Amino acid dipepetide frequency for Leucobacter sp. UCD-THU

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.389AlaAla: 21.389 ± 0.285	0.765AlaCys: 0.765 ± 0.027	7.761AlaAsp: 7.761 ± 0.121	9.868AlaGlu: 9.868 ± 0.144	3.814AlaPhe: 3.814 ± 0.062	12.715AlaGly: 12.715 ± 0.159	2.421AlaHis: 2.421 ± 0.061	5.906AlaIle: 5.906 ± 0.083	2.613AlaLys: 2.613 ± 0.068	14.276AlaLeu: 14.276 ± 0.18	2.594AlaMet: 2.594 ± 0.053	2.216AlaAsn: 2.216 ± 0.054	7.082AlaPro: 7.082 ± 0.127	4.307AlaGln: 4.307 ± 0.075	9.651AlaArg: 9.651 ± 0.127	7.227AlaSer: 7.227 ± 0.098	6.305AlaThr: 6.305 ± 0.091	11.214AlaVal: 11.214 ± 0.129	1.725AlaTrp: 1.725 ± 0.054	2.369AlaTyr: 2.369 ± 0.059	0.001AlaXaa: 0.001 ± 0.001
Cys	0.713CysAla: 0.713 ± 0.03	0.063CysCys: 0.063 ± 0.01	0.351CysAsp: 0.351 ± 0.022	0.354CysGlu: 0.354 ± 0.019	0.196CysPhe: 0.196 ± 0.014	0.691CysGly: 0.691 ± 0.028	0.116CysHis: 0.116 ± 0.011	0.2CysIle: 0.2 ± 0.013	0.059CysLys: 0.059 ± 0.008	0.436CysLeu: 0.436 ± 0.022	0.092CysMet: 0.092 ± 0.009	0.1CysAsn: 0.1 ± 0.01	0.286CysPro: 0.286 ± 0.019	0.115CysGln: 0.115 ± 0.011	0.369CysArg: 0.369 ± 0.019	0.359CysSer: 0.359 ± 0.019	0.323CysThr: 0.323 ± 0.018	0.438CysVal: 0.438 ± 0.021	0.075CysTrp: 0.075 ± 0.008	0.112CysTyr: 0.112 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.186AspAla: 8.186 ± 0.122	0.243AspCys: 0.243 ± 0.015	3.714AspAsp: 3.714 ± 0.069	4.61AspGlu: 4.61 ± 0.078	1.697AspPhe: 1.697 ± 0.041	5.621AspGly: 5.621 ± 0.097	1.129AspHis: 1.129 ± 0.034	2.07AspIle: 2.07 ± 0.055	0.797AspLys: 0.797 ± 0.036	5.6AspLeu: 5.6 ± 0.082	0.749AspMet: 0.749 ± 0.028	0.779AspAsn: 0.779 ± 0.031	4.829AspPro: 4.829 ± 0.095	1.415AspGln: 1.415 ± 0.041	4.897AspArg: 4.897 ± 0.069	2.406AspSer: 2.406 ± 0.055	2.772AspThr: 2.772 ± 0.058	4.421AspVal: 4.421 ± 0.077	0.839AspTrp: 0.839 ± 0.03	1.229AspTyr: 1.229 ± 0.039	0.001AspXaa: 0.001 ± 0.001
Glu	8.38GluAla: 8.38 ± 0.122	0.302GluCys: 0.302 ± 0.017	2.602GluAsp: 2.602 ± 0.058	3.373GluGlu: 3.373 ± 0.072	1.922GluPhe: 1.922 ± 0.038	4.672GluGly: 4.672 ± 0.066	1.752GluHis: 1.752 ± 0.042	3.023GluIle: 3.023 ± 0.066	1.282GluLys: 1.282 ± 0.047	7.613GluLeu: 7.613 ± 0.103	1.183GluMet: 1.183 ± 0.041	1.316GluAsn: 1.316 ± 0.036	3.413GluPro: 3.413 ± 0.064	3.199GluGln: 3.199 ± 0.066	6.379GluArg: 6.379 ± 0.098	3.015GluSer: 3.015 ± 0.048	3.429GluThr: 3.429 ± 0.06	4.95GluVal: 4.95 ± 0.084	0.965GluTrp: 0.965 ± 0.034	1.151GluTyr: 1.151 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.342PheAla: 4.342 ± 0.083	0.206PheCys: 0.206 ± 0.016	2.361PheAsp: 2.361 ± 0.053	2.103PheGlu: 2.103 ± 0.05	1.11PhePhe: 1.11 ± 0.039	3.435PheGly: 3.435 ± 0.075	0.521PheHis: 0.521 ± 0.024	1.26PheIle: 1.26 ± 0.041	0.497PheLys: 0.497 ± 0.026	2.66PheLeu: 2.66 ± 0.058	0.507PheMet: 0.507 ± 0.023	0.632PheAsn: 0.632 ± 0.031	1.344PhePro: 1.344 ± 0.039	0.792PheGln: 0.792 ± 0.029	1.682PheArg: 1.682 ± 0.039	1.917PheSer: 1.917 ± 0.046	2.069PheThr: 2.069 ± 0.052	2.747PheVal: 2.747 ± 0.06	0.482PheTrp: 0.482 ± 0.024	0.595PheTyr: 0.595 ± 0.026	0.002PheXaa: 0.002 ± 0.002
Gly	12.23GlyAla: 12.23 ± 0.15	0.591GlyCys: 0.591 ± 0.022	5.156GlyAsp: 5.156 ± 0.086	5.897GlyGlu: 5.897 ± 0.075	3.386GlyPhe: 3.386 ± 0.069	8.438GlyGly: 8.438 ± 0.145	1.67GlyHis: 1.67 ± 0.045	4.905GlyIle: 4.905 ± 0.072	2.0GlyLys: 2.0 ± 0.053	9.17GlyLeu: 9.17 ± 0.117	1.976GlyMet: 1.976 ± 0.051	1.609GlyAsn: 1.609 ± 0.041	3.912GlyPro: 3.912 ± 0.061	2.353GlyGln: 2.353 ± 0.048	6.659GlyArg: 6.659 ± 0.094	5.89GlySer: 5.89 ± 0.079	5.099GlyThr: 5.099 ± 0.077	8.169GlyVal: 8.169 ± 0.096	1.582GlyTrp: 1.582 ± 0.046	2.235GlyTyr: 2.235 ± 0.052	0.003GlyXaa: 0.003 ± 0.002
His	2.289HisAla: 2.289 ± 0.053	0.122HisCys: 0.122 ± 0.013	1.262HisAsp: 1.262 ± 0.036	1.351HisGlu: 1.351 ± 0.043	0.513HisPhe: 0.513 ± 0.023	2.017HisGly: 2.017 ± 0.051	0.511HisHis: 0.511 ± 0.026	0.661HisIle: 0.661 ± 0.03	0.261HisLys: 0.261 ± 0.014	2.067HisLeu: 2.067 ± 0.047	0.273HisMet: 0.273 ± 0.018	0.337HisAsn: 0.337 ± 0.019	1.494HisPro: 1.494 ± 0.043	0.493HisGln: 0.493 ± 0.022	1.686HisArg: 1.686 ± 0.043	0.968HisSer: 0.968 ± 0.033	1.005HisThr: 1.005 ± 0.03	1.414HisVal: 1.414 ± 0.043	0.314HisTrp: 0.314 ± 0.018	0.431HisTyr: 0.431 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.313IleAla: 7.313 ± 0.101	0.275IleCys: 0.275 ± 0.017	3.377IleAsp: 3.377 ± 0.058	3.344IleGlu: 3.344 ± 0.06	1.16IlePhe: 1.16 ± 0.038	4.796IleGly: 4.796 ± 0.086	0.609IleHis: 0.609 ± 0.024	1.805IleIle: 1.805 ± 0.048	0.739IleLys: 0.739 ± 0.036	3.66IleLeu: 3.66 ± 0.081	0.687IleMet: 0.687 ± 0.032	0.858IleAsn: 0.858 ± 0.03	2.397IlePro: 2.397 ± 0.051	0.881IleGln: 0.881 ± 0.036	2.714IleArg: 2.714 ± 0.06	2.372IleSer: 2.372 ± 0.059	2.731IleThr: 2.731 ± 0.057	4.377IleVal: 4.377 ± 0.076	0.563IleTrp: 0.563 ± 0.022	0.722IleTyr: 0.722 ± 0.03	0.002IleXaa: 0.002 ± 0.001
Lys	1.997LysAla: 1.997 ± 0.059	0.075LysCys: 0.075 ± 0.009	0.904LysAsp: 0.904 ± 0.036	0.82LysGlu: 0.82 ± 0.032	0.493LysPhe: 0.493 ± 0.022	1.375LysGly: 1.375 ± 0.046	0.462LysHis: 0.462 ± 0.021	0.986LysIle: 0.986 ± 0.034	0.765LysLys: 0.765 ± 0.043	1.937LysLeu: 1.937 ± 0.049	0.37LysMet: 0.37 ± 0.02	0.556LysAsn: 0.556 ± 0.029	1.157LysPro: 1.157 ± 0.037	0.79LysGln: 0.79 ± 0.036	1.691LysArg: 1.691 ± 0.046	1.09LysSer: 1.09 ± 0.041	1.226LysThr: 1.226 ± 0.04	1.358LysVal: 1.358 ± 0.045	0.259LysTrp: 0.259 ± 0.016	0.386LysTyr: 0.386 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.823LeuAla: 14.823 ± 0.168	0.548LeuCys: 0.548 ± 0.026	6.695LeuAsp: 6.695 ± 0.086	5.626LeuGlu: 5.626 ± 0.088	2.986LeuPhe: 2.986 ± 0.068	9.795LeuGly: 9.795 ± 0.128	1.913LeuHis: 1.913 ± 0.044	4.715LeuIle: 4.715 ± 0.09	1.628LeuLys: 1.628 ± 0.043	11.023LeuLeu: 11.023 ± 0.161	1.75LeuMet: 1.75 ± 0.043	1.774LeuAsn: 1.774 ± 0.05	5.713LeuPro: 5.713 ± 0.096	2.57LeuGln: 2.57 ± 0.055	7.763LeuArg: 7.763 ± 0.113	5.878LeuSer: 5.878 ± 0.089	5.86LeuThr: 5.86 ± 0.089	9.097LeuVal: 9.097 ± 0.123	1.25LeuTrp: 1.25 ± 0.036	1.51LeuTyr: 1.51 ± 0.046	0.001LeuXaa: 0.001 ± 0.001
Met	1.908MetAla: 1.908 ± 0.048	0.092MetCys: 0.092 ± 0.01	0.772MetAsp: 0.772 ± 0.029	0.72MetGlu: 0.72 ± 0.028	0.543MetPhe: 0.543 ± 0.024	1.423MetGly: 1.423 ± 0.036	0.371MetHis: 0.371 ± 0.022	0.955MetIle: 0.955 ± 0.034	0.43MetLys: 0.43 ± 0.021	2.123MetLeu: 2.123 ± 0.05	0.336MetMet: 0.336 ± 0.019	0.568MetAsn: 0.568 ± 0.024	1.035MetPro: 1.035 ± 0.03	0.564MetGln: 0.564 ± 0.026	1.509MetArg: 1.509 ± 0.039	1.53MetSer: 1.53 ± 0.042	1.482MetThr: 1.482 ± 0.041	1.303MetVal: 1.303 ± 0.038	0.193MetTrp: 0.193 ± 0.013	0.298MetTyr: 0.298 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.349AsnAla: 2.349 ± 0.054	0.102AsnCys: 0.102 ± 0.009	1.014AsnAsp: 1.014 ± 0.042	1.057AsnGlu: 1.057 ± 0.04	0.599AsnPhe: 0.599 ± 0.027	1.879AsnGly: 1.879 ± 0.051	0.345AsnHis: 0.345 ± 0.021	0.779AsnIle: 0.779 ± 0.029	0.34AsnLys: 0.34 ± 0.021	1.783AsnLeu: 1.783 ± 0.047	0.326AsnMet: 0.326 ± 0.022	0.395AsnAsn: 0.395 ± 0.024	1.51AsnPro: 1.51 ± 0.043	0.558AsnGln: 0.558 ± 0.024	1.333AsnArg: 1.333 ± 0.039	0.955AsnSer: 0.955 ± 0.036	1.087AsnThr: 1.087 ± 0.036	1.565AsnVal: 1.565 ± 0.049	0.302AsnTrp: 0.302 ± 0.014	0.441AsnTyr: 0.441 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.438ProAla: 7.438 ± 0.132	0.212ProCys: 0.212 ± 0.016	3.603ProAsp: 3.603 ± 0.075	4.7ProGlu: 4.7 ± 0.084	1.648ProPhe: 1.648 ± 0.042	5.697ProGly: 5.697 ± 0.089	1.141ProHis: 1.141 ± 0.038	2.095ProIle: 2.095 ± 0.048	1.024ProLys: 1.024 ± 0.039	5.142ProLeu: 5.142 ± 0.077	0.884ProMet: 0.884 ± 0.026	1.07ProAsn: 1.07 ± 0.032	2.225ProPro: 2.225 ± 0.061	1.709ProGln: 1.709 ± 0.049	3.642ProArg: 3.642 ± 0.081	3.057ProSer: 3.057 ± 0.069	2.655ProThr: 2.655 ± 0.054	5.03ProVal: 5.03 ± 0.079	0.775ProTrp: 0.775 ± 0.029	1.011ProTyr: 1.011 ± 0.036	0.001ProXaa: 0.001 ± 0.001
Gln	3.748GlnAla: 3.748 ± 0.071	0.126GlnCys: 0.126 ± 0.013	1.154GlnAsp: 1.154 ± 0.035	1.334GlnGlu: 1.334 ± 0.043	0.872GlnPhe: 0.872 ± 0.027	2.244GlnGly: 2.244 ± 0.049	0.807GlnHis: 0.807 ± 0.031	1.477GlnIle: 1.477 ± 0.045	0.613GlnLys: 0.613 ± 0.027	3.605GlnLeu: 3.605 ± 0.066	0.566GlnMet: 0.566 ± 0.025	0.703GlnAsn: 0.703 ± 0.028	1.766GlnPro: 1.766 ± 0.057	1.768GlnGln: 1.768 ± 0.06	2.89GlnArg: 2.89 ± 0.056	1.513GlnSer: 1.513 ± 0.048	1.564GlnThr: 1.564 ± 0.047	2.167GlnVal: 2.167 ± 0.049	0.426GlnTrp: 0.426 ± 0.021	0.6GlnTyr: 0.6 ± 0.028	0.001GlnXaa: 0.001 ± 0.001
Arg	9.773ArgAla: 9.773 ± 0.148	0.337ArgCys: 0.337 ± 0.019	4.33ArgAsp: 4.33 ± 0.072	5.184ArgGlu: 5.184 ± 0.091	2.555ArgPhe: 2.555 ± 0.058	6.149ArgGly: 6.149 ± 0.091	1.475ArgHis: 1.475 ± 0.043	4.039ArgIle: 4.039 ± 0.065	1.478ArgLys: 1.478 ± 0.044	7.656ArgLeu: 7.656 ± 0.111	1.593ArgMet: 1.593 ± 0.041	1.224ArgAsn: 1.224 ± 0.038	3.842ArgPro: 3.842 ± 0.065	2.079ArgGln: 2.079 ± 0.048	6.553ArgArg: 6.553 ± 0.119	4.345ArgSer: 4.345 ± 0.08	4.058ArgThr: 4.058 ± 0.063	6.431ArgVal: 6.431 ± 0.095	1.154ArgTrp: 1.154 ± 0.042	1.539ArgTyr: 1.539 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	7.177SerAla: 7.177 ± 0.104	0.321SerCys: 0.321 ± 0.02	3.062SerAsp: 3.062 ± 0.063	3.326SerGlu: 3.326 ± 0.071	1.951SerPhe: 1.951 ± 0.047	6.406SerGly: 6.406 ± 0.098	0.985SerHis: 0.985 ± 0.035	2.461SerIle: 2.461 ± 0.05	1.12SerLys: 1.12 ± 0.04	5.522SerLeu: 5.522 ± 0.084	1.181SerMet: 1.181 ± 0.04	1.093SerAsn: 1.093 ± 0.038	3.011SerPro: 3.011 ± 0.056	1.462SerGln: 1.462 ± 0.04	3.937SerArg: 3.937 ± 0.064	3.332SerSer: 3.332 ± 0.058	3.203SerThr: 3.203 ± 0.071	4.349SerVal: 4.349 ± 0.067	0.811SerTrp: 0.811 ± 0.03	1.066SerTyr: 1.066 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	7.332ThrAla: 7.332 ± 0.106	0.255ThrCys: 0.255 ± 0.016	2.967ThrAsp: 2.967 ± 0.064	3.146ThrGlu: 3.146 ± 0.063	1.555ThrPhe: 1.555 ± 0.05	5.854ThrGly: 5.854 ± 0.093	1.065ThrHis: 1.065 ± 0.04	2.58ThrIle: 2.58 ± 0.056	0.95ThrLys: 0.95 ± 0.037	5.514ThrLeu: 5.514 ± 0.089	0.963ThrMet: 0.963 ± 0.035	1.0ThrAsn: 1.0 ± 0.036	3.595ThrPro: 3.595 ± 0.059	1.345ThrGln: 1.345 ± 0.04	3.754ThrArg: 3.754 ± 0.061	2.999ThrSer: 2.999 ± 0.063	2.953ThrThr: 2.953 ± 0.066	5.359ThrVal: 5.359 ± 0.083	0.669ThrTrp: 0.669 ± 0.029	0.886ThrTyr: 0.886 ± 0.04	0.001ThrXaa: 0.001 ± 0.001
Val	10.99ValAla: 10.99 ± 0.123	0.559ValCys: 0.559 ± 0.024	4.966ValAsp: 4.966 ± 0.081	5.276ValGlu: 5.276 ± 0.072	3.021ValPhe: 3.021 ± 0.066	6.833ValGly: 6.833 ± 0.099	1.562ValHis: 1.562 ± 0.043	4.122ValIle: 4.122 ± 0.084	1.543ValLys: 1.543 ± 0.046	9.39ValLeu: 9.39 ± 0.123	1.542ValMet: 1.542 ± 0.041	1.698ValAsn: 1.698 ± 0.051	4.496ValPro: 4.496 ± 0.07	2.387ValGln: 2.387 ± 0.051	5.861ValArg: 5.861 ± 0.075	5.005ValSer: 5.005 ± 0.08	5.093ValThr: 5.093 ± 0.081	7.965ValVal: 7.965 ± 0.108	1.121ValTrp: 1.121 ± 0.034	1.523ValTyr: 1.523 ± 0.046	0.003ValXaa: 0.003 ± 0.002
Trp	1.572TrpAla: 1.572 ± 0.043	0.112TrpCys: 0.112 ± 0.009	0.698TrpAsp: 0.698 ± 0.03	0.649TrpGlu: 0.649 ± 0.027	0.564TrpPhe: 0.564 ± 0.025	1.095TrpGly: 1.095 ± 0.035	0.297TrpHis: 0.297 ± 0.018	0.742TrpIle: 0.742 ± 0.027	0.279TrpLys: 0.279 ± 0.019	1.635TrpLeu: 1.635 ± 0.046	0.311TrpMet: 0.311 ± 0.017	0.378TrpAsn: 0.378 ± 0.018	0.655TrpPro: 0.655 ± 0.029	0.565TrpGln: 0.565 ± 0.024	1.187TrpArg: 1.187 ± 0.04	0.919TrpSer: 0.919 ± 0.035	0.718TrpThr: 0.718 ± 0.029	1.125TrpVal: 1.125 ± 0.038	0.324TrpTrp: 0.324 ± 0.019	0.27TrpTyr: 0.27 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.271TyrAla: 2.271 ± 0.051	0.141TyrCys: 0.141 ± 0.014	1.255TyrAsp: 1.255 ± 0.047	1.182TyrGlu: 1.182 ± 0.048	0.676TyrPhe: 0.676 ± 0.026	1.791TyrGly: 1.791 ± 0.049	0.317TyrHis: 0.317 ± 0.018	0.603TyrIle: 0.603 ± 0.024	0.279TyrLys: 0.279 ± 0.018	2.103TyrLeu: 2.103 ± 0.048	0.273TyrMet: 0.273 ± 0.016	0.411TyrAsn: 0.411 ± 0.022	0.996TyrPro: 0.996 ± 0.039	0.593TyrGln: 0.593 ± 0.028	1.635TyrArg: 1.635 ± 0.043	0.998TyrSer: 0.998 ± 0.037	1.111TyrThr: 1.111 ± 0.046	1.474TyrVal: 1.474 ± 0.044	0.265TyrTrp: 0.265 ± 0.019	0.429TyrTyr: 0.429 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.002XaaCys: 0.002 ± 0.001	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.002XaaGly: 0.002 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.002XaaPro: 0.002 ± 0.002	0.0XaaGln: 0.0 ± 0.0	0.003XaaArg: 0.003 ± 0.002	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 2878 proteins (968228 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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