.064	6.297GlyGly: 6.297 ± 0.102	1.617GlyHis: 1.617 ± 0.037	5.431GlyIle: 5.431 ± 0.076	3.437GlyLys: 3.437 ± 0.058	7.749GlyLeu: 7.749 ± 0.101	2.202GlyMet: 2.202 ± 0.045	2.267GlyAsn: 2.267 ± 0.055	2.364GlyPro: 2.364 ± 0.049	2.147GlyGln: 2.147 ± 0.05	4.635GlyArg: 4.635 ± 0.06	4.652GlySer: 4.652 ± 0.069	4.171GlyThr: 4.171 ± 0.065	5.817GlyVal: 5.817 ± 0.086	1.143GlyTrp: 1.143 ± 0.035	2.64GlyTyr: 2.64 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.726HisAla: 1.726 ± 0.043	0.405HisCys: 0.405 ± 0.021	1.3HisAsp: 1.3 ± 0.039	1.442HisGlu: 1.442 ± 0.041	1.056HisPhe: 1.056 ± 0.03	2.057HisGly: 2.057 ± 0.05	0.921HisHis: 0.921 ± 0.035	1.421HisIle: 1.421 ± 0.034	0.777HisLys: 0.777 ± 0.027	2.569HisLeu: 2.569 ± 0.054	0.432HisMet: 0.432 ± 0.021	0.719HisAsn: 0.719 ± 0.024	1.408HisPro: 1.408 ± 0.036	0.978HisGln: 0.978 ± 0.035	1.677HisArg: 1.677 ± 0.039	1.156HisSer: 1.156 ± 0.031	1.175HisThr: 1.175 ± 0.034	1.244HisVal: 1.244 ± 0.033	0.299HisTrp: 0.299 ± 0.018	0.871HisTyr: 0.871 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.292IleAla: 6.292 ± 0.083	0.875IleCys: 0.875 ± 0.032	4.49IleAsp: 4.49 ± 0.067	4.331IleGlu: 4.331 ± 0.067	2.618IlePhe: 2.618 ± 0.05	5.684IleGly: 5.684 ± 0.087	1.378IleHis: 1.378 ± 0.038	4.578IleIle: 4.578 ± 0.073	2.629IleLys: 2.629 ± 0.05	5.658IleLeu: 5.658 ± 0.08	1.505IleMet: 1.505 ± 0.038	2.434IleAsn: 2.434 ± 0.05	2.945IlePro: 2.945 ± 0.051	1.661IleGln: 1.661 ± 0.035	3.481IleArg: 3.481 ± 0.059	4.418IleSer: 4.418 ± 0.065	4.075IleThr: 4.075 ± 0.072	4.835IleVal: 4.835 ± 0.075	0.641IleTrp: 0.641 ± 0.029	1.819IleTyr: 1.819 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	3.225LysAla: 3.225 ± 0.066	0.331LysCys: 0.331 ± 0.018	1.966LysAsp: 1.966 ± 0.048	2.841LysGlu: 2.841 ± 0.063	1.218LysPhe: 1.218 ± 0.033	2.625LysGly: 2.625 ± 0.049	0.872LysHis: 0.872 ± 0.028	2.798LysIle: 2.798 ± 0.054	2.774LysLys: 2.774 ± 0.068	3.61LysLeu: 3.61 ± 0.062	1.175LysMet: 1.175 ± 0.032	1.612LysAsn: 1.612 ± 0.038	1.863LysPro: 1.863 ± 0.044	1.753LysGln: 1.753 ± 0.041	2.702LysArg: 2.702 ± 0.058	2.257LysSer: 2.257 ± 0.047	2.646LysThr: 2.646 ± 0.051	2.526LysVal: 2.526 ± 0.054	0.416LysTrp: 0.416 ± 0.02	1.02LysTyr: 1.02 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	11.198LeuAla: 11.198 ± 0.12	1.296LeuCys: 1.296 ± 0.037	5.503LeuAsp: 5.503 ± 0.08	5.469LeuGlu: 5.469 ± 0.078	4.894LeuPhe: 4.894 ± 0.081	7.379LeuGly: 7.379 ± 0.101	2.364LeuHis: 2.364 ± 0.054	6.69LeuIle: 6.69 ± 0.09	4.023LeuLys: 4.023 ± 0.077	11.532LeuLeu: 11.532 ± 0.155	2.433LeuMet: 2.433 ± 0.053	3.2LeuAsn: 3.2 ± 0.059	4.99LeuPro: 4.99 ± 0.071	3.005LeuGln: 3.005 ± 0.054	6.087LeuArg: 6.087 ± 0.09	6.808LeuSer: 6.808 ± 0.081	5.539LeuThr: 5.539 ± 0.079	7.369LeuVal: 7.369 ± 0.096	1.02LeuTrp: 1.02 ± 0.037	2.703LeuTyr: 2.703 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.949MetAla: 2.949 ± 0.054	0.23MetCys: 0.23 ± 0.015	1.271MetAsp: 1.271 ± 0.039	1.487MetGlu: 1.487 ± 0.043	0.883MetPhe: 0.883 ± 0.032	1.968MetGly: 1.968 ± 0.051	0.513MetHis: 0.513 ± 0.022	1.652MetIle: 1.652 ± 0.039	1.391MetLys: 1.391 ± 0.04	2.537MetLeu: 2.537 ± 0.05	0.736MetMet: 0.736 ± 0.033	1.011MetAsn: 1.011 ± 0.034	1.076MetPro: 1.076 ± 0.033	0.919MetGln: 0.919 ± 0.029	1.548MetArg: 1.548 ± 0.037	1.513MetSer: 1.513 ± 0.041	1.395MetThr: 1.395 ± 0.034	2.211MetVal: 2.211 ± 0.051	0.203MetTrp: 0.203 ± 0.015	0.502MetTyr: 0.502 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.083AsnAla: 2.083 ± 0.044	0.4AsnCys: 0.4 ± 0.017	1.611AsnAsp: 1.611 ± 0.04	1.848AsnGlu: 1.848 ± 0.039	1.262AsnPhe: 1.262 ± 0.036	2.326AsnGly: 2.326 ± 0.058	0.808AsnHis: 0.808 ± 0.028	2.104AsnIle: 2.104 ± 0.045	1.312AsnLys: 1.312 ± 0.038	3.335AsnLeu: 3.335 ± 0.061	0.744AsnMet: 0.744 ± 0.028	1.108AsnAsn: 1.108 ± 0.035	1.962AsnPro: 1.962 ± 0.046	1.205AsnGln: 1.205 ± 0.032	2.339AsnArg: 2.339 ± 0.048	1.653AsnSer: 1.653 ± 0.037	1.7AsnThr: 1.7 ± 0.042	1.841AsnVal: 1.841 ± 0.04	0.447AsnTrp: 0.447 ± 0.022	1.029AsnTyr: 1.029 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	4.509ProAla: 4.509 ± 0.066	0.447ProCys: 0.447 ± 0.021	2.98ProAsp: 2.98 ± 0.06	3.419ProGlu: 3.419 ± 0.067	2.001ProPhe: 2.001 ± 0.048	3.67ProGly: 3.67 ± 0.068	1.219ProHis: 1.219 ± 0.036	2.51ProIle: 2.51 ± 0.046	1.418ProLys: 1.418 ± 0.036	4.717ProLeu: 4.717 ± 0.073	1.094ProMet: 1.094 ± 0.035	1.089ProAsn: 1.089 ± 0.031	2.373ProPro: 2.373 ± 0.054	1.317ProGln: 1.317 ± 0.032	2.352ProArg: 2.352 ± 0.055	2.342ProSer: 2.342 ± 0.047	2.192ProThr: 2.192 ± 0.046	3.744ProVal: 3.744 ± 0.059	0.604ProTrp: 0.604 ± 0.026	1.375ProTyr: 1.375 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.474GlnAla: 3.474 ± 0.069	0.415GlnCys: 0.415 ± 0.022	1.485GlnAsp: 1.485 ± 0.035	2.167GlnGlu: 2.167 ± 0.042	1.315GlnPhe: 1.315 ± 0.035	2.365GlnGly: 2.365 ± 0.048	0.75GlnHis: 0.75 ± 0.027	2.048GlnIle: 2.048 ± 0.045	1.473GlnLys: 1.473 ± 0.045	3.534GlnLeu: 3.534 ± 0.062	0.952GlnMet: 0.952 ± 0.028	1.091GlnAsn: 1.091 ± 0.028	1.698GlnPro: 1.698 ± 0.045	1.682GlnGln: 1.682 ± 0.053	2.404GlnArg: 2.404 ± 0.048	2.019GlnSer: 2.019 ± 0.046	1.89GlnThr: 1.89 ± 0.045	2.491GlnVal: 2.491 ± 0.048	0.544GlnTrp: 0.544 ± 0.025	0.858GlnTyr: 0.858 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	5.159ArgAla: 5.159 ± 0.086	0.834ArgCys: 0.834 ± 0.029	3.216ArgAsp: 3.216 ± 0.051	3.928ArgGlu: 3.928 ± 0.065	3.004ArgPhe: 3.004 ± 0.052	4.073ArgGly: 4.073 ± 0.071	1.633ArgHis: 1.633 ± 0.044	4.073ArgIle: 4.073 ± 0.066	2.519ArgLys: 2.519 ± 0.06	6.893ArgLeu: 6.893 ± 0.087	1.51ArgMet: 1.51 ± 0.038	1.879ArgAsn: 1.879 ± 0.041	2.557ArgPro: 2.557 ± 0.056	2.598ArgGln: 2.598 ± 0.057	4.483ArgArg: 4.483 ± 0.076	3.085ArgSer: 3.085 ± 0.061	3.055ArgThr: 3.055 ± 0.057	4.141ArgVal: 4.141 ± 0.069	0.809ArgTrp: 0.809 ± 0.031	2.182ArgTyr: 2.182 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	5.05SerAla: 5.05 ± 0.074	0.789SerCys: 0.789 ± 0.031	2.806SerAsp: 2.806 ± 0.056	3.288SerGlu: 3.288 ± 0.057	2.858SerPhe: 2.858 ± 0.057	5.263SerGly: 5.263 ± 0.078	1.28SerHis: 1.28 ± 0.034	3.719SerIle: 3.719 ± 0.07	1.779SerLys: 1.779 ± 0.044	6.149SerLeu: 6.149 ± 0.077	1.613SerMet: 1.613 ± 0.043	1.379SerAsn: 1.379 ± 0.035	2.71SerPro: 2.71 ± 0.055	1.799SerGln: 1.799 ± 0.043	3.725SerArg: 3.725 ± 0.069	3.609SerSer: 3.609 ± 0.068	2.965SerThr: 2.965 ± 0.058	4.064SerVal: 4.064 ± 0.066	0.829SerTrp: 0.829 ± 0.031	1.932SerTyr: 1.932 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.153ThrAla: 5.153 ± 0.077	0.633ThrCys: 0.633 ± 0.025	2.767ThrAsp: 2.767 ± 0.054	2.897ThrGlu: 2.897 ± 0.055	1.996ThrPhe: 1.996 ± 0.048	4.797ThrGly: 4.797 ± 0.076	1.265ThrHis: 1.265 ± 0.035	4.351ThrIle: 4.351 ± 0.066	1.766ThrLys: 1.766 ± 0.046	5.827ThrLeu: 5.827 ± 0.081	1.592ThrMet: 1.592 ± 0.043	1.6ThrAsn: 1.6 ± 0.039	2.813ThrPro: 2.813 ± 0.059	1.525ThrGln: 1.525 ± 0.035	2.944ThrArg: 2.944 ± 0.057	3.12ThrSer: 3.12 ± 0.051	3.315ThrThr: 3.315 ± 0.071	4.24ThrVal: 4.24 ± 0.079	0.565ThrTrp: 0.565 ± 0.024	1.49ThrTyr: 1.49 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	7.125ValAla: 7.125 ± 0.101	0.949ValCys: 0.949 ± 0.031	4.197ValAsp: 4.197 ± 0.056	4.556ValGlu: 4.556 ± 0.061	3.001ValPhe: 3.001 ± 0.062	5.107ValGly: 5.107 ± 0.075	1.509ValHis: 1.509 ± 0.037	4.723ValIle: 4.723 ± 0.08	2.745ValLys: 2.745 ± 0.054	7.181ValLeu: 7.181 ± 0.098	1.875ValMet: 1.875 ± 0.042	2.255ValAsn: 2.255 ± 0.045	3.011ValPro: 3.011 ± 0.057	2.048ValGln: 2.048 ± 0.048	4.049ValArg: 4.049 ± 0.066	4.495ValSer: 4.495 ± 0.073	3.852ValThr: 3.852 ± 0.067	5.872ValVal: 5.872 ± 0.086	0.729ValTrp: 0.729 ± 0.026	1.933ValTyr: 1.933 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.88TrpAla: 0.88 ± 0.033	0.166TrpCys: 0.166 ± 0.013	0.555TrpAsp: 0.555 ± 0.026	0.609TrpGlu: 0.609 ± 0.025	0.579TrpPhe: 0.579 ± 0.024	0.817TrpGly: 0.817 ± 0.03	0.276TrpHis: 0.276 ± 0.018	0.659TrpIle: 0.659 ± 0.025	0.45TrpLys: 0.45 ± 0.023	1.511TrpLeu: 1.511 ± 0.045	0.327TrpMet: 0.327 ± 0.018	0.386TrpAsn: 0.386 ± 0.018	0.523TrpPro: 0.523 ± 0.022	0.628TrpGln: 0.628 ± 0.026	0.974TrpArg: 0.974 ± 0.037	0.635TrpSer: 0.635 ± 0.027	0.417TrpThr: 0.417 ± 0.023	0.766TrpVal: 0.766 ± 0.029	0.214TrpTrp: 0.214 ± 0.014	0.417TrpTyr: 0.417 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.054TyrAla: 2.054 ± 0.044	0.444TyrCys: 0.444 ± 0.021	1.641TyrAsp: 1.641 ± 0.039	1.819TyrGlu: 1.819 ± 0.04	1.502TyrPhe: 1.502 ± 0.036	2.467TyrGly: 2.467 ± 0.048	0.816TyrHis: 0.816 ± 0.028	1.566TyrIle: 1.566 ± 0.039	0.923TyrLys: 0.923 ± 0.03	3.5TyrLeu: 3.5 ± 0.058	0.564TyrMet: 0.564 ± 0.022	0.893TyrAsn: 0.893 ± 0.036	1.485TyrPro: 1.485 ± 0.038	1.376TyrGln: 1.376 ± 0.039	2.346TyrArg: 2.346 ± 0.053	1.571TyrSer: 1.571 ± 0.043	1.424TyrThr: 1.424 ± 0.038	1.658TyrVal: 1.658 ± 0.043	0.379TyrTrp: 0.379 ± 0.019	0.918TyrTyr: 0.918 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3578 proteins (1046809 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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