Amino acid dipepetide frequency for Algoriphagus machipongonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.608AlaAla: 4.608 ± 0.08	0.546AlaCys: 0.546 ± 0.021	3.452AlaAsp: 3.452 ± 0.065	4.352AlaGlu: 4.352 ± 0.063	3.377AlaPhe: 3.377 ± 0.052	4.967AlaGly: 4.967 ± 0.068	1.094AlaHis: 1.094 ± 0.03	4.985AlaIle: 4.985 ± 0.068	4.325AlaLys: 4.325 ± 0.059	6.061AlaLeu: 6.061 ± 0.076	1.78AlaMet: 1.78 ± 0.045	3.073AlaAsn: 3.073 ± 0.047	2.253AlaPro: 2.253 ± 0.045	2.379AlaGln: 2.379 ± 0.044	2.165AlaArg: 2.165 ± 0.037	4.477AlaSer: 4.477 ± 0.06	3.239AlaThr: 3.239 ± 0.113	4.017AlaVal: 4.017 ± 0.073	0.797AlaTrp: 0.797 ± 0.021	2.435AlaTyr: 2.435 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.392CysAla: 0.392 ± 0.018	0.085CysCys: 0.085 ± 0.007	0.344CysAsp: 0.344 ± 0.016	0.405CysGlu: 0.405 ± 0.02	0.377CysPhe: 0.377 ± 0.017	0.554CysGly: 0.554 ± 0.022	0.193CysHis: 0.193 ± 0.013	0.447CysIle: 0.447 ± 0.02	0.333CysLys: 0.333 ± 0.016	0.598CysLeu: 0.598 ± 0.02	0.133CysMet: 0.133 ± 0.012	0.3CysAsn: 0.3 ± 0.016	0.284CysPro: 0.284 ± 0.016	0.274CysGln: 0.274 ± 0.014	0.202CysArg: 0.202 ± 0.011	0.487CysSer: 0.487 ± 0.019	0.336CysThr: 0.336 ± 0.014	0.336CysVal: 0.336 ± 0.016	0.061CysTrp: 0.061 ± 0.007	0.235CysTyr: 0.235 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.271AspAla: 3.271 ± 0.059	0.337AspCys: 0.337 ± 0.016	2.497AspAsp: 2.497 ± 0.055	3.958AspGlu: 3.958 ± 0.053	3.756AspPhe: 3.756 ± 0.06	4.127AspGly: 4.127 ± 0.076	1.091AspHis: 1.091 ± 0.029	3.721AspIle: 3.721 ± 0.062	3.286AspLys: 3.286 ± 0.054	6.082AspLeu: 6.082 ± 0.082	1.256AspMet: 1.256 ± 0.032	2.286AspAsn: 2.286 ± 0.048	2.86AspPro: 2.86 ± 0.066	2.64AspGln: 2.64 ± 0.042	2.199AspArg: 2.199 ± 0.039	3.482AspSer: 3.482 ± 0.059	2.271AspThr: 2.271 ± 0.041	3.146AspVal: 3.146 ± 0.082	0.901AspTrp: 0.901 ± 0.024	2.551AspTyr: 2.551 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	4.659GluAla: 4.659 ± 0.065	0.271GluCys: 0.271 ± 0.015	3.914GluAsp: 3.914 ± 0.056	6.282GluGlu: 6.282 ± 0.113	3.329GluPhe: 3.329 ± 0.056	4.626GluGly: 4.626 ± 0.073	1.012GluHis: 1.012 ± 0.031	5.783GluIle: 5.783 ± 0.075	6.139GluLys: 6.139 ± 0.087	6.949GluLeu: 6.949 ± 0.074	1.969GluMet: 1.969 ± 0.042	4.539GluAsn: 4.539 ± 0.058	1.953GluPro: 1.953 ± 0.041	2.261GluGln: 2.261 ± 0.047	2.612GluArg: 2.612 ± 0.049	4.244GluSer: 4.244 ± 0.057	3.44GluThr: 3.44 ± 0.055	4.999GluVal: 4.999 ± 0.07	0.859GluTrp: 0.859 ± 0.024	2.365GluTyr: 2.365 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.175PheAla: 3.175 ± 0.057	0.392PheCys: 0.392 ± 0.015	3.317PheAsp: 3.317 ± 0.052	3.702PheGlu: 3.702 ± 0.056	2.81PhePhe: 2.81 ± 0.054	3.868PheGly: 3.868 ± 0.06	0.94PheHis: 0.94 ± 0.034	3.501PheIle: 3.501 ± 0.055	3.016PheLys: 3.016 ± 0.054	5.246PheLeu: 5.246 ± 0.074	1.151PheMet: 1.151 ± 0.033	2.695PheAsn: 2.695 ± 0.046	2.039PhePro: 2.039 ± 0.037	2.09PheGln: 2.09 ± 0.042	1.933PheArg: 1.933 ± 0.037	4.16PheSer: 4.16 ± 0.054	2.945PheThr: 2.945 ± 0.055	2.858PheVal: 2.858 ± 0.046	0.75PheTrp: 0.75 ± 0.026	2.04PheTyr: 2.04 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	4.418GlyAla: 4.418 ± 0.067	0.477GlyCys: 0.477 ± 0.021	3.854GlyAsp: 3.854 ± 0.077	4.771GlyGlu: 4.771 ± 0.07	4.049GlyPhe: 4.049 ± 0.052	5.295GlyGly: 5.295 ± 0.111	1.208GlyHis: 1.208 ± 0.032	5.692GlyIle: 5.692 ± 0.07	5.422GlyLys: 5.422 ± 0.076	6.721GlyLeu: 6.721 ± 0.079	1.99GlyMet: 1.99 ± 0.041	3.791GlyAsn: 3.791 ± 0.082	1.957GlyPro: 1.957 ± 0.034	2.262GlyGln: 2.262 ± 0.051	2.573GlyArg: 2.573 ± 0.049	4.506GlySer: 4.506 ± 0.082	3.979GlyThr: 3.979 ± 0.087	4.802GlyVal: 4.802 ± 0.066	0.953GlyTrp: 0.953 ± 0.027	2.939GlyTyr: 2.939 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.017HisAla: 1.017 ± 0.028	0.155HisCys: 0.155 ± 0.011	0.826HisAsp: 0.826 ± 0.024	1.088HisGlu: 1.088 ± 0.027	1.131HisPhe: 1.131 ± 0.031	1.26HisGly: 1.26 ± 0.033	0.461HisHis: 0.461 ± 0.02	1.099HisIle: 1.099 ± 0.027	0.84HisLys: 0.84 ± 0.025	1.908HisLeu: 1.908 ± 0.043	0.389HisMet: 0.389 ± 0.018	0.661HisAsn: 0.661 ± 0.024	1.01HisPro: 1.01 ± 0.026	0.812HisGln: 0.812 ± 0.026	0.701HisArg: 0.701 ± 0.024	1.112HisSer: 1.112 ± 0.033	0.834HisThr: 0.834 ± 0.025	1.005HisVal: 1.005 ± 0.027	0.293HisTrp: 0.293 ± 0.017	0.726HisTyr: 0.726 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	4.978IleAla: 4.978 ± 0.067	0.573IleCys: 0.573 ± 0.022	4.172IleAsp: 4.172 ± 0.064	4.789IleGlu: 4.789 ± 0.061	3.556IlePhe: 3.556 ± 0.055	5.16IleGly: 5.16 ± 0.069	1.45IleHis: 1.45 ± 0.031	4.641IleIle: 4.641 ± 0.062	4.551IleLys: 4.551 ± 0.06	7.119IleLeu: 7.119 ± 0.094	1.353IleMet: 1.353 ± 0.034	3.781IleAsn: 3.781 ± 0.065	3.583IlePro: 3.583 ± 0.052	3.044IleGln: 3.044 ± 0.05	2.83IleArg: 2.83 ± 0.053	5.845IleSer: 5.845 ± 0.063	3.926IleThr: 3.926 ± 0.083	3.855IleVal: 3.855 ± 0.059	0.863IleTrp: 0.863 ± 0.027	2.534IleTyr: 2.534 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.772LysAla: 4.772 ± 0.063	0.252LysCys: 0.252 ± 0.013	3.897LysAsp: 3.897 ± 0.057	5.724LysGlu: 5.724 ± 0.098	2.694LysPhe: 2.694 ± 0.053	4.489LysGly: 4.489 ± 0.062	1.062LysHis: 1.062 ± 0.03	5.315LysIle: 5.315 ± 0.07	5.343LysLys: 5.343 ± 0.082	6.051LysLeu: 6.051 ± 0.085	1.842LysMet: 1.842 ± 0.038	3.812LysAsn: 3.812 ± 0.062	2.598LysPro: 2.598 ± 0.052	1.944LysGln: 1.944 ± 0.042	2.476LysArg: 2.476 ± 0.044	4.819LysSer: 4.819 ± 0.066	3.647LysThr: 3.647 ± 0.052	4.537LysVal: 4.537 ± 0.06	0.77LysTrp: 0.77 ± 0.022	2.478LysTyr: 2.478 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	6.768LeuAla: 6.768 ± 0.087	0.645LeuCys: 0.645 ± 0.025	5.727LeuAsp: 5.727 ± 0.073	7.143LeuGlu: 7.143 ± 0.086	4.88LeuPhe: 4.88 ± 0.069	6.964LeuGly: 6.964 ± 0.083	1.458LeuHis: 1.458 ± 0.037	7.293LeuIle: 7.293 ± 0.092	6.984LeuLys: 6.984 ± 0.091	8.973LeuLeu: 8.973 ± 0.121	2.304LeuMet: 2.304 ± 0.047	5.015LeuAsn: 5.015 ± 0.069	4.114LeuPro: 4.114 ± 0.059	3.074LeuGln: 3.074 ± 0.054	3.337LeuArg: 3.337 ± 0.056	6.855LeuSer: 6.855 ± 0.073	5.12LeuThr: 5.12 ± 0.101	6.006LeuVal: 6.006 ± 0.07	1.006LeuTrp: 1.006 ± 0.028	2.994LeuTyr: 2.994 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	1.867MetAla: 1.867 ± 0.041	0.106MetCys: 0.106 ± 0.009	1.547MetAsp: 1.547 ± 0.039	1.826MetGlu: 1.826 ± 0.043	0.821MetPhe: 0.821 ± 0.023	1.797MetGly: 1.797 ± 0.041	0.39MetHis: 0.39 ± 0.017	1.815MetIle: 1.815 ± 0.042	2.162MetLys: 2.162 ± 0.043	2.032MetLeu: 2.032 ± 0.042	0.703MetMet: 0.703 ± 0.025	1.328MetAsn: 1.328 ± 0.032	1.015MetPro: 1.015 ± 0.031	0.747MetGln: 0.747 ± 0.025	0.955MetArg: 0.955 ± 0.027	1.464MetSer: 1.464 ± 0.03	1.209MetThr: 1.209 ± 0.03	1.6MetVal: 1.6 ± 0.038	0.2MetTrp: 0.2 ± 0.012	0.622MetTyr: 0.622 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.989AsnAla: 2.989 ± 0.06	0.338AsnCys: 0.338 ± 0.017	2.413AsnAsp: 2.413 ± 0.044	3.298AsnGlu: 3.298 ± 0.046	2.852AsnPhe: 2.852 ± 0.051	3.683AsnGly: 3.683 ± 0.071	0.936AsnHis: 0.936 ± 0.029	3.373AsnIle: 3.373 ± 0.053	3.003AsnLys: 3.003 ± 0.059	5.387AsnLeu: 5.387 ± 0.064	1.202AsnMet: 1.202 ± 0.031	2.438AsnAsn: 2.438 ± 0.054	3.14AsnPro: 3.14 ± 0.06	2.393AsnGln: 2.393 ± 0.041	2.099AsnArg: 2.099 ± 0.04	3.729AsnSer: 3.729 ± 0.06	2.713AsnThr: 2.713 ± 0.083	2.812AsnVal: 2.812 ± 0.087	0.84AsnTrp: 0.84 ± 0.025	2.376AsnTyr: 2.376 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	2.553ProAla: 2.553 ± 0.051	0.171ProCys: 0.171 ± 0.011	2.685ProAsp: 2.685 ± 0.048	3.847ProGlu: 3.847 ± 0.057	2.157ProPhe: 2.157 ± 0.041	2.898ProGly: 2.898 ± 0.064	0.68ProHis: 0.68 ± 0.022	2.914ProIle: 2.914 ± 0.048	2.689ProLys: 2.689 ± 0.046	3.382ProLeu: 3.382 ± 0.053	0.91ProMet: 0.91 ± 0.022	2.347ProAsn: 2.347 ± 0.043	1.021ProPro: 1.021 ± 0.032	1.211ProGln: 1.211 ± 0.029	1.125ProArg: 1.125 ± 0.027	2.774ProSer: 2.774 ± 0.051	2.079ProThr: 2.079 ± 0.045	2.803ProVal: 2.803 ± 0.047	0.519ProTrp: 0.519 ± 0.021	1.516ProTyr: 1.516 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	2.458GlnAla: 2.458 ± 0.055	0.141GlnCys: 0.141 ± 0.009	1.891GlnAsp: 1.891 ± 0.036	2.939GlnGlu: 2.939 ± 0.05	1.752GlnPhe: 1.752 ± 0.036	2.245GlnGly: 2.245 ± 0.037	0.534GlnHis: 0.534 ± 0.021	2.734GlnIle: 2.734 ± 0.046	2.888GlnLys: 2.888 ± 0.048	3.564GlnLeu: 3.564 ± 0.063	0.936GlnMet: 0.936 ± 0.028	2.046GlnAsn: 2.046 ± 0.047	1.264GlnPro: 1.264 ± 0.028	1.273GlnGln: 1.273 ± 0.035	1.299GlnArg: 1.299 ± 0.037	2.329GlnSer: 2.329 ± 0.04	1.871GlnThr: 1.871 ± 0.058	2.632GlnVal: 2.632 ± 0.041	0.41GlnTrp: 0.41 ± 0.018	1.251GlnTyr: 1.251 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	2.185ArgAla: 2.185 ± 0.038	0.173ArgCys: 0.173 ± 0.01	1.945ArgAsp: 1.945 ± 0.036	2.652ArgGlu: 2.652 ± 0.049	2.009ArgPhe: 2.009 ± 0.044	2.297ArgGly: 2.297 ± 0.043	0.577ArgHis: 0.577 ± 0.02	2.932ArgIle: 2.932 ± 0.046	2.792ArgLys: 2.792 ± 0.062	3.349ArgLeu: 3.349 ± 0.059	1.07ArgMet: 1.07 ± 0.029	2.104ArgAsn: 2.104 ± 0.04	1.351ArgPro: 1.351 ± 0.031	1.21ArgGln: 1.21 ± 0.035	1.4ArgArg: 1.4 ± 0.04	2.172ArgSer: 2.172 ± 0.042	1.857ArgThr: 1.857 ± 0.035	2.369ArgVal: 2.369 ± 0.041	0.445ArgTrp: 0.445 ± 0.019	1.49ArgTyr: 1.49 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	3.791SerAla: 3.791 ± 0.058	0.608SerCys: 0.608 ± 0.022	3.813SerAsp: 3.813 ± 0.058	4.695SerGlu: 4.695 ± 0.066	3.937SerPhe: 3.937 ± 0.051	5.285SerGly: 5.285 ± 0.084	1.202SerHis: 1.202 ± 0.029	5.104SerIle: 5.104 ± 0.068	4.677SerLys: 4.677 ± 0.078	6.841SerLeu: 6.841 ± 0.085	1.551SerMet: 1.551 ± 0.033	3.519SerAsn: 3.519 ± 0.063	2.769SerPro: 2.769 ± 0.051	2.683SerGln: 2.683 ± 0.05	2.456SerArg: 2.456 ± 0.049	4.83SerSer: 4.83 ± 0.06	3.377SerThr: 3.377 ± 0.054	3.937SerVal: 3.937 ± 0.063	0.876SerTrp: 0.876 ± 0.028	2.77SerTyr: 2.77 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	3.473ThrAla: 3.473 ± 0.119	0.322ThrCys: 0.322 ± 0.016	2.808ThrAsp: 2.808 ± 0.058	3.229ThrGlu: 3.229 ± 0.049	2.813ThrPhe: 2.813 ± 0.051	4.283ThrGly: 4.283 ± 0.109	0.899ThrHis: 0.899 ± 0.028	3.807ThrIle: 3.807 ± 0.074	2.924ThrLys: 2.924 ± 0.046	5.232ThrLeu: 5.232 ± 0.091	1.01ThrMet: 1.01 ± 0.026	2.451ThrAsn: 2.451 ± 0.076	2.49ThrPro: 2.49 ± 0.047	1.848ThrGln: 1.848 ± 0.054	1.676ThrArg: 1.676 ± 0.039	3.422ThrSer: 3.422 ± 0.06	2.583ThrThr: 2.583 ± 0.064	3.34ThrVal: 3.34 ± 0.102	0.759ThrTrp: 0.759 ± 0.028	2.133ThrTyr: 2.133 ± 0.073	0.0ThrXaa: 0.0 ± 0.0
Val	4.038ValAla: 4.038 ± 0.063	0.45ValCys: 0.45 ± 0.017	3.687ValAsp: 3.687 ± 0.054	4.128ValGlu: 4.128 ± 0.058	3.319ValPhe: 3.319 ± 0.045	4.263ValGly: 4.263 ± 0.069	1.07ValHis: 1.07 ± 0.031	4.438ValIle: 4.438 ± 0.07	4.079ValLys: 4.079 ± 0.061	6.01ValLeu: 6.01 ± 0.084	1.488ValMet: 1.488 ± 0.032	3.391ValAsn: 3.391 ± 0.072	2.494ValPro: 2.494 ± 0.043	1.948ValGln: 1.948 ± 0.041	2.174ValArg: 2.174 ± 0.042	4.465ValSer: 4.465 ± 0.07	3.394ValThr: 3.394 ± 0.138	3.831ValVal: 3.831 ± 0.073	0.745ValTrp: 0.745 ± 0.024	2.288ValTyr: 2.288 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.766TrpAla: 0.766 ± 0.023	0.078TrpCys: 0.078 ± 0.007	0.76TrpAsp: 0.76 ± 0.022	0.957TrpGlu: 0.957 ± 0.027	0.607TrpPhe: 0.607 ± 0.024	0.894TrpGly: 0.894 ± 0.027	0.245TrpHis: 0.245 ± 0.013	0.912TrpIle: 0.912 ± 0.027	0.982TrpLys: 0.982 ± 0.026	1.164TrpLeu: 1.164 ± 0.035	0.42TrpMet: 0.42 ± 0.019	0.716TrpAsn: 0.716 ± 0.024	0.402TrpPro: 0.402 ± 0.018	0.474TrpGln: 0.474 ± 0.02	0.488TrpArg: 0.488 ± 0.018	0.746TrpSer: 0.746 ± 0.028	0.689TrpThr: 0.689 ± 0.026	0.812TrpVal: 0.812 ± 0.023	0.207TrpTrp: 0.207 ± 0.015	0.464TrpTyr: 0.464 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.204TyrAla: 2.204 ± 0.039	0.256TyrCys: 0.256 ± 0.013	2.169TyrAsp: 2.169 ± 0.045	2.421TyrGlu: 2.421 ± 0.043	2.404TyrPhe: 2.404 ± 0.049	2.704TyrGly: 2.704 ± 0.049	0.824TyrHis: 0.824 ± 0.027	2.099TyrIle: 2.099 ± 0.041	2.086TyrLys: 2.086 ± 0.042	3.993TyrLeu: 3.993 ± 0.055	0.747TyrMet: 0.747 ± 0.026	1.719TyrAsn: 1.719 ± 0.037	1.683TyrPro: 1.683 ± 0.041	1.89TyrGln: 1.89 ± 0.036	1.682TyrArg: 1.682 ± 0.035	2.804TyrSer: 2.804 ± 0.047	1.993TyrThr: 1.993 ± 0.07	2.001TyrVal: 2.001 ± 0.042	0.529TyrTrp: 0.529 ± 0.019	1.67TyrTyr: 1.67 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3932 proteins (1430355 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---