Amino acid dipepetide frequency for Arthrobacter crystallopoietes

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.611AlaAla: 19.611 ± 0.181	0.818AlaCys: 0.818 ± 0.027	7.05AlaAsp: 7.05 ± 0.074	8.706AlaGlu: 8.706 ± 0.093	3.626AlaPhe: 3.626 ± 0.053	12.822AlaGly: 12.822 ± 0.105	2.168AlaHis: 2.168 ± 0.043	4.975AlaIle: 4.975 ± 0.066	3.564AlaLys: 3.564 ± 0.05	12.438AlaLeu: 12.438 ± 0.117	2.891AlaMet: 2.891 ± 0.046	2.753AlaAsn: 2.753 ± 0.042	5.78AlaPro: 5.78 ± 0.078	3.924AlaGln: 3.924 ± 0.056	7.501AlaArg: 7.501 ± 0.084	6.602AlaSer: 6.602 ± 0.072	6.529AlaThr: 6.529 ± 0.073	11.023AlaVal: 11.023 ± 0.093	1.577AlaTrp: 1.577 ± 0.035	2.308AlaTyr: 2.308 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.747CysAla: 0.747 ± 0.023	0.082CysCys: 0.082 ± 0.009	0.343CysAsp: 0.343 ± 0.015	0.394CysGlu: 0.394 ± 0.017	0.222CysPhe: 0.222 ± 0.012	0.775CysGly: 0.775 ± 0.023	0.171CysHis: 0.171 ± 0.011	0.281CysIle: 0.281 ± 0.013	0.138CysLys: 0.138 ± 0.009	0.634CysLeu: 0.634 ± 0.019	0.115CysMet: 0.115 ± 0.009	0.167CysAsn: 0.167 ± 0.011	0.378CysPro: 0.378 ± 0.017	0.173CysGln: 0.173 ± 0.011	0.491CysArg: 0.491 ± 0.02	0.44CysSer: 0.44 ± 0.017	0.437CysThr: 0.437 ± 0.016	0.491CysVal: 0.491 ± 0.016	0.104CysTrp: 0.104 ± 0.01	0.134CysTyr: 0.134 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.72AspAla: 6.72 ± 0.07	0.338AspCys: 0.338 ± 0.014	2.988AspAsp: 2.988 ± 0.051	3.744AspGlu: 3.744 ± 0.053	1.873AspPhe: 1.873 ± 0.036	5.655AspGly: 5.655 ± 0.077	1.21AspHis: 1.21 ± 0.035	2.462AspIle: 2.462 ± 0.044	1.548AspLys: 1.548 ± 0.037	5.731AspLeu: 5.731 ± 0.06	1.001AspMet: 1.001 ± 0.027	1.215AspAsn: 1.215 ± 0.03	3.769AspPro: 3.769 ± 0.054	1.773AspGln: 1.773 ± 0.035	3.593AspArg: 3.593 ± 0.056	2.907AspSer: 2.907 ± 0.039	2.831AspThr: 2.831 ± 0.048	4.703AspVal: 4.703 ± 0.055	0.854AspTrp: 0.854 ± 0.026	1.336AspTyr: 1.336 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.558GluAla: 7.558 ± 0.082	0.332GluCys: 0.332 ± 0.018	3.365GluAsp: 3.365 ± 0.059	3.937GluGlu: 3.937 ± 0.064	1.837GluPhe: 1.837 ± 0.036	4.242GluGly: 4.242 ± 0.064	1.64GluHis: 1.64 ± 0.034	2.878GluIle: 2.878 ± 0.05	1.851GluLys: 1.851 ± 0.043	7.164GluLeu: 7.164 ± 0.073	1.108GluMet: 1.108 ± 0.029	1.715GluAsn: 1.715 ± 0.038	3.392GluPro: 3.392 ± 0.05	2.704GluGln: 2.704 ± 0.047	4.417GluArg: 4.417 ± 0.059	3.113GluSer: 3.113 ± 0.045	3.49GluThr: 3.49 ± 0.05	4.36GluVal: 4.36 ± 0.061	0.777GluTrp: 0.777 ± 0.023	1.268GluTyr: 1.268 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.838PheAla: 3.838 ± 0.057	0.264PheCys: 0.264 ± 0.014	2.101PheAsp: 2.101 ± 0.04	1.841PheGlu: 1.841 ± 0.041	1.154PhePhe: 1.154 ± 0.033	3.416PheGly: 3.416 ± 0.064	0.632PheHis: 0.632 ± 0.022	1.465PheIle: 1.465 ± 0.037	0.739PheLys: 0.739 ± 0.024	2.965PheLeu: 2.965 ± 0.059	0.607PheMet: 0.607 ± 0.024	0.902PheAsn: 0.902 ± 0.026	1.45PhePro: 1.45 ± 0.033	0.835PheGln: 0.835 ± 0.023	1.807PheArg: 1.807 ± 0.033	2.017PheSer: 2.017 ± 0.037	2.074PheThr: 2.074 ± 0.04	2.494PheVal: 2.494 ± 0.048	0.51PheTrp: 0.51 ± 0.017	0.76PheTyr: 0.76 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	9.714GlyAla: 9.714 ± 0.096	0.726GlyCys: 0.726 ± 0.022	4.159GlyAsp: 4.159 ± 0.055	4.917GlyGlu: 4.917 ± 0.063	3.173GlyPhe: 3.173 ± 0.051	7.462GlyGly: 7.462 ± 0.094	1.981GlyHis: 1.981 ± 0.035	4.82GlyIle: 4.82 ± 0.061	3.065GlyLys: 3.065 ± 0.053	9.286GlyLeu: 9.286 ± 0.082	2.203GlyMet: 2.203 ± 0.038	2.386GlyAsn: 2.386 ± 0.042	4.11GlyPro: 4.11 ± 0.054	3.136GlyGln: 3.136 ± 0.045	5.94GlyArg: 5.94 ± 0.069	5.835GlySer: 5.835 ± 0.065	5.895GlyThr: 5.895 ± 0.066	6.87GlyVal: 6.87 ± 0.073	1.612GlyTrp: 1.612 ± 0.037	2.37GlyTyr: 2.37 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.31HisAla: 2.31 ± 0.035	0.188HisCys: 0.188 ± 0.012	1.099HisAsp: 1.099 ± 0.025	1.235HisGlu: 1.235 ± 0.034	0.686HisPhe: 0.686 ± 0.023	2.017HisGly: 2.017 ± 0.041	0.629HisHis: 0.629 ± 0.025	0.831HisIle: 0.831 ± 0.025	0.476HisLys: 0.476 ± 0.018	2.067HisLeu: 2.067 ± 0.042	0.398HisMet: 0.398 ± 0.016	0.513HisAsn: 0.513 ± 0.02	1.44HisPro: 1.44 ± 0.035	0.646HisGln: 0.646 ± 0.023	1.583HisArg: 1.583 ± 0.03	1.159HisSer: 1.159 ± 0.027	1.053HisThr: 1.053 ± 0.028	1.607HisVal: 1.607 ± 0.033	0.311HisTrp: 0.311 ± 0.016	0.514HisTyr: 0.514 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.838IleAla: 5.838 ± 0.073	0.369IleCys: 0.369 ± 0.017	2.922IleAsp: 2.922 ± 0.052	2.746IleGlu: 2.746 ± 0.041	1.418IlePhe: 1.418 ± 0.035	4.58IleGly: 4.58 ± 0.064	0.841IleHis: 0.841 ± 0.026	2.09IleIle: 2.09 ± 0.047	1.146IleLys: 1.146 ± 0.028	3.964IleLeu: 3.964 ± 0.055	0.877IleMet: 0.877 ± 0.029	1.31IleAsn: 1.31 ± 0.03	2.475IlePro: 2.475 ± 0.038	1.209IleGln: 1.209 ± 0.028	2.756IleArg: 2.756 ± 0.043	2.801IleSer: 2.801 ± 0.044	2.746IleThr: 2.746 ± 0.044	3.76IleVal: 3.76 ± 0.059	0.581IleTrp: 0.581 ± 0.022	0.938IleTyr: 0.938 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.442LysAla: 3.442 ± 0.054	0.126LysCys: 0.126 ± 0.009	1.682LysAsp: 1.682 ± 0.034	1.559LysGlu: 1.559 ± 0.035	0.802LysPhe: 0.802 ± 0.022	1.922LysGly: 1.922 ± 0.04	0.612LysHis: 0.612 ± 0.022	1.36LysIle: 1.36 ± 0.032	1.013LysLys: 1.013 ± 0.029	2.752LysLeu: 2.752 ± 0.043	0.621LysMet: 0.621 ± 0.019	0.783LysAsn: 0.783 ± 0.024	1.724LysPro: 1.724 ± 0.04	0.975LysGln: 0.975 ± 0.027	1.824LysArg: 1.824 ± 0.038	1.595LysSer: 1.595 ± 0.038	1.726LysThr: 1.726 ± 0.04	2.305LysVal: 2.305 ± 0.046	0.346LysTrp: 0.346 ± 0.016	0.684LysTyr: 0.684 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.281LeuAla: 14.281 ± 0.128	0.678LeuCys: 0.678 ± 0.022	6.132LeuAsp: 6.132 ± 0.063	5.934LeuGlu: 5.934 ± 0.07	2.979LeuPhe: 2.979 ± 0.052	9.055LeuGly: 9.055 ± 0.084	1.992LeuHis: 1.992 ± 0.041	4.491LeuIle: 4.491 ± 0.071	2.719LeuLys: 2.719 ± 0.044	10.777LeuLeu: 10.777 ± 0.117	2.038LeuMet: 2.038 ± 0.041	2.482LeuAsn: 2.482 ± 0.035	5.741LeuPro: 5.741 ± 0.061	3.207LeuGln: 3.207 ± 0.051	6.716LeuArg: 6.716 ± 0.085	6.007LeuSer: 6.007 ± 0.069	5.913LeuThr: 5.913 ± 0.068	8.349LeuVal: 8.349 ± 0.077	1.233LeuTrp: 1.233 ± 0.031	1.8LeuTyr: 1.8 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.732MetAla: 2.732 ± 0.042	0.132MetCys: 0.132 ± 0.011	1.12MetAsp: 1.12 ± 0.034	1.032MetGlu: 1.032 ± 0.027	0.636MetPhe: 0.636 ± 0.021	1.649MetGly: 1.649 ± 0.038	0.387MetHis: 0.387 ± 0.016	0.965MetIle: 0.965 ± 0.024	0.685MetLys: 0.685 ± 0.019	2.103MetLeu: 2.103 ± 0.043	0.409MetMet: 0.409 ± 0.02	0.634MetAsn: 0.634 ± 0.021	1.214MetPro: 1.214 ± 0.028	0.653MetGln: 0.653 ± 0.019	1.231MetArg: 1.231 ± 0.028	1.572MetSer: 1.572 ± 0.031	1.668MetThr: 1.668 ± 0.034	1.684MetVal: 1.684 ± 0.037	0.224MetTrp: 0.224 ± 0.012	0.356MetTyr: 0.356 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.834AsnAla: 2.834 ± 0.047	0.203AsnCys: 0.203 ± 0.012	1.452AsnAsp: 1.452 ± 0.038	1.362AsnGlu: 1.362 ± 0.03	0.845AsnPhe: 0.845 ± 0.025	2.411AsnGly: 2.411 ± 0.049	0.547AsnHis: 0.547 ± 0.02	1.239AsnIle: 1.239 ± 0.028	0.662AsnLys: 0.662 ± 0.021	2.382AsnLeu: 2.382 ± 0.042	0.504AsnMet: 0.504 ± 0.019	0.748AsnAsn: 0.748 ± 0.026	1.914AsnPro: 1.914 ± 0.04	0.849AsnGln: 0.849 ± 0.027	1.623AsnArg: 1.623 ± 0.032	1.417AsnSer: 1.417 ± 0.031	1.369AsnThr: 1.369 ± 0.037	1.96AsnVal: 1.96 ± 0.039	0.389AsnTrp: 0.389 ± 0.014	0.61AsnTyr: 0.61 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.859ProAla: 7.859 ± 0.098	0.223ProCys: 0.223 ± 0.013	3.691ProAsp: 3.691 ± 0.05	4.528ProGlu: 4.528 ± 0.067	1.687ProPhe: 1.687 ± 0.034	5.317ProGly: 5.317 ± 0.06	1.038ProHis: 1.038 ± 0.03	1.803ProIle: 1.803 ± 0.037	1.409ProLys: 1.409 ± 0.031	4.9ProLeu: 4.9 ± 0.056	1.087ProMet: 1.087 ± 0.025	1.175ProAsn: 1.175 ± 0.028	2.239ProPro: 2.239 ± 0.05	1.845ProGln: 1.845 ± 0.034	2.87ProArg: 2.87 ± 0.049	2.981ProSer: 2.981 ± 0.052	2.747ProThr: 2.747 ± 0.043	4.942ProVal: 4.942 ± 0.064	0.789ProTrp: 0.789 ± 0.024	1.118ProTyr: 1.118 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.011GlnAla: 4.011 ± 0.053	0.177GlnCys: 0.177 ± 0.009	1.822GlnAsp: 1.822 ± 0.043	1.966GlnGlu: 1.966 ± 0.036	0.898GlnPhe: 0.898 ± 0.025	2.381GlnGly: 2.381 ± 0.038	0.738GlnHis: 0.738 ± 0.022	1.544GlnIle: 1.544 ± 0.032	0.858GlnLys: 0.858 ± 0.027	4.03GlnLeu: 4.03 ± 0.053	0.66GlnMet: 0.66 ± 0.02	0.817GlnAsn: 0.817 ± 0.023	1.912GlnPro: 1.912 ± 0.037	1.573GlnGln: 1.573 ± 0.034	2.4GlnArg: 2.4 ± 0.04	1.736GlnSer: 1.736 ± 0.037	1.719GlnThr: 1.719 ± 0.035	2.514GlnVal: 2.514 ± 0.043	0.542GlnTrp: 0.542 ± 0.02	0.659GlnTyr: 0.659 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	6.704ArgAla: 6.704 ± 0.072	0.414ArgCys: 0.414 ± 0.019	3.436ArgAsp: 3.436 ± 0.055	3.989ArgGlu: 3.989 ± 0.054	2.124ArgPhe: 2.124 ± 0.04	4.707ArgGly: 4.707 ± 0.058	1.521ArgHis: 1.521 ± 0.032	3.498ArgIle: 3.498 ± 0.05	2.088ArgLys: 2.088 ± 0.039	6.943ArgLeu: 6.943 ± 0.073	1.616ArgMet: 1.616 ± 0.031	1.828ArgAsn: 1.828 ± 0.036	3.482ArgPro: 3.482 ± 0.058	2.434ArgGln: 2.434 ± 0.044	5.509ArgArg: 5.509 ± 0.084	3.8ArgSer: 3.8 ± 0.057	3.864ArgThr: 3.864 ± 0.055	4.368ArgVal: 4.368 ± 0.06	1.078ArgTrp: 1.078 ± 0.026	1.514ArgTyr: 1.514 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	7.136SerAla: 7.136 ± 0.078	0.41SerCys: 0.41 ± 0.017	2.832SerAsp: 2.832 ± 0.044	3.066SerGlu: 3.066 ± 0.045	2.004SerPhe: 2.004 ± 0.038	6.02SerGly: 6.02 ± 0.064	1.135SerHis: 1.135 ± 0.03	2.612SerIle: 2.612 ± 0.039	1.483SerLys: 1.483 ± 0.037	5.78SerLeu: 5.78 ± 0.063	1.449SerMet: 1.449 ± 0.035	1.397SerAsn: 1.397 ± 0.032	3.178SerPro: 3.178 ± 0.05	1.7SerGln: 1.7 ± 0.04	3.715SerArg: 3.715 ± 0.049	3.622SerSer: 3.622 ± 0.059	3.49SerThr: 3.49 ± 0.048	4.576SerVal: 4.576 ± 0.058	0.894SerTrp: 0.894 ± 0.028	1.382SerTyr: 1.382 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	7.731ThrAla: 7.731 ± 0.08	0.348ThrCys: 0.348 ± 0.013	3.289ThrAsp: 3.289 ± 0.044	3.391ThrGlu: 3.391 ± 0.048	1.84ThrPhe: 1.84 ± 0.036	6.023ThrGly: 6.023 ± 0.074	1.109ThrHis: 1.109 ± 0.025	2.511ThrIle: 2.511 ± 0.042	1.44ThrLys: 1.44 ± 0.032	5.384ThrLeu: 5.384 ± 0.063	1.115ThrMet: 1.115 ± 0.026	1.392ThrAsn: 1.392 ± 0.03	3.451ThrPro: 3.451 ± 0.052	1.529ThrGln: 1.529 ± 0.03	3.078ThrArg: 3.078 ± 0.049	3.295ThrSer: 3.295 ± 0.047	3.488ThrThr: 3.488 ± 0.051	5.397ThrVal: 5.397 ± 0.073	0.744ThrTrp: 0.744 ± 0.024	1.274ThrTyr: 1.274 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	9.816ValAla: 9.816 ± 0.078	0.589ValCys: 0.589 ± 0.021	4.708ValAsp: 4.708 ± 0.065	4.868ValGlu: 4.868 ± 0.068	2.696ValPhe: 2.696 ± 0.049	6.126ValGly: 6.126 ± 0.064	1.674ValHis: 1.674 ± 0.033	3.993ValIle: 3.993 ± 0.058	1.975ValLys: 1.975 ± 0.039	9.118ValLeu: 9.118 ± 0.099	1.719ValMet: 1.719 ± 0.035	2.065ValAsn: 2.065 ± 0.037	4.782ValPro: 4.782 ± 0.057	2.449ValGln: 2.449 ± 0.035	5.229ValArg: 5.229 ± 0.056	4.873ValSer: 4.873 ± 0.054	4.758ValThr: 4.758 ± 0.065	7.336ValVal: 7.336 ± 0.076	1.027ValTrp: 1.027 ± 0.027	1.501ValTyr: 1.501 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.42TrpAla: 1.42 ± 0.034	0.114TrpCys: 0.114 ± 0.008	0.72TrpAsp: 0.72 ± 0.025	0.688TrpGlu: 0.688 ± 0.022	0.544TrpPhe: 0.544 ± 0.02	0.969TrpGly: 0.969 ± 0.025	0.356TrpHis: 0.356 ± 0.016	0.739TrpIle: 0.739 ± 0.02	0.428TrpLys: 0.428 ± 0.016	1.793TrpLeu: 1.793 ± 0.044	0.328TrpMet: 0.328 ± 0.014	0.476TrpAsn: 0.476 ± 0.017	0.691TrpPro: 0.691 ± 0.022	0.64TrpGln: 0.64 ± 0.021	1.003TrpArg: 1.003 ± 0.031	0.829TrpSer: 0.829 ± 0.023	0.869TrpThr: 0.869 ± 0.024	1.003TrpVal: 1.003 ± 0.025	0.311TrpTrp: 0.311 ± 0.016	0.321TrpTyr: 0.321 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.365TyrAla: 2.365 ± 0.04	0.187TyrCys: 0.187 ± 0.011	1.34TyrAsp: 1.34 ± 0.028	1.247TyrGlu: 1.247 ± 0.031	0.828TyrPhe: 0.828 ± 0.023	2.111TyrGly: 2.111 ± 0.043	0.381TyrHis: 0.381 ± 0.018	0.81TyrIle: 0.81 ± 0.024	0.565TyrLys: 0.565 ± 0.021	2.315TyrLeu: 2.315 ± 0.044	0.341TyrMet: 0.341 ± 0.015	0.561TyrAsn: 0.561 ± 0.021	1.128TyrPro: 1.128 ± 0.031	0.703TyrGln: 0.703 ± 0.022	1.629TyrArg: 1.629 ± 0.033	1.278TyrSer: 1.278 ± 0.031	1.164TyrThr: 1.164 ± 0.03	1.558TyrVal: 1.558 ± 0.031	0.336TyrTrp: 0.336 ± 0.018	0.551TyrTyr: 0.551 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4622 proteins (1477220 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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