Amino acid dipepetide frequency for Tannerella sp. oral taxon 808

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.432AlaAla: 9.432 ± 0.183
1.1AlaCys: 1.1 ± 0.043
5.901AlaAsp: 5.901 ± 0.107
5.969AlaGlu: 5.969 ± 0.114
3.914AlaPhe: 3.914 ± 0.091
6.384AlaGly: 6.384 ± 0.104
1.86AlaHis: 1.86 ± 0.048
5.18AlaIle: 5.18 ± 0.107
3.487AlaLys: 3.487 ± 0.088
9.148AlaLeu: 9.148 ± 0.156
2.324AlaMet: 2.324 ± 0.067
2.764AlaAsn: 2.764 ± 0.059
3.453AlaPro: 3.453 ± 0.092
2.909AlaGln: 2.909 ± 0.068
5.459AlaArg: 5.459 ± 0.106
4.824AlaSer: 4.824 ± 0.095
4.971AlaThr: 4.971 ± 0.091
6.143AlaVal: 6.143 ± 0.119
0.943AlaTrp: 0.943 ± 0.047
3.468AlaTyr: 3.468 ± 0.083
0.0AlaXaa: 0.0 ± 0.0
Cys
0.878CysAla: 0.878 ± 0.042
0.177CysCys: 0.177 ± 0.018
0.61CysAsp: 0.61 ± 0.03
0.602CysGlu: 0.602 ± 0.032
0.529CysPhe: 0.529 ± 0.029
0.969CysGly: 0.969 ± 0.044
0.334CysHis: 0.334 ± 0.023
0.68CysIle: 0.68 ± 0.036
0.399CysLys: 0.399 ± 0.023
1.051CysLeu: 1.051 ± 0.047
0.296CysMet: 0.296 ± 0.022
0.408CysAsn: 0.408 ± 0.028
0.504CysPro: 0.504 ± 0.033
0.256CysGln: 0.256 ± 0.02
0.827CysArg: 0.827 ± 0.043
0.661CysSer: 0.661 ± 0.032
0.684CysThr: 0.684 ± 0.036
0.747CysVal: 0.747 ± 0.032
0.105CysTrp: 0.105 ± 0.013
0.419CysTyr: 0.419 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
5.53AspAla: 5.53 ± 0.109
0.604AspCys: 0.604 ± 0.03
3.388AspAsp: 3.388 ± 0.09
4.179AspGlu: 4.179 ± 0.087
2.863AspPhe: 2.863 ± 0.069
4.367AspGly: 4.367 ± 0.098
1.091AspHis: 1.091 ± 0.032
3.536AspIle: 3.536 ± 0.081
2.749AspLys: 2.749 ± 0.081
5.191AspLeu: 5.191 ± 0.083
1.488AspMet: 1.488 ± 0.046
2.048AspAsn: 2.048 ± 0.059
2.626AspPro: 2.626 ± 0.068
1.063AspGln: 1.063 ± 0.038
4.176AspArg: 4.176 ± 0.085
2.721AspSer: 2.721 ± 0.078
3.176AspThr: 3.176 ± 0.079
3.94AspVal: 3.94 ± 0.073
0.681AspTrp: 0.681 ± 0.036
2.663AspTyr: 2.663 ± 0.075
0.0AspXaa: 0.0 ± 0.0
Glu
6.727GluAla: 6.727 ± 0.134
0.538GluCys: 0.538 ± 0.029
2.623GluAsp: 2.623 ± 0.071
4.207GluGlu: 4.207 ± 0.094
1.958GluPhe: 1.958 ± 0.055
4.18GluGly: 4.18 ± 0.084
1.274GluHis: 1.274 ± 0.042
3.618GluIle: 3.618 ± 0.084
3.623GluLys: 3.623 ± 0.101
5.828GluLeu: 5.828 ± 0.102
2.068GluMet: 2.068 ± 0.062
2.202GluAsn: 2.202 ± 0.069
2.151GluPro: 2.151 ± 0.063
2.587GluGln: 2.587 ± 0.07
4.875GluArg: 4.875 ± 0.106
2.794GluSer: 2.794 ± 0.076
3.264GluThr: 3.264 ± 0.067
4.456GluVal: 4.456 ± 0.09
0.733GluTrp: 0.733 ± 0.034
2.133GluTyr: 2.133 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
3.485PheAla: 3.485 ± 0.075
0.484PheCys: 0.484 ± 0.032
2.886PheAsp: 2.886 ± 0.073
2.165PheGlu: 2.165 ± 0.06
1.986PhePhe: 1.986 ± 0.064
3.396PheGly: 3.396 ± 0.069
0.972PheHis: 0.972 ± 0.041
2.47PheIle: 2.47 ± 0.064
1.749PheLys: 1.749 ± 0.059
3.644PheLeu: 3.644 ± 0.093
1.1PheMet: 1.1 ± 0.049
1.646PheAsn: 1.646 ± 0.052
1.607PhePro: 1.607 ± 0.06
0.971PheGln: 0.971 ± 0.041
3.012PheArg: 3.012 ± 0.078
2.718PheSer: 2.718 ± 0.076
2.763PheThr: 2.763 ± 0.071
2.986PheVal: 2.986 ± 0.073
0.427PheTrp: 0.427 ± 0.03
1.599PheTyr: 1.599 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
5.653GlyAla: 5.653 ± 0.102
0.926GlyCys: 0.926 ± 0.045
3.738GlyAsp: 3.738 ± 0.072
4.137GlyGlu: 4.137 ± 0.082
3.045GlyPhe: 3.045 ± 0.072
5.347GlyGly: 5.347 ± 0.108
1.656GlyHis: 1.656 ± 0.052
4.644GlyIle: 4.644 ± 0.101
3.735GlyLys: 3.735 ± 0.099
6.714GlyLeu: 6.714 ± 0.114
2.094GlyMet: 2.094 ± 0.057
2.693GlyAsn: 2.693 ± 0.084
1.59GlyPro: 1.59 ± 0.056
2.197GlyGln: 2.197 ± 0.066
5.344GlyArg: 5.344 ± 0.112
3.868GlySer: 3.868 ± 0.086
4.153GlyThr: 4.153 ± 0.086
5.026GlyVal: 5.026 ± 0.105
0.909GlyTrp: 0.909 ± 0.042
2.925GlyTyr: 2.925 ± 0.072
0.0GlyXaa: 0.0 ± 0.0
His
1.926HisAla: 1.926 ± 0.058
0.322HisCys: 0.322 ± 0.022
1.16HisAsp: 1.16 ± 0.039
1.128HisGlu: 1.128 ± 0.041
1.267HisPhe: 1.267 ± 0.044
1.455HisGly: 1.455 ± 0.049
0.593HisHis: 0.593 ± 0.039
1.55HisIle: 1.55 ± 0.058
0.829HisLys: 0.829 ± 0.037
2.128HisLeu: 2.128 ± 0.066
0.498HisMet: 0.498 ± 0.03
0.81HisAsn: 0.81 ± 0.035
1.41HisPro: 1.41 ± 0.049
0.516HisGln: 0.516 ± 0.031
1.595HisArg: 1.595 ± 0.051
1.156HisSer: 1.156 ± 0.041
1.451HisThr: 1.451 ± 0.057
1.279HisVal: 1.279 ± 0.039
0.236HisTrp: 0.236 ± 0.018
0.929HisTyr: 0.929 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
5.555IleAla: 5.555 ± 0.103
0.704IleCys: 0.704 ± 0.041
4.475IleAsp: 4.475 ± 0.093
3.963IleGlu: 3.963 ± 0.085
2.148IlePhe: 2.148 ± 0.07
4.496IleGly: 4.496 ± 0.086
1.472IleHis: 1.472 ± 0.049
3.487IleIle: 3.487 ± 0.093
2.681IleLys: 2.681 ± 0.084
5.056IleLeu: 5.056 ± 0.111
1.176IleMet: 1.176 ± 0.046
2.482IleAsn: 2.482 ± 0.061
2.832IlePro: 2.832 ± 0.068
1.538IleGln: 1.538 ± 0.054
4.433IleArg: 4.433 ± 0.089
3.43IleSer: 3.43 ± 0.075
3.74IleThr: 3.74 ± 0.095
4.331IleVal: 4.331 ± 0.091
0.464IleTrp: 0.464 ± 0.028
2.371IleTyr: 2.371 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
4.279LysAla: 4.279 ± 0.097
0.302LysCys: 0.302 ± 0.024
2.958LysAsp: 2.958 ± 0.087
3.723LysGlu: 3.723 ± 0.096
1.347LysPhe: 1.347 ± 0.052
3.322LysGly: 3.322 ± 0.079
0.975LysHis: 0.975 ± 0.038
2.798LysIle: 2.798 ± 0.089
3.425LysLys: 3.425 ± 0.098
3.787LysLeu: 3.787 ± 0.086
1.592LysMet: 1.592 ± 0.054
2.035LysAsn: 2.035 ± 0.064
2.08LysPro: 2.08 ± 0.074
1.951LysGln: 1.951 ± 0.059
3.153LysArg: 3.153 ± 0.065
2.495LysSer: 2.495 ± 0.059
2.969LysThr: 2.969 ± 0.074
3.043LysVal: 3.043 ± 0.081
0.481LysTrp: 0.481 ± 0.031
1.871LysTyr: 1.871 ± 0.054
0.0LysXaa: 0.0 ± 0.0
Leu
7.726LeuAla: 7.726 ± 0.128
1.285LeuCys: 1.285 ± 0.052
4.542LeuAsp: 4.542 ± 0.094
4.549LeuGlu: 4.549 ± 0.091
4.439LeuPhe: 4.439 ± 0.098
5.963LeuGly: 5.963 ± 0.122
2.23LeuHis: 2.23 ± 0.067
5.621LeuIle: 5.621 ± 0.112
4.621LeuLys: 4.621 ± 0.1
9.78LeuLeu: 9.78 ± 0.162
2.589LeuMet: 2.589 ± 0.067
3.536LeuAsn: 3.536 ± 0.088
4.823LeuPro: 4.823 ± 0.097
3.103LeuGln: 3.103 ± 0.065
7.45LeuArg: 7.45 ± 0.131
6.635LeuSer: 6.635 ± 0.119
6.373LeuThr: 6.373 ± 0.106
5.25LeuVal: 5.25 ± 0.11
0.937LeuTrp: 0.937 ± 0.04
3.359LeuTyr: 3.359 ± 0.083
0.0LeuXaa: 0.0 ± 0.0
Met
2.435MetAla: 2.435 ± 0.062
0.239MetCys: 0.239 ± 0.024
1.393MetAsp: 1.393 ± 0.049
1.707MetGlu: 1.707 ± 0.058
0.809MetPhe: 0.809 ± 0.038
1.752MetGly: 1.752 ± 0.059
0.655MetHis: 0.655 ± 0.035
1.616MetIle: 1.616 ± 0.051
1.962MetLys: 1.962 ± 0.06
2.522MetLeu: 2.522 ± 0.065
0.79MetMet: 0.79 ± 0.038
1.37MetAsn: 1.37 ± 0.045
1.313MetPro: 1.313 ± 0.044
1.136MetGln: 1.136 ± 0.043
1.77MetArg: 1.77 ± 0.052
1.262MetSer: 1.262 ± 0.047
1.627MetThr: 1.627 ± 0.062
1.41MetVal: 1.41 ± 0.057
0.211MetTrp: 0.211 ± 0.02
0.684MetTyr: 0.684 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
3.381AsnAla: 3.381 ± 0.082
0.344AsnCys: 0.344 ± 0.023
2.143AsnAsp: 2.143 ± 0.065
2.293AsnGlu: 2.293 ± 0.064
1.435AsnPhe: 1.435 ± 0.051
2.698AsnGly: 2.698 ± 0.072
0.774AsnHis: 0.774 ± 0.037
2.353AsnIle: 2.353 ± 0.062
1.958AsnLys: 1.958 ± 0.058
3.435AsnLeu: 3.435 ± 0.079
0.952AsnMet: 0.952 ± 0.04
1.516AsnAsn: 1.516 ± 0.053
2.177AsnPro: 2.177 ± 0.061
1.028AsnGln: 1.028 ± 0.036
2.569AsnArg: 2.569 ± 0.063
1.715AsnSer: 1.715 ± 0.056
2.199AsnThr: 2.199 ± 0.069
2.43AsnVal: 2.43 ± 0.072
0.382AsnTrp: 0.382 ± 0.027
1.615AsnTyr: 1.615 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
4.066ProAla: 4.066 ± 0.104
0.393ProCys: 0.393 ± 0.025
3.288ProAsp: 3.288 ± 0.074
3.512ProGlu: 3.512 ± 0.08
1.908ProPhe: 1.908 ± 0.056
2.923ProGly: 2.923 ± 0.069
0.926ProHis: 0.926 ± 0.037
2.564ProIle: 2.564 ± 0.068
2.088ProLys: 2.088 ± 0.095
3.854ProLeu: 3.854 ± 0.08
1.039ProMet: 1.039 ± 0.04
1.532ProAsn: 1.532 ± 0.045
1.606ProPro: 1.606 ± 0.075
1.425ProGln: 1.425 ± 0.053
2.256ProArg: 2.256 ± 0.062
2.317ProSer: 2.317 ± 0.066
2.999ProThr: 2.999 ± 0.102
2.915ProVal: 2.915 ± 0.075
0.472ProTrp: 0.472 ± 0.031
1.732ProTyr: 1.732 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
2.84GlnAla: 2.84 ± 0.072
0.293GlnCys: 0.293 ± 0.021
1.314GlnAsp: 1.314 ± 0.045
1.7GlnGlu: 1.7 ± 0.052
1.097GlnPhe: 1.097 ± 0.041
1.884GlnGly: 1.884 ± 0.055
0.678GlnHis: 0.678 ± 0.03
1.897GlnIle: 1.897 ± 0.06
1.667GlnLys: 1.667 ± 0.054
3.069GlnLeu: 3.069 ± 0.074
0.957GlnMet: 0.957 ± 0.042
1.122GlnAsn: 1.122 ± 0.043
1.538GlnPro: 1.538 ± 0.057
1.418GlnGln: 1.418 ± 0.06
2.183GlnArg: 2.183 ± 0.062
1.775GlnSer: 1.775 ± 0.059
2.0GlnThr: 2.0 ± 0.058
1.986GlnVal: 1.986 ± 0.063
0.379GlnTrp: 0.379 ± 0.024
1.068GlnTyr: 1.068 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
5.331ArgAla: 5.331 ± 0.109
0.695ArgCys: 0.695 ± 0.033
3.388ArgAsp: 3.388 ± 0.069
4.647ArgGlu: 4.647 ± 0.094
3.04ArgPhe: 3.04 ± 0.071
4.099ArgGly: 4.099 ± 0.083
1.675ArgHis: 1.675 ± 0.051
4.794ArgIle: 4.794 ± 0.087
3.239ArgLys: 3.239 ± 0.076
7.299ArgLeu: 7.299 ± 0.135
2.072ArgMet: 2.072 ± 0.063
2.559ArgAsn: 2.559 ± 0.06
3.082ArgPro: 3.082 ± 0.078
2.388ArgGln: 2.388 ± 0.069
5.955ArgArg: 5.955 ± 0.152
3.64ArgSer: 3.64 ± 0.09
4.096ArgThr: 4.096 ± 0.083
4.242ArgVal: 4.242 ± 0.08
0.863ArgTrp: 0.863 ± 0.036
2.951ArgTyr: 2.951 ± 0.08
0.0ArgXaa: 0.0 ± 0.0
Ser
4.727SerAla: 4.727 ± 0.097
0.581SerCys: 0.581 ± 0.034
3.339SerAsp: 3.339 ± 0.084
3.228SerGlu: 3.228 ± 0.079
2.67SerPhe: 2.67 ± 0.068
4.504SerGly: 4.504 ± 0.102
1.145SerHis: 1.145 ± 0.039
3.353SerIle: 3.353 ± 0.076
2.348SerLys: 2.348 ± 0.064
5.473SerLeu: 5.473 ± 0.108
1.385SerMet: 1.385 ± 0.054
2.0SerAsn: 2.0 ± 0.059
2.586SerPro: 2.586 ± 0.068
1.419SerGln: 1.419 ± 0.051
3.336SerArg: 3.336 ± 0.082
3.254SerSer: 3.254 ± 0.131
3.048SerThr: 3.048 ± 0.075
3.935SerVal: 3.935 ± 0.087
0.539SerTrp: 0.539 ± 0.03
2.259SerTyr: 2.259 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
5.496ThrAla: 5.496 ± 0.109
0.57ThrCys: 0.57 ± 0.032
3.992ThrAsp: 3.992 ± 0.077
3.419ThrGlu: 3.419 ± 0.077
2.707ThrPhe: 2.707 ± 0.065
4.413ThrGly: 4.413 ± 0.104
1.384ThrHis: 1.384 ± 0.05
3.835ThrIle: 3.835 ± 0.091
2.267ThrLys: 2.267 ± 0.058
6.401ThrLeu: 6.401 ± 0.104
1.173ThrMet: 1.173 ± 0.045
1.932ThrAsn: 1.932 ± 0.06
3.513ThrPro: 3.513 ± 0.106
1.729ThrGln: 1.729 ± 0.06
3.316ThrArg: 3.316 ± 0.073
3.051ThrSer: 3.051 ± 0.071
3.519ThrThr: 3.519 ± 0.094
4.381ThrVal: 4.381 ± 0.095
0.687ThrTrp: 0.687 ± 0.035
2.445ThrTyr: 2.445 ± 0.074
0.0ThrXaa: 0.0 ± 0.0
Val
5.885ValAla: 5.885 ± 0.118
0.998ValCys: 0.998 ± 0.044
3.98ValAsp: 3.98 ± 0.075
4.022ValGlu: 4.022 ± 0.081
2.693ValPhe: 2.693 ± 0.072
4.766ValGly: 4.766 ± 0.096
1.337ValHis: 1.337 ± 0.044
3.908ValIle: 3.908 ± 0.086
3.424ValLys: 3.424 ± 0.084
5.57ValLeu: 5.57 ± 0.123
1.721ValMet: 1.721 ± 0.055
2.601ValAsn: 2.601 ± 0.066
2.848ValPro: 2.848 ± 0.077
1.792ValGln: 1.792 ± 0.053
4.712ValArg: 4.712 ± 0.085
4.117ValSer: 4.117 ± 0.08
3.977ValThr: 3.977 ± 0.097
4.852ValVal: 4.852 ± 0.099
0.809ValTrp: 0.809 ± 0.036
2.428ValTyr: 2.428 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
0.818TrpAla: 0.818 ± 0.04
0.134TrpCys: 0.134 ± 0.015
0.604TrpAsp: 0.604 ± 0.034
0.604TrpGlu: 0.604 ± 0.03
0.419TrpPhe: 0.419 ± 0.026
0.763TrpGly: 0.763 ± 0.034
0.296TrpHis: 0.296 ± 0.024
0.72TrpIle: 0.72 ± 0.033
0.602TrpLys: 0.602 ± 0.027
1.076TrpLeu: 1.076 ± 0.045
0.416TrpMet: 0.416 ± 0.027
0.431TrpAsn: 0.431 ± 0.027
0.28TrpPro: 0.28 ± 0.022
0.488TrpGln: 0.488 ± 0.03
0.752TrpArg: 0.752 ± 0.035
0.547TrpSer: 0.547 ± 0.034
0.624TrpThr: 0.624 ± 0.035
0.659TrpVal: 0.659 ± 0.034
0.148TrpTrp: 0.148 ± 0.015
0.408TrpTyr: 0.408 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.464TyrAla: 3.464 ± 0.079
0.448TyrCys: 0.448 ± 0.027
2.354TyrAsp: 2.354 ± 0.07
2.085TyrGlu: 2.085 ± 0.059
1.794TyrPhe: 1.794 ± 0.052
2.713TyrGly: 2.713 ± 0.073
0.911TyrHis: 0.911 ± 0.045
2.21TyrIle: 2.21 ± 0.056
1.733TyrLys: 1.733 ± 0.05
3.786TyrLeu: 3.786 ± 0.082
0.932TyrMet: 0.932 ± 0.037
1.706TyrAsn: 1.706 ± 0.06
1.795TyrPro: 1.795 ± 0.053
0.951TyrGln: 0.951 ± 0.04
2.881TyrArg: 2.881 ± 0.068
2.153TyrSer: 2.153 ± 0.073
2.599TyrThr: 2.599 ± 0.066
2.427TyrVal: 2.427 ± 0.063
0.385TyrTrp: 0.385 ± 0.023
1.673TyrTyr: 1.673 ± 0.062
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1968 proteins (648991 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski